Searching for up to 100 curated homologs for BPHYT_RS25960 FitnessBrowser__BFirm:BPHYT_RS25960 (304 a.a.)
Found high-coverage hits (≥70%) to 74 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
Ac3H11_2560 ABC transporter for L-Histidine, ATPase component from Acidovorax sp. GW101-3H11
55% identity, 79% coverage of query (274 bits)
TC 3.A.1.16.2 / O05347 CynD, component of Bispecific cyanate/nitrite transporter
49% identity, 80% coverage of query (231 bits)
NRTD_SYNE7 / P38046 Nitrate import ATP-binding protein NrtD; EC 7.3.2.4 from Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) (Anacystis nidulans R2) (see paper)
TC 3.A.1.16.1 / P38046 NrtD, component of Four component nitrate/nitrite porter (see paper)
47% identity, 79% coverage of query (223 bits)
CMPD_SYNE7 / Q55108 Bicarbonate transport ATP-binding protein CmpD; EC 7.6.2.- from Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) (Anacystis nidulans R2) (see paper)
TC 3.A.1.16.3 / Q55108 CmpD, component of Bicarbonate porter (activated by low [CO2] mediated by CmpR; (Nishimura et al., 2008)) (see 2 papers)
45% identity, 76% coverage of query (216 bits)
CMPC_SYNE7 / Q55107 Bicarbonate transport ATP-binding protein CmpC; EC 7.6.2.- from Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805) (Anacystis nidulans R2) (see paper)
TC 3.A.1.16.3 / Q55107 CmpC, component of Bicarbonate porter (activated by low [CO2] mediated by CmpR; (Nishimura et al., 2008)) (see 2 papers)
45% identity, 80% coverage of query (211 bits)
SSUB_BACSU / P97027 Aliphatic sulfonates import ATP-binding protein SsuB; EC 7.6.2.14 from Bacillus subtilis (strain 168) (see paper)
43% identity, 80% coverage of query (207 bits)
AZOBR_RS18550 ABC transporter for nitrate, ATPase component from Azospirillum brasilense Sp245
45% identity, 81% coverage of query (198 bits)
TC 3.A.1.16.4 / Q8YRV8 Nitrate transport ATP-binding protein of ABC transporter, component of Nitrate uptake system, NrtABCD from Nostoc sp. (strain PCC 7120 / UTEX 2576) (see paper)
43% identity, 79% coverage of query (195 bits)
Q6RH47 taurine dehydrogenase (EC 1.4.99.2) from Paracoccus pantotrophus (see paper)
42% identity, 76% coverage of query (192 bits)
TauB / b0366 taurine ABC transporter ATP binding subunit (EC 7.6.2.7) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
TauB / Q47538 taurine ABC transporter ATP binding subunit (EC 7.6.2.7) from Escherichia coli (strain K12) (see 3 papers)
TAUB_ECOLI / Q47538 Taurine import ATP-binding protein TauB; EC 7.6.2.7 from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.17.1 / Q47538 TauB aka SSIB aka B0366, component of Taurine (2-aminoethane sulfonate) porter from Escherichia coli (see 4 papers)
44% identity, 75% coverage of query (192 bits)
TC 3.A.1.17.5 / C0LZR9 OphH, component of The phthalate uptake system, OphFGH from Burkholderia cepacia
44% identity, 74% coverage of query (191 bits)
TC 3.A.1.17.4 / Q2BM69 Putative taurin uptake ABC transporter ATP-binding protein, component of The taurine uptake system, TauABC from Neptuniibacter caesariensis
39% identity, 81% coverage of query (189 bits)
PotG / b0855 putrescine ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
PotG / P31134 putrescine ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 2 papers)
POTG_ECOLI / P31134 Putrescine transport ATP-binding protein PotG; EC 7.6.2.16 from Escherichia coli (strain K12) (see 2 papers)
TC 3.A.1.11.2 / P31134 PotG aka B0855, component of Putrescine porter from Escherichia coli (see 4 papers)
39% identity, 81% coverage of query (178 bits)
TC 3.A.1.6.7 / Q6QJE1 Chloroplast ATP-binding protein, component of The chloroplast sulfate transporter, SulP/SulP2/Sabc/Sbp from Chlamydomonas reinhardtii (see 2 papers)
43% identity, 74% coverage of query (175 bits)
TC 3.A.1.10.2 / P74127 FutC aka SLL1878, component of Ferric iron (Fe3+) porter (see paper)
43% identity, 70% coverage of query (175 bits)
PotA / b1126 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11; EC 7.6.2.16) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
PotA / P69874 spermidine preferential ABC transporter ATP binding subunit (EC 7.6.2.11) from Escherichia coli (strain K12) (see 5 papers)
POTA_ECOLI / P69874 Spermidine/putrescine import ATP-binding protein PotA; EC 7.6.2.11 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.11.1 / P69874 Spermidine/putrescine import ATP-binding protein PotA aka B1126, component of Polyamine (putrescine/spermidine) uptake porter from Escherichia coli (see 9 papers)
potA / MB|P69874 spermidine/putrescine ABC transporter, ATP-binding protein PotA; EC 3.6.3.31 from Escherichia coli K12 (see 10 papers)
41% identity, 77% coverage of query (171 bits)
2d62A / O57933 Crystal structure of multiple sugar binding transport atp- binding protein
39% identity, 70% coverage of query (164 bits)
7ahhC Opua inhibited inward-facing, sbd docked
37% identity, 70% coverage of query (149 bits)
7aheC / Q9KIF7 Opua inhibited inward facing (see paper)
37% identity, 70% coverage of query (149 bits)
Q8TTZ3 ABC-type molybdate transporter (EC 7.3.2.5) from Methanosarcina acetivorans (see paper)
3d31A / Q8TTZ3 Modbc from methanosarcina acetivorans (see paper)
36% identity, 73% coverage of query (138 bits)
4u00A / Q5SJ55 Crystal structure of ttha1159 in complex with adp (see paper)
37% identity, 81% coverage of query (136 bits)
1f3oA / Q58206 Crystal structure of mj0796 atp-binding cassette (see paper)
38% identity, 70% coverage of query (135 bits)
1l2tA Dimeric structure of mj0796, a bacterial abc transporter cassette
37% identity, 70% coverage of query (134 bits)
1vciA / O57758 Crystal structure of the atp-binding cassette of multisugar transporter from pyrococcus horikoshii ot3 complexed with atp (see paper)
38% identity, 73% coverage of query (134 bits)
MetN / b0199 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
MetN / P30750 L-methionine/D-methionine ABC transporter ATP binding subunit (EC 7.4.2.11) from Escherichia coli (strain K12) (see 3 papers)
METN_ECOLI / P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 7 papers)
P30750 ABC-type methionine transporter (subunit 2/2) (EC 7.4.2.11) from Escherichia coli (see 3 papers)
TC 3.A.1.24.1 / P30750 MetN, D-methionine transport ATP-binding protein, component of The L- and D-methionine porter (also transports formyl-L-methionine and other methionine derivatives) (Zhang et al., 2003). The 3.7A structure of MetNI has been solved. An allosteric regulatory mechanism operates at the level of transport activity, so increased intracellular levels of the transported ligand stabilize an inward-facing, ATPase-inactive state of MetNI to inhibit further ligand translocation into the cell from Escherichia coli (see 5 papers)
37% identity, 72% coverage of query (130 bits)
3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form
37% identity, 72% coverage of query (129 bits)
3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form
37% identity, 72% coverage of query (129 bits)
6cvlD / P30750 Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
37% identity, 72% coverage of query (129 bits)
7d0aB Acinetobacter mlafedb complex in adp-vanadate trapped vclose conformation
34% identity, 70% coverage of query (118 bits)
7d08B / A0A086HZU3 Acinetobacter mlafedb complex in atp-bound vtrans1 conformation (see paper)
34% identity, 70% coverage of query (118 bits)
6z5uK Cryo-em structure of the a. Baumannii mlabdef complex bound to appnhp
34% identity, 70% coverage of query (117 bits)
5lilA / Q2EHL8 Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
33% identity, 75% coverage of query (112 bits)
5lj7A / Q2EHL8 Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
33% identity, 75% coverage of query (112 bits)
4yerA / Q9X1C3 Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
32% identity, 75% coverage of query (103 bits)
P9WQK5 Uncharacterized ABC transporter ATP-binding protein Rv0073 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
30% identity, 82% coverage of query (93.2 bits)
7ch6C / P63386 Cryo-em structure of e.Coli mlafeb with amppnp (see paper)
32% identity, 70% coverage of query (92.0 bits)
6xgyA Crystal structure of e. Coli mlafb abc transport subunits in the dimeric state
32% identity, 70% coverage of query (92.0 bits)
Build an alignment for BPHYT_RS25960 and 37 homologs with ≥ 30% identity
Or download the sequences
ABCA3_HUMAN / Q99758 Phospholipid-transporting ATPase ABCA3; ABC-C transporter; ATP-binding cassette sub-family A member 3; ATP-binding cassette transporter 3; ATP-binding cassette 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Homo sapiens (Human) (see 18 papers)
TC 3.A.1.211.5 / Q99758 The surfactant-secreting porter, ABCA3 (exports lipids and proteins into lamellar bodies). Fatal surfactant deficiency (FSD) can result from mutations in ABCA3, causing abnormal intracellular localization (type I) or decreased ATP hydrolysis (type II). Other mutations cause pediatric interstitial lung disease (pILD) from Homo sapiens (Human) (see 7 papers)
ABCA3 / RF|NP_001080.2 ATP-binding cassette sub-family A member 3 from Homo sapiens (see paper)
26% identity, 81% coverage of query (92.0 bits)
8f5bA / P78363 Human abca4 structure in complex with amp-pnp
30% identity, 76% coverage of query (91.3 bits)
7cgnB The overall structure of the mlafedb complex in atp-bound eqtall conformation (mutation of e170q on mlaf)
31% identity, 70% coverage of query (90.9 bits)
ABCA3_MOUSE / Q8R420 Phospholipid-transporting ATPase ABCA3; ATP-binding cassette sub-family A member 3; Xenobiotic-transporting ATPase ABCA3; EC 7.6.2.1; EC 7.6.2.2 from Mus musculus (Mouse) (see 7 papers)
29% identity, 75% coverage of query (90.1 bits)
7w02A / Q99758 Cryo-em structure of atp-bound abca3 (see paper)
25% identity, 84% coverage of query (90.1 bits)
7e7qA / P78363 Cryo-em structure of human abca4 in atp-bound state (see paper)
30% identity, 76% coverage of query (89.7 bits)
7lkzA Structure of atp-bound human abca4
29% identity, 76% coverage of query (89.0 bits)
1b0uA / P02915 Atp-binding subunit of the histidine permease from salmonella typhimurium (see paper)
32% identity, 70% coverage of query (87.4 bits)
HISP_SALTY / P02915 Histidine/lysine/arginine/ornithine transport ATP-binding protein HisP; EC 7.4.2.1 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
TC 3.A.1.3.1 / P02915 HisP aka STM2351, component of Histidine/arginine/lysine/ornithine porter (Heuveling et al. 2014). In contrast to some homologous homodimeric systems, the heterodimeric histidine transporter of Salmonella enterica Typhimurium from Salmonella typhimurium (see 3 papers)
RF|NP_461293.1 histidine transport atp-binding protein hisp from Salmonella enterica subsp. enterica serovar Typhimurium (see 4 papers)
33% identity, 70% coverage of query (87.4 bits)
CED7_CAEEL / P34358 ABC transporter ced-7; Cell death protein 7 from Caenorhabditis elegans (see paper)
TC 3.A.1.211.4 / P34358 The aced cell death 7 (ced-7) protein (translocates molecules that mediate adhesion between dying and engulfing embryonic cells during programmed death) from Caenorhabditis elegans (see 4 papers)
ced-7 / RF|NP_001021226.1 ABC transporter ced-7 from Caenorhabditis elegans
28% identity, 80% coverage of query (86.3 bits)
7z18I E. Coli c-p lyase bound to a phnk abc dimer and atp
28% identity, 71% coverage of query (80.9 bits)
7z15I / P16678 E. Coli c-p lyase bound to a phnk/phnl dual abc dimer and adp + pi (see paper)
28% identity, 71% coverage of query (80.9 bits)
7z16I E. Coli c-p lyase bound to phnk/phnl dual abc dimer with amppnp and phnk e171q mutation
28% identity, 71% coverage of query (79.7 bits)
6pz9C Cryo-em structure of the pancreatic beta-cell sur1 bound to atp and repaglinide
28% identity, 73% coverage of query (77.8 bits)
6tejB / A0A100XE85 Structure of apo irtab devoid sid in complex with sybody syb_nl5 (see paper)
35% identity, 76% coverage of query (77.8 bits)
6pzaC Cryo-em structure of the pancreatic beta-cell sur1 bound to atp and glibenclamide
28% identity, 73% coverage of query (77.4 bits)
3bk7A / Q9UZA4 Structure of the complete abce1/rnaase-l inhibitor protein from pyrococcus abysii (see paper)
28% identity, 76% coverage of query (77.0 bits)
6c3pE / Q09428 Cryo-em structure of human katp bound to atp and adp in propeller form (see paper)
27% identity, 73% coverage of query (76.3 bits)
6c3oE / Q09428 Cryo-em structure of human katp bound to atp and adp in quatrefoil form (see paper)
27% identity, 73% coverage of query (75.9 bits)
ABCA2_HUMAN / Q9BZC7 ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; EC 7.6.2.- from Homo sapiens (Human) (see 10 papers)
25% identity, 72% coverage of query (73.9 bits)
7w4oB The structure of katp h175k mutant in pre-open state
27% identity, 74% coverage of query (73.9 bits)
6baaE / Q09427 Cryo-em structure of the pancreatic beta-cell katp channel bound to atp and glibenclamide (see paper)
26% identity, 75% coverage of query (70.9 bits)
4ayxA / Q9NRK6 Structure of the human mitochondrial abc transporter, abcb10 (rod form b) (see paper)
32% identity, 74% coverage of query (70.9 bits)
7y48B Cryo-em structure of biliverdin-bound mitochondrial abc transporter abcb10 from biortus
32% identity, 74% coverage of query (70.9 bits)
ABCBA_HUMAN / Q9NRK6 ATP-binding cassette sub-family B member 10, mitochondrial; ABC-mitochondrial erythroid protein; ABC-me protein; ATP-binding cassette transporter 10; ABC transporter 10 protein; Mitochondrial ATP-binding cassette 2; M-ABC2 from Homo sapiens (Human) (see 7 papers)
Q9NRK6 bacterial ABC-type protein transporter (EC 7.4.2.5) from Homo sapiens (see paper)
33% identity, 74% coverage of query (70.9 bits)
5yw7B Structure of pancreatic atp-sensitive potassium channel bound with glibenclamide and atpgammas (focused refinement on sur1 abc transporter module at 4.4a)
28% identity, 75% coverage of query (70.1 bits)
6jb1B / A0A1U7R319 Structure of pancreatic atp-sensitive potassium channel bound with repaglinide and atpgammas at 3.3a resolution (see paper)
28% identity, 75% coverage of query (70.1 bits)
ABCA4_BOVIN / F1MWM0 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM protein; RmP; Retinal-specific ATP-binding cassette transporter; EC 7.6.2.1 from Bos taurus (Bovine) (see 11 papers)
25% identity, 72% coverage of query (66.2 bits)
8ee6A / Q8IZY2 Cryo-em structure of human abca7 in pe/ch nanodiscs (see paper)
24% identity, 72% coverage of query (64.7 bits)
7qkrA / F2QQK6 Cryo-em structure of abc transporter ste6-2p from pichia pastoris with verapamil at 3.2 a resolution (see paper)
28% identity, 74% coverage of query (64.7 bits)
ABCAC_MOUSE / E9Q876 Glucosylceramide transporter ABCA12; ATP-binding cassette sub-family A member 12; EC 7.6.2.1 from Mus musculus (Mouse) (see 9 papers)
24% identity, 76% coverage of query (64.3 bits)
ABCA4_HUMAN / P78363 Retinal-specific phospholipid-transporting ATPase ABCA4; ATP-binding cassette sub-family A member 4; RIM ABC transporter; RIM proteinv; RmP; Retinal-specific ATP-binding cassette transporter; Stargardt disease protein; EC 7.6.2.1 from Homo sapiens (Human) (see 38 papers)
TC 3.A.1.211.2 / P78363 The retinal-specific ABC transporter (RIM protein, ABCR or ABCA4) (Stargardt's disease protein, involved in retinal/macular degeneration) in the rod outer segment. Changes in the oligomeric state of the nucleotide binding domains of ABCR are coupled to ATP hydrolysis and might represent a signal for the TMDs of ABCR to export the bound substrate (Biswas-Fiss 2006). The ABCA4 porter flips N-retinylidene-phosphatidylethanolamine, a product generated from the photobleaching of rhodopsin, from the lumen to the cytoplasmic side of disc membranes following the photobleaching of rhodopsin, insuring that retinoids do not accumulate in disc membranes (Molday, 2007; Molday et al. 2009; Tsybovsky et al. 2013). It also transports several vitamin A derivatives (Sun, 2011) and phosphatidylethanolamine in the same direction. Mutations, known to cause Stargardt disease, decrease N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine transport activities (Quazi et al. 2012). It functions as an inwardly directed retinoid flippase in the visual cycle from Homo sapiens (Human) (see 28 papers)
25% identity, 72% coverage of query (63.9 bits)
7lkpA Structure of atp-free human abca4
25% identity, 72% coverage of query (63.2 bits)
8eopA / Q8IZY2 Cryo-em structure of nanodisc reconstituted human abca7 eq mutant in atp bound closed state (see paper)
24% identity, 72% coverage of query (63.2 bits)
7e7oA / P78363 Cryo-em structure of human abca4 in nrpe-bound state (see paper)
25% identity, 72% coverage of query (62.8 bits)
ABCA1_MOUSE / P41233 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; EC 7.6.2.1 from Mus musculus (Mouse) (see 2 papers)
24% identity, 77% coverage of query (61.6 bits)
ABCA1_HUMAN / O95477 Phospholipid-transporting ATPase ABCA1; ATP-binding cassette sub-family A member 1; ATP-binding cassette transporter 1; ABC-1; ATP-binding cassette 1; Cholesterol efflux regulatory protein; EC 7.6.2.1 from Homo sapiens (Human) (see 34 papers)
TC 3.A.1.211.14 / O95477 cAMP-dependent and sulfonylurea-sensitive anion transporter, ABCA1 of 2261 aas. Key gatekeeper influencing and possibly catalyzing intracellular phospholipid and cholesterol transport from Homo sapiens
24% identity, 77% coverage of query (59.7 bits)
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Lawrence Berkeley National Laboratory