Searching for up to 100 curated homologs for BPHYT_RS26220 FitnessBrowser__BFirm:BPHYT_RS26220 (345 a.a.)
Found high-coverage hits (≥70%) to 58 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
A9H324 phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating) (EC 1.1.1.343) from Gluconacetobacter diazotrophicus (see paper)
51% identity, 97% coverage of query (338 bits)
6PGDH_GLUOX / G5EBD7 6-phosphogluconate dehydrogenase, NAD(+)-dependent, decarboxylating; 6PGDH; EC 1.1.1.343 from Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans) (see paper)
G5EBD7 phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating) (EC 1.1.1.343) from Gluconobacter oxydans (see paper)
50% identity, 97% coverage of query (335 bits)
6vpbB / A9H324 A novel membrane-bound 6-phosphogluconate dehydrogenase from the acetic acid bacteria gluconacetobacter diazotrophicus (gd6pgd) (see paper)
51% identity, 95% coverage of query (327 bits)
Q2RIZ2 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) (EC 1.1.1.44) from Moorella thermoacetica (see paper)
43% identity, 96% coverage of query (268 bits)
A0A1J5NX54 phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating) (EC 1.1.1.343); phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) (EC 1.1.1.44) from Moorella thermoacetica (see paper)
43% identity, 96% coverage of query (266 bits)
6PGD_HALVD / D4GST8 6-phosphogluconate dehydrogenase, NAD(+)-dependent, decarboxylating; 6PGDH; EC 1.1.1.343 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
D4GST8 phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating) (EC 1.1.1.343) from Haloferax volcanii (see paper)
37% identity, 96% coverage of query (184 bits)
2w90B Geobacillus stearothermophilus 6-phosphogluconate dehydrogenase with bound 6- phosphogluconate (see paper)
34% identity, 99% coverage of query (179 bits)
6PGDH_BACSU / P12013 6-phosphogluconate dehydrogenase, NAD(+)-dependent, decarboxylating; EC 1.1.1.343 from Bacillus subtilis (strain 168) (see paper)
P12013 phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating) (EC 1.1.1.343) from Bacillus subtilis (see paper)
34% identity, 90% coverage of query (172 bits)
gndA / P80859 6-phosphogluconate dehydrogenase (decarboxylating) (EC 1.1.1.44) from Bacillus subtilis (strain 168) (see paper)
6PGD_BACSU / P80859 6-phosphogluconate dehydrogenase, NADP(+)-dependent, decarboxylating; GNTZII; EC 1.1.1.44 from Bacillus subtilis (strain 168) (see paper)
P80859 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) (EC 1.1.1.44) from Bacillus subtilis (see paper)
34% identity, 90% coverage of query (171 bits)
6PGD2_YEAST / P53319 6-phosphogluconate dehydrogenase, decarboxylating 2; EC 1.1.1.44 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P53319 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) (EC 1.1.1.44) from Saccharomyces cerevisiae (see paper)
34% identity, 93% coverage of query (164 bits)
8i4qA / Q8NQI2 Crystal structure of 6-phosphogluconate dehydrogenase from corynebacterium glutamicum (see paper)
34% identity, 89% coverage of query (159 bits)
Q6NHC5 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) (EC 1.1.1.44) from Corynebacterium glutamicum (see paper)
33% identity, 89% coverage of query (156 bits)
6PGD_AGGAC / P70718 6-phosphogluconate dehydrogenase, decarboxylating; EC 1.1.1.44 from Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans) (see paper)
34% identity, 90% coverage of query (155 bits)
P96789 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) (EC 1.1.1.44) from Lactococcus lactis (see paper)
33% identity, 96% coverage of query (154 bits)
2iz1B / P96789 6pdh complexed with pex inhibitor synchrotron data (see paper)
33% identity, 96% coverage of query (154 bits)
P96789 6-phosphogluconate dehydrogenase, decarboxylating; EC 1.1.1.44 from Lactococcus lactis subsp. cremoris (strain MG1363)
33% identity, 96% coverage of query (154 bits)
2iyoA Structural characterization of a bacterial 6pdh reveals aspects of specificity, mechanism and mode of inhibition
33% identity, 96% coverage of query (154 bits)
2iypA Product rup
33% identity, 96% coverage of query (154 bits)
2iypB Product rup
33% identity, 96% coverage of query (154 bits)
P78812 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) (EC 1.1.1.44) from Schizosaccharomyces pombe (see paper)
SPBC660.16 / RF|NP_595095.1 phosphogluconate dehydrogenase, decarboxylating; EC 1.1.1.44 from Schizosaccharomyces pombe (see 3 papers)
34% identity, 97% coverage of query (151 bits)
P78812 6-phosphogluconate dehydrogenase, decarboxylating; EC 1.1.1.44 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
34% identity, 97% coverage of query (151 bits)
P52208 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) (EC 1.1.1.44) from Synechocystis sp. (see paper)
33% identity, 96% coverage of query (149 bits)
6PGD1_YEAST / P38720 6-phosphogluconate dehydrogenase, decarboxylating 1; EC 1.1.1.44 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
P38720 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) (EC 1.1.1.44) from Saccharomyces cerevisiae (see 2 papers)
33% identity, 94% coverage of query (149 bits)
7cb5B / A0A0H3KGN1 The 6-phosphogluconate dehydrogenase from staphylococcus aureus (6- phosphogluconate bound) (see paper)
31% identity, 96% coverage of query (149 bits)
6Pgd / CAD56883.1 6-phosphogluconic dehydrogenase from Bactrocera oleae (see paper)
36% identity, 90% coverage of query (149 bits)
7cb2A The 6-phosphogluconate dehydrogenase (NADP-bound) from staphylococcus aureus
31% identity, 96% coverage of query (149 bits)
2p4qA / P38720 Crystal structure analysis of gnd1 in saccharomyces cerevisiae (see paper)
33% identity, 94% coverage of query (148 bits)
Q9WYR9 phosphogluconate dehydrogenase (NAD+-dependent, decarboxylating) (EC 1.1.1.343); phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) (EC 1.1.1.44) from Thermotoga maritima (see 2 papers)
32% identity, 90% coverage of query (146 bits)
A0A0D1CRJ9 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) (EC 1.1.1.44) from Ustilago maydis (see paper)
35% identity, 93% coverage of query (145 bits)
6PGD_RAT / P85968 6-phosphogluconate dehydrogenase, decarboxylating; EC 1.1.1.44 from Rattus norvegicus (Rat) (see paper)
P85968 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) (EC 1.1.1.44) from Rattus norvegicus (see 2 papers)
34% identity, 90% coverage of query (144 bits)
Q9DCD0 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) (EC 1.1.1.44) from Mus musculus (see paper)
34% identity, 90% coverage of query (143 bits)
GND1 6-phosphogluconate dehydrogenase, decarboxylating; EC 1.1.1.44 from Candida albicans (see paper)
33% identity, 91% coverage of query (143 bits)
Gnd / b2029 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) from Escherichia coli K-12 substr. MG1655 (see 66 papers)
gnd / P00350 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) from Escherichia coli (strain K12) (see 64 papers)
6PGD_ECOLI / P00350 6-phosphogluconate dehydrogenase, decarboxylating; EC 1.1.1.44 from Escherichia coli (strain K12) (see paper)
P00350 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) (EC 1.1.1.44) from Escherichia coli (see paper)
30% identity, 93% coverage of query (140 bits)
3fwnA / P00350 Dimeric 6-phosphogluconate dehydrogenase complexed with 6- phosphogluconate and 2'-monophosphoadenosine-5'-diphosphate (see paper)
30% identity, 93% coverage of query (140 bits)
2jkvA / P52209 Structure of human phosphogluconate dehydrogenase in complex with NADPH at 2.53a
34% identity, 89% coverage of query (140 bits)
PGD / P52209 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) from Homo sapiens (see paper)
6PGD_HUMAN / P52209 6-phosphogluconate dehydrogenase, decarboxylating; EC 1.1.1.44 from Homo sapiens (Human)
P52209 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) (EC 1.1.1.44) from Homo sapiens (see 9 papers)
34% identity, 89% coverage of query (140 bits)
3fwnB Dimeric 6-phosphogluconate dehydrogenase complexed with 6- phosphogluconate and 2'-monophosphoadenosine-5'-diphosphate
30% identity, 93% coverage of query (140 bits)
2zydA Dimeric 6-phosphogluconate dehydrogenase complexed with glucose
30% identity, 93% coverage of query (140 bits)
Q762L5 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) (EC 1.1.1.44) from Klebsiella pneumoniae (see paper)
31% identity, 93% coverage of query (139 bits)
5uq9E Crystal structure of 6-phosphogluconate dehydrogenase with ((4r,5r)-5- (hydroxycarbamoyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl dihydrogen phosphate
34% identity, 89% coverage of query (139 bits)
Build an alignment for BPHYT_RS26220 and 40 homologs with ≥ 30% identity
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Q8IKT2 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) (EC 1.1.1.44) from Plasmodium falciparum (see paper)
6fqyA / Q8IKT2 Plasmodium falciparum 6-phosphogluconate dehydrogenase in its apo form, in complex with its cofactor NADP+ and in complex with its substrate 6-phosphogluconate (see paper)
28% identity, 91% coverage of query (136 bits)
6fqzA Plasmodium falciparum 6-phosphogluconate dehydrogenase in its apo form, in complex with its cofactor NADP+ and in complex with its substrate 6-phosphogluconate
28% identity, 91% coverage of query (136 bits)
6PGD_SHEEP / P00349 6-phosphogluconate dehydrogenase, decarboxylating; EC 1.1.1.44 from Ovis aries (Sheep) (see 2 papers)
32% identity, 99% coverage of query (134 bits)
1pgqA Crystallographic study of coenzyme, coenzyme analogue and substrate binding in 6-phosphogluconate dehydrogenase: implications for NADP specificity and the enzyme mechanism
32% identity, 99% coverage of query (134 bits)
1pgpA Crystallographic study of coenzyme, coenzyme analogue and substrate binding in 6-phosphogluconate dehydrogenase: implications for NADP specificity and the enzyme mechanism
32% identity, 99% coverage of query (134 bits)
1pgoA Crystallographic study of coenzyme, coenzyme analogue and substrate binding in 6-phosphogluconate dehydrogenase: implications for NADP specificity and the enzyme mechanism
32% identity, 99% coverage of query (134 bits)
1pgnA Crystallographic study of coenzyme, coenzyme analogue and substrate binding in 6-phosphogluconate dehydrogenase: implications for NADP specificity and the enzyme mechanism
32% identity, 99% coverage of query (134 bits)
gnd / AAA21136.1 phosphogluconate dehydrogenase from Escherichia coli (see paper)
30% identity, 93% coverage of query (133 bits)
6PGD1_SPIOL / Q94KU1 6-phosphogluconate dehydrogenase, decarboxylating 1; EC 1.1.1.44 from Spinacia oleracea (Spinach) (see paper)
31% identity, 90% coverage of query (129 bits)
6PGD2_ARATH / Q9FWA3 6-phosphogluconate dehydrogenase, decarboxylating 2; EC 1.1.1.44 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9FWA3 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) (EC 1.1.1.44) from Arabidopsis thaliana (see 2 papers)
30% identity, 90% coverage of query (123 bits)
8c79A / Q18L02 Crystal structure of leishmania donovani 6-phosphogluconate dehydrogenase complexed with NADPH (see paper)
28% identity, 89% coverage of query (122 bits)
6PGD1_ORYSJ / Q9LI00 6-phosphogluconate dehydrogenase, decarboxylating 1; OsG6PGH1; EC 1.1.1.44 from Oryza sativa subsp. japonica (Rice) (see paper)
Q9LI00 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) (EC 1.1.1.44) from Oryza sativa Japonica Group (see paper)
32% identity, 90% coverage of query (122 bits)
6PGD2_SPIOL / Q94KU2 6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic; EC 1.1.1.44 from Spinacia oleracea (Spinach) (see paper)
28% identity, 94% coverage of query (121 bits)
6PGD3_ARATH / Q9FFR3 6-phosphogluconate dehydrogenase, decarboxylating 3, chloroplastic; EC 1.1.1.44 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9FFR3 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) (EC 1.1.1.44) from Arabidopsis thaliana (see paper)
28% identity, 95% coverage of query (119 bits)
6PGD2_ORYSJ / Q2R480 6-phosphogluconate dehydrogenase, decarboxylating 2, chloroplastic; OsG6PGH2; EC 1.1.1.44 from Oryza sativa subsp. japonica (Rice)
30% identity, 90% coverage of query (119 bits)
6PGD1_ARATH / Q9SH69 6-phosphogluconate dehydrogenase, decarboxylating 1, chloroplastic; EC 1.1.1.44 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9SH69 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) (EC 1.1.1.44) from Arabidopsis thaliana (see paper)
27% identity, 93% coverage of query (116 bits)
Q6WAT5 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating) (EC 1.1.1.44) from Trypanosoma cruzi (see paper)
27% identity, 89% coverage of query (114 bits)
6PGD_TRYBB / P31072 6-phosphogluconate dehydrogenase, decarboxylating; EC 1.1.1.44 from Trypanosoma brucei brucei (see paper)
29% identity, 75% coverage of query (103 bits)
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