Searching for up to 100 curated homologs for BWI76_RS11580 FitnessBrowser__Koxy:BWI76_RS11580 (338 a.a.)

Found high-coverage hits (≥70%) to 40 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

AnsA / b1767 L-asparaginase 1 (EC 3.5.1.38; EC 3.5.1.1) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
ansA / P0A962 L-asparaginase 1 (EC 3.5.1.38) from Escherichia coli (strain K12) (see 11 papers)
ASPG1_ECOLI / P0A962 L-asparaginase 1; L-asparaginase I; L-ASNase I; L-asparagine amidohydrolase I; EC 3.5.1.1 from Escherichia coli (strain K12) (see paper)
    91% identity, 100% coverage of query (639 bits)

6nxcB / P0A962 Ecai(t162a) mutant in complex with citrate at ph 4 (see paper)
    89% identity, 100% coverage of query (615 bits)

2himA Crystal structure and allosteric regulation of the cytoplasmic escherichia coli l-asparaginase i
    88% identity, 99% coverage of query (600 bits)

7r6bB / A0A3N4B0Q2 Crystal structure of mutant r43d/l124d/r125a/c273s of l-asparaginase i from yersinia pestis (see paper)
    76% identity, 99% coverage of query (488 bits)

A0JNU3 1-alkyl-2-acetylglycerophosphocholine esterase (subunit 3/3) (EC 3.1.1.47) from Mus musculus (see paper)
    46% identity, 99% coverage of query (290 bits)

LPP60_RAT / O88202 60 kDa lysophospholipase; Lysophospholipase-transacylase; EC 3.1.1.5; EC 3.5.1.1; EC 3.1.1.47 from Rattus norvegicus (Rat) (see 3 papers)
    46% identity, 99% coverage of query (289 bits)

ASPG_DIRIM / Q9U518 L-asparaginase; DiAsp; L-asparagine amidohydrolase; EC 3.5.1.1 from Dirofilaria immitis (Canine heartworm) (see paper)
    42% identity, 99% coverage of query (282 bits)

ASPG / Q86U10 60 kDa lysophospholipase (EC 3.1.1.47; EC 3.5.1.38) from Homo sapiens (see 4 papers)
    47% identity, 99% coverage of query (280 bits)

CA265_RS25090 L-asparaginase (EC 3.5.1.1) from Pedobacter sp. GW460-11-11-14-LB5
    42% identity, 99% coverage of query (280 bits)

H0W0T5 asparaginase (EC 3.5.1.1) from Cavia porcellus (see paper)
    43% identity, 99% coverage of query (273 bits)

W0G253 asparaginase (EC 3.5.1.1) from Rhizomucor miehei (see paper)
    42% identity, 98% coverage of query (273 bits)

4r8lA Crystal structure of the asp-bound guinea pig l-asparaginase 1 catalytic domain
    43% identity, 99% coverage of query (273 bits)

5dndD / H0W0T5 Crystal structure of the asn-bound guinea pig l-asparaginase 1 catalytic domain active site mutant t116a (see paper)
    43% identity, 99% coverage of query (271 bits)

A0A1I0U0N3 asparaginase (EC 3.5.1.1) from Pseudomonas otitidis (see paper)
    39% identity, 98% coverage of query (194 bits)

AO353_09960 L-asparaginase (EC 3.5.1.1) from Pseudomonas fluorescens FW300-N2E3
    35% identity, 98% coverage of query (184 bits)

Pf1N1B4_2023 L-asparaginase (EC 3.5.1.1) from Pseudomonas fluorescens FW300-N1B4
    36% identity, 98% coverage of query (183 bits)

PfGW456L13_740 L-asparaginase (EC 3.5.1.1) from Pseudomonas fluorescens GW456-L13
    36% identity, 98% coverage of query (183 bits)

AO356_11100 L-asparaginase (EC 3.5.1.1) from Pseudomonas fluorescens FW300-N2C3
    37% identity, 98% coverage of query (179 bits)

Pf6N2E2_4087 L-asparaginase (EC 3.5.1.1) from Pseudomonas fluorescens FW300-N2E2
    35% identity, 98% coverage of query (174 bits)

5ot0A / Q5JIW4 The thermostable l-asparaginase from thermococcus kodakarensis (see paper)
    35% identity, 98% coverage of query (171 bits)

ASPG1_BACSU / P26900 L-asparaginase 1; L-ASNase 1; L-asparagine amidohydrolase 1; EC 3.5.1.1 from Bacillus subtilis (strain 168) (see paper)
    31% identity, 96% coverage of query (169 bits)

4q0mA / Q8TZE8 Crystal structure of pyrococcus furiosus l-asparaginase (see paper)
    33% identity, 96% coverage of query (157 bits)

ASPG_PYRFU / Q8TZE8 L-asparaginase; EC 3.5.1.1 from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) (see 5 papers)
Q8TZE8 asparaginase (EC 3.5.1.1) from Pyrococcus furiosus (see 2 papers)
    33% identity, 96% coverage of query (157 bits)

1zq1A / Q9V0T9 Structure of gatde tRNA-dependent amidotransferase from pyrococcus abyssi (see paper)
    32% identity, 82% coverage of query (152 bits)

gatD / O26802 glutamyl-tRNA(Gln) amidotransferase subunit D (EC 6.3.5.7) from Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (see paper)
    35% identity, 81% coverage of query (144 bits)

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Build an alignment for BWI76_RS11580 and 25 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

J9H7D1 asparaginase (EC 3.5.1.1) from Staphylococcus sp. (see paper)
    29% identity, 97% coverage of query (102 bits)

BPHYT_RS08815 L-asparaginase (EC 3.5.1.1) from Burkholderia phytofirmans PsJN
    29% identity, 84% coverage of query (94.7 bits)

8h4aB / A0A6I7U6Y2 Blasnase-t13a/m57p
    26% identity, 92% coverage of query (81.6 bits)

7c8qA Blasnase-t13a with d-asn
    26% identity, 92% coverage of query (81.3 bits)

Q9ZLB9 asparaginase (EC 3.5.1.1) from Helicobacter pylori J99 (see paper)
    26% identity, 96% coverage of query (79.7 bits)

7cbuA Blasnase-t13a with l-asp
    25% identity, 92% coverage of query (78.6 bits)

2wltA / Q9ZLB9 The crystal structure of helicobacter pylori l-asparaginase at 1.4 a resolution (see paper)
    26% identity, 96% coverage of query (77.8 bits)

5k3oA / P50286 Wolinella succinogenes l-asparaginase p121 and l-aspartic acid (see paper)
    26% identity, 96% coverage of query (72.0 bits)

5k45A Wolinella succinogenes l-asparaginase p121 + l-glutamic acid
    26% identity, 96% coverage of query (72.0 bits)

P50286 asparaginase (EC 3.5.1.1) from Wolinella succinogenes (see paper)
    26% identity, 97% coverage of query (70.9 bits)

ASPG_MYCTU / P9WPX5 L-asparaginase; L-ASNase; L-asparagine amidohydrolase; EC 3.5.1.1 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
    28% identity, 70% coverage of query (68.2 bits)

1djoA / P10182 Crystal structure of pseudomonas 7a glutaminase-asparaginase with the inhibitor donv covalently bound in the active site (see paper)
    26% identity, 72% coverage of query (65.5 bits)

4pgaA Glutaminase-asparaginase from pseudomonas 7a
    26% identity, 72% coverage of query (65.5 bits)

1djpA Crystal structure of pseudomonas 7a glutaminase-asparaginase with the inhibitor don covalently bound in the active site
    26% identity, 72% coverage of query (65.5 bits)

ASPQ_PSES7 / P10182 Glutaminase-asparaginase; L-ASNase/L-GLNase; L-asparagine/L-glutamine amidohydrolase; PGA; EC 3.5.1.38 from Pseudomonas sp. (strain ATCC 29598 / 7A) (see paper)
    27% identity, 72% coverage of query (65.1 bits)

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