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Searching for up to 100 curated homologs for BWI76_RS03130 FitnessBrowser__Koxy:BWI76_RS03130 (295 a.a.)

Found high-coverage hits (≥70%) to 43 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TC 3.A.1.1.18 / Q8RJU8 NgcG, component of N-Acetylglucosamine/N,N'-diacetyl chitobiose porter (NgcK (C) not identified) from Streptomyces olivaceoviridis (Streptomyces corchorusii) (see paper)
    30% identity, 92% coverage of query (135 bits)

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Build an alignment for BWI76_RS03130 and 1 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

TC 3.A.1.1.50 / Q5SLB5 Sugar ABC transporter, permease protein, component of Probable glycerophosphocholine (GPC) uptake porter (Chandravanshi et al. 2016). The system may include a receptor and three membrane proteins (of 378 aas and 6 TMSs, 299 aas and 7 TMSs, and 113 aas and 3 TMSs (?). The ATPase has not been identified from Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)
    29% identity, 75% coverage of query (121 bits)

TC 3.A.1.1.20 / Q7WWQ8 Transmembrane permease MsmG, component of The fructooligosaccharide porter, MsmEFGK from Lactobacillus acidophilus (see 2 papers)
msmG / GI|33149340 transmembrane permease MsmG from Lactobacillus acidophilus (see paper)
    30% identity, 92% coverage of query (118 bits)

ARAQ_BACSU / P94530 Arabinooligosaccharides transport system permease protein AraQ from Bacillus subtilis (strain 168) (see 3 papers)
TC 3.A.1.1.34 / P94530 L-arabinose transport system permease protein AraQ, component of The arabinosaccharide transporter AraNPQMsmX. Transports α-1,5-arabinooligosaccharides, at least up to four L-arabinosyl units; the key transporter for α-1,5-arabinotriose and α-1,5-arabinotetraose, but not for α-1,5-arabinobiose which is transported by AraE. MsmX is also used by the MdxEFG-MsmX system (3.A.1.1.36) (Ferreira and Sá-Nogueira, 2010). Involved in the uptake of pectin oligosaccharides with either MsmX or YurJ as the ATPase from Bacillus subtilis (see 5 papers)
    27% identity, 93% coverage of query (118 bits)

TC 3.A.1.1.39 / Q9WYR1 Alpha-1,4-digalacturonate porter (Nanavati et al., 2006). Regulated by pectin utilization regulon UxaR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    28% identity, 89% coverage of query (117 bits)

NGCG_STRCO / O50501 Diacetylchitobiose uptake system permease protein NgcG from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
    29% identity, 96% coverage of query (116 bits)

G9MB86 ABC-type glycerol 3-phosphate transporter (subunit 1/3) (EC 7.6.2.10) from Thermus thermophilus (see paper)
    32% identity, 78% coverage of query (116 bits)

TC 3.A.1.1.4 / P29824 LacG, component of Lactose porter from Agrobacterium radiobacter (see paper)
    28% identity, 90% coverage of query (114 bits)

TC 3.A.1.1.6 / Q48397 CymG, component of Cyclodextrin porter from Klebsiella oxytoca (see paper)
    27% identity, 83% coverage of query (108 bits)

TC 3.A.1.1.23 / Q9X9R5 CBP protein aka CebG, component of The cellobiose/cellotriose (and possibly higher cellooligosaccharides), CebEFGMsiK [MsiK functions to energize several ABC transporters including those for maltose/maltotriose and trehalose] from Streptomyces reticuli (see paper)
    30% identity, 93% coverage of query (105 bits)

Dshi_0549 ABC transporter for Xylitol, permease component 2 from Dinoroseobacter shibae DFL-12
    28% identity, 91% coverage of query (104 bits)

TC 3.A.1.1.49 / O30493 MtlG, component of The polyol (mannitol, glucitol (sorbitol), arabitol (arabinitol; lyxitol)) uptake porter, MtlEFGK from Pseudomonas fluorescens
    29% identity, 92% coverage of query (100 bits)

BPHYT_RS16105 ABC transporter for D-Sorbitol, permease component 1 from Burkholderia phytofirmans PsJN
    29% identity, 93% coverage of query (99.8 bits)

TC 3.A.1.1.41 / G4FGN6 ABC-type transporter, integral membrane subunit, component of Trehalose porter. Also binds sucrose (Boucher and Noll, 2011). Induced by glucose and trehalose. Directly regulated by trehalose-responsive regulator TreR from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
    26% identity, 89% coverage of query (99.4 bits)

PS417_12705 ABC transporter for D-Mannitol and D-Sorbitol, permease component 1 from Pseudomonas simiae WCS417
    29% identity, 92% coverage of query (98.2 bits)

TC 3.A.1.1.26 / O06991 MalG aka yvdI, component of The maltose porter, MdxEFG and MsmX from Bacillus subtilis (see 2 papers)
    28% identity, 76% coverage of query (97.8 bits)

TC 3.A.1.1.11 / Q93KB9 TogN, component of Saturated and unsaturated oligogalacturonide transporter, TogMNAB (transports di- to tetrasaccharide pectin degradation products which consist of D-galacuronate, sometimes with 4-deoxy-L-threo-5-hexosulose uronate at the reducing end of the oligosaccharide) (Hugouvieux-Cotte-Pattat et al. 2001). Regulated by pectin utilization regulator KdgR from Erwinia chrysanthemi (see paper)
    26% identity, 98% coverage of query (97.8 bits)

mtlG / Q4KC55 polyol ABC-type transporter permease component MtlG from Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) (see paper)
    28% identity, 92% coverage of query (97.8 bits)

TC 3.A.1.1.10 / Q9KWT7 AlgM2, component of Alginate (MW 27,000 Da) (and Alginate oligosaccharides) uptake porter. Sphingomonas species A1 is a 'pit-forming' bacterium that directly incorporates alginate into its cytoplasm through a pit-dependent transport system, termed a 'superchannel' (Murata et al., 2008). The pit is a novel organ acquired through the fluidity and reconstitution of cell surface molecules, and through cooperation with the transport machinery in the cells. It confers upon bacterial cells a more efficient way to secure and assimilate macromolecules from Sphingomonas sp (see paper)
    25% identity, 94% coverage of query (95.9 bits)

UgpE / b3451 sn-glycerol 3-phosphate ABC transporter membrane subunit UgpE (EC 7.6.2.10) from Escherichia coli K-12 substr. MG1655 (see paper)
UgpE / P10906 sn-glycerol 3-phosphate ABC transporter membrane subunit UgpE (EC 7.6.2.10) from Escherichia coli (strain K12) (see 20 papers)
UGPE_ECOLI / P10906 sn-glycerol-3-phosphate transport system permease protein UgpE from Escherichia coli (strain K12) (see 5 papers)
P10906 ABC-type glycerol 3-phosphate transporter (EC 7.6.2.10) from Escherichia coli (see paper)
TC 3.A.1.1.3 / P10906 UgpE aka B3451, component of Glycerol-phosphate porter. Transports both glycerol-3-P and glycerol-3-P diesters including glycerophosphocholine but not glycerol-2-P from Escherichia coli (see 5 papers)
    23% identity, 87% coverage of query (95.1 bits)

Pf1N1B4_5114 sucrose ABC transporter, permease component 2 from Pseudomonas fluorescens FW300-N1B4
    27% identity, 75% coverage of query (94.7 bits)

SM_b21654 ABC transporter for Lactose, permease component 2 from Sinorhizobium meliloti 1021
    28% identity, 86% coverage of query (94.7 bits)

YTCP_BACSU / P53561 Polygalacturonan/rhamnogalacturonan transport system permease protein YtcP from Bacillus subtilis (strain 168) (see paper)
    28% identity, 87% coverage of query (94.4 bits)

TC 3.A.1.1.24 / Q72KX4 Sugar transport system permease protein aka TT_C0326, component of The glucose/mannose porter TTC0326-8 plus MalK1 (ABC protein, shared with 3.A.1.1.25) from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (see paper)
    28% identity, 75% coverage of query (92.4 bits)

GANQ_BACSU / O07011 Galactooligosaccharides transport system permease protein GanQ from Bacillus subtilis (strain 168) (see 2 papers)
TC 3.A.1.1.2 / O07011 Putative arabinogalactan oligomer transport system permease protein ganQ, component of The galactooligosaccharide (transports the di, tri and tetrasaccharides) uptake porter GanOPQ (GanSPQ; MalEFG) functioning with the energizing ATPase MsmX (see 3.A.1.1.26) from Bacillus subtilis (see 2 papers)
    24% identity, 89% coverage of query (92.0 bits)

Pf6N2E2_1961 ABC transporter for D-sorbitol, permease component 2 from Pseudomonas fluorescens FW300-N2E2
    28% identity, 92% coverage of query (90.1 bits)

AO356_00015 ABC transporter for D-Sorbitol, permease component 1 from Pseudomonas fluorescens FW300-N2C3
    28% identity, 92% coverage of query (89.7 bits)

SM_b21105 ABC transporter for L-Fucose, permease component 2 from Sinorhizobium meliloti 1021
    26% identity, 96% coverage of query (89.7 bits)

DASC_STRCO / Q9K489 Diacetylchitobiose uptake system permease protein DasC from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (see paper)
    25% identity, 85% coverage of query (89.4 bits)

MELC_BACSU / O34518 Melibiose/raffinose/stachyose import permease protein MelC from Bacillus subtilis (strain 168) (see paper)
    27% identity, 93% coverage of query (89.0 bits)

PfGW456L13_1896 ABC transporter for D-Galactose and D-Glucose, permease component 2 from Pseudomonas fluorescens GW456-L13
    27% identity, 87% coverage of query (86.7 bits)

TC 3.A.1.1.27 / Q8DT26 MalG, component of Maltose/Maltotriose/maltodextrin (up to 7 glucose units) transporters MalXFGK (MsmK (3.A.1.1.28) can probably substitute for MalK; Webb et al., 2008) from Streptococcus mutans (see paper)
    24% identity, 93% coverage of query (85.5 bits)

Y189_MYCGE / P47435 Probable ABC transporter permease protein MG189 from Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37) (Mycoplasmoides genitalium) (see paper)
    25% identity, 87% coverage of query (84.7 bits)

SMc04257 ABC transporter for D-Cellobiose and D-Salicin, permease component 1 from Sinorhizobium meliloti 1021
    24% identity, 88% coverage of query (84.0 bits)

TC 3.A.1.1.25 / Q72H66 Maltose transport system permease protein malG aka TT_C1629, component of The trehalose/maltose/sucrose/palatinose porter (TTC1627-9) plus MalK1 (ABC protein, shared with 3.A.1.1.24) (Silva et al. 2005; Chevance et al., 2006). The receptor (TTC1627) binds disaccharide alpha-glycosides, namely trehalose (alpha-1,1), sucrose (alpha-1,2), maltose (alpha-1,4), palatinose (alpha-1,6) and glucose from Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (see paper)
    28% identity, 85% coverage of query (84.0 bits)

MALG_THELN / Q7LYX6 Trehalose/maltose transport system permease protein MalG from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see 3 papers)
TC 3.A.1.1.7 / O51925 MalG aka PF1741, component of Maltose/trehalose porter (see paper)
    26% identity, 87% coverage of query (83.6 bits)

sugB / P9WG01 ABC-type trehalose transporter integral membrane protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
SUGB_MYCTU / P9WG01 Trehalose transport system permease protein SugB from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
TC 3.A.1.1.31 / O50453 PROBABLE SUGAR-TRANSPORT INTEGRAL MEMBRANE PROTEIN ABC TRANSPORTER SUGB, component of The trehalose-recycling ABC transporter, LpqY-SugA-SugB-SugC (essential for virulence) from Mycobacterium tuberculosis (see 3 papers)
    25% identity, 90% coverage of query (83.2 bits)

TC 3.A.1.1.12 / Q9AI66 PalG, component of Palatinose (isomaltulose; 6-O-α-D-glucopyranosyl-D-fructose) uptake porter from Erwinia rhapontici (see paper)
    26% identity, 92% coverage of query (82.4 bits)

SM_b20327 ABC transporter for D-trehalose/D-maltose/sucrose, permease component 2 (ThuG) from Sinorhizobium meliloti 1021
TC 3.A.1.1.17 / Q9R9Q5 ThuG aka RB0313 aka SMB20327, component of Trehalose/maltose/sucrose porter (trehalose inducible) from Rhizobium meliloti (Sinorhizobium meliloti) (see 3 papers)
    25% identity, 89% coverage of query (80.1 bits)

YcjP / b1312 putative ABC transporter membrane subunit YcjP from Escherichia coli K-12 substr. MG1655 (see 2 papers)
TC 3.A.1.1.46 / P77716 Inner membrane ABC transporter permease protein YcjP, component of Probable glucoside uptake porter, YcjNOPV from Escherichia coli (strain K12)
    25% identity, 86% coverage of query (79.3 bits)

TC 3.A.1.1.33 / Q8KN17 Putative sugar transporter integral membrane protein, component of The N,N'-diacetylchitobiose uptake transporter, DasABC/MsiK (MsiK energizes several ABC transporters (see 3.A.1.1.23)) from Streptomyces sp. 139 (see 2 papers)
    25% identity, 90% coverage of query (79.3 bits)

smoH / Q7CS31 ABC-type 3-(6-sulfo-α-D-quinovosyl)-sn-glycerol transporter permease subunit from Agrobacterium fabrum (strain C58 / ATCC 33970) (see paper)
    25% identity, 85% coverage of query (79.0 bits)

TC 3.A.1.1.44 / Q9KZ08 Putative maltose permease, component of MalEFG (K unknown), involved in maltose and maltodextrin uptake from Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    25% identity, 76% coverage of query (76.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory