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Searching for up to 100 curated homologs for BWI76_RS08725 FitnessBrowser__Koxy:BWI76_RS08725 (318 a.a.)

Found high-coverage hits (≥70%) to 64 curated proteins.

Removed hits that are identical to the query, leaving 63

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

HUTGL_PSEAE / Q9HZ59 Formimidoylglutamase; Formiminoglutamase; Formiminoglutamate hydrolase; EC 3.5.3.8 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    47% identity, 96% coverage of query (226 bits)

4mynA / Q4DSA0 Crystal structure of trypanosoma cruzi formiminoglutamase n114h variant with mn2+2 (see paper)
    32% identity, 79% coverage of query (113 bits)

Q4DSA0 formimidoylglutamase (EC 3.5.3.8) from Trypanosoma cruzi (see paper)
    31% identity, 79% coverage of query (110 bits)

Build an alignment

Build an alignment for BWI76_RS08725 and 3 homologs with ≥ 30% identity

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Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

Sama_3201 Formiminoglutamase (EC 3.5.3.8) from Shewanella amazonensis SB2B
    29% identity, 79% coverage of query (75.9 bits)

3pzlB / Q97BB8 The crystal structure of agmatine ureohydrolase of thermoplasma volcanium
    28% identity, 79% coverage of query (73.6 bits)

speB / P70999 agmatinase (EC 3.5.3.11) from Bacillus subtilis (strain 168) (see paper)
    26% identity, 85% coverage of query (66.2 bits)

6dktA Crystal structure of arginase from bacillus subtilis
    26% identity, 84% coverage of query (65.5 bits)

6dktE / P39138 Crystal structure of arginase from bacillus subtilis
    27% identity, 83% coverage of query (65.1 bits)

1wogA / Q9RZ04 Crystal structure of agmatinase reveals structural conservation and inhibition mechanism of the ureohydrolase superfamily (see paper)
    26% identity, 89% coverage of query (64.3 bits)

HUTG_BACSU / P42068 Formimidoylglutamase; Formiminoglutamase; Formiminoglutamate hydrolase; N-formimino-L-glutamate formiminohydrolase; EC 3.5.3.8 from Bacillus subtilis (strain 168) (see paper)
    23% identity, 79% coverage of query (64.3 bits)

3m1rD / P42068 The crystal structure of formimidoylglutamase from bacillus subtilis subsp. Subtilis str. 168
    23% identity, 79% coverage of query (64.3 bits)

6nfpD 1.7 angstrom resolution crystal structure of arginase from bacillus subtilis subsp. Subtilis str. 168
    26% identity, 84% coverage of query (64.3 bits)

2ef5A / Q5SI78 Crystal structure of the arginase from thermus thermophilus
    29% identity, 84% coverage of query (63.5 bits)

gbh / Q8KZT5 guanidinobutyrase subunit (EC 3.5.3.7) from Arthrobacter sp. (strain KUJ 8602) (see paper)
Q8KZT5 D-arginase (EC 3.5.3.10); guanidinobutyrase (EC 3.5.3.7) from Arthrobacter sp. (see paper)
    26% identity, 89% coverage of query (62.0 bits)

ARGI_KLULA / Q6CLS8 Arginase; EC 3.5.3.1 from Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) (see paper)
    24% identity, 77% coverage of query (61.6 bits)

6nfpA / P39138 1.7 angstrom resolution crystal structure of arginase from bacillus subtilis subsp. Subtilis str. 168
    25% identity, 84% coverage of query (61.6 bits)

argI / P39138 arginase (EC 3.5.3.1) from Bacillus subtilis (strain 168) (see 3 papers)
ARGI_BACSU / P39138 Arginase; EC 3.5.3.1 from Bacillus subtilis (strain 168) (see 2 papers)
P39138 arginase (EC 3.5.3.1) from Bacillus subtilis (see paper)
    25% identity, 84% coverage of query (60.8 bits)

5cevA Arginase from bacillus caldevelox, l-lysine complex
    26% identity, 83% coverage of query (59.7 bits)

4cevA Arginase from bacillus caldevelox, l-ornithine complex
    26% identity, 83% coverage of query (59.7 bits)

3cevA Arginase from bacillus caldevelox, complexed with l-arginine
    26% identity, 83% coverage of query (59.7 bits)

2cevB Arginase from bacillus caldevelox, native structure at ph 8.5
    26% identity, 83% coverage of query (59.7 bits)

ARGI_BACCD / P53608 Arginase; EC 3.5.3.1 from Bacillus caldovelox (see paper)
P53608 arginase (EC 3.5.3.1) from [Bacillus] caldovelox (see paper)
1cevA / P53608 Arginase from bacillus caldovelox, native structure at ph 5.6 (see paper)
    26% identity, 83% coverage of query (59.3 bits)

gdmH / P73270 Ni2+-dependent guanidine hydrolase monomer from Synechocystis sp. (strain PCC 6803 / Kazusa) (see 2 papers)
    22% identity, 89% coverage of query (57.0 bits)

6ss2AAA / P78540 of arginase-2 in complex with the inhibitory human antigen-binding fragment fab c0021158' (see paper)
    25% identity, 84% coverage of query (57.0 bits)

6q39A Complex of arginase 2 with example 49
    25% identity, 84% coverage of query (57.0 bits)

6q37A Complex of arginase 2 with example 23
    25% identity, 84% coverage of query (57.0 bits)

4ixvA Crystal structure of human arginase-2 complexed with inhibitor 2d: {(5r)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4- yl]pentyl}(trihydroxy)borate(1-)
    25% identity, 84% coverage of query (57.0 bits)

4ixuA Crystal structure of human arginase-2 complexed with inhibitor 11d: {(5r)-5-amino-5-carboxy-5-[(3-endo)-8-(3,4-dichlorobenzyl)-8- azabicyclo[3.2.1]oct-3-yl]pentyl}(trihydroxy)borate(1-)
    25% identity, 84% coverage of query (57.0 bits)

4ie3A Crystal structure of human arginase-2 complexed with inhbitor 1o
    25% identity, 84% coverage of query (57.0 bits)

4ie2A Crystal structure of human arginase-2 complexed with inhibitor 1h
    25% identity, 84% coverage of query (57.0 bits)

4i06A Crystal structure of human arginase-2 complexed with inhibitor 14
    25% identity, 84% coverage of query (57.0 bits)

4hzeA Crystal structure of human arginase-2 complexed with inhibitor 9
    25% identity, 84% coverage of query (57.0 bits)

1pq3A Human arginase ii: crystal structure and physiological role in male and female sexual arousal
    25% identity, 84% coverage of query (57.0 bits)

ARG2 / P78540 Arginase-2, mitochondrial (EC 3.5.3.1) from Homo sapiens (see 8 papers)
ARGI2_HUMAN / P78540 Arginase-2, mitochondrial; Arginase II; Kidney-type arginase; Non-hepatic arginase; Type II arginase; EC 3.5.3.1 from Homo sapiens (Human) (see 7 papers)
P78540 arginase (EC 3.5.3.1) from Homo sapiens (see 5 papers)
    25% identity, 84% coverage of query (57.0 bits)

SPEB_METJA / Q57757 Agmatinase; EC 3.5.3.11 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Q57757 agmatinase (EC 3.5.3.11) from Methanocaldococcus jannaschii (see paper)
    25% identity, 78% coverage of query (56.6 bits)

W5PHZ9 agmatinase (EC 3.5.3.11) from Ovis aries (see 2 papers)
    24% identity, 86% coverage of query (56.6 bits)

7esrA / P73270 Crystal structure of synechocystis sp pcc6803 guanidinium hydrolase (r32) (see paper)
    22% identity, 89% coverage of query (56.6 bits)

ARGI2_MOUSE / O08691 Arginase-2, mitochondrial; Arginase II; Kidney-type arginase; Non-hepatic arginase; Type II arginase; EC 3.5.3.1 from Mus musculus (Mouse) (see 6 papers)
    24% identity, 80% coverage of query (54.7 bits)

SPEBH_THET2 / Q72JK8 N(1)-aminopropylagmatine ureohydrolase; Protein SpeB homolog; EC 3.5.3.24 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see 2 papers)
    24% identity, 78% coverage of query (52.4 bits)

SPEB_PROMI / Q7X3P1 Agmatinase; Agmatine ureohydrolase; AUH; EC 3.5.3.11 from Proteus mirabilis (see paper)
    23% identity, 88% coverage of query (51.6 bits)

TTHA1129 / Q5SJ85 aminopropylagmatine ureohydrolase (EC 3.5.3.24) from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
SEPBH_THET8 / Q5SJ85 N(1)-aminopropylagmatine ureohydrolase; Protein SpeB homolog; EC 3.5.3.24 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
Q5SJ85 N1-aminopropylagmatine ureohydrolase (EC 3.5.3.24) from Thermus thermophilus (see paper)
    24% identity, 78% coverage of query (51.6 bits)

gbuA / A0A0A1DPD5 5-guanidino-2-oxopentanoate ureohydrolase (EC 3.5.3.7) from Nocardioides simplex (see paper)
    24% identity, 85% coverage of query (51.6 bits)

4dz4B / Q2T3W4 X-ray crystal structure of a hypothetical agmatinase from burkholderia thailandensis (see paper)
    27% identity, 81% coverage of query (51.2 bits)

6nbkA / W8YSI5 Crystal structure of arginase from bacillus cereus
    24% identity, 83% coverage of query (50.4 bits)

N515DRAFT_0348 Arginase (EC 3.5.3.1) from Dyella japonica UNC79MFTsu3.2
    24% identity, 83% coverage of query (50.4 bits)

Q6WVP6 arginase (EC 3.5.3.1) from Schistosoma mansoni (see paper)
    23% identity, 81% coverage of query (50.4 bits)

1gq6B / P0DJQ3 Proclavaminate amidino hydrolase from streptomyces clavuligerus (see paper)
    25% identity, 82% coverage of query (50.4 bits)

pah / P0DJQ3 proclavaminate amidino hydrolase subunit (EC 3.5.3.22) from Streptomyces clavuligerus (see paper)
PAH_STRCL / P0DJQ3 Proclavaminate amidinohydrolase; Proclavaminic acid amidino hydrolase; EC 3.5.3.22 from Streptomyces clavuligerus (see paper)
    25% identity, 82% coverage of query (50.1 bits)

GDAH_MOUSE / A2AS89 Guanidino acid hydrolase, mitochondrial; Arginase, mitochondrial; Guanidinobutyrase, mitochondrial; Guanidinopropionase, mitochondrial; EC 3.5.3.-; EC 3.5.3.1; EC 3.5.3.7; EC 3.5.3.17 from Mus musculus (Mouse) (see paper)
    25% identity, 87% coverage of query (49.7 bits)

4q3vC / Q6WVP6 Crystal structure of schistosoma mansoni arginase in complex with inhibitor bec (see paper)
    24% identity, 81% coverage of query (45.4 bits)

4q41A Crystal structure of schistosoma mansoni arginase in complex with l- lysine
    25% identity, 75% coverage of query (45.4 bits)

4q3uA Crystal structure of schistosoma mansoni arginase in complex with inhibitor nor-noha
    24% identity, 81% coverage of query (45.4 bits)

4q3tA Crystal structure of schistosoma mansoni arginase in complex with inhibitor noha
    24% identity, 81% coverage of query (45.4 bits)

gbuA / Q9I3S3 guanidinobutyrase subunit (EC 3.5.3.7) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
GBUA_PSEAE / Q9I3S3 Guanidinobutyrase; EC 3.5.3.7 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
Q9I3S3 guanidinobutyrase (EC 3.5.3.7) from Pseudomonas aeruginosa (see paper)
    22% identity, 86% coverage of query (45.1 bits)

3nioA / Q9I3S3 Crystal structure of pseudomonas aeruginosa guanidinobutyrase (see paper)
    22% identity, 86% coverage of query (45.1 bits)

4q40A Crystal structure of schistosoma mansoni arginase in complex with l- valine
    25% identity, 75% coverage of query (44.7 bits)

4q3sA Crystal structure of schistosoma mansoni arginase in complex with inhibitor abhpe
    25% identity, 75% coverage of query (44.7 bits)

4q3qA Crystal structure of schistosoma mansoni arginase in complex with inhibitor abh
    25% identity, 75% coverage of query (44.7 bits)

4q42A Crystal structure of schistosoma mansoni arginase in complex with l- ornithine
    25% identity, 75% coverage of query (44.7 bits)

4q3rA Crystal structure of schistosoma mansoni arginase in complex with inhibitor abhdp
    25% identity, 75% coverage of query (44.7 bits)

SpeB / b2937 agmatinase (EC 3.5.3.11) from Escherichia coli K-12 substr. MG1655 (see 2 papers)
speB / P60651 agmatinase (EC 3.5.3.11) from Escherichia coli (strain K12) (see 35 papers)
SPEB_ECOLI / P60651 Agmatinase; Agmatine ureohydrolase; AUH; EC 3.5.3.11 from Escherichia coli (strain K12) (see 2 papers)
speB / RF|NP_417412 agmatinase; EC 3.5.3.11 from Escherichia coli K12 (see 7 papers)
    23% identity, 88% coverage of query (44.3 bits)

7lolA The structure of agmatinase from e. Coli at 1.8 a displaying urea and agmatine
    24% identity, 82% coverage of query (44.3 bits)

7lbaB / P60651 E. Coli agmatinase (see paper)
    23% identity, 88% coverage of query (43.9 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory