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Searching for up to 100 curated homologs for BPHYT_RS29185 BPHYT_RS29185 sugar ABC transporter permease (314 a.a.)

Found high-coverage hits (≥70%) to 53 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

SMc04258 ABC transporter for D-Cellobiose and D-Salicin, permease component 2 from Sinorhizobium meliloti 1021
    48% identity, 86% coverage of query (273 bits)

PS417_22140 glucose/xylose ABC transporter, permease component 2 from Pseudomonas simiae WCS417
    44% identity, 88% coverage of query (256 bits)

PfGW456L13_1895 ABC transporter for D-Galactose and D-Glucose, permease component 1 from Pseudomonas fluorescens GW456-L13
    44% identity, 88% coverage of query (255 bits)

TC 3.A.1.1.30 / Q88P37 GtsB (GLcF), component of Glucose porter, GtsABCD from Pseudomonas putida (strain KT2440) (see paper)
    43% identity, 88% coverage of query (253 bits)

Ac3H11_2064 glucose ABC transporter, permease component 1 from Acidovorax sp. GW101-3H11
    45% identity, 84% coverage of query (248 bits)

Build an alignment

Build an alignment for BPHYT_RS29185 and 5 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

XACH_HALVD / D4GP36 Xylose/arabinose import permease protein XacH from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
    28% identity, 92% coverage of query (119 bits)

MELD_BACSU / O34706 Melibiose/raffinose/stachyose import permease protein MelD from Bacillus subtilis (strain 168) (see paper)
    29% identity, 88% coverage of query (111 bits)

SM_b21104 ABC transporter for L-Fucose, permease component 1 from Sinorhizobium meliloti 1021
    28% identity, 78% coverage of query (110 bits)

TC 3.A.1.1.42 / TC 3.A.1.1.43 / Q9FBS6 Putative sugar-transporter integral membrane protein, component of α-glucoside uptake permease, Agl3E/Agl3F/Agl3G. Plays a role in normal morphogenesis and antibiotic production. Strongly induced by trehalose and melibiose, and weakly induced by lactose and glycerol but not glucose (Hillerich and Westpheling 2006).The operon is controlled by a GntR homologue, Agl3R, and downstream of the gntR from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    31% identity, 76% coverage of query (110 bits)

TC 3.A.1.1.25 / Q72H67 Maltose transport system permease protein malF aka TT_C1628, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (see paper)
    29% identity, 78% coverage of query (110 bits)

TC 3.A.1.1.20 / Q7WWQ9 Transmembrane permease MsmF, component of The fructooligosaccharide porter, MsmEFGK from Lactobacillus acidophilus (see 2 papers)
msmF / GI|33149339 transmembrane permease MsmF from Lactobacillus acidophilus (see paper)
    30% identity, 70% coverage of query (108 bits)

TC 3.A.1.1.41 / G4FGN7 ABC-type transporter, integral membrane subunit, component of Trehalose porter. Also binds sucrose (Boucher and Noll, 2011). Induced by glucose and trehalose. Directly regulated by trehalose-responsive regulator TreR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    29% identity, 73% coverage of query (106 bits)

SM_b21653 ABC transporter for Lactose, permease component 1 from Sinorhizobium meliloti 1021
    27% identity, 93% coverage of query (106 bits)

GGTC_SYNY3 / Q55472 Osmoprotective compounds uptake permease protein GgtC from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
TC 3.A.1.1.32 / Q55472 Membrane bound sugar transport protein, component of The glucosylglycerol uptake transporter (functions in osmoprotection and also transports sucrose and trehalose (Mikkat and Hagemann, 2000) (most similar to 3.A.1.1.8) from Synechocystis sp. (strain PCC 6803) (see paper)
    26% identity, 74% coverage of query (101 bits)

NGCF_STRCO / O50500 Diacetylchitobiose uptake system permease protein NgcF from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
    26% identity, 77% coverage of query (100 bits)

TC 3.A.1.1.4 / P29823 LacF, component of Lactose porter from Agrobacterium radiobacter (see paper)
    27% identity, 92% coverage of query (99.0 bits)

TC 3.A.1.1.45 / Q8NMV4 ABC-type sugar transport system, permease component, component of Maltose transporter, MusEFGKI from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
    26% identity, 94% coverage of query (98.2 bits)

TC 3.A.1.1.37 / Q9WYB4 Predicted arabinoside porter. Regulated by arabinose-responsive regulator AraR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    29% identity, 86% coverage of query (97.4 bits)

MALF_THELN / O51924 Trehalose/maltose transport system permease protein MalF from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see 3 papers)
    28% identity, 89% coverage of query (89.0 bits)

TC 3.A.1.1.19 / Q8L125 PalF, component of Platinose (isomaltulose) (6-O-α-D-glucopyranosyl-D-fructofuranose) porter from Agrobacterium tumefaciens (see 3 papers)
    24% identity, 92% coverage of query (88.2 bits)

TC 3.A.1.1.28 / Q00750 MsmF aka SMU.879, component of The raffinose/stachyose transporter, MsmEFGK (MalK (3.A.1.1.27) can probably substitute for MsmK; Webb et al., 2008). This system may also transport melibiose, isomaltotriose and sucrose as well as isomaltosaccharides from Streptococcus mutans (see 2 papers)
    25% identity, 85% coverage of query (87.8 bits)

SM_b20326 ABC transporter for D-trehalose/D-maltose/sucrose, permease component 1 (ThuF) from Sinorhizobium meliloti 1021
TC 3.A.1.1.17 / Q9R9Q6 ThuF aka RB0312 aka SMB20326, component of Trehalose/maltose/sucrose porter (trehalose inducible) from Rhizobium meliloti (Sinorhizobium meliloti) (see 3 papers)
    24% identity, 95% coverage of query (87.0 bits)

PGA1_c27940 N-Acetyl-D-glucosamine ABC transport system, permease component 1 from Phaeobacter inhibens BS107
    28% identity, 88% coverage of query (85.1 bits)

TC 3.A.1.1.21 / Q9L026 BxlF, component of The xylobiose porter; BxlEFG(K) from Streptomyces coelicolor (see paper)
    25% identity, 89% coverage of query (84.7 bits)

Q6MNM0 ABC-type maltose transporter (EC 7.5.2.1) from Bdellovibrio bacteriovorus (see paper)
TC 3.A.1.1.51 / Q6MNM0 Maltose - maltoheptose transporter, MalEFGK from Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100)
    23% identity, 83% coverage of query (84.0 bits)

Dshi_1651 glucose/maltose/trehalose/sucrose ABC transporter, permease component 1 from Dinoroseobacter shibae DFL-12
    27% identity, 86% coverage of query (83.2 bits)

smoG / Q7CS30 ABC-type 3-(6-sulfo-α-D-quinovosyl)-sn-glycerol transporter permease subunit from Agrobacterium fabrum (strain C58 / ATCC 33970) (see paper)
    28% identity, 80% coverage of query (82.8 bits)

SMc02872 ABC transporter for N-Acetyl-D-glucosamine, permease protein 1 from Sinorhizobium meliloti 1021
    28% identity, 74% coverage of query (82.4 bits)

sugA / P9WG03 ABC-type trehalose transporter integral membrane protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGA_MYCTU / P9WG03 Trehalose transport system permease protein SugA from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
TC 3.A.1.1.31 / O50452 PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER SUGA, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 2 papers)
    28% identity, 83% coverage of query (81.3 bits)

7cagA / A0R2C2 Mycobacterium smegmatis lpqy-sugabc complex in the catalytic intermediate state (see paper)
    28% identity, 85% coverage of query (80.9 bits)

TC 3.A.1.1.13 / Q97UZ0 GlcT, component of Glucose, mannose, galactose porter from Sulfolobus solfataricus (see paper)
    24% identity, 84% coverage of query (79.0 bits)

HSERO_RS17005 ABC transporter for D-sorbitol/xylitol, permease component 1 from Herbaspirillum seropedicae SmR1
    25% identity, 75% coverage of query (78.6 bits)

DASB_STRCO / Q9K490 Diacetylchitobiose uptake system permease protein DasB from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
    28% identity, 70% coverage of query (77.4 bits)

Ac3H11_2943 ABC transporter for D-Sorbitol, permease component 2 from Acidovorax sp. GW101-3H11
    23% identity, 86% coverage of query (77.0 bits)

TC 3.A.1.1.7 / O51924 MalF, component of Maltose/trehalose porter from Thermococcus litoralis (see paper)
    28% identity, 91% coverage of query (76.3 bits)

TC 3.A.1.1.18 / Q8RJU9 NgcF, component of N-Acetylglucosamine/N,N'-diacetyl chitobiose porter (NgcK (C) not identified) from Streptomyces olivaceoviridis (Streptomyces corchorusii) (see paper)
    23% identity, 75% coverage of query (75.5 bits)

TC 3.A.1.1.48 / D6ZW63 MalF-type ABC sugar transport systems permease component, component of The lacto-N-biose I (LNB; Gal β-1,3-GlcNAc)/galacto-N-biose (GNB; Gal β-1,3-GalNAc) transporter from Bifidobacterium longum subsp. longum (strain JDM301)
    25% identity, 91% coverage of query (75.1 bits)

mtlF / Q4KC56 polyol ABC-type transporter permease component MtlF from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see paper)
    22% identity, 94% coverage of query (73.9 bits)

PGA1_c13200 ABC transporter for D-Sorbitol, permease component 2 from Phaeobacter inhibens BS107
    23% identity, 84% coverage of query (73.6 bits)

Ac3H11_793 ABC transporter for Glycerol, permease component 1 from Acidovorax sp. GW101-3H11
    23% identity, 88% coverage of query (73.6 bits)

TC 3.A.1.1.50 / Q5SLB6 Sugar ABC transporter, permease protein, component of Probable glycerophosphocholine (GPC) uptake porter (Chandravanshi et al. 2016). The system may include a receptor and three membrane proteins (of 378 aas and 6 TMSs, 299 aas and 7 TMSs, and 113 aas and 3 TMSs (?). The ATPase has not been identified from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
    26% identity, 73% coverage of query (73.2 bits)

SM_b21220 ABC transporter for D-Glucosamine, permease component 2 from Sinorhizobium meliloti 1021
    26% identity, 78% coverage of query (73.2 bits)

AO356_00020 ABC transporter for D-Sorbitol, permease component 2 from Pseudomonas fluorescens FW300-N2C3
    23% identity, 86% coverage of query (72.8 bits)

Pf6N2E2_1962 ABC transporter for D-sorbitol, permease component 1 from Pseudomonas fluorescens FW300-N2E2
    23% identity, 86% coverage of query (72.0 bits)

TC 3.A.1.1.35 / G3LHZ0 GlpP, component of Glycerol uptake porter, GlpSTPQV from Rhizobium leguminosarum bv. viciae
    25% identity, 74% coverage of query (71.6 bits)

TC 3.A.1.1.16 / Q8TZP9 MalF, component of Maltooligosaccharide porter (Maltose is not a substrate, but maltotriose is.) from Pyrococcus furiosus
    24% identity, 72% coverage of query (70.9 bits)

PS417_12710 ABC transporter for D-Mannitol and D-Sorbitol, permease component 2 from Pseudomonas simiae WCS417
    23% identity, 76% coverage of query (70.5 bits)

TC 3.A.1.1.49 / O30492 MtlF, component of The polyol (mannitol, glucitol (sorbitol), arabitol (arabinitol; lyxitol)) uptake porter, MtlEFGK from Pseudomonas fluorescens
    22% identity, 90% coverage of query (70.1 bits)

TC 3.A.1.1.11 / Q93KC0 TogM, component of Saturated and unsaturated oligogalacturonide transporter, TogMNAB (transports di- to tetrasaccharide pectin degradation products which consist of D-galacuronate, sometimes with 4-deoxy-L-threo-5-hexosulose uronate at the reducing end of the oligosaccharide) (Hugouvieux-Cotte-Pattat et al. 2001). Regulated by pectin utilization regulator KdgR from Erwinia chrysanthemi (see paper)
    24% identity, 76% coverage of query (70.1 bits)

UgpA / b3452 sn-glycerol 3-phosphate ABC transporter membrane subunit UgpA (EC 7.6.2.10) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
UgpA / P10905 sn-glycerol 3-phosphate ABC transporter membrane subunit UgpA (EC 7.6.2.10) from Escherichia coli (strain K12) (see 20 papers)
UGPA_ECOLI / P10905 sn-glycerol-3-phosphate transport system permease protein UgpA from Escherichia coli (strain K12) (see 5 papers)
P10905 ABC-type glycerol 3-phosphate transporter (EC 7.6.2.10) from Escherichia coli (see paper)
TC 3.A.1.1.3 / P10905 UgpA aka B3452, component of Glycerol-phosphate porter. Transports both glycerol-3-P and glycerol-3-P diesters including glycerophosphocholine but not glycerol-2-P from Escherichia coli (see 5 papers)
    25% identity, 77% coverage of query (69.7 bits)

TC 3.A.1.1.6 / Q48396 CymF, component of Cyclodextrin porter from Klebsiella oxytoca (see paper)
    24% identity, 79% coverage of query (68.9 bits)

4ki0F / P02916 Crystal structure of the maltose-binding protein/maltose transporter complex in an outward-facing conformation bound to maltohexaose (see paper)
    21% identity, 73% coverage of query (50.8 bits)

MalF / b4033 maltose ABC transporter membrane subunit MalF (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 14 papers)
MalF / P02916 maltose ABC transporter membrane subunit MalF (EC 7.5.2.1) from Escherichia coli (strain K12) (see 13 papers)
MALF_ECOLI / P02916 Maltose/maltodextrin transport system permease protein MalF from Escherichia coli (strain K12) (see 4 papers)
P02916 ABC-type maltose transporter (subunit 1/3) (EC 7.5.2.1) from Escherichia coli (see paper)
TC 3.A.1.1.1 / P02916 MalF aka B4033, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 14 papers)
    21% identity, 73% coverage of query (50.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory