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Searching for up to 100 curated homologs for BPHYT_RS34990 FitnessBrowser__BFirm:BPHYT_RS34990 (421 a.a.)

Found high-coverage hits (≥70%) to 95 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

ahpH / CAH04397.1 ferredoxin reductase from Mycobacterium sp. HXN-1500 (see paper)
    38% identity, 95% coverage of query (267 bits)

cnbAa / F4Y9I5 nitroarene dioxygenase ferredoxin reductase component (EC 1.14.12.23) from Stutzerimonas stutzeri (see 2 papers)
F4Y9I5 nitroarene dioxygenase (subunit 4/4) (EC 1.14.12.23) from Pseudomonas stutzeri ZWLR2-1 (see paper)
    48% identity, 76% coverage of query (265 bits)

picB2 / A0A1X9WE60 6-hydroxypicolinate 3-monooxygenase subunit 2 from Alcaligenes faecalis (see paper)
    37% identity, 95% coverage of query (260 bits)

camA / P16640 NADH-putidaredoxin reductase (EC 1.18.1.5) from Pseudomonas putida (see 4 papers)
CAMA_PSEPU / P16640 Putidaredoxin reductase CamA; Pdr; Putidaredoxin--NAD(+) reductase; EC 1.18.1.5 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 4 papers)
P16640 putidaredoxin-NAD+ reductase (EC 1.18.1.5) from Pseudomonas putida (see 9 papers)
    38% identity, 96% coverage of query (259 bits)

1q1wA / P16640 Crystal structure of putidaredoxin reductase from pseudomonas putida (see paper)
    38% identity, 95% coverage of query (258 bits)

8pxkA / Q52437 Structure of nadh-dependent ferredoxin reductase, bpha4, solved at wavelength 5.76 a (see paper)
    39% identity, 96% coverage of query (247 bits)

2gr2A Crystal structure of ferredoxin reductase, bpha4 (oxidized form)
    39% identity, 96% coverage of query (247 bits)

2gr0A Crystal structure of ferredoxin reductase, bpha4 (oxidized form, NAD+ complex)
    39% identity, 96% coverage of query (247 bits)

2yvjA Crystal structure of the ferredoxin-ferredoxin reductase (bpha3-bpha4)complex
    39% identity, 96% coverage of query (247 bits)

1f3pA Ferredoxin reductase (bpha4)-nadh complex
    39% identity, 96% coverage of query (247 bits)

4h4uA Crystal structure of ferredoxin reductase, bpha4 t176r mutant (reduced form)
    39% identity, 96% coverage of query (246 bits)

cmtAa / Q51973 p-cumate 2,3-dioxygenase system, ferredoxin--NAD+ reductase component (EC 1.14.12.25) from Pseudomonas putida (see paper)
CMTAA_PSEPU / Q51973 p-cumate 2,3-dioxygenase system, ferredoxin--NAD(+) reductase component; EC 1.18.1.3 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 3 papers)
Q51973 p-cumate 2,3-dioxygenase (subunit 4/4) (EC 1.14.12.25) from Pseudomonas putida (see paper)
cmtAa / AAB62284.1 p-cumate dioxygenase ferredoxin reductase subunit from Pseudomonas putida (see 3 papers)
    37% identity, 95% coverage of query (244 bits)

4h4wA Crystal structure of ferredoxin reductase, bpha4 e175c/t176r/q177g mutant (reduced form)
    39% identity, 96% coverage of query (244 bits)

3fg2P / Q6N3B2 Crystal structure of ferredoxin reductase for the cyp199a2 system from rhodopseudomonas palustris (see paper)
    36% identity, 95% coverage of query (231 bits)

YfhY / b2542 putative 3-phenylpropionate/cinnamate dioxygenase ferredoxin reductase subunit (EC 1.14.12.19) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
hcaD / P77650 putative 3-phenylpropionate/cinnamate dioxygenase ferredoxin reductase subunit (EC 1.14.12.19) from Escherichia coli (strain K12) (see 2 papers)
    39% identity, 95% coverage of query (229 bits)

mdpD / A2SP72 MTBE monooxygenase rubredoxin reductase component from Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1) (see 4 papers)
    37% identity, 94% coverage of query (223 bits)

bedA / Q07946 benzene 1,2-dioxygenase ferredoxin reductase subunit (EC 1.14.12.3) from Pseudomonas putida (see 3 papers)
bedA / AAA17761.1 BedA from Pseudomonas putida (see 3 papers)
    35% identity, 95% coverage of query (218 bits)

andAa / Q84BZ0 anthranilate dioxygenase reductase component (EC 1.14.12.1) from Burkholderia cepacia (see paper)
ANDAA_BURCE / Q84BZ0 Anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase component; EC 1.18.1.3 from Burkholderia cepacia (Pseudomonas cepacia) (see paper)
    38% identity, 95% coverage of query (218 bits)

bpdA / AAB07753.1 ferrodoxin reductase from Rhodococcus sp. M5 (see paper)
    36% identity, 95% coverage of query (216 bits)

fdr / D5IGG6 carbazole 1,9a-dioxygenase ferredoxin reductase component (EC 1.14.12.22) from Sphingomonas sp. (see paper)
FDR_SPHSX / D5IGG6 Ferredoxin--NAD(P)(+) reductase fdr; Carbazole 1,9a-dioxygenase, ferredoxin reductase component; CARDO; EC 1.18.1.2; EC 1.18.1.3 from Sphingomonas sp. (see paper)
    34% identity, 91% coverage of query (216 bits)

LIGXD_SPHSK / G2ITT5 5,5'-dehydrodivanillate O-demethylase ferredoxin reductase subunit; DDVA O-demethylase ferredoxin reductase subunit; EC 1.14.13.- from Sphingobium sp. (strain NBRC 103272 / SYK-6) (see paper)
    35% identity, 91% coverage of query (215 bits)

CTMF_CASD6 / W8X9R5 Probable ferredoxin reductase CtmF; EC 1.-.-.- from Castellaniella defragrans (strain DSM 12143 / CCUG 39792 / 65Phen) (Alcaligenes defragrans) (see paper)
    35% identity, 95% coverage of query (212 bits)

CNDC1_RHIWD / X5CY81 Chloroacetanilide N-alkylformylase, ferredoxin reductase component; Ferredoxin--NAD(+) reductase; EC 1.18.1.3 from Rhizorhabdus wittichii (strain DC-6 / KACC 16600) (Sphingomonas wittichii) (see paper)
    36% identity, 91% coverage of query (207 bits)

bphAd / BAM76239.1 biphenyl 2,3-dioxygenase, ferredoxin reductase from Janibacter sp. TYM3221 (see paper)
    35% identity, 95% coverage of query (206 bits)

kdR / BAM93336.1 FAD-dependent ferredoxin reductase from Sphingomonas sp. KSM1 (see paper)
    34% identity, 91% coverage of query (204 bits)

3lxdA / Q2GBV9 Crystal structure of ferredoxin reductase arr from novosphingobium aromaticivorans (see paper)
    34% identity, 91% coverage of query (202 bits)

DDMA1_STEMA / Q5S3I2 Dicamba O-demethylase 1, ferredoxin reductase component; Ferredoxin--NAD(+) reductase; EC 1.18.1.3 from Stenotrophomonas maltophilia (Pseudomonas maltophilia) (Xanthomonas maltophilia) (see 3 papers)
    32% identity, 95% coverage of query (199 bits)

DDMA2_STEMA / Q5S3I1 Dicamba O-demethylase 2, ferredoxin reductase component; Ferredoxin--NAD(+) reductase; EC 1.18.1.3 from Stenotrophomonas maltophilia (Pseudomonas maltophilia) (Xanthomonas maltophilia) (see paper)
    32% identity, 95% coverage of query (198 bits)

todA / A5W4E9 toluene dioxygenase reductase subunit (EC 1.14.12.11) from Pseudomonas putida (strain ATCC 700007 / DSM 6899 / BCRC 17059 / F1) (see paper)
    35% identity, 95% coverage of query (196 bits)

4emjA / A5W4E9 Complex between the reductase and ferredoxin components of toluene dioxygenase (see paper)
    35% identity, 95% coverage of query (196 bits)

4emiA Toluene dioxygenase reductase in reduced state in complex with NAD+
    35% identity, 95% coverage of query (196 bits)

BPHA4_RHOJR / Q0S032 Biphenyl 2,3-dioxygenase, ferredoxin reductase component; Biphenyl 2,3-dioxygenase, electron transfer component BphA4; Biphenyl dioxygenase system, ferredoxin--NAD(+) reductase component; BDO, ferredoxin reductase component; EC 1.18.1.3 from Rhodococcus jostii (strain RHA1) (see paper)
    33% identity, 91% coverage of query (194 bits)

tecA4 / O24679 chlorobenzene dioxygenase terminal oxidase ferredoxin reductase subunit (EC 1.14.12.26; EC 1.14.12.18; EC 1.14.12.12) from Cupriavidus sp. (strain PS12) (see 2 papers)
TECA4_CUPXP / O24679 Chlorobenzene dioxygenase, ferredoxin reductase component; EC 1.18.1.3 from Cupriavidus sp. (strain PS12) (see 2 papers)
    35% identity, 95% coverage of query (194 bits)

tcbAd / Q52386 chlorobenzene dioxygenase, NADH-ferredoxin reductase component (EC 1.14.12.26) from Pseudomonas sp. (see 2 papers)
Q52386 chlorobenzene dioxygenase (subunit 1/4) (EC 1.14.12.26) from Pseudomonas sp. P51 (see 2 papers)
    35% identity, 95% coverage of query (193 bits)

bphA4 / BAA06871.1 biphenyl dioxygenase from Rhodococcus jostii RHA1 (see paper)
    33% identity, 91% coverage of query (192 bits)

redA2 / CAA05635.1 redA2 from Sphingomonas sp (see paper)
    32% identity, 95% coverage of query (190 bits)

dpaAd / C3UVB8 diphenylamine dioxygenase ferredoxin reductase component from Burkholderia sp. JS667 (see paper)
    35% identity, 94% coverage of query (185 bits)

6tukB / Q47QF8 Crystal structure of fdr9 (see paper)
    33% identity, 95% coverage of query (179 bits)

phtA4 / BAC54161.1 ferredoxin reductase of phthalate dioxygenase from Terrabacter sp. DBF63 (see paper)
    35% identity, 89% coverage of query (176 bits)

bphA4 / A0A097SRE8 biphenyl 2,3-dioxygenase ferredoxin reductase subunit (EC 1.14.12.18) from Cupriavidus sp. WS (see paper)
    34% identity, 95% coverage of query (175 bits)

alkT / P17052 rubredoxin-NAD(+) reductase (EC 1.18.1.1) from Pseudomonas oleovorans (see paper)
RURE_PSEOL / P17052 Rubredoxin-NAD(+) reductase; RdxR; EC 1.18.1.1 from Pseudomonas oleovorans (see 3 papers)
alkT / CAB54063.1 rubredoxin reductase from Pseudomonas putida (see 6 papers)
    36% identity, 81% coverage of query (168 bits)

MDAR_ARATH / P92947 Monodehydroascorbate reductase, chloroplastic/mitochondrial; Monodehydroascorbate reductase 5, mitochondrial; AtMDAR5; Monodehydroascorbate reductase 6, chloroplastic; AtMDAR6; EC 1.6.5.4 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
P92947 monodehydroascorbate reductase (NADH) (EC 1.6.5.4) from Arabidopsis thaliana (see paper)
    32% identity, 95% coverage of query (156 bits)

B3EYD3 monodehydroascorbate reductase (NADH) (EC 1.6.5.4) from Solanum lycopersicum (see paper)
    31% identity, 89% coverage of query (151 bits)

MDAR_SOLLC / Q43497 Monodehydroascorbate reductase; MDAR; Ascorbate free radical reductase; AFR reductase; EC 1.6.5.4 from Solanum lycopersicum (Tomato) (Lycopersicon esculentum) (see paper)
    31% identity, 82% coverage of query (151 bits)

Build an alignment

Build an alignment for BPHYT_RS34990 and 44 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

MDAR5_ORYSJ / Q84PW3 Monodehydroascorbate reductase 5, chlorplastic; OsMADR5; OsMDHAR5; EC 1.6.5.4 from Oryza sativa subsp. japonica (Rice) (see paper)
    29% identity, 95% coverage of query (147 bits)

MDAR_PEA / Q40977 Monodehydroascorbate reductase; MDAR; Ascorbate free radical reductase; AFR reductase; EC 1.6.5.4 from Pisum sativum (Garden pea) (Lathyrus oleraceus) (see paper)
    31% identity, 81% coverage of query (146 bits)

AIFM3_HUMAN / Q96NN9 Apoptosis-inducing factor 3; Apoptosis-inducing factor-like protein; EC 1.-.-.- from Homo sapiens (Human) (see paper)
    26% identity, 91% coverage of query (144 bits)

MDAR4_ARATH / Q9LK94 Monodehydroascorbate reductase 4, peroxisomal; AtMDAR4; EC 1.6.5.4 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9LK94 monodehydroascorbate reductase (NADH) (EC 1.6.5.4) from Arabidopsis thaliana (see paper)
    30% identity, 75% coverage of query (133 bits)

YgaL / b2711 NADH:flavorubredoxin reductase from Escherichia coli K-12 substr. MG1655 (see 12 papers)
norW / P37596 NADH:flavorubredoxin reductase (EC 1.18.1.1) from Escherichia coli (strain K12) (see 11 papers)
NORW_ECODH / B1XCN8 Nitric oxide reductase FlRd-NAD(+) reductase; Flavorubredoxin reductase; FlRd-reductase; FlavoRb reductase; EC 1.18.1.- from Escherichia coli (strain K12 / DH10B) (see paper)
    33% identity, 74% coverage of query (129 bits)

E2RWY5 monodehydroascorbate reductase (NADH) (EC 1.6.5.4) from Malpighia glabra (see paper)
BAJ23958.1 monodehydroascorbate reductase from Malpighia glabra (see paper)
    29% identity, 75% coverage of query (126 bits)

Q93X74 monodehydroascorbate reductase (NADH) (EC 1.6.5.4) from Brassica rapa subsp. pekinensis (see paper)
    29% identity, 82% coverage of query (126 bits)

MDAR1_ARATH / Q9LFA3 Monodehydroascorbate reductase 1, peroxisomal; AtMDAR1; EC 1.6.5.4 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    29% identity, 82% coverage of query (124 bits)

A0A0A7R8U8 monodehydroascorbate reductase (NADH) (EC 1.6.5.4) from Eleusine coracana (see paper)
    30% identity, 80% coverage of query (122 bits)

5jclA Structure and catalytic mechanism of monodehydroascorbate reductase, mdhar, from oryza sativa l. Japonica
    29% identity, 76% coverage of query (122 bits)

MDAR3_ORYSJ / Q652L6 Monodehydroascorbate reductase 3, cytosolic; OsMDAR3; OsMDHAR3; EC 1.6.5.4 from Oryza sativa subsp. japonica (Rice) (see 3 papers)
Q652L6 monodehydroascorbate reductase (NADH) (EC 1.6.5.4) from Oryza sativa Japonica Group (see paper)
    29% identity, 76% coverage of query (120 bits)

5jciA Structure and catalytic mechanism of monodehydroascorbate reductase, mdhar, from oryza sativa l. Japonica
    29% identity, 76% coverage of query (120 bits)

5jcnA Structure and catalytic mechanism of monodehydroascorbate reductase, mdhar, from oryza sativa l. Japonica
    29% identity, 76% coverage of query (119 bits)

5jcmA Structure and catalytic mechanism of monodehydroascorbate reductase, mdhar, from oryza sativa l. Japonica
    29% identity, 76% coverage of query (119 bits)

aifA apoptosis-inducing factor (Eurofung) from Emericella nidulans (see paper)
    30% identity, 77% coverage of query (117 bits)

Q2I828 monodehydroascorbate reductase (NADH) (EC 1.6.5.4) from Physcomitrium patens (see paper)
    25% identity, 87% coverage of query (116 bits)

MDAR2_ORYSJ / Q8S3R2 Monodehydroascorbate reductase 2, peroxisomal; OsMDAR2; OsMDHAR2; EC 1.6.5.4 from Oryza sativa subsp. japonica (Rice) (see paper)
    28% identity, 85% coverage of query (115 bits)

MDAR3_ARATH / Q9SR59 Monodehydroascorbate reductase 3; AtMDAR3; EC 1.6.5.4 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9SR59 monodehydroascorbate reductase (NADH) (EC 1.6.5.4) from Arabidopsis thaliana (see paper)
    26% identity, 81% coverage of query (112 bits)

C3VPH7 monodehydroascorbate reductase (NADH) (EC 1.6.5.4) from Avicennia marina (see paper)
    30% identity, 80% coverage of query (111 bits)

K4HRS2 monodehydroascorbate reductase (NADH) (EC 1.6.5.4) from Triticum aestivum (see 2 papers)
    29% identity, 76% coverage of query (109 bits)

MDAR4_ORYSJ / Q6ZJ08 Monodehydroascorbate reductase 4, cytosolic; OsMADR4; OsMDHAR4; EC 1.6.5.4 from Oryza sativa subsp. japonica (Rice) (see 2 papers)
    27% identity, 75% coverage of query (109 bits)

AIFM1_DICDI / Q9GRX6 Apoptosis-inducing factor 1, mitochondrial; Ddaif; EC 1.6.99.- from Dictyostelium discoideum (Social amoeba) (see paper)
    25% identity, 76% coverage of query (109 bits)

MDAR2_ARATH / Q93WJ8 Monodehydroascorbate reductase 2; AtMDAR2; EC 1.6.5.4 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    26% identity, 76% coverage of query (109 bits)

8d3oA Crystal structure of human apoptosis-inducing factor (aif) complexed with 8-methoxyquinolin-4-amine
    26% identity, 88% coverage of query (108 bits)

8d3kA Crystal structure of human apoptosis-inducing factor (aif) complexed with 8-fluoro-2-methylquinolin-4-amine
    25% identity, 88% coverage of query (108 bits)

Q2I827 monodehydroascorbate reductase (NADH) (EC 1.6.5.4) from Physcomitrium patens (see paper)
    27% identity, 85% coverage of query (106 bits)

Q5JFZ8 NAD(P)H oxidase (H2O2-forming) (EC 1.6.3.1) from Thermococcus kodakarensis (see 2 papers)
    30% identity, 74% coverage of query (106 bits)

8d3jA Crystal structure of human apoptosis-inducing factor (aif) complexed with 6-fluoro-2-methylquinolin-4-amine
    25% identity, 88% coverage of query (106 bits)

8d3iA / O95831 Crystal structure of human apoptosis-inducing factor (aif) w196a mutant complexed with quinolin-4-amine
    25% identity, 88% coverage of query (105 bits)

8d3eA Crystal structure of human apoptosis-inducing factor (aif) w196a mutant complexed with 6-fluoroquinolin-4-amine
    25% identity, 88% coverage of query (105 bits)

8d3hA Crystal structure of human apoptosis-inducing factor (aif) w196a mutant complexed with 7-chloroquinolin-4-amine
    25% identity, 88% coverage of query (105 bits)

8c0zE / Q5P142 Cryoem structure of a tungsten-containing aldehyde oxidoreductase from aromatoleum aromaticum (see paper)
    29% identity, 73% coverage of query (104 bits)

6krtA Monodehydroascorbate reductase, mdhar, from antarctic hairgrass deschampsia antarctica
    28% identity, 76% coverage of query (101 bits)

7btjC Crystal structure of pennisetum glaucum monodehydroascorbate reductase in complex with fadh2
    28% identity, 76% coverage of query (100 bits)

8d3gA Crystal structure of human apoptosis-inducing factor (aif) w196a mutant complexed with 6-chloroquinolin-4-amine
    25% identity, 88% coverage of query (99.8 bits)

5fs9B / O95831 Crystal structure of the g338e mutant of human apoptosis inducing factor (see paper)
    24% identity, 88% coverage of query (96.7 bits)

3gd4B Crystal structure of the reduced, NAD-bound form of murine apoptosis inducing factor
    25% identity, 88% coverage of query (94.0 bits)

3gd4A Crystal structure of the reduced, NAD-bound form of murine apoptosis inducing factor
    24% identity, 88% coverage of query (90.1 bits)

AIFM1 / O95831 apoptosis-inducing factor 1, mitochondrial (EC 1.6.5.9) from Homo sapiens (see 6 papers)
AIFM1_HUMAN / O95831 Apoptosis-inducing factor 1, mitochondrial; Programmed cell death protein 8; EC 1.6.99.- from Homo sapiens (Human) (see 21 papers)
O95831 NADH:ubiquinone reductase (H+-translocating) (EC 7.1.1.2) from Homo sapiens (see paper)
    25% identity, 73% coverage of query (90.1 bits)

8a56B / Q82ZQ9 Coenzyme a-persulfide reductase (coapr) from enterococcus faecalis (see paper)
    28% identity, 71% coverage of query (87.8 bits)

3gd3A Crystal structure of a naturally folded murine apoptosis inducing factor
    24% identity, 88% coverage of query (84.3 bits)

AIFM1_MOUSE / Q9Z0X1 Apoptosis-inducing factor 1, mitochondrial; Programmed cell death protein 8; EC 1.6.99.- from Mus musculus (Mouse) (see 6 papers)
    25% identity, 73% coverage of query (82.4 bits)

1gv4A / Q9Z0X1 Murine apoptosis-inducing factor (aif) (see paper)
    25% identity, 73% coverage of query (82.4 bits)

RURE_PSEAE / Q9HTK9 Rubredoxin-NAD(+) reductase; RdxR; EC 1.18.1.1 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 3 papers)
    29% identity, 72% coverage of query (80.1 bits)

2v3aA / Q9HTK9 Crystal structure of rubredoxin reductase from pseudomonas aeruginosa. (see paper)
    29% identity, 72% coverage of query (80.1 bits)

5vn0A Water-forming nadh oxidase from lactobacillus brevis (lbnox) bound to nadh.
    23% identity, 73% coverage of query (71.6 bits)

5er0A / Q03Q85 Water-forming nadh oxidase from lactobacillus brevis (lbnox) (see paper)
    23% identity, 73% coverage of query (71.2 bits)

5vohA Crystal structure of engineered water-forming NADPH oxidase (tpnox) bound to NADPH. The g159a, d177a, a178r, m179s, p184r mutant of lbnox.
    23% identity, 73% coverage of query (67.4 bits)

2bcpA Structural analysis of streptococcus pyogenes nadh oxidase: c44s nox with azide
    20% identity, 74% coverage of query (50.4 bits)

2bc0A / Q5XC60 Structural analysis of streptococcus pyogenes nadh oxidase: wild-type nox (see paper)
    21% identity, 74% coverage of query (50.4 bits)

NAOX_STRP6 / Q5XC60 NADH oxidase; NOXase; EC 1.6.3.4 from Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394) (see paper)
    21% identity, 74% coverage of query (50.1 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory