Searching for up to 100 curated homologs for BWI76_RS04020 FitnessBrowser__Koxy:BWI76_RS04020 (394 a.a.)
Found high-coverage hits (≥70%) to 42 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
pobA / Q9R9T1 p-hydroxybenzoate hydroxylase (EC 1.14.13.2) from Pseudomonas putida (see paper)
Q9R9T1 4-hydroxybenzoate 3-monooxygenase (EC 1.14.13.2) from Pseudomonas putida (see paper)
75% identity, 100% coverage of query (601 bits)
6dllB / Q88H28 2.2 angstrom resolution crystal structure of p-hydroxybenzoate hydroxylase from pseudomonas putida in complex with fad. (see paper)
73% identity, 100% coverage of query (593 bits)
PHHY_PSEAE / P20586 p-hydroxybenzoate hydroxylase; PHBH; 4-hydroxybenzoate 3-monooxygenase; EC 1.14.13.2 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 7 papers)
1d7lA / P20586 Structure-function correlations of the reaction of reduced nicotinamide analogs with p-hydroxybenzoate hydroxylase substituted with a series of 8-substituted flavins (see paper)
69% identity, 100% coverage of query (554 bits)
1iusA P-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate at ph 5.0
69% identity, 100% coverage of query (554 bits)
1dodA The mobil flavin of 4-oh benzoate hydroxylase: motion of a prosthetic group regulates catalysis
69% identity, 100% coverage of query (554 bits)
1pbcA Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate, 2,4-dihydroxybenzoate and 2-hydroxy- 4-aminobenzoate and of the try222ala mutant, complexed with 2- hydroxy-4-aminobenzoate. Evidence for a proton channel and a new binding mode of the flavin ring
69% identity, 99% coverage of query (553 bits)
pobA / P00438 p-hydroxybenzoate hydroxylase (EC 1.14.13.2) from Pseudomonas fluorescens (see 2 papers)
PHHY_PSEFL / P00438 p-hydroxybenzoate hydroxylase; PHBH; PHBHase; 4-hydroxybenzoate 3-monooxygenase; EC 1.14.13.2 from Pseudomonas fluorescens (see 13 papers)
68% identity, 100% coverage of query (552 bits)
1bf3A P-hydroxybenzoate hydroxylase (phbh) mutant with cys 116 replaced by ser (c116s) and arg 42 replaced by lys (r42k), in complex with fad and 4-hydroxybenzoic acid
69% identity, 99% coverage of query (552 bits)
1k0lA Pseudomonas aeruginosa phbh r220q free of p-ohb
68% identity, 100% coverage of query (552 bits)
1k0jA Pseudomonas aeruginosa phbh r220q in complex with NADPH and free of p- ohb
68% identity, 100% coverage of query (552 bits)
2phhA The coenzyme analogue adenosine 5-diphosphoribose displaces fad in the active site of p-hydroxybenzoate hydroxylase. An x-ray crystallographic investigation
69% identity, 99% coverage of query (551 bits)
1pdhA Crystal structure of p-hydroxybenzoate hydroxylase reconstituted with the modified fad present in alcohol oxidase from methylotrophic yeasts: evidence for an arabinoflavin
69% identity, 99% coverage of query (551 bits)
1ykjB A45g p-hydroxybenzoate hydroxylase with p-hydroxybenzoate bound
68% identity, 100% coverage of query (544 bits)
Pf6N2E2_2914 4-hydroxybenzoate 3-monooxygenase (EC 1.14.13.2) from Pseudomonas fluorescens FW300-N2E2
66% identity, 100% coverage of query (530 bits)
pobA / F2JUE7 4-hydroxybenzoate 3-monooxygenase (EC 1.14.13.2) from Marinomonas mediterranea (strain ATCC 700492 / JCM 21426 / NBRC 103028 / MMB-1) (see paper)
62% identity, 99% coverage of query (506 bits)
pobA / AAA73519.1 4-hydroxybenzoate hydroxylase from Rhizobium leguminosarum (see paper)
58% identity, 99% coverage of query (467 bits)
RR42_RS21940 4-hydroxybenzoate 3-monooxygenase (EC 1.14.13.2) from Cupriavidus basilensis FW507-4G11
60% identity, 99% coverage of query (441 bits)
PRAI_PAESP / C4TP09 4-hydroxybenzoate 3-monooxygenase (NAD(P)H); 4-hydroxybenzoate 3-hydroxylase; 4HB 3-hydroxylase; EC 1.14.13.33 from Paenibacillus sp. (see paper)
praI / BAH79107.1 4-hydroxybenzoate 3-hydroxylase from Paenibacillus sp. JJ-1b (see paper)
51% identity, 99% coverage of query (394 bits)
7on9A / C4TP09 Crystal structure of para-hydroxybenzoate-3-hydroxylase prai (see paper)
51% identity, 99% coverage of query (394 bits)
8jqoA Protocatecuate hydroxylase from xylophilus ampelinus complexed with imidazole (see paper)
47% identity, 99% coverage of query (372 bits)
8jqoD Protocatecuate hydroxylase from xylophilus ampelinus complexed with imidazole (see paper)
39% identity, 99% coverage of query (269 bits)
Build an alignment for BWI76_RS04020 and 21 homologs with ≥ 30% identity
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6c7sA Structure of rifampicin monooxygenase with product bound
25% identity, 82% coverage of query (63.5 bits)
5koxA Structure of rifampicin monooxygenase complexed with rifampicin
25% identity, 82% coverage of query (63.5 bits)
ROX_NOCFA / Q5YTV5 Rifampicin monooxygenase; RIFMO; EC 1.14.13.211 from Nocardia farcinica (strain IFM 10152) (see 3 papers)
Q5YTV5 rifampicin monooxygenase (EC 1.14.13.211) from Nocardia farcinica (see paper)
25% identity, 82% coverage of query (63.5 bits)
5kowA / Q5YTV5 Structure of rifampicin monooxygenase (see paper)
25% identity, 82% coverage of query (63.2 bits)
6ui5A / Q1MX79 Tmn9 in complex with cofactor fad
25% identity, 82% coverage of query (62.4 bits)
stiL / CAD19095.1 cytochrome P450 dependent monooxygenase from Stigmatella aurantiaca (see paper)
25% identity, 78% coverage of query (62.0 bits)
ctcN / Q53657 anhydrotetracycline 6-monooxygenase (EC 1.14.13.38) from Kitasatospora aureofaciens (see 2 papers)
cts8 / BAA07387.1 6-hydroxylation enzyme of tetracycline from Kitasatospora aureofaciens (see paper)
27% identity, 83% coverage of query (61.6 bits)
OTCC_STRRM / Q58PK7 Anhydrotetracycline monooxygenase; EC 1.14.13.38 from Streptomyces rimosus (see paper)
Q58PK7 anhydrotetracycline 6-monooxygenase (EC 1.14.13.38) from Streptomyces rimosus (see paper)
26% identity, 83% coverage of query (61.2 bits)
4k2xB / L8EUQ6 Oxys anhydrotetracycline hydroxylase from streptomyces rimosus (see paper)
26% identity, 83% coverage of query (61.2 bits)
oxyS / L8EUQ6 anhydrotetracycline monooxygenase monomer (EC 1.14.13.234; EC 1.14.13.38) from Streptomyces rimosus subsp. rimosus (strain ATCC 10970 / DSM 40260 / JCM 4667 / NRRL 2234) (see 6 papers)
OXYS_STRR1 / L8EUQ6 12-dehydrotetracycline 5-monooxygenase/anhydrotetracycline 6-monooxygenase; EC 1.14.13.234; EC 1.14.13.38 from Streptomyces rimosus subsp. rimosus (strain ATCC 10970 / DSM 40260 / JCM 4667 / NRRL 2234) (see paper)
L8EUQ6 5a,11a-dehydrotetracycline 5-monooxygenase (EC 1.14.13.234) from Streptomyces rimosus subsp. rimosus (see paper)
26% identity, 83% coverage of query (60.1 bits)
SDNN_SORAA / A0A1B4XBH7 FAD-dependent monooxygenase sdnN; Sordarin/hypoxysordarin biosynthesis cluster protein N; EC 1.-.-.- from Sordaria araneosa (Pleurage araneosa) (see paper)
22% identity, 88% coverage of query (59.7 bits)
TERD_ASPTN / Q0D1P2 FAD-dependent monooxygenase terD; Terrein biosynthesis cluster protein terD; EC 1.-.-.- from Aspergillus terreus (strain NIH 2624 / FGSC A1156) (see 13 papers)
22% identity, 83% coverage of query (58.9 bits)
6brdA / F2R776 Crystal structure of rifampin monooxygenase from streptomyces venezuelae, complexed with rifampin and fad (see paper)
25% identity, 82% coverage of query (52.4 bits)
ROX_STRVP / F2R776 Rifampicin monooxygenase; RIFMO; EC 1.14.13.211 from Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745) (see paper)
25% identity, 82% coverage of query (52.4 bits)
7vwpB / A0A136PK59 Structure of the flavin-dependent monooxygenase flso1 from the biosynthesis of fluostatinsin
26% identity, 83% coverage of query (52.0 bits)
PYRE3_STRRG / K7QRJ5 Dialkyldecalin synthase; FAD-dependent [4+2] cyclase; EC 5.5.1.- from Streptomyces rugosporus (see 2 papers)
25% identity, 83% coverage of query (50.1 bits)
7yj0D Structural basis of oxepinone formation by a flavin-monooxygenase vibo
24% identity, 83% coverage of query (50.1 bits)
5xgvA / K7QRJ5 The structure of diels-alderase pyre3 in the biosynthetic pathway of pyrroindomycins (see paper)
25% identity, 82% coverage of query (48.5 bits)
7oujAAA / Q8KY42 7oujAAA (see paper)
25% identity, 78% coverage of query (47.8 bits)
6fhoA / Q9HWJ1 Crystal structure of pqsl, a probable fad-dependent monooxygenase from pseudomonas aeruginosa - new refinement (see paper)
23% identity, 76% coverage of query (44.7 bits)
6sw2A Crystal structure of p. Aeruginosa pqsl in complex with 2- aminobenzoylacetate
23% identity, 76% coverage of query (44.7 bits)
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Lawrence Berkeley National Laboratory