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Searching for up to 100 curated homologs for BPHYT_RS29180 FitnessBrowser__BFirm:BPHYT_RS29180 (306 a.a.)

Found high-coverage hits (≥70%) to 43 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

SMc04257 ABC transporter for D-Cellobiose and D-Salicin, permease component 1 from Sinorhizobium meliloti 1021
    60% identity, 97% coverage of query (370 bits)

Ac3H11_2065 glucose ABC transporter, permease component 2 from Acidovorax sp. GW101-3H11
    52% identity, 91% coverage of query (290 bits)

PfGW456L13_1896 ABC transporter for D-Galactose and D-Glucose, permease component 2 from Pseudomonas fluorescens GW456-L13
    48% identity, 93% coverage of query (264 bits)

PS417_22135 glucose/xylose ABC transporter, permease component 1 from Pseudomonas simiae WCS417
    48% identity, 93% coverage of query (255 bits)

TC 3.A.1.1.30 / Q88P36 GtsC (GLcG), component of Glucose porter, GtsABCD from Pseudomonas putida (strain KT2440) (see paper)
    49% identity, 91% coverage of query (247 bits)

TC 3.A.1.1.24 / Q72KX4 Sugar transport system permease protein aka TT_C0326, component of The glucose/mannose porter TTC0326-8 plus MalK1 (ABC protein, shared with 3.A.1.1.25) from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (see paper)
    41% identity, 91% coverage of query (202 bits)

GGTD_SYNY3 / Q55473 Osmoprotective compounds uptake permease protein GgtD from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
TC 3.A.1.1.32 / Q55473 Membrane bound sugar transport protein, component of The glucosylglycerol uptake transporter (functions in osmoprotection and also transports sucrose and trehalose (Mikkat and Hagemann, 2000) (most similar to 3.A.1.1.8) from Synechocystis sp. (strain PCC 6803) (see paper)
    30% identity, 97% coverage of query (127 bits)

TC 3.A.1.1.13 / Q97UY9 GlcU, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see paper)
    30% identity, 89% coverage of query (116 bits)

Build an alignment

Build an alignment for BPHYT_RS29180 and 8 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

TC 3.A.1.1.14 / Q97UF3 AraU, component of Arabinose, fructose, xylose porter from Sulfolobus solfataricus (see paper)
    28% identity, 86% coverage of query (114 bits)

NGCG_STRCO / O50501 Diacetylchitobiose uptake system permease protein NgcG from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
    30% identity, 75% coverage of query (110 bits)

XACI_HALVD / D4GP37 Xylose/arabinose import permease protein XacI from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
    28% identity, 90% coverage of query (106 bits)

ARAQ_BACSU / P94530 Arabinooligosaccharides transport system permease protein AraQ from Bacillus subtilis (strain 168) (see 3 papers)
TC 3.A.1.1.34 / P94530 L-arabinose transport system permease protein AraQ, component of The arabinosaccharide transporter AraNPQMsmX. Transports α-1,5-arabinooligosaccharides, at least up to four L-arabinosyl units; the key transporter for α-1,5-arabinotriose and α-1,5-arabinotetraose, but not for α-1,5-arabinobiose which is transported by AraE. MsmX is also used by the MdxEFG-MsmX system (3.A.1.1.36) (Ferreira and Sá-Nogueira, 2010). Involved in the uptake of pectin oligosaccharides with either MsmX or YurJ as the ATPase from Bacillus subtilis (see 5 papers)
    24% identity, 93% coverage of query (106 bits)

SMc03063 ABC transporter for D-maltose/D-trehalose/sucrose, permease component 2 (AglG) from Sinorhizobium meliloti 1021
TC 3.A.1.1.8 / Q9Z3R7 AglG aka R00697 aka SMC03063, component of Sucrose/maltose/trehalose porter (sucrose-inducible) from Rhizobium meliloti (Sinorhizobium meliloti) (see 2 papers)
    33% identity, 77% coverage of query (106 bits)

TC 3.A.1.1.39 / Q9WYR1 Alpha-1,4-digalacturonate porter (Nanavati et al., 2006). Regulated by pectin utilization regulon UxaR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    28% identity, 89% coverage of query (103 bits)

Dshi_1650 glucose/maltose/trehalose/sucrose ABC transporter, permease component 2 from Dinoroseobacter shibae DFL-12
    30% identity, 70% coverage of query (101 bits)

TC 3.A.1.1.18 / Q8RJU8 NgcG, component of N-Acetylglucosamine/N,N'-diacetyl chitobiose porter (NgcK (C) not identified) from Streptomyces olivaceoviridis (Streptomyces corchorusii) (see paper)
    26% identity, 97% coverage of query (98.2 bits)

SMc02871 ABC transporter for N-Acetyl-D-glucosamine, permease protein 2 from Sinorhizobium meliloti 1021
    29% identity, 95% coverage of query (96.7 bits)

MELC_BACSU / O34518 Melibiose/raffinose/stachyose import permease protein MelC from Bacillus subtilis (strain 168) (see paper)
    29% identity, 86% coverage of query (95.9 bits)

PGA1_c27950 N-Acetyl-D-glucosamine ABC transport system, permease component 2 from Phaeobacter inhibens BS107
    29% identity, 88% coverage of query (92.8 bits)

BPHYT_RS16105 ABC transporter for D-Sorbitol, permease component 1 from Burkholderia phytofirmans PsJN
    27% identity, 90% coverage of query (91.7 bits)

TC 3.A.1.1.20 / Q7WWQ8 Transmembrane permease MsmG, component of The fructooligosaccharide porter, MsmEFGK from Lactobacillus acidophilus (see 2 papers)
msmG / GI|33149340 transmembrane permease MsmG from Lactobacillus acidophilus (see paper)
    30% identity, 86% coverage of query (89.4 bits)

TC 3.A.1.1.45 / Q8NMV5 ABC-type transporter, permease components, component of Maltose transporter, MusEFGKI from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
    26% identity, 97% coverage of query (89.0 bits)

TC 3.A.1.1.41 / G4FGN6 ABC-type transporter, integral membrane subunit, component of Trehalose porter. Also binds sucrose (Boucher and Noll, 2011). Induced by glucose and trehalose. Directly regulated by trehalose-responsive regulator TreR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    23% identity, 91% coverage of query (87.8 bits)

UgpE / b3451 sn-glycerol 3-phosphate ABC transporter membrane subunit UgpE (EC 7.6.2.10) from Escherichia coli K-12 substr. MG1655 (see paper)
UgpE / P10906 sn-glycerol 3-phosphate ABC transporter membrane subunit UgpE (EC 7.6.2.10) from Escherichia coli (strain K12) (see 20 papers)
UGPE_ECOLI / P10906 sn-glycerol-3-phosphate transport system permease protein UgpE from Escherichia coli (strain K12) (see 5 papers)
P10906 ABC-type glycerol 3-phosphate transporter (EC 7.6.2.10) from Escherichia coli (see paper)
TC 3.A.1.1.3 / P10906 UgpE aka B3451, component of Glycerol-phosphate porter. Transports both glycerol-3-P and glycerol-3-P diesters including glycerophosphocholine but not glycerol-2-P from Escherichia coli (see 5 papers)
    27% identity, 85% coverage of query (86.7 bits)

TC 3.A.1.1.6 / Q48397 CymG, component of Cyclodextrin porter from Klebsiella oxytoca (see paper)
    26% identity, 89% coverage of query (85.9 bits)

TC 3.A.1.1.28 / Q00751 MsmG aka SMU.880, component of The raffinose/stachyose transporter, MsmEFGK (MalK (3.A.1.1.27) can probably substitute for MsmK; Webb et al., 2008). This system may also transport melibiose, isomaltotriose and sucrose as well as isomaltosaccharides from Streptococcus mutans (see 2 papers)
    24% identity, 89% coverage of query (85.5 bits)

sugB / P9WG01 ABC-type trehalose transporter integral membrane protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGB_MYCTU / P9WG01 Trehalose transport system permease protein SugB from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
TC 3.A.1.1.31 / O50453 PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER SUGB, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 3 papers)
    26% identity, 86% coverage of query (85.1 bits)

SM_b21105 ABC transporter for L-Fucose, permease component 2 from Sinorhizobium meliloti 1021
    27% identity, 95% coverage of query (84.7 bits)

smoH / Q7CS31 ABC-type 3-(6-sulfo-α-D-quinovosyl)-sn-glycerol transporter permease subunit from Agrobacterium fabrum (strain C58 / ATCC 33970) (see paper)
    25% identity, 91% coverage of query (84.3 bits)

TC 3.A.1.1.42 / TC 3.A.1.1.43 / Q9FBS7 Putative sugar-binding integral membrane transport protein, component of α-glucoside uptake permease, Agl3E/Agl3F/Agl3G. Plays a role in normal morphogenesis and antibiotic production. Strongly induced by trehalose and melibiose, and weakly induced by lactose and glycerol but not glucose (Hillerich and Westpheling 2006).The operon is controlled by a GntR homologue, Agl3R, and downstream of the gntR from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    28% identity, 89% coverage of query (83.6 bits)

Psest_0865 maltose ABC transporter, permease component 2 (MalG) from Pseudomonas stutzeri RCH2
    27% identity, 94% coverage of query (82.0 bits)

TC 3.A.1.1.33 / Q8KN17 Putative sugar transporter integral membrane protein, component of The N,N'-diacetylchitobiose uptake transporter, DasABC/MsiK (MsiK energizes several ABC transporters (see 3.A.1.1.23)) from Streptomyces sp. 139 (see 2 papers)
    26% identity, 86% coverage of query (81.6 bits)

TC 3.A.1.1.5 / O30833 SmoG, component of Hexitol (glucitol; mannitol) porter from Rhodobacter sphaeroides (Rhodopseudomonas sphaeroides) (see paper)
    24% identity, 79% coverage of query (77.8 bits)

TC 3.A.1.1.12 / Q9AI66 PalG, component of Palatinose (isomaltulose; 6-O-α-D-glucopyranosyl-D-fructose) uptake porter from Erwinia rhapontici (see paper)
    27% identity, 87% coverage of query (77.4 bits)

TC 3.A.1.1.11 / Q93KB9 TogN, component of Saturated and unsaturated oligogalacturonide transporter, TogMNAB (transports di- to tetrasaccharide pectin degradation products which consist of D-galacuronate, sometimes with 4-deoxy-L-threo-5-hexosulose uronate at the reducing end of the oligosaccharide) (Hugouvieux-Cotte-Pattat et al. 2001). Regulated by pectin utilization regulator KdgR from Erwinia chrysanthemi (see paper)
    23% identity, 89% coverage of query (77.0 bits)

TC 3.A.1.1.44 / Q9KZ08 Putative maltose permease, component of MalEFG (K unknown), involved in maltose and maltodextrin uptake from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    23% identity, 96% coverage of query (76.3 bits)

Ac3H11_794 ABC transporter for Glycerol, permease component 2 from Acidovorax sp. GW101-3H11
    26% identity, 89% coverage of query (76.3 bits)

DASC_STRCO / Q9K489 Diacetylchitobiose uptake system permease protein DasC from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
    26% identity, 88% coverage of query (75.5 bits)

Pf1N1B4_5114 sucrose ABC transporter, permease component 2 from Pseudomonas fluorescens FW300-N1B4
    23% identity, 87% coverage of query (71.6 bits)

YcjP / b1312 putative ABC transporter membrane subunit YcjP from Escherichia coli K-12 substr. MG1655 (see 2 papers)
TC 3.A.1.1.46 / P77716 Inner membrane ABC transporter permease protein YcjP, component of Probable glucoside uptake porter, YcjNOPV from Escherichia coli (strain K12)
    23% identity, 92% coverage of query (70.9 bits)

TC 3.A.1.1.26 / O06991 MalG aka yvdI, component of The maltose porter, MdxEFG and MsmX from Bacillus subtilis (see 2 papers)
    25% identity, 91% coverage of query (70.5 bits)

TC 3.A.1.1.25 / Q72H66 Maltose transport system permease protein malG aka TT_C1629, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (see paper)
    25% identity, 85% coverage of query (69.7 bits)

SM_b21219 ABC transporter for D-Glucosamine, permease component 1 from Sinorhizobium meliloti 1021
    25% identity, 90% coverage of query (68.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory