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Searching for up to 100 curated homologs for BWI76_RS09585 FitnessBrowser__Koxy:BWI76_RS09585 (231 a.a.)

Found high-coverage hits (≥70%) to 95 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

BniP / b0875 water channel AqpZ from Escherichia coli K-12 substr. MG1655 (see 28 papers)
aqpZ / P60844 water channel AqpZ from Escherichia coli (strain K12) (see 40 papers)
AQPZ_ECOLI / P60844 Aquaporin Z; Bacterial nodulin-like intrinsic protein; Water channel AqpZ from Escherichia coli (strain K12) (see 5 papers)
TC 1.A.8.3.1 / P60844 Aquaporin Z water channel (aqpZ gene expression is under sigma S control; induced at the onset of stationary phase) from Escherichia coli (see 13 papers)
    89% identity, 100% coverage of query (394 bits)

2o9eA / P60844 Crystal structure of aqpz mutant t183c complexed with mercury (see paper)
    88% identity, 100% coverage of query (385 bits)

3nkaA Crystal structure of aqpz h174g,t183f
    89% identity, 99% coverage of query (381 bits)

TC 1.A.8.12.1 / P08995 Nodulin-26 aquaporin and glycerol facilitator, NIP (de Paula Santos Martins et al. 2015). Transports NH3 5-fold better than water in Hg2+-sensitive fashion from Glycine max (Soybean) (see 3 papers)
    39% identity, 96% coverage of query (134 bits)

TC 1.A.8.8.13 / Q9V5Z7 The Drosophila melanogaster from Drosophila melanogaster (see 2 papers)
    37% identity, 100% coverage of query (134 bits)

CAA68906.1 NLM1 protein (NodLikeMip1) from Arabidopsis thaliana (see paper)
    38% identity, 97% coverage of query (134 bits)

NIP1-1 / Q8VZW1 aquaglyceroporin NIP1-1 from Arabidopsis thaliana (see 10 papers)
NIP11_ARATH / Q8VZW1 Aquaporin NIP1-1; NOD26-like intrinsic protein 1-1; AtNIP1;1; Nodulin-26-like major intrinsic protein 1; NodLikeMip1; Protein NLM1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 1.A.8.12.8 / Q8VZW1 Aquaporin NIP1-1 (NOD26-like intrinsic protein 1-1) (AtNIP1;1) (Nodulin-26-like major intrinsic protein 1) (NodLikeMip1) (Protein NLM1) from Arabidopsis thaliana (see 5 papers)
    38% identity, 97% coverage of query (134 bits)

P08995 Nodulin-26; N-26 from Glycine max (Soybean) (Glycine hispida)
    39% identity, 96% coverage of query (134 bits)

NIP12_ARATH / Q8LFP7 Aquaporin NIP1-2; NOD26-like intrinsic protein 1-2; AtNIP1;2; Nodulin-26-like major intrinsic protein 2; NodLikeMip2; Protein NLM2 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 1.A.8.12.7 / Q8LFP7 Aquaporin NIP1-2 (NOD26-like intrinsic protein 1-2) (AtNIP1;2) (Nodulin-26-like major intrinsic protein 2) (NodLikeMip2) (Protein NLM2) from Arabidopsis thaliana (see 5 papers)
nlm2 / CAC14597.1 aquaglyceroporin from Arabidopsis thaliana (see paper)
    38% identity, 97% coverage of query (132 bits)

AQP5_MOUSE / Q9WTY4 Aquaporin-5; AQP-5 from Mus musculus (Mouse) (see 7 papers)
    38% identity, 98% coverage of query (127 bits)

GLPF6_LACPL / F9UUD2 Glycerol uptake facilitator protein-like 6 from Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) (Lactobacillus plantarum) (see paper)
    40% identity, 97% coverage of query (125 bits)

AQP5_MILTA / G5CTG2 Aquaporin-5; AQP-5 from Milnesium tardigradum (Water bear) (Tardigrade) (see paper)
    37% identity, 96% coverage of query (125 bits)

NIP11_ORYSJ / Q40746 Aquaporin NIP1-1; NOD26-like intrinsic protein 1-1; OsNIP1;1 from Oryza sativa subsp. japonica (Rice) (see 2 papers)
YK347 / BAA04257.1 major intrinsic protein from Oryza sativa (see paper)
    38% identity, 91% coverage of query (124 bits)

TC 1.A.8.8.14 / Q06019 Lens fiber major intrinsic protein (MIP26) (MP26) from Rana pipiens (see paper)
    38% identity, 99% coverage of query (121 bits)

PregAQP1 / BAM26200.1 aquaporin from Phormia regina (see paper)
    35% identity, 100% coverage of query (119 bits)

TC 1.A.8.8.6 / A5A7N9 Aqp1 water channel of the sleeping chironomid (functions in water removal during anhydrobiosis, from Polypedilum vanderplanki (sleeping chironomid) (see paper)
    37% identity, 97% coverage of query (119 bits)

MIP_SHEEP / Q6J8I9 Lens fiber major intrinsic protein; Aquaporin-0 from Ovis aries (Sheep) (see 5 papers)
    38% identity, 99% coverage of query (118 bits)

AQP1_HUMAN / P29972 Aquaporin-1; AQP-1; Aquaporin-CHIP; Urine water channel; Water channel protein for red blood cells and kidney proximal tubule from Homo sapiens (Human) (see 5 papers)
TC 1.A.8.8.1 / P29972 Aquaporin 1 (CO2-, O2- and nitrous oxide-permeable and water-selective) (Zwiazek et al. 2017). Aquaporin-1 tunes pain perception by interacting with Na(v)1.8 Na+ channels in dorsal root ganglion neurons (Zhang and Verkman, 2010). It is upregulated in skeletal muscle in muscular dystrophy (Au et al. 2008). AQP1 has been reported to first insert as a four-helical intermediate, where helices 2 and 4 are not inserted into the membrane. In a second step this intermediate is folded into a six-helical topology. During this process, the orientation of the third helix is inverted, and it can shift out the membrane core from Homo sapiens (Human) (see 19 papers)
    38% identity, 100% coverage of query (118 bits)

P09011 Lens fiber major intrinsic protein; Aquaporin-0; MIP26; MP26 from Rattus norvegicus (Rat)
    40% identity, 99% coverage of query (118 bits)

MIP_BOVIN / P06624 Lens fiber major intrinsic protein; Aquaporin-0; MIP26; MP26 from Bos taurus (Bovine) (see 5 papers)
TC 1.A.8.8.2 / P06624 The lens fiber MIP aquaporin (Aqp0) of B. taurus (forms membrane junctions in vivo and double layered crystals in vitro that resemble the in vivo junctions). The water pore is closed in the in vitro structure (Gonen et al., 2004b). It interacts directly with the intracellular loop of connexin 45.6 via its C-terminal extension (Yu et al., 2005). Forms human cataract lens membranes from Bos taurus (Bovine) (see 4 papers)
    38% identity, 99% coverage of query (117 bits)

8ct2D / P29972 Local refinement of aqp1 tetramer (c1; refinement mask included d1 of protein 4.2 and ankyrin-1 ar1-5) in class 2 of erythrocyte ankyrin-1 complex (see paper)
    38% identity, 100% coverage of query (117 bits)

AQP1_MOUSE / Q02013 Aquaporin-1; AQP-1; Aquaporin-CHIP; Delayed early response protein 2; DER2; Water channel protein for red blood cells and kidney proximal tubule from Mus musculus (Mouse) (see 3 papers)
    38% identity, 100% coverage of query (117 bits)

AQP5_RAT / P47864 Aquaporin-5; AQP-5 from Rattus norvegicus (Rat) (see paper)
    36% identity, 98% coverage of query (117 bits)

8sjxA / Q6J8I9 Structure of lens aquaporin-0 array in sphingomyelin/cholesterol bilayer (2sm:1chol)
    38% identity, 97% coverage of query (116 bits)

AQP1_CANLF / Q9N2J4 Aquaporin-1; AQP-1; Aquaporin-CHIP; Water channel protein for red blood cells and kidney proximal tubule from Canis lupus familiaris (Dog) (Canis familiaris) (see paper)
    38% identity, 100% coverage of query (116 bits)

AQP5_HUMAN / P55064 Aquaporin-5; AQP-5 from Homo sapiens (Human) (see 6 papers)
TC 1.A.8.8.9 / P55064 Aquaporin 5 (x-ray structure at 2.0 Å resolution (PDB# 3D9S) is available) (Horsefield et al., 2008). Aqp5 is a marker for proliferation and migration of human breast cancer cells (Jung et al., 2011). Plays a role in chronic obstructive pulmonary diseases (COPD) from Homo sapiens (see 2 papers)
    38% identity, 97% coverage of query (115 bits)

MIP_HUMAN / P30301 Lens fiber major intrinsic protein; Aquaporin-0; MIP26; MP26 from Homo sapiens (Human) (see 14 papers)
    38% identity, 99% coverage of query (115 bits)

5dyeD / P55064 Crystal structure of the full length s156e mutant of human aquaporin 5 (see paper)
    38% identity, 97% coverage of query (114 bits)

TC 1.A.8.8.12 / E4W5Y5 Aquaporin, Aqp1 in the gall fly. Transports water but not glycerol or urea. Promotes freeze-tolerance from Eurosta solidaginis (see paper)
    36% identity, 99% coverage of query (113 bits)

AQP2_MOUSE / P56402 Aquaporin-2; AQP-2; ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct from Mus musculus (Mouse) (see 5 papers)
    34% identity, 97% coverage of query (112 bits)

TC 1.A.8.8.15 / B5L019 Mercury-sensitive whitefly aquaporin-1 of the specialized filter chamber of the alimentary tract from Bemisia tabaci
    35% identity, 100% coverage of query (111 bits)

TC 1.A.8.8.18 / B6ZHB9 Aqp-x2 water channel in the luminal epithelium of urinary bladder cells and lungs from Xenopus laevis
    34% identity, 97% coverage of query (110 bits)

4nefA / P41181 X-ray structure of human aquaporin 2 (see paper)
    34% identity, 97% coverage of query (110 bits)

AQP2_HUMAN / P41181 Aquaporin-2; AQP-2; ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct from Homo sapiens (Human) (see 23 papers)
TC 1.A.8.8.8 / P41181 Vasopressin-sensitive aquaporin-2 (Aqp2) in the apical membrane of the renal collecting duct from Homo sapiens (Human) (see 22 papers)
    34% identity, 97% coverage of query (109 bits)

AQP2_RAT / P34080 Aquaporin-2; AQP-2; ADH water channel; Aquaporin-CD; AQP-CD; Collecting duct water channel protein; WCH-CD; Water channel protein for renal collecting duct from Rattus norvegicus (Rat) (see 3 papers)
    34% identity, 97% coverage of query (109 bits)

PIP27_ORYSJ / Q651D5 Probable aquaporin PIP2-7; OsPIP2;7; Plasma membrane intrinsic protein 2-7 from Oryza sativa subsp. japonica (Rice) (see paper)
    33% identity, 99% coverage of query (109 bits)

NIP12_ORYSJ / Q0JPT5 Aquaporin NIP1-2; NOD26-like intrinsic protein 1-2; OsNIP1;2 from Oryza sativa subsp. japonica (Rice) (see paper)
    35% identity, 95% coverage of query (108 bits)

NIP21_ARATH / Q8W037 Aquaporin NIP2-1; NOD26-like intrinsic protein 2-1; AtNIP2;1; Nodulin-26-like major intrinsic protein 4; NodLikeMip4; Protein NLM4 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
TC 1.A.8.12.4 / Q8W037 The root-expressed MIP transporter of lactic acid, NIP2;1 (Nod26-like MIP-4; NLM4) (induced by water logging and anoxic stress; shows minimal water and glycerol transport). It may play a role in adaptation to lactic fermentaion under anaerobic stress (Choi and Roberts, 2007). Lactic acid transport is induced by anoxic stress from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
NIP2-1 / RF|NP_180986.1 aquaporin NIP2-1 from Arabidopsis thaliana
    32% identity, 97% coverage of query (108 bits)

TC 1.A.8.8.16 / Q32ZE5 Aquaporin-1 or Aquaporin1, Aqp1, of 258 aas and 6 TMSs. Three Aqp1 isoforms are differentially from Sparus aurata
    33% identity, 99% coverage of query (107 bits)

NIP1 / CAD67694.1 Nod26-like protein from Cucurbita pepo (see paper)
    36% identity, 96% coverage of query (106 bits)

AQP4_MOUSE / P55088 Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4 from Mus musculus (Mouse) (see 11 papers)
    33% identity, 97% coverage of query (106 bits)

TC 1.A.8.8.11 / F2YNF6 Water channel, Aqp1; inhibited by HgCl2 from Anopheles gambiae (see paper)
    34% identity, 99% coverage of query (104 bits)

TC 1.A.8.13.2 / Q9C4Z5 Hg2+-inhibitable aquaporin, AqpM (transports both water and glycerol as well as CO2) (Kozono et al., 2003; Araya-Secchi et al., 2011). Its 3-d structure has been determined to 1.7 Å. In AqpM, isoleucine replaces a key histidine residue found in the lumen of water channels, which becomes a glycine residue in aquaglyceroporins. As a result of this and other side-chain substituents in the walls of the channel, the channel is intermediate in size and exhibits differentially tuned electrostatics when compared with the other subfamilies from Methanobacterium thermoautotrophicum (strain Marburg / DSM 2133) (see 2 papers)
    36% identity, 95% coverage of query (103 bits)

AQP4_BOVIN / O77750 Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4 from Bos taurus (Bovine) (see paper)
    35% identity, 84% coverage of query (103 bits)

2evuA / Q9C4Z5 Crystal structure of aquaporin aqpm at 2.3a resolution (see paper)
    36% identity, 95% coverage of query (103 bits)

AQP4_RAT / P47863 Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4 from Rattus norvegicus (Rat) (see 7 papers)
    35% identity, 81% coverage of query (103 bits)

TC 1.A.8.8.10 / G8YY04 Water and urea transporting aquaporin (cockroach) from Blattella germanica (see paper)
    31% identity, 98% coverage of query (103 bits)

PIP25_ORYSJ / Q8GRI8 Aquaporin PIP2-5; OsPIP2;5; Plasma membrane intrinsic protein 2-5 from Oryza sativa subsp. japonica (Rice) (see paper)
    33% identity, 85% coverage of query (101 bits)

MIP_CAVPO / Q6RZ07 Lens fiber major intrinsic protein; Aquaporin-0 from Cavia porcellus (Guinea pig) (see paper)
    38% identity, 99% coverage of query (101 bits)

TC 1.A.8.8.19 / A7BIX4 Contractile vacuole aquaporin of 295 aas and 6 TMSs, Aqp from Amoeba proteus
    32% identity, 97% coverage of query (101 bits)

AQP4_DIPME / Q923J4 Aquaporin-4; AQP-4 from Dipodomys merriami (Merriam's kangaroo rat) (see paper)
    35% identity, 81% coverage of query (100 bits)

PIP27_ARATH / P93004 Aquaporin PIP2-7; Plasma membrane intrinsic protein 2-7; AtPIP2;7; Plasma membrane intrinsic protein 3; At-PIP3; Salt stress-induced major intrinsic protein from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
    31% identity, 98% coverage of query (100 bits)

AQP1_SHEEP / P56401 Aquaporin-1; AQP-1; Aquaporin-CHIP; Water channel protein for red blood cells and kidney proximal tubule from Ovis aries (Sheep) (see paper)
    38% identity, 84% coverage of query (100 bits)

PIP24_ORYSJ / Q8GRT8 Aquaporin PIP2-4; OsPIP2;4; Plasma membrane intrinsic protein 2-4 from Oryza sativa subsp. japonica (Rice) (see paper)
    33% identity, 85% coverage of query (100 bits)

AQP4_HUMAN / P55087 Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; WCH4 from Homo sapiens (Human) (see 6 papers)
TC 1.A.8.8.5 / P55087 Aquaporin-4 (AQP4) is the major water channel in the central nervous system and plays an important role in the brain's water balance, including edema formation and clearance. There are 6 splice variants; the shorter ones assemble into functional, tetrameric square arrays; the longer is palmitoylated on N-terminal cysteyl residues) (Suzuki et al., 2008). The longest, Aqp4e, has a novel N-terminal domain and forms a water channel in the plasma membrane although various shorter variants don't (Moe et al., 2008). AQP4, like AQP0 (1.A.8.8.2), forms water channels but also forms adhesive junctions (Engel et al., 2008) (causes cytotoxic brain swelling in mice (Yang et al., 2008)) Mice lacking Aqp4 have impaired olfactions (Lu et al., 2008). Aqp4 is down regulated in skeletal muscle in muscular dystrophy (Au et al. 2008). The crystal structure is known to 2.8 Å resolution (Tani et al., 2009). The structure reveals 8 water molecules in each of the four channels, supporting a hydrogen-bond isolation mechanism and explains its fast and selective water conduction and proton exclusion (Tani et al., 2009; Cui and Bastien, 2011). It is an important antigen in Neuromyelitis optica (NMO) patients from Homo sapiens (Human) (see 4 papers)
    35% identity, 81% coverage of query (100 bits)

PIP24_MAIZE / Q9ATM6 Aquaporin PIP2-4; Plasma membrane intrinsic protein 2-4; ZmPIP2-4; ZmPIP2;4 from Zea mays (Maize) (see 2 papers)
    34% identity, 85% coverage of query (100 bits)

PIP26_ORYSJ / Q7XLR1 Probable aquaporin PIP2-6; OsPIP2;6; Plasma membrane intrinsic protein 2-6 from Oryza sativa subsp. japonica (Rice) (see paper)
    31% identity, 98% coverage of query (100 bits)

PIP22_ORYSJ / Q6K215 Probable aquaporin PIP2-2; OsPIP2;2; Plasma membrane intrinsic protein 2-2 from Oryza sativa subsp. japonica (Rice) (see paper)
    34% identity, 85% coverage of query (99.4 bits)

pip2.5 / CAH60724.1 putative plasma membrane intrinsic protein from Populus tremula x Populus tremuloides (see paper)
    34% identity, 85% coverage of query (99.4 bits)

TC 1.A.8.13.1 / O28846 MIP family homologue from Archaeoglobus fulgidus (see paper)
    34% identity, 98% coverage of query (98.6 bits)

TC 1.A.8.11.1 / P25794 Tonoplast intrinsic protein (ωTIP) from Pisum sativum (Garden pea) (see 2 papers)
    33% identity, 84% coverage of query (98.6 bits)

PIP15_ARATH / Q8LAA6 Probable aquaporin PIP1-5; AtPIP1;5; Plasma membrane intrinsic protein 1d; PIP1d from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    31% identity, 98% coverage of query (97.8 bits)

PIP12_MUSAM / A0A804KTT0 Aquaporin PIP1-2; Plasma membrane intrinsic protein 1-2; MusaPIP1-2; MusaPIP1;2 from Musa acuminata subsp. malaccensis (Wild banana) (Musa malaccensis) (see paper)
    33% identity, 84% coverage of query (97.8 bits)

TC 1.A.8.11.2 / O24662 The plasma membrane aquaporin, NtAQP1 (H2O and CO2 permeable; important for photosynthesis, stomatal opening and leaf growth) from Nicotiana tabacum (Common tobacco) (see paper)
    34% identity, 84% coverage of query (97.4 bits)

PIP25_MAIZE / Q9XF58 Aquaporin PIP2-5; Plasma membrane intrinsic protein 2-5; ZmPIP2-5; ZmPIP2;5; ZmPIP2a from Zea mays (Maize) (see 4 papers)
TC 1.A.8.11.7 / Q9XF58 Aquaporin PIP2;5 (PIP2-5) of 285 aas from Zea mays
    34% identity, 85% coverage of query (97.4 bits)

PIP23_ORYSJ / Q7XUA6 Probable aquaporin PIP2-3; OsPIP2;3; Plasma membrane intrinsic protein 2-3 from Oryza sativa subsp. japonica (Rice) (see paper)
    34% identity, 85% coverage of query (97.4 bits)

PIP21_ORYSJ / Q8H5N9 Probable aquaporin PIP2-1; OsPIP2;1; Plasma membrane intrinsic protein 2-1; Plasma membrane intrinsic protein 2a; PIP2a from Oryza sativa subsp. japonica (Rice) (see 2 papers)
    33% identity, 85% coverage of query (97.4 bits)

PIP13_ARATH / Q08733 Aquaporin PIP1-3; AtPIP1;3; Plasma membrane intrinsic protein 1c; PIP1c; Transmembrane protein B; TMP-B from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    30% identity, 98% coverage of query (97.1 bits)

PIP21_ARATH / P43286 Aquaporin PIP2-1; Plasma membrane intrinsic protein 2-1; AtPIP2;1; Plasma membrane intrinsic protein 2a; PIP2a from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
TC 1.A.8.11.4 / P43286 Plasma membrane intrinsic protein 2a (forms active heterotetramers with PIP1;1 (TC# 1.A.8.11.3); down regulated under drought stress (Najafabadi et al., 2008). Transports H2O2 (Dynowski et al., 2008). The Mesembryanthemum crystallinum PIP2;1 orthologue is an aquaporin impermeable to urea and glycerol. It is positively regulated by PKA- and PKC- mediated phosphorylation (Amezcua-Romero et al., 2010). PIP1;1 and PIP2;2 (Q9ATM8) co-expression modulates the membrane water permeability in the halophyte Beta vulgaris storage root through a pH regulatory response, enhancing membrane versatility to adjust its water transfer capacity from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
    33% identity, 85% coverage of query (95.9 bits)

PIP23_ARATH / P30302 Aquaporin PIP2-3; Plasma membrane intrinsic protein 2-3; AtPIP2;3; Plasma membrane intrinsic protein 2c; PIP2c; RD28-PIP; TMP2C; Water stress-induced tonoplast intrinsic protein; WSI-TIP from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    32% identity, 85% coverage of query (94.4 bits)

PIP12_ARATH / Q06611 Aquaporin PIP1-2; AtPIP1;2; Plasma membrane intrinsic protein 1b; PIP1b; Transmembrane protein A; AthH2; TMP-A from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    34% identity, 82% coverage of query (94.0 bits)

PIP14_ARATH / Q39196 Probable aquaporin PIP1-4; Plasma membrane intrinsic protein 1-4; AtPIP1;4; Transmembrane protein C; TMP-C from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    32% identity, 84% coverage of query (94.0 bits)

PIP22_ARATH / P43287 Aquaporin PIP2-2; Plasma membrane intrinsic protein 2-2; AtPIP2;2; Plasma membrane intrinsic protein 2b; PIP2b; TMP2b from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    32% identity, 85% coverage of query (92.8 bits)

PIP11_ARATH / P61837 Aquaporin PIP1-1; AtPIP1;1; Plasma membrane aquaporin-1; Plasma membrane intrinsic protein 1a; PIP1a from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 1.A.8.11.3 / P61837 Plasma membrane aquaporin 1, PIP1, of 286 aas and 6 TMSs from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
PIP1-1 / RF|NP_191702.1 aquaporin PIP1-1 from Arabidopsis thaliana (see paper)
    33% identity, 84% coverage of query (92.8 bits)

NIP61_ARATH / Q9SAI4 Aquaporin NIP6-1; NOD26-like intrinsic protein 6-1; AtNIP6;1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 1.A.8.12.9 / Q9SAI4 Aquaporin NIP6-1 (NOD26-like intrinsic protein 6-1) (AtNIP6;1) from Arabidopsis thaliana (see 3 papers)
    33% identity, 97% coverage of query (92.0 bits)

BIB_DROME / P23645 Neurogenic protein big brain from Drosophila melanogaster (Fruit fly) (see 6 papers)
TC 1.A.8.8.3 / P23645 The BIB aquaporin of D. melanogaster (transports ions by a channel mechanism involving E71 in TMS1) (Yool, 2007) from Drosophila melanogaster (Fruit fly) (see 9 papers)
bib / RF|NP_476837.1 neurogenic protein big brain from Drosophila melanogaster (see paper)
    31% identity, 100% coverage of query (87.0 bits)

NIP2-1 / Q6Z2T3 aquaporin NIP2-1 from Oryza sativa subsp. japonica (see 7 papers)
NIP21_ORYSJ / Q6Z2T3 Aquaporin NIP2-1; Low silicon protein 1; NOD26-like intrinsic protein 2-1; OsNIP2;1; Silicon influx transporter LSI1 from Oryza sativa subsp. japonica (Rice) (see 6 papers)
TC 1.A.8.12.2 / Q6Z2T3 The silicon (silicic acid) (undissociated form) transporter, Lsi1 (Ma et al., 2007a, b; Mitani et al., 2008). The barley orthologue Lsi1 (also called NIP2-1) is also a silicon (silicic acid) uptake channel (Chiba et al., 2009). Rice Lsi1 also transports arsenite and pentavalent mono and dimethyl arsenite (Li et al., 2009). In addition to silicon (Si), selenite (Se) uptake is mediated by Lsi1, also called NIP2;1 from Oryza sativa (Rice) (see 6 papers)
NIP2-1 / GI|90855460 aquaporin NIP2-1 from Oryza sativa (japonica cultivar-group) (see paper)
    32% identity, 97% coverage of query (84.0 bits)

TIP21_ARATH / Q41951 Aquaporin TIP2-1; Delta-tonoplast intrinsic protein; Delta-TIP; Tonoplast intrinsic protein 2-1; AtTIP2;1 from Arabidopsis thaliana (Mouse-ear cress) (see 7 papers)
TC 1.A.8.10.10 / Q41951 Aquaporin TIP2-1 (Delta-tonoplast intrinsic protein) (Delta-TIP) (Tonoplast intrinsic protein 2-1) (AtTIP2;1) (Daniels et al. 1996). Transports water and ammonia, and can be activated by mercury (Kirscht et al. 2016). The 3-d structure is known to 1.2Å resolution (Kirscht et al. 2016). It may participate in vacuolar compartmentation and detoxification of ammonium from Arabidopsis thaliana (see 10 papers)
AAC49281.1 delta tonoplast integral protein from Arabidopsis thaliana (see paper)
    33% identity, 100% coverage of query (81.3 bits)

PIP11_MAIZE / Q41870 Aquaporin PIP1-1; Plasma membrane intrinsic protein 1-1; ZmPIP1-1; ZmPIP1;1; ZmPIP1a from Zea mays (Maize) (see 3 papers)
    31% identity, 84% coverage of query (81.3 bits)

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Additional hits (identity < 30%)

PDUF_SALTY / P37451 Propanediol uptake facilitator PduF from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 3 papers)
    29% identity, 100% coverage of query (76.6 bits)

PDUF_CITFR / B1VB61 Propanediol uptake facilitator PduF from Citrobacter freundii (see paper)
    29% identity, 100% coverage of query (75.9 bits)

TIP11_ARATH / P25818 Aquaporin TIP1-1; Aquaporin TIP; Gamma-tonoplast intrinsic protein; Gamma-TIP; Tonoplast intrinsic protein 1-1; AtTIP1;1; Tonoplast intrinsic protein, root-specific RB7 from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
TC 1.A.8.10.3 / P25818 Tonoplast intrinsic protein 1.1 (permeable to water and H2O2) from Arabidopsis thaliana (Mouse-ear cress) (see 14 papers)
TIP1-1 / RF|NP_181221.1 aquaporin TIP1-1 from Arabidopsis thaliana
    35% identity, 96% coverage of query (75.5 bits)

AQP8_HUMAN / O94778 Aquaporin-8; AQP-8 from Homo sapiens (Human) (see 10 papers)
TC 1.A.8.10.15 / O94778 The Aquaporin-8 (Aqp8) transporter is permeable to water, NH3, formamide and H2O2, and it is present in the inner membrane of mitochondria and the plasma membrane (Bienert et al., 2007; Saparov et al., 2007; Soria et al., 2010). Cholesterol, via sterol regulatory element-binding protein (SREBP) transcription factors, activates or represses genes involved in its hepatic biosynthetic pathway, and also modulates the expression of hepatocyte mitochondrial aquaporin-8 (mtAQP8), a channel that can function as peroxiporin by facilitating the transmembrane diffusion of H2O2. The peroxiporin, mtAQP8, plays a role in the SREBP-controlled hepatocyte cholesterogenesis from Homo sapiens (Human) (see 3 papers)
    31% identity, 87% coverage of query (75.1 bits)

1fx8A / P0AER0 Crystal structure of the e. Coli glycerol facilitator (glpf) with substrate glycerol (see paper)
    30% identity, 97% coverage of query (71.6 bits)

GlpF / b3927 glycerol facilitator from Escherichia coli K-12 substr. MG1655 (see 43 papers)
glpF / P0AER0 glycerol facilitator from Escherichia coli (strain K12) (see 57 papers)
GLPF_ECOLI / P0AER0 Glycerol uptake facilitator protein; Aquaglyceroporin; Glycerol facilitator from Escherichia coli (strain K12) (see 9 papers)
TC 1.A.8.1.1 / P0AER0 Glycerol facilitator, GlpF. Transports various polyols with decreasing rates as size increases (Heller et al. 1980); also transports arsenite (As(III) and antimonite (Sb(III)) (Meng et al., 2004). Oligomerization may play a role in determining the rate of transport from Escherichia coli (see 11 papers)
glpF / RF|NP_418362 aquaglyceroporin from Escherichia coli K12 (see 44 papers)
    30% identity, 97% coverage of query (71.2 bits)

AQP1_RHIO9 / I1CR68 Aquaporin-1 from Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar) (see paper)
    32% identity, 95% coverage of query (70.9 bits)

8c9hA / O14520 Aqp7_inhibitor (see paper)
    29% identity, 97% coverage of query (68.2 bits)

6n1gA Crystal structure of aquaglyceroporin aqp7
    29% identity, 97% coverage of query (68.2 bits)

AQP7 / O14520 aquaporin-7 from Homo sapiens (see 7 papers)
AQP7_HUMAN / O14520 Aquaporin-7; AQP-7; Aquaglyceroporin-7; Aquaporin adipose; AQPap; Aquaporin-7-like from Homo sapiens (Human) (see 6 papers)
    29% identity, 97% coverage of query (68.2 bits)

AQPB_DICDI / Q54WT8 Aquaporin-B from Dictyostelium discoideum (Social amoeba) (see paper)
TC 1.A.8.10.8 / Q54WT8 Aquaporin-B, AqpB of 294 aas and 6 TMSs from Dictyostelium discoideum (see 2 papers)
    25% identity, 95% coverage of query (65.1 bits)

5bn2A / F2QVG4 Room temperature structure of pichia pastoris aquaporin at 1.3 a
    30% identity, 97% coverage of query (63.5 bits)

AQP10_HUMAN / Q96PS8 Aquaporin-10; AQP-10; Aquaglyceroporin-10; Small intestine aquaporin from Homo sapiens (Human) (see 6 papers)
TC 1.A.8.9.5 / Q96PS8 Aquaporin 10 from Homo sapiens
    27% identity, 97% coverage of query (62.0 bits)

6f7hC / Q96PS8 Crystal structure of human aqp10 (see paper)
    27% identity, 97% coverage of query (61.6 bits)

3c02A / Q8WPZ6 X-ray structure of the aquaglyceroporin from plasmodium falciparum (see paper)
    26% identity, 98% coverage of query (48.1 bits)

AQY1_YEAST / P0CD91 Aquaporin-1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
AQY1 aquaporin-1 from Saccharomyces cerevisiae S288c (see paper)
    25% identity, 81% coverage of query (46.6 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory