Searching for up to 100 curated homologs for BWI76_RS03450 FitnessBrowser__Koxy:BWI76_RS03450 (454 a.a.)
Found high-coverage hits (≥70%) to 42 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
YeeM / b1981 shikimate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 3 papers)
shiA / P76350 shikimate:H+ symporter from Escherichia coli (strain K12) (see 3 papers)
SHIA_ECOLI / P76350 Shikimate transporter; Shikimate permease from Escherichia coli (strain K12) (see 3 papers)
TC 2.A.1.6.6 / P76350 Shikimate:H+ symporter from Escherichia coli (see 5 papers)
37% identity, 97% coverage of query (317 bits)
ABAF_ACIBT / P0DPR5 Fosfomycin resistance protein AbaF; Acinetobacter baumannii fosfomycin efflux from Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377) (see paper)
40% identity, 93% coverage of query (293 bits)
TC 2.A.1.6.5 / Q45082 4-Methyl-o-phthalate:H+ symporter from Burkholderia cepacia (Pseudomonas cepacia) (see paper)
37% identity, 91% coverage of query (280 bits)
SHIA_CORGB / A4QH18 Shikimate transporter; Shikimate permease from Corynebacterium glutamicum (strain R) (see paper)
36% identity, 98% coverage of query (256 bits)
ProP proline/betaine MFS transporter / b4111 osmolyte:H+ symporter ProP from Escherichia coli K-12 substr. MG1655 (see 64 papers)
proP / P0C0L7 osmolyte:H+ symporter ProP from Escherichia coli (strain K12) (see 66 papers)
PROP_ECOLI / P0C0L7 Proline/betaine transporter; Proline porter II; PPII from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.6.4 / P0C0L7 (Proline/glycine-betaine):(H+/Na+) symporter, ProP (also transports taurine, ectoine, pipecolate, proline-betaine, N,N-dimethylglycine, carnitine, and 1-carboxymethyl-pyridinium) (subject to osmotic activation). Transmembrane helix I and periplasmic loop 1 are involved in osmosensing and osmoprotectant transport from Escherichia coli (see 6 papers)
proP / RF|NP_418535 proline porter II from Escherichia coli K12 (see 22 papers)
proP / AAB00919.1 a proline/betaine transporter from Escherichia coli (see paper)
30% identity, 94% coverage of query (246 bits)
YhjE / b3523 putative transporter YhjE from Escherichia coli K-12 substr. MG1655 (see 3 papers)
TC 2.A.1.6.10 / P37643 Inner membrane metabolite transport protein YhjE from Escherichia coli (strain K12) (see 4 papers)
38% identity, 97% coverage of query (243 bits)
YdfJ / b1543 putative transporter YdfJ from Escherichia coli K-12 substr. MG1655 (see 3 papers)
YDFJ_ECOLI / P77228 Putative transporter YdfJ from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.6.9 / P77228 YdfJ. Can function as an inward rectifying K+ channel when expressed in animal cells as measured by whole cell patch clamping. Blocked by barium and protopine from Escherichia coli (strain K12) (see 4 papers)
32% identity, 91% coverage of query (234 bits)
OUSA_DICD3 / Q47421 Glycine betaine/proline/ectoine/pipecolic acid transporter OusA; Osmoprotectant uptake system A from Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)) (see 3 papers)
31% identity, 91% coverage of query (227 bits)
TC 2.A.1.6.13 / M1Q159 Acetate/monochloroacetate permease, Deh4p, of 468 aas and 12 TMSs from Dehalococcoides mccartyi DCMB5
33% identity, 92% coverage of query (226 bits)
TC 2.A.1.6.8 / Q7X4L6 The acetate/monochloroacetate (haloacid) permease, Deh4p (Km = 5.5 mμM for acetate; 9 mμM for monochloroacetate) from Burkholderia cepacia (see 2 papers)
39% identity, 71% coverage of query (213 bits)
TC 2.A.1.6.11 / F8SVK1 Acetate/haloacid transporter, Dehp2, with a possible atypical topology from Burkholderia sp. MBA4
36% identity, 72% coverage of query (209 bits)
PROP_CORGL / Q79VC4 Ectoine/proline transporter ProP from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 3 papers)
30% identity, 87% coverage of query (197 bits)
TC 3.A.7.9.1 / Q5ZYB5 TphA aka ProP, component of The Icm/Dot or Dot/Icm multicomponent protein secretion system. IcmS and IcmW form a complex that interacts with and may translocate substrate proteins (Ninio et al., 2005; De Buck et al., 2007; Cambronne and Roy, 2007). The crystal structure of the IcmR-IcmQ complex has been solved (Raychaudhury et al., 2009). Legionella pneumophila survives and replicates inside host cells by secreting ~300 effectors through the defective in organelle trafficking (Dot)/intracellular multiplication (Icm) type IVB secretion system (T4BSS). Ghosal et al. 2019, using electron cryotomography mapped the location of the core and accessory components of the Legionella core transmembrane subcomplex, revealing a well-ordered central channel that opens into a large, windowed secretion chamber with an unusual 13-fold symmetry. Immunofluorescence microscopy deciphered an early-stage assembly process that begins with the targeting of Dot/Icm components to the bacterial poles. Polar targeting of this T4BSS is mediated by two Dot/Icm proteins, DotU and IcmF, that are homologues of the T6SS membrane complex components TssL and TssM, suggesting that the Dot/Icm T4BSS is a hybrid system. Thus, the Dot/Icm complex assembles in an 'axial-to-peripheral' pattern from Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) (see paper)
31% identity, 92% coverage of query (196 bits)
AO356_17790 alpha-ketoglutarate permease (MHS family) from Pseudomonas fluorescens FW300-N2C3
31% identity, 89% coverage of query (190 bits)
AO353_03810 Alpha-ketoglutarate permease, MFS superfamily from Pseudomonas fluorescens FW300-N2E3
31% identity, 88% coverage of query (187 bits)
TC 2.A.1.6.1 / P16482 Citrate:H+ symporter from Klebsiella pneumoniae (see paper)
31% identity, 95% coverage of query (183 bits)
citA / GB|AAA88472.1 citrate transporter from Escherichia coli (see paper)
32% identity, 87% coverage of query (177 bits)
tcuC / P0A2G3 propane-1,2,3-tricarboxylate-proton symporter from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
CITA_SALTY / P0A2G3 Citrate-proton symporter; Citrate carrier protein; Citrate transporter; Citrate utilization determinant; Citrate utilization protein A from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
TC 2.A.1.6.7 / P0A2G3 The citrate/tricarballylate:H+ symporter (CitA or TcuC); probably orthologous to 2.A.1.6.1 from Salmonella typhimurium (see 2 papers)
32% identity, 87% coverage of query (173 bits)
HSERO_RS16820 2-oxoglutarate:H+ symporter from Herbaspirillum seropedicae SmR1
31% identity, 84% coverage of query (167 bits)
WitA / b2587 α-ketoglutarate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 6 papers)
kgtP / P0AEX3 α-ketoglutarate:H+ symporter from Escherichia coli (strain K12) (see 6 papers)
KGTP_ECOLI / P0AEX3 Alpha-ketoglutarate permease from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.6.2 / P0AEX3 α-Ketoglutarate (oxoglutarate):H+ symporter from Escherichia coli (see 9 papers)
30% identity, 88% coverage of query (161 bits)
Build an alignment for BWI76_RS03450 and 20 homologs with ≥ 30% identity
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TC 2.A.1.6.3 / Q52000 Dicarboxylate:H+ symporter from Pseudomonas putida
29% identity, 83% coverage of query (151 bits)
NanT / b3224 N-acetylneuraminate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 10 papers)
nanT / P41036 N-acetylneuraminate:H+ symporter from Escherichia coli (strain K12) (see 16 papers)
NANT_ECOLI / P41036 Sialic acid transporter NanT; Sialic acid permease; Sialic acid/H(+) symporter from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.12.1 / P41036 The sialic acid porter, NanT. N-acetylneuraminic acid (Neu5Ac) serves as a sole source of carbon and nitrogen for E. coli. It is a mucus-derived carbon source in the mammalian gut. NanT can also take up and allow efficient growth on the related sialic acids, N-glycolylneuraminic acid (Neu5Gc) and 3-keto-3-deoxy-d-glycero-d-galactonononic acid (KDN) from Escherichia coli (see 4 papers)
24% identity, 74% coverage of query (92.4 bits)
S22A2_HUMAN / O15244 Solute carrier family 22 member 2; Organic cation transporter 2; hOCT2 from Homo sapiens (Human) (see 25 papers)
TC 2.A.1.19.30 / O15244 Solute carrier family 22 member 2 (Organic cation transporter 2) (hOCT2) from Homo sapiens (see 23 papers)
23% identity, 73% coverage of query (55.5 bits)
S22A2_RAT / Q9R0W2 Solute carrier family 22 member 2; Organic cation transporter 2; rOCT2 from Rattus norvegicus (Rat) (see 15 papers)
TC 2.A.1.19.19 / Q9R0W2 The rat kidney basolateral potential-driven symport carrier, Oct2 (transports tetraethylammonium and many other organic cations) from Rattus norvegicus (see 12 papers)
23% identity, 71% coverage of query (55.5 bits)
8bw7A Cryo-em structure of rat slc22a6 bound to alpha-ketoglutaric acid
23% identity, 74% coverage of query (54.7 bits)
8et9A / O15244 Cryo-em structure of the organic cation transporter 2 in complex with 1-methyl-4-phenylpyridinium (see paper)
26% identity, 71% coverage of query (53.5 bits)
8bvsA Cryo-em structure of rat slc22a6 bound to tenofovir
24% identity, 74% coverage of query (53.5 bits)
8bvtA / O35956 Cryo-em structure of rat slc22a6 bound to probenecid (see paper)
23% identity, 74% coverage of query (52.8 bits)
S22A6_MOUSE / Q8VC69 Solute carrier family 22 member 6; Kidney-specific transport protein; Novel kidney transcript; mNKT; Organic anion transporter 1; mOAT1; Renal organic anion transporter 1; mROAT1 from Mus musculus (Mouse) (see 6 papers)
24% identity, 71% coverage of query (52.4 bits)
8et8A Cryo-em structure of the organic cation transporter 1 in complex with verapamil
22% identity, 73% coverage of query (52.4 bits)
8et7A / O15245 Cryo-em structure of the organic cation transporter 1 in complex with diphenhydramine (see paper)
22% identity, 73% coverage of query (52.4 bits)
S22A1_MOUSE / O08966 Solute carrier family 22 member 1; Organic cation transporter 1; mOCT1 from Mus musculus (Mouse) (see 12 papers)
24% identity, 73% coverage of query (52.0 bits)
S22A1_HUMAN / O15245 Solute carrier family 22 member 1; Organic cation transporter 1; hOCT1 from Homo sapiens (Human) (see 26 papers)
TC 2.A.1.19.29 / O15245 Solute carrier family 22 member 1 (Organic cation transporter 1) (hOCT1) from Homo sapiens (see 18 papers)
24% identity, 71% coverage of query (51.2 bits)
8sc2A / O15245 Human oct1 bound to diltiazem in inward-open conformation (see paper)
24% identity, 71% coverage of query (49.7 bits)
5eqiA Human glut1 in complex with cytochalasin b
23% identity, 70% coverage of query (49.3 bits)
5eqhA Human glut1 in complex with inhibitor (2~{s})-3-(2-bromophenyl)-2-[2- (4-methoxyphenyl)ethanoylamino]-~{n}-[(1~{s})-1- phenylethyl]propanamide
23% identity, 70% coverage of query (49.3 bits)
5eqgA / P11166 Human glut1 in complex with inhibitor (2~{s})-3-(4-fluorophenyl)-2-[2- (3-hydroxyphenyl)ethanoylamino]-~{n}-[(1~{s})-1- phenylethyl]propanamide (see paper)
23% identity, 70% coverage of query (49.3 bits)
SLC2A1 / P11166 solute carrier family 2, facilitated glucose transporter member 1 from Homo sapiens (see 25 papers)
GTR1_HUMAN / P11166 Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; HepG2 glucose transporter from Homo sapiens (Human) (see 34 papers)
TC 2.A.1.1.28 / P11166 The erythrocyte/brain hexose facilitator, glucose transporter-1, Gtr1 or Glut1. Transports D-glucose, dehydroascorbate, arsenite and the flavonone, quercetin, via one pathway and water via a distinct channel. Sugar transport has been suggested to function via a sliding mechanism involving several sugar binding sites (Cunningham et al., 2006). Glut1 is the receptor for human T-cell leukemia virus (HTLV)) (Manel et al., 2003). It is regulated by stomatin (TC# 8.A.21) to take up dehydroascorbate (Montel-Hagen et al., 2008). Mutations cause Glut1 deficiency syndrome, a human encephalopathy that results from decreased glucose flux through the blood brain barrier from Homo sapiens (Human) (see 21 papers)
23% identity, 70% coverage of query (48.9 bits)
8sc6A Human oct1 bound to thiamine in inward-open conformation
24% identity, 71% coverage of query (47.0 bits)
GTR1_MOUSE / P17809 Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; GT1 from Mus musculus (Mouse) (see 7 papers)
23% identity, 70% coverage of query (46.6 bits)
S22A2_RABIT / Q8MJI6 Solute carrier family 22 member 2; Organic cation transporter 2 from Oryctolagus cuniculus (Rabbit) (see paper)
22% identity, 73% coverage of query (44.7 bits)
P36035 Carboxylic acid transporter protein homolog from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
22% identity, 74% coverage of query (44.3 bits)
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Lawrence Berkeley National Laboratory