Searching for up to 100 curated homologs for BPHYT_RS33455 FitnessBrowser__BFirm:BPHYT_RS33455 (234 a.a.)

Found high-coverage hits (≥70%) to 40 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q0SH27 protocatechuate 3,4-dioxygenase (subunit 2/2) (EC 1.13.11.3) from Rhodococcus jostii (see paper)
    53% identity, 94% coverage of query (243 bits)

pcaH / AAC38243.1 protocatechuate dioxygenase beta subunit from Rhodococcus opacus (see paper)
    53% identity, 93% coverage of query (242 bits)

pcaH2 / Q93PS2 protocatechuate 3,4-dioxygenase type II β subunit (EC 1.13.11.3) from Hydrogenophaga intermedia (see 4 papers)
    52% identity, 94% coverage of query (233 bits)

pcaH / P00437 protocatechuate 3,4-dioxygenase β subunit (EC 1.13.11.3) from Pseudomonas putida (see paper)
pcaH / AAB41024.1 protocatechuate 3,4-dioxygenase, beta subunit from Pseudomonas putida (see paper)
    48% identity, 99% coverage of query (219 bits)

P00437 Protocatechuate 3,4-dioxygenase beta chain; 3,4-PCD; EC 1.13.11.3 from Pseudomonas putida (Arthrobacter siderocapsulatus)
    48% identity, 99% coverage of query (219 bits)

4whqF Alkylperoxo reaction intermediate trapped in protocatechuate 3,4- dioxygenase (pseudomonas putida) at ph 6.5
    48% identity, 99% coverage of query (219 bits)

4whrB Anhydride reaction intermediate trapped in protocatechuate 3,4- dioxygenase (pseudomonas putida) at ph 8.5
    48% identity, 99% coverage of query (219 bits)

4whqB Alkylperoxo reaction intermediate trapped in protocatechuate 3,4- dioxygenase (pseudomonas putida) at ph 6.5
    48% identity, 99% coverage of query (219 bits)

I0DHJ1 protocatechuate 3,4-dioxygenase (subunit 1/2) (EC 1.13.11.3) from Stenotrophomonas maltophilia (see 2 papers)
    48% identity, 99% coverage of query (218 bits)

3lktM / P00437 Tyrosine 447 of protocatechuate 3,4-dioxygenase controls efficient progress through catalysis
    48% identity, 99% coverage of query (217 bits)

3lxvM Tyrosine 447 of protocatechuate 3,4-dioxygenase controls efficient progress through catalysis
    48% identity, 99% coverage of query (217 bits)

3pckM Structure of protocatechuate 3,4-dioxygenase complexed with 6- hydroxynicotinic acid n-oxide
    48% identity, 99% coverage of query (215 bits)

3pcjM Structure of protocatechuate 3,4-dioxygenase complexed with 2- hydroxyisonicotinic acid n-oxide
    48% identity, 99% coverage of query (215 bits)

3pciM Structure of protocatechuate 3,4-dioxygenase complexed with 3-iodo-4- hydroxybenzoate
    48% identity, 99% coverage of query (215 bits)

3pchM Structure of protocatechuate 3,4-dioxygenase complexed with 3-chloro- 4-hydroxybenzoate
    48% identity, 99% coverage of query (215 bits)

3pcgM Structure of protocatechuate 3,4-dioxygenase complexed with the inhibitor 4-hydroxyphenylacetate
    48% identity, 99% coverage of query (215 bits)

3pcfM Structure of protocatechuate 3,4-dioxygenase complexed with 3-fluro-4- hydroxybenzoate
    48% identity, 99% coverage of query (215 bits)

3pceM Structure of protocatechuate 3,4-dioxygenase complexed with 3- hydroxyphenylacetate
    48% identity, 99% coverage of query (215 bits)

3pcbM Structure of protocatechuate 3,4-dioxygenase complexed with 3- hydroxybenzoate
    48% identity, 99% coverage of query (215 bits)

3mv4M Axial ligand swapping in double mutant maintains intradiol-cleavage chemistry in protocatechuate 3,4-dioxygenase
    47% identity, 99% coverage of query (214 bits)

3mi5M Axial ligand swapping in double mutant maintains intradiol-cleavage chemistry in protocatechuate 3,4-dioxygenase
    47% identity, 99% coverage of query (214 bits)

3mflM Axial ligand swapping in double mutant maintains intradiol-cleavage chemistry in protocatechuate 3,4-dioxygenase
    47% identity, 99% coverage of query (214 bits)

A0A193DXP2 protocatechuate 3,4-dioxygenase (subunit 1/2) (EC 1.13.11.3) from Rhizobium sp. LMB-1 (see paper)
    52% identity, 97% coverage of query (210 bits)

pcaH / RF|YP_046375.1 protocatechuate 3,4-dioxygenase, beta chain; EC 1.13.11.3 from Acinetobacter sp. ADP1 (see 3 papers)
pcaH / AAC37153.1 protocatechuate 3,4-dioxygenase beta subunit from Acinetobacter baylyi (see 11 papers)
    48% identity, 98% coverage of query (209 bits)

2bumB / P20372 Crystal structure of wild-type protocatechuate 3,4-dioxygenase from acinetobacter sp. Adp1 (see paper)
    48% identity, 98% coverage of query (209 bits)

pcaH / AAF34268.1 protocatechuate 3,4-dioxygenase beta chain from Agrobacterium tumefaciens (see 2 papers)
    52% identity, 97% coverage of query (209 bits)

2buqB Crystal structure of wild-type protocatechuate 3,4-dioxygenase from acinetobacter sp. Adp1 in complex with catechol
    48% identity, 98% coverage of query (209 bits)

1eocB Crystal structure of acinetobacter sp. Adp1 protocatechuate 3,4- dioxygenase in complex with 4-nitrocatechol
    48% identity, 98% coverage of query (209 bits)

1eoaB Crystal structure of acinetobacter sp. Adp1 protocatechuate 3,4- dioxygenase in complex with cyanide
    48% identity, 98% coverage of query (209 bits)

1eo9B Crystal structure of acinetobacter sp. Adp1 protocatechuate 3,4- dioxygenase at ph < 7.0
    48% identity, 98% coverage of query (209 bits)

A8I4B3 protocatechuate 3,4-dioxygenase (EC 1.13.11.3) from Chromohalobacter sp. (see paper)
    44% identity, 99% coverage of query (197 bits)

pcaG / AAC37154.1 protocatechuate 3,4-dioxygenase alpha subunit from Acinetobacter baylyi (see 11 papers)
    34% identity, 76% coverage of query (85.5 bits)

2buqA / P20371 Crystal structure of wild-type protocatechuate 3,4-dioxygenase from acinetobacter sp. Adp1 in complex with catechol (see paper)
    34% identity, 76% coverage of query (85.1 bits)

pcaG / RF|YP_046376.1 protocatechuate 3,4-dioxygenase, alpha chain; EC 1.13.11.3 from Acinetobacter sp. ADP1 (see 3 papers)
    34% identity, 76% coverage of query (85.1 bits)

2buuA Crystal structure of protocatechuate 3,4-dioxygenase from acinetobacter sp. Adp1 mutant r457s in complex with 4-nitrocatechol
    34% identity, 76% coverage of query (85.1 bits)

A0A193DXA9 protocatechuate 3,4-dioxygenase (subunit 2/2) (EC 1.13.11.3) from Rhizobium sp. LMB-1 (see paper)
    36% identity, 75% coverage of query (80.9 bits)

pcaG2 / Q93PS1 protocatechuate 3,4-dioxygenase type II α subunit (EC 1.13.11.3) from Hydrogenophaga intermedia (see 4 papers)
    31% identity, 73% coverage of query (79.3 bits)

pcaG / AAF34267.1 protocatechuate 3,4-dioxygenase alpha chain from Agrobacterium tumefaciens (see 2 papers)
    33% identity, 75% coverage of query (78.6 bits)

Build an alignment

Build an alignment for BPHYT_RS33455 and 38 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

HQDA_ASPNC / A2QAP8 Intradiol ring-cleavage dioxygenase hqdA; EC 1.13.11.1; EC 1.13.11.37 from Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
    29% identity, 72% coverage of query (67.0 bits)

A8I4B7 protocatechuate 3,4-dioxygenase (EC 1.13.11.3) from Chromohalobacter sp. (see paper)
    30% identity, 71% coverage of query (58.2 bits)

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