Searching for up to 100 curated homologs for BWI76_RS09735 FitnessBrowser__Koxy:BWI76_RS09735 (760 a.a.)

Found high-coverage hits (≥70%) to 28 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Pfl / b0903 pyruvate formate-lyase from Escherichia coli K-12 substr. MG1655 (see 3 papers)
pflB / P09373 pyruvate formate-lyase from Escherichia coli (strain K12) (see 28 papers)
PFLB_ECOLI / P09373 Formate acetyltransferase 1; Pyruvate formate-lyase 1; EC 2.3.1.54 from Escherichia coli (strain K12) (see 3 papers)
P09373 formate C-acetyltransferase (EC 2.3.1.54) from Escherichia coli (see 10 papers)
    94% identity, 100% coverage of query (1513 bits)

1h16A Pyruvate formate-lyase (e.Coli) in complex with pyruvate and coa
    94% identity, 100% coverage of query (1511 bits)

1cm5A / P09373 Crystal structure of c418a,c419a mutant of pfl from e.Coli (see paper)
    94% identity, 100% coverage of query (1504 bits)

TDCE_ECOLI / P42632 PFL-like enzyme TdcE; Keto-acid formate acetyltransferase; Keto-acid formate-lyase; Ketobutyrate formate-lyase; KFL; Pyruvate formate-lyase; PFL; EC 2.3.1.-; EC 2.3.1.54 from Escherichia coli (strain K12) (see paper)
tdcE / EW|b3114 pyruvate formate-lyase 4/2-ketobutyrate formate-lyase from Escherichia coli K12 (see paper)
    79% identity, 99% coverage of query (1287 bits)

PFLB_STAAC / Q5HJF4 Formate acetyltransferase; Pyruvate formate-lyase; EC 2.3.1.54 from Staphylococcus aureus (strain COL) (see paper)
    66% identity, 100% coverage of query (1063 bits)

pfl / Q46266 pyruvate formate-lyase subunit (EC 2.3.1.54) from Clostridium pasteurianum (see 6 papers)
Q46266 formate C-acetyltransferase (EC 2.3.1.54) from Clostridium pasteurianum (see paper)
    62% identity, 99% coverage of query (946 bits)

PFL1 / Q1RS83 pyruvate formate lyase (EC 2.3.1.54) from Chlamydomonas reinhardtii (see 6 papers)
Q1RS83 formate C-acetyltransferase (EC 2.3.1.54) from Chlamydomonas reinhardtii (see paper)
    58% identity, 97% coverage of query (880 bits)

pfl / Q59934 pyruvate formate-lyase subunit (EC 2.3.1.54) from Streptococcus mutans serotype c (strain ATCC 700610 / UA159) (see 2 papers)
    44% identity, 99% coverage of query (622 bits)

O66391 formate C-acetyltransferase (EC 2.3.1.54) from Streptococcus equinus (see paper)
    43% identity, 99% coverage of query (620 bits)

Q5M2Y4 formate C-acetyltransferase (EC 2.3.1.54) from Streptococcus thermophilus (see paper)
    44% identity, 99% coverage of query (616 bits)

A0A0H2ZQE4 formate C-acetyltransferase (EC 2.3.1.54) from Streptococcus pneumoniae (see paper)
    43% identity, 99% coverage of query (608 bits)

pfl / CAA03991.1 pyruvate formate-lyase from Lactococcus lactis (see paper)
    43% identity, 99% coverage of query (603 bits)

Build an alignment

Build an alignment for BWI76_RS09735 and 12 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

Q8GEZ8 glycerol dehydratase (EC 4.2.1.30) from Clostridium butyricum (see 2 papers)
    27% identity, 87% coverage of query (194 bits)

1r9dA / Q8GEZ8 Glycerol bound form of the b12-independent glycerol dehydratase from clostridium butyricum (see paper)
    27% identity, 87% coverage of query (193 bits)

YbiW / b0823 putative pyruvate formate lyase from Escherichia coli K-12 substr. MG1655 (see 2 papers)
    27% identity, 70% coverage of query (183 bits)

2f3oA / O28823 Crystal structure of a glycyl radical enzyme from archaeoglobus fulgidus (see paper)
    24% identity, 87% coverage of query (145 bits)

O28823 formate C-acetyltransferase (EC 2.3.1.54) from Archaeoglobus fulgidus (see paper)
    24% identity, 87% coverage of query (145 bits)

8id1A Crystal structure of n-methyl-cis-4-hydroxy-l-proline dehydratase in intestinibacter bartlettii
    25% identity, 71% coverage of query (142 bits)

t4LhypD / Q180C6 trans-4-hydroxy-L-proline dehydratase (EC 4.2.1.172) from Clostridioides difficile (strain 630) (see paper)
    25% identity, 85% coverage of query (135 bits)

HYPD_CLODI / A0A031WDE4 Trans-4-hydroxy-L-proline dehydratase; Glycyl radical enzyme; Hyp dehydratase; EC 4.2.1.172 from Clostridioides difficile (Peptoclostridium difficile) (see paper)
6vxeA / A0A031WDE4 Crystal structure of hydroxyproline dehydratase (hypd) from clostridioides difficile with substrate trans-4-hydroxy-l-proline bound (see paper)
    25% identity, 85% coverage of query (134 bits)

5fawB / Q30W70 T502a mutant of choline tma-lyase (see paper)
    24% identity, 71% coverage of query (129 bits)

6nd3A Wild-type choline tma lyase in complex with betaine aldehyde
    24% identity, 71% coverage of query (129 bits)

CUTC_OLEA2 / Q30W70 Choline trimethylamine-lyase; Choline TMA-lyase; Choline utilization protein C; Glycyl radical enzyme CutC; GRE CutC; EC 4.3.99.4 from Oleidesulfovibrio alaskensis (strain ATCC BAA-1058 / DSM 17464 / G20) (Desulfovibrio alaskensis) (see 2 papers)
Q30W70 choline trimethylamine-lyase (EC 4.3.99.4) from Oleidesulfovibrio alaskensis (see 2 papers)
    24% identity, 71% coverage of query (128 bits)

6vueA Wild-type choline tma lyase in complex with 1-methyl-1,2,3,6- tetrahydropyridin-3-ol
    24% identity, 71% coverage of query (128 bits)

8iofC / A0A0F0CL90 Crystal structure of n-methyl-cis-4-hydroxy-d-proline dehydratase in clostridium sp. Fs41
    24% identity, 85% coverage of query (123 bits)

B8J0I2 choline trimethylamine-lyase (EC 4.3.99.4) from Desulfovibrio desulfuricans (see paper)
    24% identity, 71% coverage of query (122 bits)

5a0uH / A0A0M3KL44 Structure of cutc choline lyase choline bound form from klebsiella pneumoniae. (see paper)
    23% identity, 75% coverage of query (121 bits)

IAD_TRASO / A0A100YXA1 Indoleacetate decarboxylase; IAD; OsIAD; EC 4.1.1.115 from Tractidigestivibacter scatoligenes (Olsenella scatoligenes) (see paper)
A0A100YXA1 indoleacetate decarboxylase (EC 4.1.1.115) from Tractidigestivibacter scatoligenes (see paper)
    23% identity, 83% coverage of query (106 bits)

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