Sites on a Tree

 

Searching for up to 100 curated homologs for BWI76_RS01830 FitnessBrowser__Koxy:BWI76_RS01830 (396 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

Removed hits that are identical to the query, leaving 99

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

MalE / b4034 maltose ABC transporter periplasmic binding protein (EC 7.5.2.1) from Escherichia coli K-12 substr. MG1655 (see 50 papers)
MalE / P0AEX9 maltose ABC transporter periplasmic binding protein (EC 7.5.2.1) from Escherichia coli (strain K12) (see 74 papers)
MALE_ECOLI / P0AEX9 Maltose/maltodextrin-binding periplasmic protein; MMBP; Maltodextrin-binding protein; Maltose-binding protein; MBP from Escherichia coli (strain K12) (see 5 papers)
P0AEX9 ABC-type maltose transporter (subunit 1/4) (EC 7.5.2.1) from Escherichia coli (see paper)
P0AEY0 single-stranded DNA cytosine deaminase (EC 3.5.4.38) from Escherichia coli O157:H7 (see paper)
TC 3.A.1.1.1 / P0AEX9 Maltose-binding periplasmic protein MalE aka B4034, component of Maltooligosaccharide porter. The 3-D structure has been reported by Oldham et al. (2007). An altering access mechanism has been suggested for the maltose transporter resulting from rigid-body rotations (Khare et al., 2009). Bordignon et al. (2010) and Schneider et al. (2012) have reviewed the extensive knowledge available on MalEFGK2, its mode of action and its regulatory interactions from Escherichia coli (see 12 papers)
malE / RF|NP_418458 maltose-binding periplasmic protein from Escherichia coli K12 (see 14 papers)
    94% identity, 100% coverage of query (765 bits)

3jyrA Crystal structures of the gach receptor of streptomyces glaucescens gla.O in the unliganded form and in complex with acarbose and an acarbose homolog. Comparison with acarbose-loaded maltose binding protein of salmonella typhimurium.
    94% identity, 93% coverage of query (719 bits)

4xajB / P0AEX9,Q9Y466 Crystal structure of human nr2e1/tlx (see paper)
    93% identity, 93% coverage of query (718 bits)

4my2A / P0AEX9,Q00604 Crystal structure of norrin in fusion with maltose binding protein (see paper)
    93% identity, 92% coverage of query (716 bits)

4xaiA / P0AEY0,Q9NCL0 Crystal structure of red flour beetle nr2e1/tlx (see paper)
    93% identity, 92% coverage of query (716 bits)

1llsA Crystal structure of unliganded maltose binding protein with xenon
    94% identity, 93% coverage of query (716 bits)

1ez9B Structure of maltotetraitol bound to open-form maltodextrin binding protein in p1 crystal form
    94% identity, 93% coverage of query (716 bits)

4xajC Crystal structure of human nr2e1/tlx
    93% identity, 92% coverage of query (716 bits)

6k7fA / P0AEX9,P53220 Crystal structure of mbpholo-tim21 fusion protein with a 17-residue helical linker (see paper)
    93% identity, 93% coverage of query (715 bits)

5azaA / I6V0B8,P0AEX9 Crystal structure of mbp-saglb fusion protein with a 20-residue spacer in the connector helix (see paper)
    93% identity, 93% coverage of query (715 bits)

8h68A / P0AEX9,Q8MNT9 Crystal structure of caenorhabditis elegans nmad-1 in complex with nog and mg(ii) (see paper)
    93% identity, 92% coverage of query (714 bits)

4pqkB / B1B3N6,P0AEX9 C-terminal domain of DNA binding protein (see paper)
    93% identity, 93% coverage of query (714 bits)

5z0rB / P0AEX9,Q32ZE1 Structural insight into the zika virus capsid encapsulating the viral genome (see paper)
    93% identity, 93% coverage of query (714 bits)

6zhoA / O60894,P0AEX9,Q16602 Crystal structure of a cgrp receptor ectodomain heterodimer with bound high affinity inhibitor (see paper)
    93% identity, 93% coverage of query (714 bits)

8g3sA / Q07820 Mbp-mcl1 in complex with ligand 11 (see paper)
    93% identity, 92% coverage of query (713 bits)

7uajB / P03126,P0AEX9 Crystal structure of apo hpv16 e6
    93% identity, 92% coverage of query (713 bits)

5az7A / P0AEX9,Q62760 Crystal structure of mbp-tom20 fusion protein with a 4-residue spacer in the connector helix (see paper)
    93% identity, 93% coverage of query (713 bits)

7p0fA Crystal structure of a cgrp receptor ectodomain heterodimer bound to macrocyclic inhibitor htl0028125
    93% identity, 93% coverage of query (713 bits)

8ax7A Crystal structure of a cgrp receptor ectodomain heterodimer bound to macrocyclic inhibitor htl0031448
    93% identity, 93% coverage of query (713 bits)

8ax6A Crystal structure of a cgrp receptor ectodomain heterodimer bound to macrocyclic inhibitor htl0029882
    93% identity, 93% coverage of query (713 bits)

7p0iA Crystal structure of a cgrp receptor ectodomain heterodimer bound to macrocyclic inhibitor compound 13
    93% identity, 93% coverage of query (713 bits)

8qsoA Crystal structure of human mcl-1 in complex with compound 1
    93% identity, 92% coverage of query (713 bits)

8g3xA Mbp-mcl1 in complex with ligand 32
    93% identity, 92% coverage of query (713 bits)

8g3wA Mbp-mcl1 in complex with ligand 28
    93% identity, 92% coverage of query (713 bits)

8g3uA Mbp-mcl1 in complex with ligand 21
    93% identity, 92% coverage of query (713 bits)

8g3tA Mbp-mcl1 in complex with ligand 12
    93% identity, 92% coverage of query (713 bits)

8ax5A Crystal structure of a cgrp receptor ectodomain heterodimer bound to macrocyclic inhibitor htl0029881
    93% identity, 93% coverage of query (713 bits)

6anvA / L7P7M1,P0AEX9 Crystal structure of anti-crispr protein acrf1 (see paper)
    91% identity, 96% coverage of query (712 bits)

3csbA / P0AEX9 Crystal structure of monobody ysx1/maltose binding protein fusion complex (see paper)
    93% identity, 92% coverage of query (712 bits)

4nufA / P0AEX9,Q62227 Crystal structure of shp/eid1 (see paper)
    93% identity, 92% coverage of query (712 bits)

8el0A Structure of mbp-mcl-1 in complex with a macrocyclic compound
    93% identity, 92% coverage of query (712 bits)

6x91A / P0AEX9,P41238 Crystal structure of mbp-fused human apobec1 (see paper)
    93% identity, 92% coverage of query (711 bits)

5jonA / O88703,P0AEY0 Crystal structure of the unliganded form of hcn2 cnbd (see paper)
    93% identity, 92% coverage of query (711 bits)

4rwfA / O60895,P0AEX9,Q16602 Crystal structure of the clr:ramp2 extracellular domain heterodimer with bound adrenomedullin (see paper)
    93% identity, 92% coverage of query (711 bits)

3woaA / P03034,P0AEX9 Crystal structure of lambda repressor (1-45) fused with maltose- binding protein (see paper)
    92% identity, 94% coverage of query (711 bits)

4rwgA Crystal structure of the clr:ramp1 extracellular domain heterodimer with bound high affinity cgrp analog
    93% identity, 92% coverage of query (711 bits)

4rwgB Crystal structure of the clr:ramp1 extracellular domain heterodimer with bound high affinity cgrp analog
    93% identity, 92% coverage of query (711 bits)

6x91B Crystal structure of mbp-fused human apobec1
    93% identity, 92% coverage of query (711 bits)

5fsgA / P05133,P0AEX9 Structure of the hantavirus nucleoprotein provides insights into the mechanism of RNA encapsidation and a template for drug design (see paper)
    94% identity, 91% coverage of query (710 bits)

5w1cA Crystal structure of mbp fused activation-induced cytidine deaminase (aid) in complex with cytidine
    93% identity, 92% coverage of query (710 bits)

4wthB Ataxin-3 carboxy terminal region - crystal c2 (triclinic)
    93% identity, 92% coverage of query (710 bits)

3oaiA / P0AEX9,P25189 Crystal structure of the extra-cellular domain of human myelin protein zero (see paper)
    93% identity, 93% coverage of query (709 bits)

1r6zZ / P0AEX9,Q9VUQ5 The crystal structure of the argonaute2 paz domain (as a mbp fusion) (see paper)
    93% identity, 92% coverage of query (709 bits)

3n96A / P0AEX9,Q13324 Crystal structure of human crfr2 alpha extracellular domain in complex with urocortin 1
    93% identity, 92% coverage of query (709 bits)

2vgqA / P0AEX9,Q7Z434 Crystal structure of human ips-1 card (see paper)
    93% identity, 92% coverage of query (709 bits)

4b3nA / P0AEX9,Q0PF16 Crystal structure of rhesus trim5alpha pry/spry domain (see paper)
    93% identity, 92% coverage of query (709 bits)

6pfoA / P30988 Crystal structure of n-glycosylated human calcitonin receptor extracellular domain in complex with salmon calcitonin (16-32) (see paper)
    93% identity, 93% coverage of query (709 bits)

3c4mA Structure of human parathyroid hormone in complex with the extracellular domain of its g-protein-coupled receptor (pth1r)
    93% identity, 93% coverage of query (709 bits)

3rumA New strategy to analyze structures of glycopeptide antibiotic-target complexes
    93% identity, 93% coverage of query (708 bits)

5cfvA / P0AEX9 Fusion of maltose-binding protein and pila from acinetobacter nosocomialis m2 (see paper)
    93% identity, 92% coverage of query (707 bits)

1y4cA / P0AEX9 Designed helical protein fusion mbp (see paper)
    93% identity, 92% coverage of query (707 bits)

1ytvA Maltose-binding protein fusion to a c-terminal fragment of the v1a vasopressin receptor
    93% identity, 92% coverage of query (707 bits)

4h1gA / C4YKK8,P0AEX9 Structure of candida albicans kar3 motor domain fused to maltose- binding protein (see paper)
    94% identity, 90% coverage of query (706 bits)

3n94A / P0AEX9,P41586 Crystal structure of human pituitary adenylate cyclase 1 receptor- short n-terminal extracellular domain (see paper)
    93% identity, 92% coverage of query (706 bits)

3l2jA / P0AEX9,Q03431 Dimeric structure of the ligand-free extracellular domain of the human parathyroid hormone receptor (pth1r) (see paper)
    93% identity, 92% coverage of query (706 bits)

8svyA Mbp-mcl1 in complex with ligand 10
    93% identity, 92% coverage of query (706 bits)

3a3cA / P0AEX9,P36046 Crystal structure of tim40/mia40 fusing mbp, c296s and c298s mutant (see paper)
    93% identity, 92% coverage of query (705 bits)

4ozqB / L0N7N1 Crystal structure of the mouse kif14 motor domain (see paper)
    94% identity, 90% coverage of query (705 bits)

2v93A Equillibrium mixture of open and partially-closed species in the apo state of maltodextrin-binding protein by paramagnetic relaxation enhancement nmr
    93% identity, 92% coverage of query (705 bits)

8el1A Structure of mbp-mcl-1 in complex with abbv-467
    93% identity, 91% coverage of query (705 bits)

6l0zA The crystal structure of salmonella enterica sugar-binding protein male
    94% identity, 92% coverage of query (705 bits)

4wmxA The structure of mbp-mcl1 bound to ligand 6 at 2.0a
    93% identity, 92% coverage of query (704 bits)

7b01A / P0AEX9,Q76LX8 Adamts13-cub12 (see paper)
    94% identity, 90% coverage of query (703 bits)

5eduB / P0AEX9,Q9UBN7 Crystal structure of human histone deacetylase 6 catalytic domain 2 in complex with trichostatin a (see paper)
    94% identity, 90% coverage of query (702 bits)

1hsjA / P0AEX9,Q9F0R1 Sarr mbp fusion structure (see paper)
    94% identity, 90% coverage of query (702 bits)

3hpiA Crystal structure of maltose-binding protein mutant with bound sucrose
    92% identity, 93% coverage of query (702 bits)

4kegA / P0AEX9,Q9NP55 Crystal structure of mbp fused human splunc1
    94% identity, 90% coverage of query (701 bits)

1zjlA Crystal structure of zinc-bound engineered maltose binding protein
    92% identity, 93% coverage of query (701 bits)

8g3yA Mbp-mcl1 in complex with ligand 34
    93% identity, 92% coverage of query (701 bits)

6dd5A / F2K1V9,P0AEX9 Crystal structure of the cas6 domain of marinomonas mediterranea mmb-1 cas6-rt-cas1 fusion protein (see paper)
    94% identity, 90% coverage of query (700 bits)

3f5fA / P0AEX9,Q76KB1 Crystal structure of heparan sulfate 2-o-sulfotransferase from gallus gallus as a maltose binding protein fusion. (see paper)
    94% identity, 90% coverage of query (700 bits)

4qszA / P0AEX9,P0C872 Crystal structure of mouse jmjd7 fused with maltose-binding protein
    94% identity, 90% coverage of query (700 bits)

5c7rA / P0AEX9 Revealing surface waters on an antifreeze protein by fusion protein crystallography (see paper)
    94% identity, 90% coverage of query (700 bits)

3ef7A Zp-n domain of mammalian sperm receptor zp3 (crystal form iii)
    94% identity, 90% coverage of query (700 bits)

6ybkA Structure of mbp-mcl-1 in complex with compound 4d
    92% identity, 92% coverage of query (700 bits)

6qynA Structure of mbp-mcl-1 in complex with compound 10d
    92% identity, 92% coverage of query (699 bits)

6qyoA Structure of mbp-mcl-1 in complex with compound 18a
    92% identity, 92% coverage of query (699 bits)

6ybjA Structure of mbp-mcl-1 in complex with compound 3e
    92% identity, 92% coverage of query (699 bits)

5lofA Crystal structure of the mbp-mcl1 complex with highly selective and potent inhibitor of mcl1
    92% identity, 92% coverage of query (699 bits)

5jj4A Crystal structure of a variant human activation-induced deoxycytidine deaminase as an mbp fusion protein
    94% identity, 90% coverage of query (699 bits)

4wmwA The structure of mbp-mcl1 bound to ligand 5 at 1.9a
    92% identity, 92% coverage of query (699 bits)

4wmvA Structure of mbp-mcl1 bound to ligand 4 at 2.4a
    92% identity, 92% coverage of query (699 bits)

3d4gE / P0AEX9,P10761 Zp-n domain of mammalian sperm receptor zp3 (crystal form ii) (see paper)
    94% identity, 90% coverage of query (698 bits)

4wgiA A single diastereomer of a macrolactam core binds specifically to myeloid cell leukemia 1 (mcl1)
    92% identity, 92% coverage of query (698 bits)

3o3uN / P0AEX9,Q15109 Crystal structure of human receptor for advanced glycation endproducts (rage) (see paper)
    94% identity, 90% coverage of query (697 bits)

4edqA / O70468,P0AEX9 Mbp-fusion protein of myosin-binding protein c residues 149-269
    94% identity, 90% coverage of query (697 bits)

3mp8A / P0AEX9,P25554 Crystal structure of sgf29 tudor domain (see paper)
    94% identity, 90% coverage of query (697 bits)

2xz3A / P0AEX9,Q90M13 Blv tm hairpin (see paper)
    94% identity, 90% coverage of query (697 bits)

6wh0A / A7LM80,C3SHQ8 Crystal structure of hybcl-2-4 with hybax bh3 (see paper)
    93% identity, 92% coverage of query (697 bits)

7omtA / P0AEX9 Crystal structure of promacrobody 21 with bound maltose (see paper)
    93% identity, 91% coverage of query (697 bits)

4bl8B / P0AEX9,Q9UMX1 Crystal structure of full-length human suppressor of fused (sufu) (see paper)
    94% identity, 90% coverage of query (697 bits)

3dm0A / O24456,P0AEX9 Maltose binding protein fusion with rack1 from a. Thaliana (see paper)
    93% identity, 90% coverage of query (697 bits)

3mp1A Complex structure of sgf29 and trimethylated h3k4
    94% identity, 90% coverage of query (697 bits)

1a7lA Dominant b-cell epitope from the pres2 region of hepatitis b virus in the form of an inserted peptide segment in maltodextrin-binding protein
    93% identity, 92% coverage of query (697 bits)

6m4wA Crystal structure of mbp fused split fkbp-frb t2098l mutant in complex with rapamycin
    92% identity, 92% coverage of query (697 bits)

3io4C Huntingtin amino-terminal region with 17 gln residues - crystal c90
    94% identity, 90% coverage of query (697 bits)

6yblA Structure of mbp-mcl-1 in complex with compound 9m
    92% identity, 92% coverage of query (697 bits)

6qylA Structure of mbp-mcl-1 in complex with compound 8a
    92% identity, 92% coverage of query (697 bits)

6qgdA Structure of human mcl-1 in complex with thienopyrimidine inhibitor
    92% identity, 92% coverage of query (697 bits)

Build an alignment

Build an alignment for BWI76_RS01830 and 99 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory