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Searching for up to 100 curated homologs for BWI76_RS03870 FitnessBrowser__Koxy:BWI76_RS03870 (254 a.a.)

Found high-coverage hits (≥70%) to 51 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

hpaG / Q46978 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase (EC 4.1.1.68) from Escherichia coli (see 2 papers)
    75% identity, 96% coverage of query (325 bits)

HPCE_ECOLX / P37352 Homoprotocatechuate catabolism bifunctional isomerase/decarboxylase; EC 5.3.3.10; EC 4.1.1.68 from Escherichia coli (see 2 papers)
    73% identity, 96% coverage of query (321 bits)

1gttA / P37352 Crystal structure of hpce (see paper)
    72% identity, 96% coverage of query (306 bits)

SM_b21112 L-2,4-diketo-3-deoxyrhamnonate hydrolase; 2,4-dioxopentanoate hydrolase from Sinorhizobium meliloti 1021
    41% identity, 77% coverage of query (164 bits)

BMULJ_04921 / A0A0H3KT28 2,4-didehydro-3-deoxy-L-fuconate hydrolase (EC 3.7.1.26) from Burkholderia multivorans (strain ATCC 17616 / 249) (see 2 papers)
    46% identity, 70% coverage of query (164 bits)

YISK_BACSU / O06724 Uncharacterized protein YisK from Bacillus subtilis (strain 168) (see paper)
    40% identity, 81% coverage of query (154 bits)

8skyB / A0A0D6X359 Crystal structure of yisk from bacillus subtilis in complex with oxalate (see paper)
    40% identity, 81% coverage of query (154 bits)

8sutA Crystal structure of yisk from bacillus subtilis in complex with reaction product 4-hydroxy-2-oxoglutaric acid
    40% identity, 81% coverage of query (154 bits)

Y2993_MYCTU / I6Y276 Protein Rv2993c from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    40% identity, 79% coverage of query (153 bits)

8gsrA / Q1NEI7 Crystal structure of l-2,4-diketo-3-deoxyrhamnonate hydrolase from sphingomonas sp. (Apo-form) (see paper)
    42% identity, 76% coverage of query (151 bits)

8gstC Crystal structure of l-2,4-diketo-3-deoxyrhamnonate hydrolase from sphingomonas sp. (Pyruvate bound-form)
    42% identity, 76% coverage of query (151 bits)

FAHD1_MOUSE / Q8R0F8 Acylpyruvase FAHD1, mitochondrial; Fumarylacetoacetate hydrolase domain-containing protein 1; Oxaloacetate decarboxylase; OAA decarboxylase; EC 3.7.1.5; EC 4.1.1.112 from Mus musculus (Mouse) (see 2 papers)
    41% identity, 75% coverage of query (150 bits)

6sbiA / Q8R0F8 X-ray structure of murine fumarylacetoacetate hydrolase domain containing protein 1 (fahd1) in complex with inhibitor oxalate (see paper)
    41% identity, 75% coverage of query (150 bits)

lra6 / Q1NEI7 2,4-didehydro-3-deoxy-L-fuconate hydrolase (EC 3.7.1.26) from Sphingomonas sp. (strain SKA58) (see paper)
    42% identity, 76% coverage of query (150 bits)

C785_RS20550 / A0A2E7P912 5-hydroxy-2,4-dioxopentanoate hydrolase (EC 3.7.1.26) from Herbaspirillum sp. (see paper)
    42% identity, 70% coverage of query (149 bits)

HSERO_RS06355 2,4-diketo-3-deoxy-L-fuconate hydrolase (EC 3.7.1.26) from Herbaspirillum seropedicae SmR1
    41% identity, 70% coverage of query (148 bits)

BPHYT_RS34210 2,4-diketo-3-deoxy-L-rhamnonate hydrolase (EC 3.7.1.-) from Burkholderia phytofirmans PsJN
    39% identity, 81% coverage of query (147 bits)

UGL_BURL3 / Q39BA7 Ureidoglycolate lyase; UGL; Ureidoglycolase; Ureidoglycolatase; Ureidoglycolate hydrolase; EC 4.3.2.3 from Burkholderia lata (strain ATCC 17760 / DSM 23089 / LMG 22485 / NCIMB 9086 / R18194 / 383) (see paper)
    41% identity, 78% coverage of query (147 bits)

FAHD1_HUMAN / Q6P587 Acylpyruvase FAHD1, mitochondrial; Fumarylacetoacetate hydrolase domain-containing protein 1; FAH domain-containing protein 1; Oxaloacetate decarboxylase; OAA decarboxylase; YisK-like protein; EC 3.7.1.5; EC 4.1.1.112 from Homo sapiens (Human) (see 3 papers)
Q6P587 acylpyruvate hydrolase (EC 3.7.1.5); oxaloacetate decarboxylase (EC 4.1.1.112) from Homo sapiens (see 3 papers)
    41% identity, 75% coverage of query (147 bits)

6fogA / Q6P587 X-ray structure of homo sapiens fumarylacetoacetate hydrolase domain containing protein 1 (fahd1) in complex with inhibitor oxalate at 1.94a resolution. (see paper)
    41% identity, 75% coverage of query (147 bits)

FAHD1_ARATH / Q93ZE5 Probable acylpyruvase FAHD1, mitochondrial; Fumarylacetoacetate hydrolase domain-containing protein 1; FAH domain-containing protein 1; EC 3.7.1.5 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    38% identity, 76% coverage of query (139 bits)

YcgM / b1180 putative isomerase/hydrolase from Escherichia coli K-12 substr. MG1655 (see 2 papers)
    39% identity, 75% coverage of query (138 bits)

FAHD2_ARATH / Q9LUR3 Probable acylpyruvase FAHD2, mitochondrial; Fumarylacetoacetate hydrolase domain-containing protein 2; FAH domain-containing protein 2; EC 3.7.1.5 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    39% identity, 75% coverage of query (137 bits)

G2IPX5 maleylpyruvate hydrolase (EC 3.7.1.23) from Sphingobium sp. SYK-6 (see paper)
    34% identity, 97% coverage of query (135 bits)

dntG / Q8VUC7 2,4-dihydroxy-5-methyl-6-oxohexa-2,4-dienoate isomerase from Burkholderia cepacia (see 2 papers)
    35% identity, 79% coverage of query (131 bits)

6jvwB / G2IPX5 Crystal structure of maleylpyruvate hydrolase from sphingobium sp. Syk-6 in complex with manganese (ii) ion and pyruvate (see paper)
    32% identity, 97% coverage of query (130 bits)

6iymA / K0A9N9 Fumarylacetoacetate hydrolase (eafah) from psychrophilic exiguobacterium antarcticum (see paper)
    36% identity, 81% coverage of query (130 bits)

6v77B / A0QTY3 Crystal structure of a putative hpce protein from mycobacterium smegmatis
    37% identity, 79% coverage of query (130 bits)

3qdfA / B2HIH3 Crystal structure of 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase from mycobacterium marinum (see paper)
    38% identity, 72% coverage of query (129 bits)

A0A076VF18 fumarylacetoacetase (EC 3.7.1.2) from Rhodotorula diobovata (see paper)
    39% identity, 79% coverage of query (128 bits)

K0A9N9 fumarylacetoacetase (EC 3.7.1.2) from Exiguobacterium antarcticum (see paper)
    36% identity, 81% coverage of query (127 bits)

hbzF / Q0QFQ3 maleylpyruvate hydrolase monomer (EC 3.7.1.23) from Pseudomonas alcaligenes (see 2 papers)
HBZF_PSEAC / Q0QFQ3 Maleylpyruvate hydrolase; MPH11; EC 3.7.1.23 from Pseudomonas alcaligenes (see 3 papers)
Q0QFQ3 maleylpyruvate hydrolase (EC 3.7.1.23) from Pseudomonas alcaligenes (see 2 papers)
    36% identity, 83% coverage of query (127 bits)

1nr9A / P76004 Crystal structure of escherichia coli 1262 (apc5008), putative isomerase
    38% identity, 75% coverage of query (127 bits)

1nr9C / P76004 Crystal structure of escherichia coli 1262 (apc5008), putative isomerase
    38% identity, 75% coverage of query (127 bits)

A0A1R4GQY2 3-fumarylpyruvate hydrolase (EC 3.7.1.20) from Corynebacterium glutamicum (see paper)
    36% identity, 80% coverage of query (123 bits)

6j5xA / Q8NLC0 Crystal structure of fumarylpyruvate hydrolase from corynebacterium glutamicum in complex with mn2+ and pyruvate (see paper)
    36% identity, 80% coverage of query (123 bits)

6j5xB Crystal structure of fumarylpyruvate hydrolase from corynebacterium glutamicum in complex with mn2+ and pyruvate
    36% identity, 80% coverage of query (123 bits)

4dbhA / Q8NQY2 Crystal structure of cg1458 with inhibitor (see paper)
    35% identity, 78% coverage of query (112 bits)

6j5yA / Q9I111 Crystal structure of fumarylpyruvate hydrolase from pseudomonas aeruginosa in complex with mn2+ and pyruvate (see paper)
    33% identity, 78% coverage of query (108 bits)

A0A080VH08 3-fumarylpyruvate hydrolase (EC 3.7.1.20) from Pseudomonas aeruginosa (see paper)
    33% identity, 78% coverage of query (108 bits)

YOS9_SCHPO / Q9P7L4 Uncharacterized hydrolase C21C3.09c; EC 3.-.-.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    35% identity, 72% coverage of query (108 bits)

A0A0M3SVN7 fumarylacetoacetase (EC 3.7.1.2) from Cupriavidus gilardii (see paper)
    35% identity, 75% coverage of query (104 bits)

3r6oA / B1MJ53 Crystal structure of a probable 2-hydroxyhepta-2,4-diene-1, 7- dioateisomerase from mycobacterium abscessus (see paper)
    33% identity, 70% coverage of query (104 bits)

naaD / F8QQ75 3-fumarylpyruvate hydrolase (EC 3.7.1.20) from Bradyrhizobium sp. JS329 (see paper)
    35% identity, 81% coverage of query (102 bits)

3v77A / D2YW46 Crystal structure of a putative fumarylacetoacetate isomerase/hydrolase from oleispira antarctica (see paper)
    33% identity, 73% coverage of query (102 bits)

A0A0D5YDA5 fumarylacetoacetase (EC 3.7.1.2) from Acinetobacter baumannii (see paper)
    30% identity, 75% coverage of query (89.7 bits)

CPH_NEONM / A0A3G9JYJ6 Caffeoylpyruvate hydrolase; CPH; Fungal bioluminescence cycle protein cph; EC 3.7.-.- from Neonothopanus nambi (Agaricus nambi) (see 2 papers)
    32% identity, 78% coverage of query (86.7 bits)

Build an alignment

Build an alignment for BWI76_RS03870 and 47 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

FMP41_YEAST / P53889 Uncharacterized mitochondrial hydrolase FMP41; EC 3.-.-.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
    27% identity, 74% coverage of query (76.6 bits)

1nkqA / P53889 Crystal structure of yeast ynq8, a fumarylacetoacetate hydrolase family protein
    28% identity, 74% coverage of query (73.2 bits)

A0A1B0ZSC0 fumarylacetoacetase (EC 3.7.1.2) from Phaeobacter gallaeciensis (see paper)
    29% identity, 81% coverage of query (72.4 bits)

xacE / D4GP28 2-dehydro-3-deoxy-L-arabinonate dehydratase (EC 4.2.1.43; EC 4.2.1.141) from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (see 3 papers)
KDXD_HALVD / D4GP28 Probable 2-keto-3-deoxyxylonate dehydratase; KDXD; EC 4.2.1.141 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see 2 papers)
    30% identity, 70% coverage of query (57.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory