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Searching for up to 100 curated homologs for BWI76_RS05440 FitnessBrowser__Koxy:BWI76_RS05440 (251 a.a.)

Found high-coverage hits (≥70%) to 31 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

YafR / b0212 hydroxyacylglutathione hydrolase GloB (EC 3.1.2.6) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
gloB / P0AC84 hydroxyacylglutathione hydrolase GloB (EC 3.1.2.6) from Escherichia coli (strain K12) (see 9 papers)
GLO2_ECOLI / P0AC84 Hydroxyacylglutathione hydrolase GloB; Glyoxalase II; Glx II; EC 3.1.2.6 from Escherichia coli (strain K12) (see 2 papers)
6rz0A / P0AC84 Crystal structure of escherichia coli glyoxalase ii
gloB / MB|P0AC84 hydroxyacylglutathione hydrolase; EC 3.1.2.6 from Escherichia coli K12 (see 3 papers)
    76% identity, 100% coverage of query (398 bits)

2qedA / Q8ZRM2 Crystal structure of salmonella thyphimurium lt2 glyoxalase ii (see paper)
    75% identity, 100% coverage of query (394 bits)

GLO2_SALTY / Q8ZRM2 Hydroxyacylglutathione hydrolase; Glyoxalase II; Glx II; EC 3.1.2.6 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
Q8ZRM2 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
    75% identity, 100% coverage of query (394 bits)

Q940L0 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Oryza sativa (see 3 papers)
    40% identity, 98% coverage of query (194 bits)

8ewoA / Q9I2T1 Crystal structure of putative glyoxylase ii from pseudomonas aeruginosa
    43% identity, 98% coverage of query (194 bits)

GLO2N_ARATH / Q9SID3 Hydroxyacylglutathione hydrolase 2, mitochondrial; Glyoxalase II; Glx II; EC 3.1.2.6 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    40% identity, 98% coverage of query (189 bits)

2q42A / Q9SID3 Ensemble refinement of the protein crystal structure of glyoxalase ii from arabidopsis thaliana gene at2g31350 (see paper)
    40% identity, 100% coverage of query (189 bits)

Q8YZ99 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Nostoc sp. PCC 7120 = FACHB-418 (see paper)
    39% identity, 100% coverage of query (184 bits)

GLO2M_ARATH / O24495 Hydroxyacylglutathione hydrolase 1, mitochondrial; Glyoxalase II; Glx II; EC 3.1.2.6 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    41% identity, 89% coverage of query (176 bits)

GLO2C_ARATH / O24496 Hydroxyacylglutathione hydrolase cytoplasmic; Glyoxalase II; Glx II; EC 3.1.2.6 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    35% identity, 100% coverage of query (167 bits)

GLO2_RAT / O35952 Hydroxyacylglutathione hydrolase, mitochondrial; Glyoxalase II; Glx II; Round spermatid protein RSP29; EC 3.1.2.6 from Rattus norvegicus (Rat) (see 2 papers)
O35952 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Rattus norvegicus (see paper)
    32% identity, 100% coverage of query (146 bits)

GLO2_HUMAN / Q16775 Hydroxyacylglutathione hydrolase, mitochondrial; Glyoxalase II; Glx II; EC 3.1.2.6 from Homo sapiens (Human) (see 3 papers)
Q16775 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Homo sapiens (see 8 papers)
    30% identity, 100% coverage of query (134 bits)

1qh3A / Q16775 Human glyoxalase ii with cacodylate and acetate ions present in the active site (see paper)
    30% identity, 100% coverage of query (134 bits)

1qh5B Human glyoxalase ii with s-(n-hydroxy-n-bromophenylcarbamoyl) glutathione
    30% identity, 100% coverage of query (134 bits)

1qh5A Human glyoxalase ii with s-(n-hydroxy-n-bromophenylcarbamoyl) glutathione
    30% identity, 100% coverage of query (134 bits)

PNKD_MOUSE / Q69ZP3 Probable hydrolase PNKD; Myofibrillogenesis regulator 1; MR-1; Paroxysmal nonkinesiogenic dyskinesia protein; EC 3.-.-.- from Mus musculus (Mouse) (see 3 papers)
    35% identity, 87% coverage of query (131 bits)

PNKD_HUMAN / Q8N490 Probable hydrolase PNKD; Myofibrillogenesis regulator 1; MR-1; Paroxysmal nonkinesiogenic dyskinesia protein; Trans-activated by hepatitis C virus core protein 2; EC 3.-.-.- from Homo sapiens (Human) (see 8 papers)
    35% identity, 87% coverage of query (129 bits)

GLO22_SCHPO / O94250 Probable hydroxyacylglutathione hydrolase C13B11.03c; Glyoxalase II; Glx II; EC 3.1.2.6 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    32% identity, 90% coverage of query (128 bits)

GLO2 / Q05584 glyoxalase II (cytoplasmic) (EC 3.1.2.6) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 2 papers)
GLO2_YEAST / Q05584 Hydroxyacylglutathione hydrolase, cytoplasmic isozyme; Glyoxalase II; Glx II; EC 3.1.2.6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
GLO2 / CAA71335.1 glyoxalase-II from Saccharomyces cerevisiae (see paper)
    30% identity, 95% coverage of query (102 bits)

Build an alignment

Build an alignment for BWI76_RS05440 and 19 homologs with ≥ 30% identity

Select sequences

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Change minimum %identity:

Additional hits (identity < 30%)

Q6KF36 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Trypanosoma brucei (see paper)
GLXII / GI|47604513 glyoxalase II from Trypanosoma brucei brucei (see paper)
glxII / CAD37800.1 glyoxalase II from Trypanosoma brucei brucei (see paper)
    29% identity, 90% coverage of query (100 bits)

2p18A / Q2PYN0 Crystal structure of the leishmania infantum glyoxalase ii (see paper)
    29% identity, 91% coverage of query (94.4 bits)

Q2PYN0 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Leishmania infantum (see 3 papers)
    28% identity, 91% coverage of query (91.3 bits)

GLO4 / Q12320 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 6 papers)
Q12320 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Saccharomyces cerevisiae (see paper)
GLO4 / CAA58065.1 glyoxalase-II from Saccharomyces cerevisiae (see 3 papers)
    28% identity, 84% coverage of query (77.8 bits)

Q581U6 hydroxyacylglutathione hydrolase (EC 3.1.2.6) from Trypanosoma brucei (see paper)
    22% identity, 99% coverage of query (75.1 bits)

BAEB_BACVZ / A7Z4X7 Probable polyketide biosynthesis zinc-dependent hydrolase BaeB; EC 3.-.-.- from Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42) (Bacillus amyloliquefaciens subsp. plantarum) (see paper)
    30% identity, 76% coverage of query (73.2 bits)

BLH_XYLFA / Q9PFB0 Beta-lactamase hydrolase-like protein; BLH; EC 3.-.-.- from Xylella fastidiosa (strain 9a5c) (see paper)
    26% identity, 76% coverage of query (66.6 bits)

BLH_AGRFC / Q8UAA9 Beta-lactamase hydrolase-like protein; BLH; EC 3.-.-.- from Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens (strain C58)) (see paper)
    25% identity, 80% coverage of query (58.9 bits)

3r2uB 2.1 angstrom resolution crystal structure of metallo-beta-lactamase from staphylococcus aureus subsp. Aureus col
    26% identity, 79% coverage of query (55.5 bits)

VrtG / D7PHZ8 12a-deshydroxy-desmethylanthrotainin thioesterase from Penicillium aethiopicum (see 2 papers)
VRTG_PENAE / D7PHZ8 Lactamase-like protein vrtG; Viridicatumtoxin synthesis protein G; EC 3.1.-.- from Penicillium aethiopicum (see 4 papers)
    28% identity, 73% coverage of query (54.3 bits)

CLAF_PASFU / P0CU68 Atrochrysone carboxyl ACP thioesterase; ACTE; Cladofulvin biosynthesis cluster protein F; EC 3.1.2.- from Passalora fulva (Tomato leaf mold) (Cladosporium fulvum) (see 3 papers)
    24% identity, 79% coverage of query (47.8 bits)

4efzA / Q3JRV4 Crystal structure of a hypothetical metallo-beta-lactamase from burkholderia pseudomallei
    23% identity, 73% coverage of query (45.8 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory