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Searching for up to 100 curated homologs for BWI76_RS01730 FitnessBrowser__Koxy:BWI76_RS01730 (265 a.a.)

Found high-coverage hits (≥70%) to 25 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

PTRC_KLEPN / P37082 PTS system sorbose-specific EIIC component; EIIC-Sor; Sorbose permease IIC component from Klebsiella pneumoniae (see 2 papers)
TC 4.A.6.1.3 / P37082 PTRC aka SORA, component of Sorbose porter from Klebsiella pneumoniae (see 2 papers)
    93% identity, 100% coverage of query (477 bits)

PTRC_LACCA / Q9RGG3 PTS system sorbose-specific EIIC component; EIIC-Sor; Sorbose permease IIC component from Lacticaseibacillus casei (Lactobacillus casei) (see paper)
Q9RGG3 protein-Npi-phosphohistidine-L-sorbose phosphotransferase (subunit 2/4) (EC 2.7.1.206) from Lacticaseibacillus casei (see paper)
    66% identity, 100% coverage of query (355 bits)

ManY / b1818 mannose-specific PTS enzyme IIC component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
ManY / P69801 mannose-specific PTS enzyme IIC component (EC 2.7.1.191; EC 2.7.1.199; EC 2.7.1.193) from Escherichia coli (strain K12) (see 5 papers)
PTNC_ECOLI / P69801 PTS system mannose-specific EIIC component; EII-P-Man; EIIC-Man; Mannose permease IIC component from Escherichia coli (strain K12) (see 9 papers)
TC 4.A.6.1.1 / P69801 PTNC aka MANY aka PTSP aka PEL aka B1818, component of The mannose (glucose, 2-deoxyglucose, glucosamine, N-acetylglucosamine, N-acetylmannosamine, mannosamine and fructose) PTS porter/group translocator, ManXYZ (Rephaeli and Saier 1980; Plumbridge 2015). Catalyzes xylose facilitated diffusion in lactobacilli. The order of D-sugar substrate affinities is: glucose > mannose > 2-deoxyglucose > N-acetylglucosamine > glucosamine > N-acetylmannosamine > mannosamine > fructose from Escherichia coli (see 7 papers)
manY mannose permease IIC component from Escherichia coli K12 (see 7 papers)
    62% identity, 100% coverage of query (307 bits)

7dyrY / P69801 Cryoem structure of mannose transporter manyz and microcin e492 (mcea) complex (see paper)
    65% identity, 93% coverage of query (302 bits)

TC 4.A.6.1.16 / Q8Y8W0 Lmo0782 protein, component of Constitutively synthesized sensor, MpoABCD, controlling man operon (see TC# 4.A.6.1.15) expression by interacting with and phosphorylating ManR, the transcriptional regulator of the man operon from Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
    61% identity, 93% coverage of query (288 bits)

TC 4.A.6.1.2 / P26381 PTFC aka LEVF, component of Fructose group translocator, LevDEFG from Bacillus subtilis (see 3 papers)
    55% identity, 96% coverage of query (219 bits)

7vlxY / S5LAD9 Cryo-em structures of listeria monocytogenes man-pts (see paper)
    47% identity, 91% coverage of query (204 bits)

TC 4.A.6.1.15 / E1UCI1 PTS system, mannose/fructose/sorbose family, IIC component, component of The primary glucose /mannose uptake transporter, ManLMN from Listeria monocytogenes serotype 4a (strain L99)
    47% identity, 91% coverage of query (204 bits)

TC 4.A.6.1.7 / Q5M5W7 ManM, component of The glucose/mannose/2-deoxyglucose/fructose phosphotransferase systems (phosphorylates without transport), ManLMN from Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311) (see paper)
    42% identity, 92% coverage of query (188 bits)

TC 4.A.6.1.10 / Q04GK0 Mannose-specific PTS system component IIC, component of The hexose (glucose and fructose demonstrated) PTS uptake system from Oenococcus oeni (strain BAA-331 / PSU-1) (see paper)
    45% identity, 91% coverage of query (187 bits)

TC 4.A.6.1.6 / Q2QKM3 ManM aka EIIC, component of Glucose porter, ManLMN from Lactobacillus casei (see paper)
    47% identity, 91% coverage of query (180 bits)

7xtgD / Q38YH6 Cryo-em structure of listeria monocytogenes man-pts complexed with pediocin pa-1 (see paper)
    44% identity, 92% coverage of query (174 bits)

TC 4.A.6.1.11 / D2BKY8 Mannose-specific PTS system, IIC component, component of Mannose enzyme II complex, IIAB, IIC, IID. IIC/IID serve allows entry of some bacteriocins including pediocin (class IIa) and lactococcin A (class IIc) (Kjos et al., 2011). Transports and phosphorylates Glucose, Mannose and Glucosamine from Lactococcus lactis subsp. lactis (strain KF147) (see 2 papers)
    42% identity, 94% coverage of query (162 bits)

8hfsY / D2BKY8 The structure of lcna, lcia, and the man-pts of lactococcus lactis (see paper)
    45% identity, 85% coverage of query (159 bits)

TC 4.A.6.1.9 / Q97N93 PTS system, IIC component, component of The fucose PTS uptake transporter, IIA/IIB/IIC/IIDFuc (FcsABCD) (Manzoor et al. 2015). Expression in response to fucose is under the control of the FcsR transcriptional activator, and its DNA binding site has been identified from Streptococcus pneumoniae (see paper)
    33% identity, 90% coverage of query (130 bits)

gfrC / A0A0F6BB79 fructoselysine/glucoselysine PTS enzyme IIC component from Salmonella typhimurium (strain 14028s / SGSC 2262) (see paper)
TC 4.A.6.1.19 / V7RE14 PTS sugar transporter, component of PTS uptake system for glucoselysine and fructoselysine, GfrABCD from Salmonella enterica subsp. enterica serovar Give var. 15 str. CFSAN004343
    32% identity, 89% coverage of query (117 bits)

Build an alignment

Build an alignment for BWI76_RS01730 and 16 homologs with ≥ 30% identity

Select sequences

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Change minimum %identity:

Additional hits (identity < 30%)

TC 4.A.6.1.4 / Q9KIQ3 AgaW, component of N-acetyl galactosamine (GalNAc or Aga) porter (used the same IIA protein (AgaF) as does 4.A.6.1.5) from Escherichia coli (see paper)
    29% identity, 100% coverage of query (103 bits)

TC 4.A.6.1.5 / Q9KIP7 AgaC, component of Galactosamine (GalN or Gam) porter (used the same IIA protein (AgaF) as does 4.A.6.1.4) from Escherichia coli (see paper)
    28% identity, 98% coverage of query (101 bits)

AgaC / b3139 galactosamine-specific PTS enzyme IIC component from Escherichia coli K-12 substr. MG1655 (see 2 papers)
    28% identity, 98% coverage of query (101 bits)

TC 4.A.6.1.13 / B3WB10 PTS system, IIC component, component of Fucosyl-α-1,3-N-acetylglucosamine PTS uptake porter, AlfEFG (next to an operon encoding a fucosidase (AlfB) and a transcriptional regulator of the GntR family, AlfR) from Lactobacillus casei (strain BL23)
    32% identity, 89% coverage of query (100 bits)

TC 4.A.6.1.25 / CAQ67972.1 CAQ67972.1 C component PTS system mannose-specific enzyme II, component of D-ribitol (D-aldonitol) (a pentitol) PTS Enzyme II complex RtlABCD from Lactobacillus casei BL23
    33% identity, 80% coverage of query (94.0 bits)

dgaC / A0A0F6B8S6 D-glucosaminate PTS permease components EIIC (EC 2.7.1.203) from Salmonella typhimurium (strain 14028s / SGSC 2262) (see paper)
TC 4.A.6.1.17 / D0ZLR5 Putative phosphotransferase system enzyme IIC, component of D-glucosaminate group translocating uptake porter, DgaABCD (IIA-141 aas, IIB-161 aas, IIC-249 aas, and IID-285 aas, respectively) from Salmonella typhimurium (strain 14028s / SGSC 2262)
    29% identity, 78% coverage of query (92.4 bits)

TC 4.A.6.1.14 / Q8DR75 Phosphotransferase system sugar-specific EII component, component of Probable PTS uptake porter (IIA - IID) of disaccharides of gluconate and N-acetyglucosamine derived from degradation of hyaluronate and chondroitin by hyaluronidase (Marion et al. 2012). The cytoplasmic disaccharide may be hydrolyzed by the enzyme Ugl from Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
    28% identity, 92% coverage of query (80.5 bits)

TC 4.A.6.1.8 / Q82ZC5 PTS system, IIC component, component of The gluconate PTS uptake system. IIAGnt and IIBGnt form a high affinity 2:2 heterotetrameric complex from Enterococcus faecalis (see paper)
    23% identity, 86% coverage of query (67.4 bits)

TC 4.A.6.1.18 / B3W755 Phosphotransferase system sugar-specific EIIC component, component of Uptake porter/group translocator of galacto N-biose (Gal-β-1,3-GalNAc: galactose linked β-1,3 to N-acetylgalactosamine), lacto N-biose (Gal-β-1,3-GlcNAc: galactose linked β-1,3 to N-acetylglucosamine), and D-N-acetylgalactosamine (Bidart et al. 2014). The system is designated the GnbABCD system where GnbA = IIA, GnbB = IIB, GnbC = IIC, and GnbD = IID of the mannose-type PTS Enzyme II complex from Lactobacillus casei (strain BL23)
    28% identity, 73% coverage of query (60.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory