Sites on a Tree

 

Searching for up to 100 curated homologs for BWI76_RS08490 FitnessBrowser__Koxy:BWI76_RS08490 (149 a.a.)

Found high-coverage hits (≥70%) to 12 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

1i9cA Glutamate mutase from clostridium cochlearium: complex with adenosylcobalamin and substrate
    57% identity, 91% coverage of query (163 bits)

1cb7A / P80078 Glutamate mutase from clostridium cochlearium reconstituted with methyl-cobalamin (see paper)
    57% identity, 91% coverage of query (162 bits)

1ccwA Structure of the coenzyme b12 dependent enzyme glutamate mutase from clostridium cochlearium
    57% identity, 91% coverage of query (162 bits)

GMSS_CLOCO / P80078 Glutamate mutase sigma subunit; Glutamate mutase S chain; Glutamate mutase small subunit; Methylaspartate mutase; EC 5.4.99.1 from Clostridium cochlearium (see 5 papers)
P80078 methylaspartate mutase (EC 5.4.99.1) from Clostridium cochlearium (see paper)
    56% identity, 91% coverage of query (161 bits)

GMSS_CLOTT / Q05488 Glutamate mutase sigma subunit; Glutamate mutase S chain; Glutamate mutase small subunit; Methylaspartate mutase; EC 5.4.99.1 from Clostridium tetanomorphum (see paper)
Q05488 methylaspartate mutase (subunit 2/2) (EC 5.4.99.1) from Clostridium tetanomorphum (see paper)
1id8A / Q05488 Nmr structure of glutamate mutase (b12-binding subunit) complexed with the vitamin b12 nucleotide (see paper)
    60% identity, 83% coverage of query (160 bits)

mamA / Q5V467 glutamate mutase α subunit (EC 5.4.99.1) from Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) (see paper)
    45% identity, 88% coverage of query (126 bits)

Build an alignment

Build an alignment for BWI76_RS08490 and 6 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

A4YIE3 methylmalonyl-CoA mutase (subunit 1/2) (EC 5.4.99.2) from Metallosphaera sedula (see paper)
    26% identity, 94% coverage of query (49.7 bits)

mgm / Q59268 α-methyleneglutarate mutase subunit (EC 5.4.99.4) from Eubacterium barkeri (see 4 papers)
MGM_EUBBA / Q59268 2-methyleneglutarate mutase; Alpha-methyleneglutarate mutase; EC 5.4.99.4 from Eubacterium barkeri (Clostridium barkeri) (see 7 papers)
    26% identity, 91% coverage of query (48.9 bits)

MTR / Q99707 cobalamin-dependent methionine synthase (EC 2.1.1.13) from Homo sapiens (see 5 papers)
METH_HUMAN / Q99707 Methionine synthase; MS; 5-methyltetrahydrofolate--homocysteine methyltransferase; Cobalamin-dependent methionine synthase; Vitamin-B12 dependent methionine synthase; EC 2.1.1.13 from Homo sapiens (Human) (see 7 papers)
Q99707 methionine synthase (EC 2.1.1.13) from Homo sapiens (see paper)
    27% identity, 71% coverage of query (47.4 bits)

METH_RAT / Q9Z2Q4 Methionine synthase; MS; 5-methyltetrahydrofolate--homocysteine methyltransferase; Cobalamin-dependent methionine synthase; Vitamin-B12 dependent methionine synthase; EC 2.1.1.13 from Rattus norvegicus (Rat) (see 2 papers)
Q9Z2Q4 methionine synthase (EC 2.1.1.13) from Rattus norvegicus (see paper)
    27% identity, 71% coverage of query (46.6 bits)

kamE / Q8RHX8 L-β-lysine-5,6-aminomutase β subunit (EC 5.4.3.3) from Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355) (see paper)
KAME_FUSNN / Q8RHX8 Lysine 5,6-aminomutase beta subunit; 5,6-LAM; D-lysine 5,6-aminomutase beta subunit; L-beta-lysine 5,6-aminomutase beta subunit; EC 5.4.3.3 from Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355) (see paper)
Q8RHX8 lysine 5,6-aminomutase (subunit 1/2) (EC 5.4.3.3) from Fusobacterium nucleatum (see paper)
    28% identity, 89% coverage of query (46.6 bits)

icmB / Q9RJ84 isobutyryl-CoA mutase small subunit (EC 5.4.99.13) from Streptomyces virginiae (see 2 papers)
icmB / CAB59633.1 isobutyryl-CoA mutase, small subunit from Streptomyces cinnamonensis (see 2 papers)
    27% identity, 88% coverage of query (45.8 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory