Searching for up to 100 curated homologs for BWI76_RS04380 FitnessBrowser__Koxy:BWI76_RS04380 (419 a.a.)
Found high-coverage hits (≥70%) to 23 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
VCA0025 / Q9KNE0 dicarboxylate:Na+ symporter from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) (see 6 papers)
TC 2.A.47.5.2 / Q9KNE0 Dicarboxylate (succinate, fumarate, malate) transporter, vcINDY from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
31% identity, 95% coverage of query (148 bits)
6okzB Structure of vcindy bound to fumarate
31% identity, 95% coverage of query (148 bits)
7t9gA / Q9KNE0 Structure of vcindy-na+ (see paper)
31% identity, 95% coverage of query (147 bits)
6wtxA Structure of vcindy in complex with terephthalate
31% identity, 95% coverage of query (147 bits)
Build an alignment for BWI76_RS04380 and 4 homologs with ≥ 30% identity
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TC 2.A.47.5.1 / Q58086 Hypothetical Na+ cotransporter, Orfl from Methanococcus jannaschii (see paper)
29% identity, 93% coverage of query (145 bits)
4f35B / Q9KNE0 Crystal structure of a bacterial dicarboxylate/sodium symporter (see paper)
31% identity, 95% coverage of query (137 bits)
SDCS_STAAM / Q99SX1 Sodium-dependent dicarboxylate transporter SdcS; Na(+)/dicarboxylate symporter from Staphylococcus aureus (strain Mu50 / ATCC 700699) (see 2 papers)
24% identity, 95% coverage of query (107 bits)
TC 2.A.47.1.11 / Q2FFH9 The Na+ (or Li+):dicarboxylate (2:1) symporter, SdcS (catalyzes succinate:succinate antiport as well as electroneutral symport in reconstituted proteoliposomes from Staphylococcus aureus (strain USA300) (see paper)
24% identity, 95% coverage of query (105 bits)
TC 2.A.47.1.12 / A4QAL6 The aerobic dicarboxylate (succinate (Km, 30 μM), fumarate (Km, 79 from Corynebacterium glutamicum (strain R) (see paper)
27% identity, 96% coverage of query (95.5 bits)
NAD3_CAEEL / Q21339 Sodium-dependent high-affinity dicarboxylate transporter 3; Na(+)/dicarboxylate cotransporter 3; NaDC-3; ceNaDC3 from Caenorhabditis elegans (see paper)
TC 2.A.47.1.8 / Q21339 High affinity dicarboxylate:Na+ symporter, NaDC2 (INDY2) (relative affinities: fumarate > malate > α-ketoglutarate > maleate > succinate > lactate) (see 2 papers)
25% identity, 95% coverage of query (91.3 bits)
YBH4_SCHPO / O59712 Uncharacterized transporter C3B8.04c from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
26% identity, 95% coverage of query (79.0 bits)
TC 2.A.47.1.13 / Q65NC0 The Na+-coupled dicarboxylate (succinate; malate; fumarate) transporter, SdcL (transports aspartate, α-ketoglutarate and oxaloacetate with low affinity). Km for succinate, ~6 from Bacillus licheniformis (strain DSM 13 / ATCC 14580) (see 2 papers)
24% identity, 91% coverage of query (77.8 bits)
7jsjA / Q86YT5 Structure of the nact-pf2 complex (see paper)
23% identity, 93% coverage of query (76.6 bits)
TDT_ARATH / Q8LG88 Tonoplast dicarboxylate transporter; AttDT; Sodium-dicarboxylate cotransporter-like; AtSDAT; Vacuolar malate transporter from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 2.A.47.1.6 / Q8LG88 The tonoplast dicarboxylate (malate) transporter, AtDCT (see 3 papers)
TDT / GB|BAA96091.1 tonoplast dicarboxylate transporter from Arabidopsis thaliana (see paper)
22% identity, 95% coverage of query (76.6 bits)
NAD1_CAEEL / Q93655 Sodium-dependent low-affinity dicarboxylate transporter 1; Na(+)/dicarboxylate cotransporter 1; NaDC-1; ceNaDC1 from Caenorhabditis elegans (see paper)
TC 2.A.47.1.7 / Q93655 Low affinity dicarboxylate:Na+ symporter, NaDC1 (INDY1) (relative affinities: succinate > fumarate > α-ketoglutarate > malate > lactate > maleate) (see 2 papers)
23% identity, 94% coverage of query (75.1 bits)
PHO90_YEAST / P39535 Low-affinity phosphate transporter PHO90 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
P39535 ABC-type phosphate transporter (EC 7.3.2.1) from Saccharomyces cerevisiae (see paper)
TC 2.A.47.2.3 / P39535 Low affinity phosphate transporters (881aas). Also transports selenite from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 6 papers)
23% identity, 84% coverage of query (58.9 bits)
AAA99493.1 46 kDa protein from Mycobacterium leprae (see paper)
22% identity, 91% coverage of query (55.5 bits)
TC 2.A.47.2.4 / Q4DX24 Contractile vacuole phosphate:Na+ symporter of 727 aas and 12 TMSs, Pho91 (Pho90; Pho87) from Trypanosoma cruzi (strain CL Brener)
25% identity, 88% coverage of query (53.1 bits)
PHO87 / P25360 low-affinity phosphate transporter PHO87 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 15 papers)
PHO87_YEAST / P25360 Inorganic phosphate transporter PHO87 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P25360 ABC-type phosphate transporter (EC 7.3.2.1) from Saccharomyces cerevisiae (see paper)
TC 2.A.47.2.1 / P25360 Inorganic phosphate transporter, Pho87. Also transports selenite from Saccharomyces cerevisiae (Baker's yeast) (see 6 papers)
PHO87 / RF|NP_009966.2 inorganic phosphate transporter PHO87 from Saccharomyces cerevisiae
26% identity, 84% coverage of query (52.0 bits)
MAMN_MAGGM / Q6NE56 Magnetosome protein MamN; Putative ion transporter MamN from Magnetospirillum gryphiswaldense (strain DSM 6361 / JCM 21280 / NBRC 15271 / MSR-1) (see 5 papers)
mamN / CAJ30121.1 magnetosome protein MamN from Magnetospirillum gryphiswaldense (see paper)
22% identity, 98% coverage of query (50.1 bits)
ArsF / b3502 arsenite/antimonite:H+ antiporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
arsB / P0AB93 arsenite/antimonite:H+ antiporter from Escherichia coli (strain K12) (see 4 papers)
TC 3.A.4.1.1 / P0AB93 Arsenical pump membrane protein ArsB aka ARSF aka B3502, component of Arsenical resistance efflux pump (ATP-dependent) from Escherichia coli (see 6 papers)
arsB arsenic efflux pump protein ArsB from Escherichia coli K12 (see paper)
23% identity, 95% coverage of query (49.7 bits)
INDY1_DROME / Q9VVT2 Protein I'm not dead yet; INDY transporter protein; drIndy from Drosophila melanogaster (Fruit fly) (see 3 papers)
TC 2.A.47.1.10 / Q9VVT2 Cation-independent, electroneutral tri- and di-carboxylate transporter with a preference for tricarboxylates, Indy (I'm not dead yet) [When Indy is mutated flies live about twice as long as wild type] from Drosophila melanogaster (Fruit fly) (see 7 papers)
Indy / RF|NP_730363.2 protein I'm not dead yet from Drosophila melanogaster (see paper)
20% identity, 89% coverage of query (48.1 bits)
arsB / AAB42204.1 transmembrane protein of arsenite pump from Yersinia enterocolitica (see paper)
22% identity, 95% coverage of query (48.1 bits)
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Lawrence Berkeley National Laboratory