Searching for up to 100 curated homologs for BWI76_RS03640 FitnessBrowser__Koxy:BWI76_RS03640 (447 a.a.)
Found high-coverage hits (≥70%) to 56 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
puuP / BAD88704.1 putrescine importer, partial from Escherichia coli K-12 (see paper)
32% identity, 95% coverage of query (233 bits)
YcjJ / b1296 putrescine:H+ symporter PuuP from Escherichia coli K-12 substr. MG1655 (see 4 papers)
puuP / P76037 putrescine:H+ symporter PuuP from Escherichia coli (strain K12) (see 2 papers)
PUUP_ECOLI / P76037 Putrescine importer PuuP from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.3.1.13 / P76037 Putrescine importer, PuuP from Escherichia coli (strain K12) (see 4 papers)
32% identity, 95% coverage of query (233 bits)
YeeF / b2014 putrescine:H+ symporter PlaP from Escherichia coli K-12 substr. MG1655 (see paper)
plaP / P0AA47 putrescine:H+ symporter PlaP from Escherichia coli (strain K12) (see 5 papers)
PLAP_ECOLI / P0AA47 Low-affinity putrescine importer PlaP; Putrescine low affinity permease from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.3.1.14 / P0AA47 Low-affinity putrescine importer PlaP from Escherichia coli (strain K12) (see 5 papers)
32% identity, 94% coverage of query (210 bits)
Build an alignment for BWI76_RS03640 and 3 homologs with ≥ 30% identity
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MTRTR_BACSU / Q797A7 Methylthioribose transporter from Bacillus subtilis (strain 168) (see paper)
28% identity, 95% coverage of query (113 bits)
BCAP_BACSU / O07576 Branched-chain amino acid permease BcaP; BCAA permease from Bacillus subtilis (strain 168) (see 4 papers)
28% identity, 84% coverage of query (111 bits)
CCNA_00435 L-proline transporter from Caulobacter crescentus NA1000
26% identity, 87% coverage of query (84.7 bits)
TC 2.A.3.3.23 / S6EX81 Branched chain amino acid (Leucine/isoleucine/valine) uptake transporter of 469 aas and 12 TMSs, BcaP or CitA from Lactococcus lactis subsp. lactis A12
23% identity, 98% coverage of query (84.3 bits)
N515DRAFT_2924 L-proline transporter from Dyella japonica UNC79MFTsu3.2
24% identity, 95% coverage of query (82.8 bits)
BCAP_LACLM / A2RHI9 Branched-chain amino acid permease BcaP; BCAA permease; BCAA transporter from Lactococcus lactis subsp. cremoris (strain MG1363) (see 2 papers)
23% identity, 95% coverage of query (82.4 bits)
CAAT4_ARATH / Q8W4K3 Cationic amino acid transporter 4, vacuolar from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 2.A.3.3.14 / Q8W4K3 Cationic amino acid transporter 4, vacuolar from Arabidopsis thaliana (see 4 papers)
24% identity, 83% coverage of query (81.3 bits)
AIMA_BACSU / Q45577 Glutamate/serine transporter AimA; Amino acid importer A from Bacillus subtilis (strain 168) (see 2 papers)
24% identity, 96% coverage of query (78.6 bits)
Ga0059261_1577 L-glutamine and L-histidine transporter from Sphingomonas koreensis DSMZ 15582
26% identity, 81% coverage of query (74.3 bits)
CAAT9_ARATH / Q9C5D6 Cationic amino acid transporter 9, chloroplastic from Arabidopsis thaliana (Mouse-ear cress) (see paper)
23% identity, 85% coverage of query (74.3 bits)
CAAT2_ARATH / Q9ASS7 Cationic amino acid transporter 2, vacuolar from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 2.A.3.3.13 / Q9ASS7 Cationic amino acid transporter 2, vacuolar from Arabidopsis thaliana (see 4 papers)
24% identity, 83% coverage of query (74.3 bits)
CAAT5_ARATH / O64759 Cationic amino acid transporter 5 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
TC 2.A.3.3.12 / O64759 Cationic amino acid transporter 5 from Arabidopsis thaliana (see 3 papers)
24% identity, 92% coverage of query (70.9 bits)
CAAT3_ARATH / Q8GYB4 Cationic amino acid transporter 3, mitochondrial from Arabidopsis thaliana (Mouse-ear cress) (see paper)
23% identity, 84% coverage of query (70.1 bits)
BPHYT_RS17540 L-aspartate/L-glutamate/L-glutamine:H+ symporter from Burkholderia phytofirmans PsJN
23% identity, 79% coverage of query (68.2 bits)
TC 2.A.3.3.24 / ALD51314.1 Plastidic cationic amino acid transporter, CAT, of 582 aas and 14 TMSs from Petunia x hybrida
24% identity, 74% coverage of query (67.4 bits)
6f34A / Q5L1G5 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. (see paper)
21% identity, 87% coverage of query (67.0 bits)
5oqtA Crystal structure of a bacterial cationic amino acid transporter (cat) homologue
21% identity, 87% coverage of query (65.9 bits)
CAAT6_ARATH / Q9LZ20 Cationic amino acid transporter 6, chloroplastic from Arabidopsis thaliana (Mouse-ear cress) (see paper)
TC 2.A.3.3.4 / Q9LZ20 The amino acid transporter, CAT6. Mediates electrogenic transport of large neutral and cationic amino acids in preference to other amino acids. Present in lateral root primordia, flowers and seeds from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
T1E3_130 / GI|13430548 amino acid transport-like protein from Arabidopsis thaliana (see paper)
23% identity, 83% coverage of query (65.5 bits)
7cmhB / Q9UHI5 The lat2-4f2hc complex in complex with tryptophan (see paper)
21% identity, 86% coverage of query (64.7 bits)
ROCE_BACSU / P39137 Amino-acid permease RocE from Bacillus subtilis (strain 168) (see paper)
TC 2.A.3.1.11 / P39137 L-Arginine permease, RocE from Bacillus subtilis (see 3 papers)
22% identity, 98% coverage of query (64.7 bits)
7cmiB The lat2-4f2hc complex in complex with leucine
21% identity, 86% coverage of query (64.7 bits)
7b00A Human lat2-4f2hc complex in the apo-state
21% identity, 86% coverage of query (64.7 bits)
LAT2_RABIT / Q9N1Q4 Large neutral amino acids transporter small subunit 2; 4F2-LC5; L-type amino acid transporter 2; Solute carrier family 7 member 8 from Oryctolagus cuniculus (Rabbit) (see paper)
22% identity, 86% coverage of query (64.3 bits)
YLAT1_MOUSE / Q9Z1K8 Y+L amino acid transporter 1; Solute carrier family 7 member 7; y(+)L-type amino acid transporter 1; Y+LAT1; y+LAT-1 from Mus musculus (Mouse) (see 3 papers)
22% identity, 93% coverage of query (63.9 bits)
SLC7A8 / Q9UHI5 large neutral amino acids transporter small subunit 2 from Homo sapiens (see 4 papers)
LAT2_HUMAN / Q9UHI5 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; hLAT2; Solute carrier family 7 member 8 from Homo sapiens (Human) (see 14 papers)
TC 2.A.3.8.20 / Q9UHI5 Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2) (Solute carrier family 7 member 8). Certain detergents stabilize and allow purification of the 4F2hc-LAT2 complex, allowing the measurement of substrate binding. In addition, an improved 3D map could be obtained from Homo sapiens (see 12 papers)
21% identity, 86% coverage of query (63.5 bits)
CAAT1_ARATH / Q84MA5 Cationic amino acid transporter 1; Amino acid transporter 1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
22% identity, 87% coverage of query (63.5 bits)
YLAT1_RAT / Q9R0S5 Y+L amino acid transporter 1; Solute carrier family 7 member 7; y(+)L-type amino acid transporter 1; Y+LAT1; y+LAT-1 from Rattus norvegicus (Rat) (see 2 papers)
TC 2.A.3.8.7 / Q9R0S5 y+LAT1 (transports neutral amino acids (i.e., Leu) in symport with Na+, Li+ or H+ in 1:1 stoichiometry; transports basic amino acids (i.e., Lys) by facilitated diffusion without a symported cation). Also transports the neurotoxicant, methylmercury-L-cysteine by molecular mimicry. Causes the Lysinuric protein intolerance condition in humans (Q9UM01) (Broer, 2008) (see 2 papers)
22% identity, 93% coverage of query (62.4 bits)
TC 2.A.3.8.29 / F1R8V8 Cationic amino acid transporter, y+LAT1 from Danio rerio
21% identity, 91% coverage of query (62.4 bits)
STET_BACSU / O34739 Serine/threonine exchanger SteT from Bacillus subtilis (strain 168) (see paper)
TC 2.A.3.8.12 / O34739 The Ser/Thr exchange transporter (SteT) (also transports aromatic amino acids with lower efficiency) (Reig et al., 2007). The substrate-bound state of SteT shows increased conformational flexibility and kinetic stability, enabling transport of substrate across the cell membrane (Bippes et al. 2009). TMS8 sculpts the substrate-binding site and undergoes conformational changes during the transport cycle of SteT (Bartoccioni et al., 2010). Mutations allow substrate binding but not translocation. Other mutations stabilize the protein and result in higher production levels from Bacillus subtilis (see 2 papers)
24% identity, 87% coverage of query (62.4 bits)
PheP / b0576 phenylalanine:H+ symporter PheP from Escherichia coli K-12 substr. MG1655 (see 3 papers)
pheP / P24207 phenylalanine:H+ symporter PheP from Escherichia coli (strain K12) (see 3 papers)
PHEP_ECOLI / P24207 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) (see 6 papers)
TC 2.A.3.1.1 / P24207 Phenylalanine:H+ symporter, PheP of 458 aas and 12 established TMSs from Escherichia coli (see 6 papers)
24% identity, 73% coverage of query (61.2 bits)
LAT2_MOUSE / Q9QXW9 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; mLAT2; Solute carrier family 7 member 8 from Mus musculus (Mouse) (see 6 papers)
22% identity, 86% coverage of query (60.5 bits)
LAT2_RAT / Q9WVR6 Large neutral amino acids transporter small subunit 2; L-type amino acid transporter 2; Solute carrier family 7 member 8 from Rattus norvegicus (Rat) (see 4 papers)
TC 2.A.3.8.6 / Q9WVR6 L-type neutral amino acid transporter, LAT2 (Na+-independent with broad specificity for all L-isomers of neutral amino acids; preferred substrate: Phe, His, Trp, Ile, Val, Leu, Gln, Cys, Ser; catalyzes obligatory exchange with μM affinities on the outside and mM affinities on the inside [1000x difference]). Both LAT2 and LAT1 (2.A.3.8.1) catalyze uptake of S-nitro-L-cysteine (Li and Whorton, 2005). Also transports thyroid hormones from Rattus norvegicus (Rat) (see 3 papers)
21% identity, 90% coverage of query (60.1 bits)
SLC7A6 / Q92536 Y+L amino acid transporter 2 from Homo sapiens (see 3 papers)
YLAT2_HUMAN / Q92536 Y+L amino acid transporter 2; Cationic amino acid transporter, y+ system; Solute carrier family 7 member 6; y(+)L-type amino acid transporter 2; Y+LAT2; y+LAT-2 from Homo sapiens (Human) (see 13 papers)
TC 2.A.3.8.23 / Q92536 Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2) from Homo sapiens (see 14 papers)
21% identity, 92% coverage of query (60.1 bits)
CTR1_HUMAN / P30825 High affinity cationic amino acid transporter 1; CAT-1; CAT1; Ecotropic retroviral leukemia receptor homolog; Ecotropic retrovirus receptor homolog; Solute carrier family 7 member 1; System Y+ basic amino acid transporter from Homo sapiens (Human) (see 4 papers)
TC 2.A.3.3.9 / P30825 High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor homologue) (Ecotropic retrovirus receptor homologue) (ERR) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter) from Homo sapiens (see 6 papers)
24% identity, 86% coverage of query (59.7 bits)
YLAT1_HUMAN / Q9UM01 Y+L amino acid transporter 1; Monocyte amino acid permease 2; MOP-2; Solute carrier family 7 member 7; y(+)L-type amino acid transporter 1; Y+LAT1; y+LAT-1 from Homo sapiens (Human) (see 18 papers)
TC 2.A.3.8.22 / Q9UM01 Y+L amino acid transporter 1 (Monocyte amino acid permease 2) (MOP-2) (Solute carrier family 7 member 7) (y(+)L-type amino acid transporter 1) (Y+LAT1) (y+LAT-1) from Homo sapiens (see 20 papers)
21% identity, 93% coverage of query (58.9 bits)
MmuP / b0260 CP4-6 prophage; S-methyl-L-methionine transporter from Escherichia coli K-12 substr. MG1655 (see 3 papers)
mmuP / Q47689 CP4-6 prophage; S-methyl-L-methionine transporter from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.3.1.10 / Q47689 S-Methylmethionine permease, MmuP from Escherichia coli (see 3 papers)
22% identity, 98% coverage of query (58.9 bits)
CTR1_RAT / P30823 High affinity cationic amino acid transporter 1; CAT-1; CAT1; Ecotropic retroviral leukemia receptor; Ecotropic retrovirus receptor; EcoR; Solute carrier family 7 member 1; System Y+ basic amino acid transporter from Rattus norvegicus (Rat) (see paper)
23% identity, 86% coverage of query (58.2 bits)
TC 2.A.3.8.11 / Q50E62 The aromatic-preferring amino acid transporter (ArpAT or Slc7a15). Functions with rBAT or 4F2hc (8.A.9) and transports preferentially tyr and 3,4-dihydroxyphenylalanine (L-DOPA), but also ala, glu, ser, cys and arg by a Na+-independent mechanism (present in mouse, rat, dog and chicken, but silenced in humans and chimps)(Fernández et al., 2005; Sato et al., 2005) from Mus musculus (Mouse) (see 2 papers)
26% identity, 81% coverage of query (57.0 bits)
CAAT8_ARATH / Q9SHH0 Cationic amino acid transporter 8, vacuolar from Arabidopsis thaliana (Mouse-ear cress) (see paper)
TC 2.A.3.3.11 / Q9SHH0 Cationic amino acid transporter 8, vacuolar from Arabidopsis thaliana (see 4 papers)
23% identity, 84% coverage of query (56.2 bits)
TC 2.A.3.8.2 / O13020 L-type neutral amino acid transporter, ASUR4 (Na+-independent) of 507 aas and 12 TMSs. Pregabalin (PGB), a drug for the treatment of epilepsy, neuropathic pain, fibromyalgia, and generalized anxiety disorder, may be transported by L-type transporters from Xenopus laevis (African clawed frog) (see 2 papers)
23% identity, 87% coverage of query (55.8 bits)
CTR1_MOUSE / Q09143 High affinity cationic amino acid transporter 1; CAT-1; CAT1; Ecotropic retroviral leukemia receptor; Ecotropic retrovirus receptor; ERR; EcoR; Solute carrier family 7 member 1; System Y+ basic amino acid transporter from Mus musculus (Mouse) (see 7 papers)
TC 2.A.3.3.1 / Q09143 System Y+ high affinity basic amino acid transporter (CAT1) (ecotropic retrovival leukemia virus receptor (ERR)) (transports arginine, lysine and ornithine; Na+-independent) from Mus musculus (Mouse) (see 2 papers)
Slc7a1 / RF|NP_031539.3 high affinity cationic amino acid transporter 1 from Mus musculus
22% identity, 83% coverage of query (55.8 bits)
AAA1_MOUSE / P63115 Asc-type amino acid transporter 1; Asc-1; D-serine transporter; Solute carrier family 7 member 10 from Mus musculus (Mouse) (see 5 papers)
AAA1_RAT / P63116 Asc-type amino acid transporter 1; Asc-1; D-serine transporter; Solute carrier family 7 member 10 from Rattus norvegicus (Rat) (see paper)
TC 2.A.3.8.13 / P63115 The Asc-type small neutral D- and L-amino acid:H+ symport transporter-1, Asc-1 (Slc7a10). Also transports amino acid related compounds. Heterodimeric; associates with 4F2hc (TC# 8.A.9.2.1) Most highly expressed in brain and lung, but to a lesser degree in placenta and small intestine. from Mus musculus (Mouse) (see 3 papers)
Slc7a10 Asc-type amino acid transporter 1 from Mus musculus (see paper)
22% identity, 87% coverage of query (55.8 bits)
CadR / b2156 lysine:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 15 papers)
lysP / P25737 lysine:H+ symporter from Escherichia coli (strain K12) (see 13 papers)
LYSP_ECOLI / P25737 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) (see 7 papers)
TC 2.A.3.1.2 / P25737 Lysine:H+ symporter. Forms a stable complex with CadC to allow lysine-dependent adaptation to acidic stress (Rauschmeier et al. 2013). The Salmonella orthologue is 95% identical to the E. coli protein and is highly specific for Lysine. Residues involved in lysine binding have been identified from Escherichia coli (see 5 papers)
lysP lysine-specific permease from Escherichia coli K12 (see 5 papers)
22% identity, 75% coverage of query (55.1 bits)
AroR / b0112 aromatic amino acid:H+ symporter AroP from Escherichia coli K-12 substr. MG1655 (see 5 papers)
aroP / P15993 aromatic amino acid:H+ symporter AroP from Escherichia coli (strain K12) (see 6 papers)
AROP_ECOLI / P15993 Aromatic amino acid transport protein AroP; Aromatic amino acid:H(+) symporter AroP; General aromatic amino acid permease; General aromatic transport system from Escherichia coli (strain K12) (see 8 papers)
TC 2.A.3.1.3 / P15993 Aromatic amino acid:H+ symporter, AroP of 457 aas and 12 TMSs (Cosgriff and Pittard 1997). Transports phenylalanine, tyrosine and tryptophan from Escherichia coli (see 6 papers)
25% identity, 86% coverage of query (51.2 bits)
6irtB Human lat1-4f2hc complex bound with bch
22% identity, 75% coverage of query (50.8 bits)
7dsqB Overall structure of the lat1-4f2hc bound with 3,5-diiodo-l-tyrosine
22% identity, 75% coverage of query (50.8 bits)
7dsnB Overall structure of the lat1-4f2hc bound with jx-119
22% identity, 75% coverage of query (50.8 bits)
7dslB Overall structure of the lat1-4f2hc bound with jx-078
22% identity, 75% coverage of query (50.8 bits)
7dskB / Q01650 Overall structure of the lat1-4f2hc bound with jx-075 (see paper)
22% identity, 75% coverage of query (50.8 bits)
SLC7A5 / Q01650 large neutral amino acids transporter small subunit 1 from Homo sapiens (see 4 papers)
LAT1_HUMAN / Q01650 Large neutral amino acids transporter small subunit 1; 4F2 light chain; 4F2 LC; 4F2LC; CD98 light chain; Integral membrane protein E16; E16; L-type amino acid transporter 1; hLAT1; Solute carrier family 7 member 5; y+ system cationic amino acid transporter from Homo sapiens (Human) (see 19 papers)
TC 2.A.3.8.25 / Q01650 Large neutral amino acids transporter small subunit 1 (4F2 light chain) (4F2 LC) (4F2LC) (CD98 light chain; SLC3A2) (Integral membrane protein E16) (L-type amino acid transporter 1) (hLAT1) (Solute carrier family 7 member 5) (y+ system cationic and neutral amino acid transporter) from Homo sapiens (see 24 papers)
22% identity, 75% coverage of query (50.1 bits)
7p9uB / Q9UPY5 Cryo em structure of system xc- in complex with glutamate (see paper)
22% identity, 78% coverage of query (47.8 bits)
SLC7A11 / Q9UPY5 cystine/glutamate transporter from Homo sapiens (see paper)
XCT_HUMAN / Q9UPY5 Cystine/glutamate transporter; Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; Solute carrier family 7 member 11; xCT from Homo sapiens (Human) (see 9 papers)
TC 2.A.3.8.18 / Q9UPY5 Cystine/glutamate antiporter (Amino acid transport system xCT) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) from Homo sapiens (see 7 papers)
22% identity, 78% coverage of query (47.8 bits)
7epzB Overall structure of erastin-bound xct-4f2hc complex
22% identity, 78% coverage of query (47.8 bits)
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Lawrence Berkeley National Laboratory