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Searching for up to 100 curated homologs for BWI76_RS01660 FitnessBrowser__Koxy:BWI76_RS01660 (533 a.a.)

Found high-coverage hits (≥70%) to 27 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Mas / b4014 malate synthase A (EC 2.3.3.9) from Escherichia coli K-12 substr. MG1655 (see 14 papers)
aceB / P08997 malate synthase A (EC 2.3.3.9) from Escherichia coli (strain K12) (see 15 papers)
    90% identity, 100% coverage of query (1017 bits)

3cuzA / P08997 Atomic resolution structures of escherichia coli and bacillis anthracis malate synthase a: comparison with isoform g and implications for structure based drug design (see paper)
    90% identity, 99% coverage of query (1011 bits)

3cv1A Atomic resolution structures of escherichia coli and bacillis anthracis malate synthase a: comparison with isoform g and implications for structure based drug design
    90% identity, 99% coverage of query (1011 bits)

3cv2A Atomic resolution structures of escherichia coli and bacillis anthracis malate synthase a: comparison with isoform g and implications for structure based drug design
    90% identity, 98% coverage of query (1003 bits)

SO1483 Malate synthase (EC 2.3.3.9) from Shewanella oneidensis MR-1
    67% identity, 99% coverage of query (743 bits)

3cuxA / A0A6L8PPD0 Atomic resolution structures of escherichia coli and bacillis anthracis malate synthase a: comparison with isoform g and implications for structure based drug design (see paper)
    52% identity, 99% coverage of query (533 bits)

GCP_CAEEL / Q10663 Bifunctional glyoxylate cycle protein; Gex-3-interacting protein 7; EC 4.1.3.1; EC 2.3.3.9 from Caenorhabditis elegans (see 2 papers)
    52% identity, 96% coverage of query (509 bits)

MLS / Q9LZC3 malate synthase (EC 2.3.3.9) from Arabidopsis thaliana (see paper)
MASY_ARATH / Q9LZC3 Malate synthase; EC 2.3.3.9 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    50% identity, 95% coverage of query (504 bits)

BPHYT_RS12305 Malate synthase (EC 2.3.3.9) from Burkholderia phytofirmans PsJN
    50% identity, 95% coverage of query (498 bits)

MASY_DICDI / Q8T2K9 Malate synthase; EC 2.3.3.9 from Dictyostelium discoideum (Social amoeba) (see paper)
    49% identity, 96% coverage of query (494 bits)

Q5YLB8 malate synthase (EC 2.3.3.9) from Paracoccidioides brasiliensis (see 2 papers)
    48% identity, 98% coverage of query (493 bits)

Q9ZH77 malate synthase (EC 2.3.3.9) from Streptomyces clavuligerus (see paper)
    48% identity, 97% coverage of query (492 bits)

CH_124037 putative malate synthase [Candida tropicalis] from Magnaporthe grisea 70-15 (see paper)
    50% identity, 95% coverage of query (486 bits)

acuE malate synthase; EC 2.3.3.9 from Emericella nidulans (see 5 papers)
    48% identity, 98% coverage of query (477 bits)

MASY_ORYSJ / Q7XUG1 Malate synthase; EC 2.3.3.9 from Oryza sativa subsp. japonica (Rice) (see paper)
    49% identity, 97% coverage of query (476 bits)

CAA40262.1 malate synthase from Cucurbita hybrid cultivar (see paper)
    48% identity, 96% coverage of query (475 bits)

MLS1 malate synthase; EC 2.3.3.9 from Candida albicans (see paper)
    46% identity, 97% coverage of query (456 bits)

MLS1 / P30952 malate synthase (EC 2.3.3.7; EC 2.3.3.9) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 2 papers)
MLS1_YEAST / P30952 Malate synthase 1; EC 2.3.3.9 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
    45% identity, 97% coverage of query (429 bits)

DAL7 / P21826 malate synthase 2 (EC 2.3.3.7; EC 2.3.3.9) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 2 papers)
MLS2_YEAST / P21826 Malate synthase 2; Degradation of allantoin protein 7; EC 2.3.3.9 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
    45% identity, 96% coverage of query (428 bits)

Build an alignment

Build an alignment for BWI76_RS01660 and 19 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

1n8iA Biochemical and structural studies of malate synthase from mycobacterium tuberculosis
    24% identity, 77% coverage of query (63.5 bits)

6dljA Crystal structure of mycobacterium tuberculosis malate synthase in complex with 2-nitro-phenyldiketoacid
    24% identity, 77% coverage of query (62.8 bits)

5driA Crystal structure of mycobacterium tuberculosis malate synthase in complex with 2-hydroxy-4-(1h-indol-5-yl)-4-oxobut-2-enoic acid inhibitor
    24% identity, 77% coverage of query (60.1 bits)

5cc7A Crystal structure of mycobacterium tuberculosis malate synthase in complex with 1h-indole-6-carboxylic acid
    24% identity, 77% coverage of query (59.7 bits)

5cc6A Crystal structure of mycobacterium tuberculosis malate synthase in complex with 1h-indole-5-carboxylic acid
    24% identity, 77% coverage of query (59.3 bits)

5ecvA Crystal structure of mycobacterium tuberculosis malate synthase in complex with 2-hydroxy-4-(4-methyl-1h-indol-5-yl)-4-oxobut-2-enoic acid
    24% identity, 77% coverage of query (57.4 bits)

6asuA Crystal structure of mycobacterium tuberculosis malate synthase in complex with 4-methyl-phenyldiketoacid
    24% identity, 77% coverage of query (54.3 bits)

MASZ_MYCLB / B8ZSN3 Malate synthase G; EC 2.3.3.9 from Mycobacterium leprae (strain Br4923)
    24% identity, 75% coverage of query (51.2 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory