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Searching for up to 100 curated homologs for BWI76_RS10220 FitnessBrowser__Koxy:BWI76_RS10220 (335 a.a.)

Found high-coverage hits (≥70%) to 64 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

iolG / Q9WYP5 myo-inositol 2-dehydrogenase (EC 1.1.1.18) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
IOLG_THEMA / Q9WYP5 Myo-inositol 2-dehydrogenase; EC 1.1.1.18 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
Q9WYP5 D-chiro-inositol 1-dehydrogenase (EC 1.1.1.369) from Thermotoga maritima (see paper)
    39% identity, 98% coverage of query (234 bits)

iolX / P40332 scyllo-inositol 2-dehydrogenase (NAD+) (EC 1.1.1.370) from Bacillus subtilis (strain 168) (see paper)
IOLX_BACSU / P40332 scyllo-inositol 2-dehydrogenase (NAD(+)); EC 1.1.1.370 from Bacillus subtilis (strain 168) (see paper)
P40332 scyllo-inositol 2-dehydrogenase (NAD+) (EC 1.1.1.370) from Bacillus subtilis (see 2 papers)
    38% identity, 99% coverage of query (226 bits)

HSERO_RS12095 Myo-inositol 2-dehydrogenase (EC 1.1.1.18) from Herbaspirillum seropedicae SmR1
    35% identity, 99% coverage of query (177 bits)

Build an alignment

Build an alignment for BWI76_RS10220 and 3 homologs with ≥ 30% identity

Select sequences

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Additional hits (identity < 30%)

E1U888 inositol 2-dehydrogenase (EC 1.1.1.18) from Lacticaseibacillus casei (see paper)
    28% identity, 99% coverage of query (147 bits)

4n54A / A0A0J9X1Y7 Crystal structure of scyllo-inositol dehydrogenase from lactobacillus casei with bound cofactor NAD(h) and scyllo-inositol
    28% identity, 98% coverage of query (144 bits)

3ceaA / F9ULF9 Crystal structure of myo-inositol 2-dehydrogenase (np_786804.1) from lactobacillus plantarum at 2.40 a resolution
    29% identity, 98% coverage of query (141 bits)

3ec7A / Q8ZK57 Crystal structure of putative dehydrogenase from salmonella typhimurium lt2
    31% identity, 96% coverage of query (132 bits)

Q9EZV8 inositol 2-dehydrogenase (EC 1.1.1.18) from Sinorhizobium fredii (see paper)
    35% identity, 98% coverage of query (131 bits)

iolG / P26935 inositol 2-dehydrogenase monomer (EC 1.1.1.18; EC 1.1.1.369) from Bacillus subtilis (strain 168) (see 5 papers)
IOLG_BACSU / P26935 Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase; Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase; MI 2-dehydrogenase/DCI 3-dehydrogenase; EC 1.1.1.18; EC 1.1.1.369 from Bacillus subtilis (strain 168) (see 3 papers)
P26935 inositol 2-dehydrogenase (EC 1.1.1.18); D-chiro-inositol 1-dehydrogenase (EC 1.1.1.369) from Bacillus subtilis (see 7 papers)
    30% identity, 98% coverage of query (127 bits)

3nt5A Crystal structure of myo-inositol dehydrogenase from bacillus subtilis with bound cofactor and product inosose
    30% identity, 98% coverage of query (127 bits)

3nt4A Crystal structure of myo-inositol dehydrogenase from bacillus subtilis with bound cofactor nadh and inositol
    30% identity, 98% coverage of query (127 bits)

3nt2B Crystal structure of myo-inositol dehydrogenase from bacillus subtilis with bound cofactor
    30% identity, 98% coverage of query (127 bits)

3nt2A Crystal structure of myo-inositol dehydrogenase from bacillus subtilis with bound cofactor
    30% identity, 98% coverage of query (127 bits)

4l8vA / P26935 Crystal structure of a12k/d35s mutant myo-inositol dehydrogenase from bacillus subtilis with bound cofactor NADP (see paper)
    29% identity, 98% coverage of query (126 bits)

E1U887 inositol 2-dehydrogenase (EC 1.1.1.18) from Lacticaseibacillus casei (see paper)
    33% identity, 90% coverage of query (124 bits)

4minA / A0A0J9X1Y2 Crystal structure of myo-inositol dehydrogenase from lactobacillus casei with bound cofactor NAD
    33% identity, 90% coverage of query (124 bits)

4mjlD Crystal structure of myo-inositol dehydrogenase from lactobacillus casei in complex with NAD and d-chiro-inositol
    33% identity, 90% coverage of query (124 bits)

4mioD Crystal structure of myo-inositol dehydrogenase from lactobacillus casei in complex with NAD(h) and myo-inositol
    33% identity, 90% coverage of query (124 bits)

4mioA Crystal structure of myo-inositol dehydrogenase from lactobacillus casei in complex with NAD(h) and myo-inositol
    33% identity, 90% coverage of query (124 bits)

SM_b20899 Inositol 2-dehydrogenase (EC 1.1.1.18) from Sinorhizobium meliloti 1021
MI2D_RHIME / O68965 Inositol 2-dehydrogenase; Myo-inositol 2-dehydrogenase; MI-dehydrogenase; EC 1.1.1.18 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
O68965 inositol 2-dehydrogenase (EC 1.1.1.18) from Sinorhizobium meliloti (see paper)
    35% identity, 98% coverage of query (122 bits)

iolG / A0A0H3FQ94 myo-inositol 2-dehydrogenase (EC 1.1.1.18) from Klebsiella aerogenes (strain ATCC 13048 / DSM 30053 / CCUG 1429 / JCM 1235 / KCTC 2190 / NBRC 13534 / NCIMB 10102 / NCTC 10006 / CDC 819-56) (see 2 papers)
    29% identity, 98% coverage of query (121 bits)

BWI76_RS03095 Inositol 2-dehydrogenase (EC 1.1.1.18) from Klebsiella michiganensis M5al
    29% identity, 98% coverage of query (120 bits)

PS417_11875 Inositol 2-dehydrogenase (EC 1.1.1.18) from Pseudomonas simiae WCS417
    29% identity, 98% coverage of query (115 bits)

AO353_21365 Inositol 2-dehydrogenase (EC 1.1.1.18) from Pseudomonas fluorescens FW300-N2E3
    30% identity, 98% coverage of query (109 bits)

AO356_23190 Inositol 2-dehydrogenase (EC 1.1.1.18) from Pseudomonas fluorescens FW300-N2C3
    32% identity, 74% coverage of query (108 bits)

mocA / GB|CAA55269.1 rhizopine catabolism protein MocA from Sinorhizobium meliloti (see paper)
    30% identity, 94% coverage of query (102 bits)

Q8NTY7 inositol 2-dehydrogenase (EC 1.1.1.18) from Corynebacterium glutamicum (see paper)
    26% identity, 96% coverage of query (96.7 bits)

afr / Q2I8V6 1,5-anhydro-D-fructose reductase (EC 1.1.1.292) from Ensifer adhaerens (see 3 papers)
AFR_ENSAD / Q2I8V6 1,5-anhydro-D-fructose reductase; Anhydrofructose reductase; 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming); EC 1.1.1.292 from Ensifer adhaerens (Sinorhizobium morelense) (see 2 papers)
Q2I8V6 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) (EC 1.1.1.292) from Ensifer adhaerens (see 2 papers)
    28% identity, 98% coverage of query (95.9 bits)

UGNO_METMP / Q6M0B9 UDP-N-acetylglucosamine 3-dehydrogenase; UDP-GlcNAc oxidoreductase; UDP-N-acetyl-alpha-D-glucosamine:NAD(+) 3-oxidoreductase; EC 1.1.1.374 from Methanococcus maripaludis (strain S2 / LL) (see paper)
Q6M0B9 UDP-N-acetylglucosamine 3-dehydrogenase (EC 1.1.1.374) from Methanococcus maripaludis (see paper)
    27% identity, 96% coverage of query (94.4 bits)

2glxA / Q2I8V6 Crystal structure analysis of bacterial 1,5-af reductase (see paper)
    28% identity, 98% coverage of query (94.4 bits)

6jw7A / Q6L737 The crystal structure of kand2 in complex with nadh and 3"-deamino-3"- hydroxykanamycin a (see paper)
    30% identity, 75% coverage of query (91.3 bits)

A0A064C3N0 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) (EC 1.1.1.292) from Streptococcus pneumoniae (see paper)
    29% identity, 78% coverage of query (91.3 bits)

6jw6A The crystal structure of kand2 in complex with NAD
    30% identity, 75% coverage of query (91.3 bits)

6jw8A The crystal structure of kand2 in complex with nadh and 3"-deamino-3"- hydroxykanamycin b
    30% identity, 75% coverage of query (91.3 bits)

7x2yA / A0A076PYH9 Crystal structure of cis-4,5-dihydrodiol phthalate dehydrogenase in complex with NAD+ and 3-hydroxybenzoate (see paper)
    29% identity, 98% coverage of query (87.8 bits)

Q92KZ3 1,5-anhydro-D-fructose reductase (EC 1.1.1.263); 1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) (EC 1.1.1.292) from Sinorhizobium meliloti (see paper)
4koaA / Q92KZ3 Crystal structure analysis of 1,5-anhydro-d-fructose reductase from sinorhizobium meliloti (see paper)
    27% identity, 99% coverage of query (85.1 bits)

5a03C / Q9A8X3 Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with xylose (see paper)
    25% identity, 84% coverage of query (82.8 bits)

5a05A Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with maltotriose
    25% identity, 84% coverage of query (82.8 bits)

5a04A Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with glucose
    25% identity, 84% coverage of query (82.8 bits)

5a03E Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with xylose
    25% identity, 84% coverage of query (82.8 bits)

5a02A Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with glycerol
    25% identity, 84% coverage of query (82.8 bits)

5a06A Crystal structure of aldose-aldose oxidoreductase from caulobacter crescentus complexed with sorbitol
    25% identity, 84% coverage of query (82.8 bits)

6o15A / P39353 Crystal structure of a putative oxidoreductase yjhc from escherichia coli in complex with NAD(h) (see paper)
    26% identity, 99% coverage of query (82.4 bits)

K7ZP76 scyllo-inositol 2-dehydrogenase (NAD+) (EC 1.1.1.370) from Paracoccus laeviglucosivorans (see paper)
lgdA / BAM68195.1 scyllo-inositol dehydrogenase with L-glucose dehydrogenase activity from Paracoccus laeviglucosivorans (see 2 papers)
    30% identity, 81% coverage of query (81.6 bits)

6ktkC / K7ZP76 Crystal structure of scyllo-inositol dehydrogenase r178a mutant, complexed with nadh and l-glucono-1,5-lactone, from paracoccus laeviglucosivorans (see paper)
    30% identity, 81% coverage of query (79.7 bits)

5yaqB Crystal structure of scyllo-inositol dehydrogenase with l-glucose dehydrogenase activity complexed with scyllo-inosose
    30% identity, 81% coverage of query (79.3 bits)

5ya8A Crystal structure of scyllo-inositol dehydrogenase with l-glucose dehydrogenase activity complexed with myo-inositol
    30% identity, 81% coverage of query (79.3 bits)

3q2kC / Q79H45 Crystal structure of the wlba dehydrogenase from bordetella pertussis in complex with nadh and udp-glcnaca (see paper)
    26% identity, 97% coverage of query (77.0 bits)

3q2kK / Q79H45 Crystal structure of the wlba dehydrogenase from bordetella pertussis in complex with nadh and udp-glcnaca (see paper)
    27% identity, 77% coverage of query (77.0 bits)

cbaC / Q44258 3-chlorobenzoate-cis-diol hydrogenase from Comamonas testosteroni (see paper)
cbaC / AAC45718.1 1-carboxy-3-chloro-3,4-dihydroxycyclohexa-1, 5-diene dehydrogenase from Conidiobolus coronatus (see 4 papers)
    29% identity, 73% coverage of query (77.0 bits)

3q2iA / Q7NQL0 Crystal structure of the wlba dehydrognase from chromobactrium violaceum in complex with nadh and udp-glcnaca at 1.50 a resolution (see paper)
    24% identity, 98% coverage of query (72.0 bits)

orf19.6899 putative uncharacterized protein CaJ7.0133 from Candida albicans (see paper)
    24% identity, 100% coverage of query (70.5 bits)

3e18A / Q929L3 Crystal structure of NAD-binding protein from listeria innocua
    29% identity, 70% coverage of query (70.5 bits)

Q7NQL0 UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase (EC 1.1.1.335) from Chromobacterium violaceum (see paper)
    23% identity, 98% coverage of query (68.9 bits)

Q9DBB8 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.20) from Mus musculus (see paper)
    27% identity, 75% coverage of query (65.5 bits)

PLH35_FORAG / T2KNC8 Oxidoreductase P35; P35_oxidoreductase; Polysaccharide utilization locus H protein P35; PUL H protein P35; EC 1.-.-.- from Formosa agariphila (strain DSM 15362 / KCTC 12365 / LMG 23005 / KMM 3901 / M-2Alg 35-1) (see paper)
    23% identity, 72% coverage of query (64.7 bits)

SM_b20330 glucoside 3-dehydrogenase; active on raffinose or trehalose (thuB) (EC 1.1.99.13) from Sinorhizobium meliloti 1021
    26% identity, 80% coverage of query (64.3 bits)

XDH2_HALVD / D4GP30 D-xylose 1-dehydrogenase (NADP(+)) 2; XDH 2; EC 1.1.1.179 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
D4GP30 D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming) (EC 1.1.1.179) from Haloferax volcanii (see paper)
    26% identity, 87% coverage of query (62.8 bits)

gnnA / Q6QHI6 UDP-N-acetylglucosamine 3-dehydrogenase (EC 1.1.1.374) from Acidithiobacillus ferrooxidans (see 12 papers)
7bvjA / B7JA34 Udp-n-acetylglucosamine 3-dehydrogenase gnna from acidithiobacillus ferrooxidans (p21) (see paper)
    27% identity, 96% coverage of query (58.5 bits)

5b3uB / P72782 Crystal structure of biliverdin reductase in complex with NADP+ from synechocystis sp. Pcc 6803 (see paper)
    28% identity, 73% coverage of query (56.2 bits)

5b3vA Crystal structure of biliverdin reductase in complex with biliverdin and NADP+ from synechocystis sp. Pcc 6803
    28% identity, 73% coverage of query (56.2 bits)

7d5nA Crystal structure of inositol dehydrogenase homolog complexed with nadh and myo-inositol from azotobacter vinelandii
    26% identity, 84% coverage of query (55.1 bits)

KIJDR_ACTKI / B3TMR8 dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase; 3-ketoreductase; NADPH-dependent C3-ketoreductase; EC 1.1.1.384 from Actinomadura kijaniata (see paper)
B3TMR8 dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase (EC 1.1.1.384) from Actinomadura kijaniata (see paper)
    23% identity, 92% coverage of query (53.9 bits)

3rc1A / B3TMR8 Crystal structure of kijd10, a 3-ketoreductase from actinomadura kijaniata incomplex with NADP and tdp-benzene (see paper)
    23% identity, 92% coverage of query (53.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory