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Searching for up to 100 curated homologs for BPHYT_RS31690 FitnessBrowser__BFirm:BPHYT_RS31690 (383 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

slcD / A3SN06 sulfolactate dehydrogenase from Roseovarius nubinhibens (strain ATCC BAA-591 / DSM 15170 / ISM) (see paper)
    39% identity, 94% coverage of query (243 bits)

6bfgA / P20932 Crystal structure of monotopic membrane protein (s)-mandelate dehydrogenase (see paper)
    35% identity, 97% coverage of query (228 bits)

mdlB / P20932 (S)-mandelate dehydrogenase (EC 1.1.99.31) from Pseudomonas putida (see 2 papers)
MDLB_PSEPU / P20932 (S)-mandelate dehydrogenase; MDH; L(+)-mandelate dehydrogenase; EC 1.1.99.31 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 5 papers)
P20932 (S)-mandelate dehydrogenase (EC 1.1.99.31) from Pseudomonas putida (see 5 papers)
    35% identity, 97% coverage of query (228 bits)

lldA / AAB09666.1 lactate dehydrogenase from Neisseria meningitidis (see paper)
    33% identity, 94% coverage of query (223 bits)

SM_b20850 L-lactate dehydrogenase (cytochrome) (EC 1.1.2.3) from Sinorhizobium meliloti 1021
    34% identity, 97% coverage of query (217 bits)

Ac3H11_1623 L-lactate dehydrogenase (cytochrome) (EC 1.1.2.3) from Acidovorax sp. GW101-3H11
    34% identity, 95% coverage of query (205 bits)

PS417_19130 L-lactate dehydrogenase (cytochrome) (EC 1.1.2.3) from Pseudomonas simiae WCS417
    34% identity, 96% coverage of query (204 bits)

HMO_AMYOR / O52792 4-hydroxymandelate oxidase; EC 1.1.3.46 from Amycolatopsis orientalis (Nocardia orientalis) (see 3 papers)
O52792 4-hydroxymandelate oxidase (EC 1.1.3.46) from Amycolatopsis orientalis (see 2 papers)
    37% identity, 94% coverage of query (204 bits)

6a24A The crystal structure of mandelate oxidase with 3-fluoropyruvate
    37% identity, 94% coverage of query (204 bits)

5zzqA / O52792 The crystal structure of mandelate oxidase with (s)-4-hydroxymandelic acid (see paper)
    37% identity, 94% coverage of query (203 bits)

Q9I197 L-lactate dehydrogenase (cytochrome) (EC 1.1.2.3) from Pseudomonas aeruginosa (see paper)
    34% identity, 96% coverage of query (201 bits)

HAOX2_HUMAN / Q9NYQ3 2-Hydroxyacid oxidase 2; HAOX2; (S)-2-hydroxy-acid oxidase, peroxisomal; Cell growth-inhibiting gene 16 protein; Long chain alpha-hydroxy acid oxidase; Long-chain L-2-hydroxy acid oxidase; EC 1.1.3.15 from Homo sapiens (Human) (see paper)
Q9NYQ3 (S)-2-hydroxy-acid oxidase (EC 1.1.3.15) from Homo sapiens (see paper)
    35% identity, 96% coverage of query (199 bits)

6a08A / O52792 The crystal structure of mandelate oxidase with benzoyl-formic acid (see paper)
    35% identity, 94% coverage of query (197 bits)

Q9HV37 L-lactate dehydrogenase (cytochrome) (EC 1.1.2.3) from Pseudomonas aeruginosa (see paper)
    35% identity, 96% coverage of query (196 bits)

Lct / b3605 L-lactate dehydrogenase from Escherichia coli K-12 substr. MG1655 (see 7 papers)
lldD / P33232 L-lactate dehydrogenase from Escherichia coli (strain K12) (see 6 papers)
LLDD_ECOLI / P33232 L-lactate dehydrogenase; EC 1.1.-.- from Escherichia coli (strain K12) (see 2 papers)
lldD L-lactate dehydrogenase [cytochrome]; EC 1.1.2.3 from Escherichia coli K12 (see paper)
lctD / AAA03585.1 L-lactate dehydrogenase from Escherichia coli (see paper)
    34% identity, 96% coverage of query (195 bits)

6a1aA Mandelate oxidase mutant-y128f with 4-hydroxymandelic acid
    35% identity, 94% coverage of query (195 bits)

6a01A The crystal structure of mandelate oxidase y128f with 3,3-difluoro-2, 2-dihydroxy-3-phenylpropionic acid
    35% identity, 94% coverage of query (195 bits)

6a1wA Mandelate oxidase with the enoyl fmn epoxide adduct
    36% identity, 94% coverage of query (194 bits)

6a00A The crystal structure of mandelate oxidase with (s)-2-phenylpropionate
    36% identity, 94% coverage of query (194 bits)

5zzrA The crystal structure of mandelate oxidase with (s)-mandelic acid
    36% identity, 94% coverage of query (194 bits)

6gmcA 1.2 a resolution structure of human hydroxyacid oxidase 1 bound with fmn and 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1,2,3-thiadiazole
    33% identity, 95% coverage of query (194 bits)

Q8H3I4 (S)-2-hydroxy-acid oxidase (EC 1.1.3.15) from Oryza sativa Japonica Group (see paper)
    33% identity, 95% coverage of query (193 bits)

HAOX1_HUMAN / Q9UJM8 2-Hydroxyacid oxidase 1; HAOX1; Glycolate oxidase; GO; GOX; Glyoxylate oxidase; EC 1.1.3.15; EC 1.2.3.5 from Homo sapiens (Human) (see 4 papers)
Q9UJM8 (S)-2-hydroxy-acid oxidase (EC 1.1.3.15) from Homo sapiens (see 2 papers)
    33% identity, 95% coverage of query (193 bits)

1huvA / P05414,P20932 Crystal structure of a soluble mutant of the membrane-associated (s)- mandelate dehydrogenase from pseudomonas putida at 2.15a resolution (see paper)
    33% identity, 97% coverage of query (193 bits)

6gmbA / Q9UJM8 Structure of human hydroxyacid oxidase 1 bound with fmn and glycolate
    33% identity, 95% coverage of query (193 bits)

5zztA The crystal structure of mandelate oxidase with 3,3-difluoro-2- hydroxy-3-phenylpropionic acid
    35% identity, 94% coverage of query (193 bits)

5qigA Pandda analysis group deposition of models with modelled events (e.G. Bound ligands) -- crystal structure of hao1 in complex with z1407672867
    33% identity, 95% coverage of query (193 bits)

5qifA Pandda analysis group deposition of models with modelled events (e.G. Bound ligands) -- crystal structure of hao1 in complex with z31792168
    33% identity, 95% coverage of query (193 bits)

2rdwA Crystal structure of human glycolate oxidase in complex with sulfate
    33% identity, 95% coverage of query (193 bits)

2rduA Crystal structure of human glycolate oxidase in complex with glyoxylate
    33% identity, 95% coverage of query (193 bits)

7bsrA Mandelate oxidase with the 2-hydroxy-3-oxosuccinic acid
    35% identity, 94% coverage of query (193 bits)

6a39A The crystal structure of mandelate oxidase y128f with c4a-malic acid- monooxide-fmn adduct
    35% identity, 94% coverage of query (193 bits)

6a0mA Mandelate oxidase mutant-y128f with 2-phenylacetic acid
    35% identity, 94% coverage of query (193 bits)

6a4hA Mandelate oxidase mutant-y128f with the peroxide fmn adduct
    35% identity, 94% coverage of query (193 bits)

6a0gA The crystal structure of mandelate oxidase mutant y128f with b- phenyllactate
    35% identity, 94% coverage of query (193 bits)

6a23A Mandelate oxidase mutant-y128f with the n5-benzyl-fmn adduct
    35% identity, 94% coverage of query (193 bits)

6a1nA Mandelate oxidase mutant-y128f with (2r,3s)-3-fluoro-2-hydroxy-3- phenylpropanoic acid
    35% identity, 94% coverage of query (193 bits)

6a1rA Mandelate oxidase mutant-y128f with the n5-phenylacetyl-fmn adduct
    35% identity, 94% coverage of query (192 bits)

6a3tA The crystal structure of mandelate oxidase r163l with 2-hydroxy- phenylacetamide
    35% identity, 95% coverage of query (192 bits)

6a0bA The crystal structure of mandelate oxidase mutant y128f with (r)-3,3, 3-trifluoro-2-hydroxy-propionic acid
    35% identity, 94% coverage of query (192 bits)

5zzxA The crystal structure of mandelate oxidase mutant y128f with (r)- mandelic acid
    35% identity, 94% coverage of query (192 bits)

HAOX1_MOUSE / Q9WU19 2-Hydroxyacid oxidase 1; HAOX1; Glycolate oxidase; GOX; Glyoxylate oxidase; EC 1.1.3.15; EC 1.2.3.5 from Mus musculus (Mouse) (see paper)
Q9WU19 (S)-2-hydroxy-acid oxidase (EC 1.1.3.15) from Mus musculus (see 3 papers)
    33% identity, 95% coverage of query (191 bits)

6a21A Mandelate oxidase mutant-y128f with the n5-malonyl-fmn adduct
    35% identity, 94% coverage of query (191 bits)

6a1hA Mandelate oxidase mutant-y128f with 5-deazariboflavin mononucleotide
    35% identity, 94% coverage of query (191 bits)

6a0oA Mandelate oxidase mutant-y128f with benzaldehyde
    35% identity, 94% coverage of query (191 bits)

6a1bA Mandelate oxidase mutant-y128f with 3,3,3-trifluoro-2,2- dihydroxypropanoic acid
    35% identity, 94% coverage of query (191 bits)

6a11A Mandelate oxidase mutant-y128f with phenylpyruvic acid
    35% identity, 94% coverage of query (191 bits)

6a36A Mandelate oxidase mutant-y128f with the 3-fluoropyruvic acid fmn adduct
    35% identity, 94% coverage of query (191 bits)

QULF_PENCI / P0DUR7 FMN-dependent alpha-hydroxy acid dehydrogenase qulF; Quinolactacin A2 biosynthesis cluster protein F; EC 1.13.12.- from Penicillium citrinum (see paper)
    34% identity, 97% coverage of query (190 bits)

5qieA Pandda analysis group deposition of models with modelled events (e.G. Bound ligands) -- crystal structure of hao1 in complex with z2856434894
    33% identity, 95% coverage of query (190 bits)

2a85A Crystal structure of the g81a mutant of the active chimera of (s)- mandelate dehydrogenase in complex with its substrate 2- hydroxyoctanoate
    33% identity, 97% coverage of query (190 bits)

2a7pA Crystal structure of the g81a mutant of the active chimera of (s)- mandelate dehydrogenase in complex with its substrate 3-indolelactate
    33% identity, 97% coverage of query (190 bits)

6a3dA The crystal structure of mandelate oxidase y128f with 4-br-2-hydroxy- methylphenylacetate
    35% identity, 94% coverage of query (190 bits)

7r4nA Structure of human hydroxyacid oxidase 1 bound with 5-bromo-n-methyl- 1h-indazole-3-carboxamide
    33% identity, 95% coverage of query (189 bits)

LOX_NOSS1 / Q8Z0C8 L-lactate oxidase; LOX; Glyoxylate oxidase; No-LOX; EC 1.1.3.-; EC 1.2.3.5 from Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) (see 2 papers)
Q8Z0C8 L-lactate oxidase (EC 1.1.3.2) from Nostoc sp. PCC 7120 = FACHB-418 (see paper)
    36% identity, 96% coverage of query (187 bits)

5qihA Pandda analysis group deposition of models with modelled events (e.G. Bound ligands) -- crystal structure of hao1 in complex with z2697514548
    33% identity, 95% coverage of query (187 bits)

5qidA Pandda analysis group deposition of models with modelled events (e.G. Bound ligands) -- crystal structure of hao1 in complex with z1787627869
    33% identity, 95% coverage of query (187 bits)

5qicA Pandda analysis group deposition of models with modelled events (e.G. Bound ligands) -- crystal structure of hao1 in complex with z30620520
    33% identity, 95% coverage of query (187 bits)

5qibA Pandda analysis group deposition of models with modelled events (e.G. Bound ligands) -- crystal structure of hao1 in complex with fmopl000388a
    33% identity, 95% coverage of query (187 bits)

B9S0Y9 (S)-2-hydroxy-acid oxidase (EC 1.1.3.15) from Ricinus communis (see paper)
    32% identity, 96% coverage of query (186 bits)

HAOX2_RAT / Q07523 2-Hydroxyacid oxidase 2; HAOX2; (S)-2-hydroxy-acid oxidase, peroxisomal; Long chain alpha-hydroxy acid oxidase; Long-chain L-2-hydroxy acid oxidase; LCHAO; EC 1.1.3.15 from Rattus norvegicus (Rat) (see 5 papers)
    34% identity, 95% coverage of query (184 bits)

5zbmB / E1AXT8 Structure of glycolate oxidase containing fmn from nicotiana benthamiana (see paper)
    33% identity, 94% coverage of query (184 bits)

G4V4S8 4-hydroxymandelate oxidase (EC 1.1.3.46) from Amycolatopsis orientalis (see 2 papers)
    37% identity, 95% coverage of query (184 bits)

7r4oA Structure of human hydroxyacid oxidase 1 bound with 2-((4h-1,2,4- triazol-3-yl)thio)-1-(4-(3-chlorophenyl)piperazin-1-yl)ethan-1-one
    32% identity, 95% coverage of query (184 bits)

GLO1_ARATH / Q9LRR9 Glycolate oxidase 1; AtGLO1; GOX1; (S)-2-hydroxy-acid oxidase GLO1; Short chain alpha-hydroxy acid oxidase GLO1; EC 1.1.3.15 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q9LRR9 (S)-2-hydroxy-acid oxidase (EC 1.1.3.15) from Arabidopsis thaliana (see paper)
    33% identity, 97% coverage of query (182 bits)

GOX1_MAIZE / A0A3L6E0R4 Glycolate oxidase 1; GOX; EC 1.1.3.15 from Zea mays (Maize) (see 2 papers)
    34% identity, 95% coverage of query (182 bits)

E1AXT8 (S)-2-hydroxy-acid oxidase (EC 1.1.3.15) from Nicotiana benthamiana (see 2 papers)
    33% identity, 94% coverage of query (182 bits)

GLO2_ARATH / Q9LRS0 Glycolate oxidase 2; AtGLO2; GOX2; (S)-2-hydroxy-acid oxidase GLO2; Short chain alpha-hydroxy acid oxidase GLO2; EC 1.1.3.15 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    33% identity, 97% coverage of query (181 bits)

2w0uA Crystal structure of human glycolate oxidase in complex with the inhibitor 5-[(4-chlorophenyl)sulfanyl]- 1,2,3-thiadiazole-4- carboxylate.
    32% identity, 95% coverage of query (180 bits)

B9ST74 (S)-2-hydroxy-acid oxidase (EC 1.1.3.15) from Ricinus communis (see paper)
    31% identity, 93% coverage of query (179 bits)

HAOX2_MOUSE / Q9NYQ2 2-Hydroxyacid oxidase 2; HAOX2; (S)-2-hydroxy-acid oxidase, peroxisomal; Medium chain alpha-hydroxy acid oxidase; Medium-chain L-2-hydroxy acid oxidase; EC 1.1.3.15 from Mus musculus (Mouse) (see paper)
Q9NYQ2 (S)-2-hydroxy-acid oxidase (EC 1.1.3.15) from Mus musculus (see paper)
    33% identity, 95% coverage of query (179 bits)

GLO1_ORYSJ / Q10CE4 Glycolate oxidase 1; GOX 1; OsGLO1; Peroxisomal (S)-2-hydroxy-acid oxidase GLO1; Short chain alpha-hydroxy acid oxidase GLO1; EC 1.1.3.15 from Oryza sativa subsp. japonica (Rice) (see 4 papers)
Q10CE4 (S)-2-hydroxy-acid oxidase (EC 1.1.3.15) from Oryza sativa Japonica Group (see paper)
    33% identity, 93% coverage of query (178 bits)

Q7FAS1 (S)-2-hydroxy-acid oxidase (EC 1.1.3.15) from Oryza sativa Japonica Group (see paper)
    32% identity, 95% coverage of query (178 bits)

7r4pA / Q9UJM8 Structure of human hydroxyacid oxidase 1 bound with 6-amino-1-benzyl- 5-(methylamino)pyrimidine-2,4(1h,3h)-dione
    32% identity, 95% coverage of query (178 bits)

6w4cA Crystal structure of hao1 in complex with indazole acid inhibitor - compound 5
    31% identity, 95% coverage of query (178 bits)

6w44A Crystal structure of hao1 in complex with indazole acid inhibitor - compound 4
    31% identity, 95% coverage of query (178 bits)

3sgzA / Q07523 High resolution crystal structure of rat long chain hydroxy acid oxidase in complex with the inhibitor 4-carboxy-5-[(4-chiorophenyl) sulfanyl]-1, 2, 3-thiadiazole. (see paper)
    32% identity, 95% coverage of query (177 bits)

CH_124019 putative FMN dependent dehydrogenase [Aspergillus fumigatus Af293] from Magnaporthe grisea 70-15 (see paper)
    33% identity, 96% coverage of query (177 bits)

LOX_LYSSC / B1HZY7 L-lactate oxidase; LOX; (S)-2-hydroxy-acid oxidase; EC 1.1.3.-; EC 1.1.3.15 from Lysinibacillus sphaericus (strain C3-41) (see paper)
    31% identity, 96% coverage of query (177 bits)

A0A0P0KG57 4-hydroxymandelate oxidase (EC 1.1.3.46) from Streptomyces sp. (see paper)
    37% identity, 94% coverage of query (176 bits)

1al7A Three-dimensional structures of glycolate oxidase with bound active- site inhibitors
    31% identity, 95% coverage of query (176 bits)

7m2oA Crystal structure of human glycolate oxidase with inhibitor compound 15
    31% identity, 95% coverage of query (176 bits)

2rdtA Crystal structure of human glycolate oxidase (go) in complex with cdst
    31% identity, 95% coverage of query (176 bits)

YKN3_SCHPO / Q9HDX2 FMN-dependent alpha-hydroxy acid dehydrogenase PB1A11.03; EC 1.13.12.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    34% identity, 89% coverage of query (175 bits)

GOX_SPIOL / P05414 Glycolate oxidase; GAO; GOX; Short chain alpha-hydroxy acid oxidase; EC 1.1.3.15 from Spinacia oleracea (Spinach) (see 5 papers)
P05414 (S)-2-hydroxy-acid oxidase (EC 1.1.3.15) from Spinacia oleracea (see paper)
    31% identity, 95% coverage of query (175 bits)

HAOX1_ARATH / Q9LJH5 Peroxisomal (S)-2-hydroxyacid oxidase GLO4; Glycolate oxidase 4; AtGLO4; GOX 4; lHAOX1; EC 1.1.3.15 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q9LJH5 (S)-2-hydroxy-acid oxidase (EC 1.1.3.15) from Arabidopsis thaliana (see paper)
    31% identity, 96% coverage of query (174 bits)

HAOX2_ARATH / Q24JJ8 Peroxisomal (S)-2-hydroxyacid oxidase GLO3; Glycolate oxidase 3; AtGLO3; GOX 3; Short chain alpha-hydroxy acid oxidase GLO3; lHAOX2; EC 1.1.3.15 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q24JJ8 (S)-2-hydroxy-acid oxidase (EC 1.1.3.15) from Arabidopsis thaliana (see paper)
    31% identity, 96% coverage of query (173 bits)

W1QKE8 L-lactate dehydrogenase (cytochrome) (EC 1.1.2.3) from Ogataea angusta (see 2 papers)
    31% identity, 95% coverage of query (169 bits)

LOX_ALIDK / F4G5A4 L-lactate oxidase; LOX; Glycolate oxidase; EC 1.1.3.-; EC 1.1.3.15 from Alicycliphilus denitrificans (strain DSM 14773 / CIP 107495 / K601) (see paper)
    34% identity, 96% coverage of query (169 bits)

B7FUG8 (S)-2-hydroxy-acid oxidase (EC 1.1.3.15) from Phaeodactylum tricornutum (see paper)
    30% identity, 97% coverage of query (168 bits)

6w45A Crystal structure of hao1 in complex with biaryl acid inhibitor - compound 3
    30% identity, 95% coverage of query (167 bits)

LOX_ROSS0 / B7RR92 L-lactate oxidase; LOX; (S)-2-hydroxy-acid oxidase; EC 1.1.3.-; EC 1.1.3.15 from Roseobacter sp. (strain GAI101) (see paper)
    34% identity, 96% coverage of query (166 bits)

1al8A Three-dimensional structure of glycolate oxidase with bound active- site inhibitors
    31% identity, 95% coverage of query (164 bits)

CYB2 / P00175 L-lactate dehydrogenase subunit (EC 1.1.2.3) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 2 papers)
CYB2_YEAST / P00175 L-lactate dehydrogenase (cytochrome); Cytochrome b2; Flavocytochrome b2; FCB2; L-lactate ferricytochrome c oxidoreductase; L-LCR; EC 1.1.2.3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 8 papers)
P00175 L-lactate dehydrogenase (cytochrome) (EC 1.1.2.3) from Saccharomyces cerevisiae (see 9 papers)
    30% identity, 99% coverage of query (163 bits)

1kbiA / P00175 Crystallographic study of the recombinant flavin-binding domain of baker's yeast flavocytochrome b2: comparison with the intact wild- type enzyme (see paper)
    30% identity, 99% coverage of query (163 bits)

1fcbB Molecular structure of flavocytochrome b2 at 2.4 angstroms resolution
    30% identity, 99% coverage of query (160 bits)

1szeA L230a mutant flavocytochrome b2 with benzoylformate
    30% identity, 99% coverage of query (159 bits)

Q9CG58 (S)-2-hydroxy-acid oxidase (EC 1.1.3.15) from Lactococcus lactis (see 2 papers)
    31% identity, 92% coverage of query (156 bits)

6a4gA Mandelate oxidase mutant-y128f with the monooxide fmn adduct
    31% identity, 93% coverage of query (156 bits)

Build an alignment

Build an alignment for BPHYT_RS31690 and 99 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

A9QH69 (S)-2-hydroxy-acid oxidase (EC 1.1.3.15); L-lactate oxidase (EC 1.1.3.2) from Streptococcus iniae (see paper)
    29% identity, 93% coverage of query (155 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory