Searching for up to 100 curated homologs for BPHYT_RS33445 FitnessBrowser__BFirm:BPHYT_RS33445 (377 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
Ac3H11_1849 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Acidovorax sp. GW101-3H11
43% identity, 94% coverage of query (263 bits)
Pf6N2E2_456 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Pseudomonas fluorescens FW300-N2E2
42% identity, 94% coverage of query (261 bits)
PfGW456L13_2935 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Pseudomonas fluorescens GW456-L13
41% identity, 94% coverage of query (259 bits)
AO356_22845 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Pseudomonas fluorescens FW300-N2C3
41% identity, 94% coverage of query (259 bits)
AO353_26925 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Pseudomonas fluorescens FW300-N2E3
41% identity, 94% coverage of query (259 bits)
1cjxA / P80064 Crystal structure of pseudomonas fluorescens hppd (see paper)
40% identity, 94% coverage of query (258 bits)
Psest_3514 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Pseudomonas stutzeri RCH2
40% identity, 96% coverage of query (257 bits)
P80064 4-hydroxyphenylpyruvate dioxygenase subunit (EC 1.13.11.27) from Pseudomonas sp. (strain P.J. 874) (see 3 papers)
P80064 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Pseudomonas fluorescens (see paper)
41% identity, 94% coverage of query (257 bits)
7x8eA Crystal structure of pfhppd-y13287 complex
41% identity, 94% coverage of query (256 bits)
7xntA Crystal structure of pfhppd-y13161 complex
41% identity, 94% coverage of query (249 bits)
Q09PG8 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from uncultured soil bacterium (see paper)
40% identity, 94% coverage of query (247 bits)
7xntC / A0A0W0HIR1 Crystal structure of pfhppd-y13161 complex
40% identity, 93% coverage of query (247 bits)
LLY_LEGPC / P69053 4-hydroxyphenylpyruvate dioxygenase; 4HPPD; HPD; HPPDase; Legiolysin; EC 1.13.11.27 from Legionella pneumophila (strain Corby) (see paper)
39% identity, 94% coverage of query (243 bits)
SO1962 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Shewanella oneidensis MR-1
Q8EFK9 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Shewanella oneidensis (see paper)
33% identity, 95% coverage of query (207 bits)
DSD_PSEAE / Q9I6P6 3-dehydroshikimate dehydratase; DSD; EC 4.2.1.118 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
35% identity, 97% coverage of query (154 bits)
DSD_PSEPK / Q88JU3 3-dehydroshikimate dehydratase; DSD; EC 4.2.1.118 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
33% identity, 93% coverage of query (150 bits)
5hmqD / Q88JU3 Xylose isomerase-like tim barrel/4-hydroxyphenylpyruvate dioxygenase fusion protein
33% identity, 92% coverage of query (150 bits)
Build an alignment for BPHYT_RS33445 and 17 homologs with ≥ 30% identity
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HPPD_STRAW / Q53586 4-hydroxyphenylpyruvate dioxygenase; 4HPPD; HPD; HPPDase; EC 1.13.11.27 from Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) (see paper)
29% identity, 98% coverage of query (122 bits)
1t47A / Q53586 Structure of fe2-hppd bound to ntbc (see paper)
29% identity, 94% coverage of query (119 bits)
7yvvA / A0A7H8HIR4 Acmp1, r-4-hydroxymandelate synthase
31% identity, 77% coverage of query (117 bits)
Q6KZ98 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Picrophilus torridus (see paper)
28% identity, 81% coverage of query (117 bits)
2r5vA / O52791 Hydroxymandelate synthase crystal structure (see paper)
30% identity, 82% coverage of query (102 bits)
HMAS_AMYOR / O52791 4-hydroxymandelate synthase; HMS; HmaS; 4-hydroxyphenylpyruvate dioxygenase II; EC 1.13.11.46 from Amycolatopsis orientalis (Nocardia orientalis) (see 3 papers)
O52791 4-hydroxymandelate oxidase (EC 1.1.3.46) from Amycolatopsis orientalis (see paper)
30% identity, 82% coverage of query (99.4 bits)
HPPD1_ASPFU / Q4WHU1 4-hydroxyphenylpyruvate dioxygenase; 4HPPD; HPD; HPPDase; L-tyrosine degradation gene cluster protein hppD; Pyomelanin biosynthesis cluster protein hppD; EC 1.13.11.27 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see 3 papers)
26% identity, 91% coverage of query (94.4 bits)
HPPD_PIG / Q02110 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; EC 1.13.11.27 from Sus scrofa (Pig) (see paper)
26% identity, 89% coverage of query (92.0 bits)
HPD / P32754 4-hydroxyphenylpyruvate dioxygenase subunit (EC 1.13.11.27) from Homo sapiens (see 4 papers)
HPPD_HUMAN / P32754 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; EC 1.13.11.27 from Homo sapiens (Human) (see 3 papers)
P32754 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Homo sapiens (see 5 papers)
26% identity, 89% coverage of query (91.7 bits)
5ec3A / P32754 Structural insight into the catalyitc mechanism of human 4- hydroxyphenylpyruvate dioxygenase
26% identity, 89% coverage of query (91.3 bits)
8im2A Crystal structure of human hppd complexed with ntbc
26% identity, 89% coverage of query (91.3 bits)
8im3A Crystal structure of human hppd complexed with compound a10
26% identity, 89% coverage of query (91.3 bits)
3zgjB / Q9Z4X7 S221m v223f y359a mutant of 4-hydroxymandelate synthase from streptomyces coelicolor (see paper)
28% identity, 91% coverage of query (89.7 bits)
HPPD_RAT / P32755 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; F Alloantigen; F protein; EC 1.13.11.27 from Rattus norvegicus (Rat) (see 3 papers)
P32755 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Rattus norvegicus (see 2 papers)
26% identity, 90% coverage of query (89.4 bits)
1sqiA Structural basis for inhibitor selectivity revealed by crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases
26% identity, 87% coverage of query (83.6 bits)
1sqiB / P32755 Structural basis for inhibitor selectivity revealed by crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases (see paper)
25% identity, 87% coverage of query (81.6 bits)
hppD / Q55810 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
23% identity, 92% coverage of query (79.0 bits)
hppd / BAF74636.1 hydroxyphenylpyruvate dioxygenase from Coptis japonica var. dissecta (see paper)
26% identity, 95% coverage of query (73.9 bits)
qsuB / A4QB63 dehydroshikimate dehydratase (EC 4.2.1.118) from Corynebacterium glutamicum (strain R) (see paper)
27% identity, 94% coverage of query (68.6 bits)
1sp8D 4-hydroxyphenylpyruvate dioxygenase (see paper)
29% identity, 72% coverage of query (67.4 bits)
7e0xA Crystal structure of arabidopsis thaliana hppd complexed with 4- hydroxyphenylacetic acid
27% identity, 77% coverage of query (66.2 bits)
8i2sA Crystal structure of athppd-y18979 complex
27% identity, 77% coverage of query (66.2 bits)
8i36A Crystal structure of athppd-y18980 complex
27% identity, 77% coverage of query (66.2 bits)
8i2uA Crystal structure of athppd-yh20282 complex
27% identity, 77% coverage of query (66.2 bits)
HPPD_ARATH / P93836 4-hydroxyphenylpyruvate dioxygenase; 4-hydroxyphenylpyruvic acid oxidase; 4HPPD; HPD; HPPDase; EC 1.13.11.27 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
27% identity, 77% coverage of query (65.5 bits)
8h6bA Crystal structure of athppd complexed with yh20702
26% identity, 77% coverage of query (65.1 bits)
7x8hA Crystal structure of athppd-(+)-usnic acid complex
26% identity, 77% coverage of query (64.7 bits)
A0A1S5V3J7 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) from Medicago sativa (see paper)
24% identity, 90% coverage of query (64.3 bits)
7x5rA / P93836 Crystal structure of athppd-lancotrione complex
26% identity, 77% coverage of query (63.9 bits)
8hz9A Crystal structure of athppd-y181136 complex
26% identity, 77% coverage of query (63.9 bits)
8hz7A Crystal structure of athppd-y181135 complex
26% identity, 77% coverage of query (63.9 bits)
8gwdA Crystal structure of athppd-y18734 complex
26% identity, 77% coverage of query (63.9 bits)
7x5zA Crystal structure of athppd-y13162 complex
26% identity, 77% coverage of query (63.9 bits)
6lgtA Complex structure of hppd with an inhibitor y16542
26% identity, 77% coverage of query (63.9 bits)
8hzaA Crystal structure of athppd-yh20326 complex
26% identity, 77% coverage of query (63.9 bits)
7v6xA Crystal structure of hppd complexed with y18556
26% identity, 77% coverage of query (63.9 bits)
8hyoA Crystal structure of athppd-y18031 complex
26% identity, 77% coverage of query (63.9 bits)
7wj8A Complex structure of athppd-pyq1
26% identity, 77% coverage of query (63.9 bits)
7vo8A Structure of athppd complexed with lsy-1
26% identity, 77% coverage of query (63.9 bits)
7vc8A Complex structure of athppd with inhibitor pyq3
26% identity, 77% coverage of query (63.9 bits)
7cqsA Complex structure of hppd with topramezone
26% identity, 77% coverage of query (63.9 bits)
8i15A Crystal structure of athppd-yh20335 complex
26% identity, 77% coverage of query (63.5 bits)
8i0gA Crystal structure of athppd-y19543 complex
26% identity, 77% coverage of query (63.5 bits)
8hysA Crystal structure of athppd-y19802 complex
26% identity, 77% coverage of query (63.5 bits)
8hypA Crystal structure of athppd-y18400 complex
26% identity, 77% coverage of query (63.5 bits)
8hymA Crystal structure of athppd-y18030 complex
26% identity, 77% coverage of query (63.5 bits)
8hxhA Crystal structure of athppd-y18024 complex
26% identity, 77% coverage of query (63.5 bits)
8hxfA Crystal structure of athppd-y181188 complex
26% identity, 77% coverage of query (63.5 bits)
8hx2A Crystal structure of athppd-y18405 complex
26% identity, 77% coverage of query (63.5 bits)
8hwrA Crystal structure of athppd-y191193 complex
26% identity, 77% coverage of query (63.5 bits)
8howA Crystal structure of athppd-y191052 complex
26% identity, 77% coverage of query (63.5 bits)
7x8dA Crystal structure of athppd-phenylpyruvate complex
26% identity, 77% coverage of query (63.5 bits)
7x69A Crystal structure of athppd-y191053 complex
26% identity, 77% coverage of query (63.5 bits)
7x62A Crystal structure of athppd-y191051 complex
26% identity, 77% coverage of query (63.5 bits)
7x5yA Crystal structure of athppd-y14240 complex
26% identity, 77% coverage of query (63.5 bits)
7x5xA Crystal structure of athppd-yh20533 complex
26% identity, 77% coverage of query (63.5 bits)
7wjkA Complex structure of athppd-zwj
26% identity, 77% coverage of query (63.5 bits)
7wjjA Complex structure of athppd-pyq2
26% identity, 77% coverage of query (63.5 bits)
7cjkA Complex structure of athppd with inhibitor y18093
26% identity, 77% coverage of query (63.5 bits)
8i0yA Crystal structure of athppd-y191713 complex
26% identity, 77% coverage of query (63.2 bits)
7x6nA Crystal structure of athppd-y191710 complex
26% identity, 77% coverage of query (63.2 bits)
8h6aA Crystal structure of athppd complexed with yh21477
26% identity, 77% coverage of query (63.2 bits)
6m6dA Structure of hppd complexed with a synthesized inhibitor
27% identity, 77% coverage of query (63.2 bits)
8i2pA Crystal structure of athppd-y19060 complex
27% identity, 77% coverage of query (63.2 bits)
7ezqA Complex structure of athppd with inhibitor y15832
27% identity, 77% coverage of query (62.8 bits)
7x8iA Crystal structure of athppd-shikonin complex
27% identity, 77% coverage of query (62.4 bits)
7x64A Crystal structure of athppd-y18027 complex
27% identity, 77% coverage of query (62.4 bits)
7x5sA Crystal structure of athppd-y14157 complex
27% identity, 77% coverage of query (62.4 bits)
8hzuA Crystal structure of athppd-xhd complex
26% identity, 77% coverage of query (62.0 bits)
7x6mA Crystal structure of athppd-y191058 complex
26% identity, 77% coverage of query (62.0 bits)
7x5uA Crystal structure of athppd-diketonitrile complex
26% identity, 77% coverage of query (62.0 bits)
7x5wA Crystal structure of athppd-y18022 complex
26% identity, 77% coverage of query (62.0 bits)
8hz6A Crystal structure of athppd-qry2089 complex
26% identity, 77% coverage of query (61.6 bits)
8hx4A Crystal structure of athppd-y18549 complex
26% identity, 77% coverage of query (61.6 bits)
8hxgA Crystal structure of athppd-y14116 complex
26% identity, 77% coverage of query (61.2 bits)
7x67A Crystal structure of athppd-y18406 complex
26% identity, 77% coverage of query (61.2 bits)
7cqrA Complex structure of hppd with y16550
26% identity, 77% coverage of query (61.2 bits)
6jx9A Structure of y17107 complexed hppd
26% identity, 77% coverage of query (61.2 bits)
7x7lA Crystal structure of zmhppd-y13161 complex
28% identity, 72% coverage of query (60.5 bits)
6isdA Crystal structure of arabidopsis thaliana hppd complexed with sulcotrione
25% identity, 72% coverage of query (59.7 bits)
1sp9B 4-hydroxyphenylpyruvate dioxygenase
25% identity, 78% coverage of query (59.7 bits)
1tg5A Crystal structures of plant 4-hydroxyphenylpyruvate dioxygenases complexed with das645
26% identity, 77% coverage of query (59.7 bits)
5ywiA Crystal structure of arabidopsis thaliana hppd truncated mutant complexed with ntbc
26% identity, 76% coverage of query (58.9 bits)
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Lawrence Berkeley National Laboratory