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Searching for up to 100 curated homologs for BPHYT_RS22385 FitnessBrowser__BFirm:BPHYT_RS22385 (309 a.a.)

Found high-coverage hits (≥70%) to 18 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

cdhC / Q9HTH7 3-dehydrocarnitine cleavage enzyme from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    87% identity, 95% coverage of query (494 bits)

Pf6N2E2_4692 dehydrocarnitine cleavage enzyme (EC 2.3.1.-) from Pseudomonas fluorescens FW300-N2E2
    81% identity, 96% coverage of query (470 bits)

kce / Q8RHX2 3-keto,5-aminohexanoate cleavage enzyme subunit (EC 2.3.1.247) from Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355) (see 2 papers)
KCE_FUSNN / Q8RHX2 3-keto-5-aminohexanoate cleavage enzyme; EC 2.3.1.247 from Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355) (see 2 papers)
Q8RHX2 3-keto-5-aminohexanoate cleavage enzyme (EC 2.3.1.247) from Fusobacterium nucleatum subsp. nucleatum (see 2 papers)
    39% identity, 94% coverage of query (192 bits)

3lotD / O29058 Crystal structure of protein of unknown function (np_070038.1) from archaeoglobus fulgidus at 1.89 a resolution
    37% identity, 94% coverage of query (168 bits)

3e49A / Q13GE9 Crystal structure of a prokaryotic domain of unknown function (duf849) with a tim barrel fold (bxe_c0966) from burkholderia xenovorans lb400 at 1.75 a resolution
    33% identity, 94% coverage of query (155 bits)

2y7dD / B0VHH0 Crystal structure of the 3-keto-5-aminohexanoate cleavage enzyme (kce) from candidatus cloacamonas acidaminovorans (orthorombic form) (see paper)
    35% identity, 94% coverage of query (153 bits)

2y7fD Crystal structure of the 3-keto-5-aminohexanoate cleavage enzyme (kce) from c. Cloacamonas acidaminovorans in complex with the substrate 3- keto-5-aminohexanoate
    35% identity, 94% coverage of query (153 bits)

2y7fA Crystal structure of the 3-keto-5-aminohexanoate cleavage enzyme (kce) from c. Cloacamonas acidaminovorans in complex with the substrate 3- keto-5-aminohexanoate
    35% identity, 94% coverage of query (153 bits)

2y7gA Crystal structure of the 3-keto-5-aminohexanoate cleavage enzyme (kce) from c. Cloacamonas acidaminovorans in complex with the product acetoacetate
    35% identity, 94% coverage of query (153 bits)

KCE_CLOAI / B0VHH0 3-keto-5-aminohexanoate cleavage enzyme; EC 2.3.1.247 from Cloacimonas acidaminovorans (strain Evry) (see paper)
B0VHH0 3-keto-5-aminohexanoate cleavage enzyme (EC 2.3.1.247) from Candidatus Cloacimonas acidaminovorans (see paper)
kce / CAO80785.1 3-keto-5-aminohexanoate cleavage enzyme from Candidatus Cloacimonas acidaminovorans str. Evry (see paper)
    35% identity, 93% coverage of query (152 bits)

H281DRAFT_00641 2-deoxy-3-keto-D-ribonate cleavage enzyme from Paraburkholderia bryophila 376MFSha3.1
    33% identity, 94% coverage of query (149 bits)

PS417_07250 2-deoxy-3-keto-D-ribonoate cleavage enzyme from Pseudomonas simiae WCS417
    35% identity, 96% coverage of query (146 bits)

3e02A / Q13I95 Crystal structure of a duf849 family protein (bxe_c0271) from burkholderia xenovorans lb400 at 1.90 a resolution
    33% identity, 94% coverage of query (141 bits)

3chvA / Q6SJB6 Crystal structure of a prokaryotic domain of unknown function (duf849) member (spoa0042) from silicibacter pomeroyi dss-3 at 1.45 a resolution
    31% identity, 95% coverage of query (125 bits)

3fa5A / A1B7S1 Crystal structure of a duf849 family protein (pden_3495) from paracoccus denitrificans pd1222 at 1.90 a resolution
    32% identity, 93% coverage of query (122 bits)

3no5E / Q471D6 Crystal structure of a pfam duf849 domain containing protein (reut_a1631) from ralstonia eutropha jmp134 at 1.90 a resolution
    30% identity, 94% coverage of query (121 bits)

5zmuD / F1LJ99 Crystal structure of a cis-epoxysuccinate hydrolase producing d(-)- tartaric acids (see paper)
    32% identity, 88% coverage of query (101 bits)

5zmyA Crystal structure of a cis-epoxysuccinate hydrolase producing d(-)- tartaric acids
    31% identity, 88% coverage of query (91.7 bits)

Build an alignment

Build an alignment for BPHYT_RS22385 and 18 homologs with ≥ 30% identity

Select sequences

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory