Searching for up to 100 curated homologs for BWI76_RS12790 FitnessBrowser__Koxy:BWI76_RS12790 (329 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
4cukA / Q8Z780 Structure of salmonella d-lactate dehydrogenase in complex with nadh
92% identity, 100% coverage of query (631 bits)
HtpH / b1380 D-lactate dehydrogenase (EC 1.1.1.28) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
ldhA / P52643 D-lactate dehydrogenase (EC 1.1.1.28) from Escherichia coli (strain K12) (see 22 papers)
ldhA D-lactate dehydrogenase; EC 1.1.1.28 from Escherichia coli K12 (see 7 papers)
90% identity, 100% coverage of query (621 bits)
A0A140N893 D-lactate dehydrogenase (EC 1.1.1.28) from Escherichia coli (see 2 papers)
89% identity, 100% coverage of query (619 bits)
Q8EI78 D-lactate dehydrogenase (EC 1.1.1.28) from Shewanella oneidensis (see paper)
62% identity, 100% coverage of query (433 bits)
Q9I530 D-lactate dehydrogenase (EC 1.1.1.28) from Pseudomonas aeruginosa (see 2 papers)
55% identity, 99% coverage of query (357 bits)
5z20F / Q9I530 The ternary structure of d-lactate dehydrogenase from pseudomonas aeruginosa with nadh and oxamate (see paper)
55% identity, 99% coverage of query (357 bits)
TR07_CURCL / A0A348AXY0 Probable dehydrogenase TR07; KK-1 biosynthesis cluster protein TR07; EC 1.1.1.- from Curvularia clavata (see paper)
50% identity, 100% coverage of query (344 bits)
8grvA / Q54UF7 Dictyostelium discoideum lactate dehydrogenase (dicldha)with NAD
47% identity, 96% coverage of query (312 bits)
5z21B / Q8RG11 The ternary structure of d-lactate dehydrogenase from fusobacterium nucleatum with nadh and oxamate (see paper)
46% identity, 99% coverage of query (307 bits)
Q8RG11 D-lactate dehydrogenase (EC 1.1.1.28) from Fusobacterium nucleatum subsp. nucleatum (see 2 papers)
46% identity, 99% coverage of query (307 bits)
HADHA_ASPOR / Q2UH56 2-hydroxyacid dehydrogenase A; 2-HadhA; EC 1.1.1.272 from Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) (see paper)
48% identity, 100% coverage of query (304 bits)
F8A9V0 D-lactate dehydrogenase (EC 1.1.1.28) from Thermodesulfatator indicus (see paper)
45% identity, 96% coverage of query (292 bits)
4zgsA / B0LUZ5 Identification of the pyruvate reductase of chlamydomonas reinhardtii (see paper)
48% identity, 94% coverage of query (282 bits)
FLDH_CLOS1 / J7SHB8 Aromatic 2-oxoacid reductase; Indolelactate dehydrogenase; EC 1.1.1.110 from Clostridium sporogenes (strain ATCC 15579) (see 2 papers)
40% identity, 100% coverage of query (260 bits)
fldH / G9EZR6 aromatic 2-oxoacid reductase (EC 1.1.1.110) from Clostridium sporogenes (strain ATCC 7955 / DSM 767 / NBRC 16411 / NCIMB 8053 / NCTC 8594 / PA 3679) (see 6 papers)
FLDH_CLOS3 / G9EZR6 Aromatic 2-oxoacid reductase; Phenyllactate dehydrogenase; EC 1.1.1.110 from Clostridium sporogenes (strain ATCC 7955 / DSM 767 / NBRC 16411 / NCIMB 8053 / NCTC 8594 / PA 3679) (see paper)
40% identity, 100% coverage of query (259 bits)
A0A0R1RJ30 D-lactate dehydrogenase (EC 1.1.1.28) from Furfurilactobacillus rossiae (see 2 papers)
37% identity, 97% coverage of query (207 bits)
D-ldh / P51011 D-lactate dehydrogenase subunit (EC 1.1.1.28) from Leuconostoc mesenteroides subsp. cremoris (see 3 papers)
CH_091801 D-lactate dehydrogenase; EC 1.1.1.28 from Leuconostoc mesenteroides subsp. cremoris (see paper)
38% identity, 98% coverage of query (204 bits)
ldhD / Q88VJ2 D-lactate dehydrogenase subunit (EC 1.1.1.28) from Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) (see paper)
C0LJH4 D-lactate dehydrogenase (EC 1.1.1.28) from Lactiplantibacillus plantarum subsp. plantarum (see paper)
36% identity, 96% coverage of query (199 bits)
E0NDE9 D-lactate dehydrogenase (EC 1.1.1.28) from Pediococcus acidilactici (see paper)
34% identity, 100% coverage of query (198 bits)
CH_091795 D-lactate dehydrogenase; EC 1.1.1.28 from Lactobacillus pentosus (see 2 papers)
36% identity, 96% coverage of query (196 bits)
1dxyA / P17584 Structure of d-2-hydroxyisocaproate dehydrogenase (see paper)
34% identity, 96% coverage of query (196 bits)
DHD2_LACPA / P17584 D-2-hydroxyisocaproate dehydrogenase; D-HICDH; EC 1.1.1.- from Lacticaseibacillus paracasei (Lactobacillus paracasei) (see paper)
P17584 D-2-hydroxyacid dehydrogenase (NAD+) (EC 1.1.1.345) from Lacticaseibacillus paracasei (see 2 papers)
CH_091798 D-2-hydroxyisocaproate dehydrogenase; EC 1.1.1.- from Lactobacillus paracasei (see 2 papers)
34% identity, 96% coverage of query (196 bits)
LDHD_PEDAC / Q59642 D-lactate/D-glycerate dehydrogenase; D-LDH/GDH; D-specific 2-hydroxyacid dehydrogenase; EC 1.1.1.28; EC 1.1.1.29 from Pediococcus acidilactici (see paper)
ldhD / GI|897794 D-lactate dehydrogenase; EC 1.1.1.28; EC 1.1.1.81 from Pediococcus acidilactici (see paper)
34% identity, 100% coverage of query (195 bits)
LDHD_LACDA / P26297 D-lactate dehydrogenase; D-LDH; D-specific 2-hydroxyacid dehydrogenase; EC 1.1.1.28 from Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / BCRC 10696 / JCM 1002 / NBRC 13953 / NCIMB 11778 / NCTC 12712 / WDCM 00102 / Lb 14) (see paper)
ldhA / OMNI|NTL01LD0096 D-lactate dehydrogenase; EC 1.1.1.28 from Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 (see 3 papers)
35% identity, 97% coverage of query (193 bits)
P30901 D-lactate dehydrogenase (EC 1.1.1.28) from Lactobacillus helveticus (see paper)
2dldA / P30901 D-lactate dehydrogenase complexed with nadh and oxamate
GB|CAA47255.1 D-lactate dehydrogenase; EC 1.1.1.28 from Lactobacillus helveticus (see 2 papers)
34% identity, 99% coverage of query (192 bits)
P30901 D-lactate dehydrogenase; D-LDH; D-specific 2-hydroxyacid dehydrogenase; EC 1.1.1.28 from Lactobacillus helveticus (Lactobacillus suntoryeus)
34% identity, 99% coverage of query (192 bits)
O83080 D-lactate dehydrogenase (EC 1.1.1.28) from Treponema pallidum (see paper)
34% identity, 98% coverage of query (191 bits)
1j49A / P26297 Insights into domain closure, substrate specificity and catalysis of d-lactate dehydrogenase from lactobacillus bulgaricus (see paper)
34% identity, 97% coverage of query (189 bits)
O66939 D-lactate dehydrogenase (EC 1.1.1.28) from Aquifex aeolicus (see paper)
3kb6B / O66939 Crystal structure of d-lactate dehydrogenase from aquifex aeolicus complexed with NAD and lactic acid (see paper)
36% identity, 84% coverage of query (178 bits)
vanH / Q7B609 D-lactate dehydrogenase (EC 1.1.1.28) from Enterococcus faecium (see paper)
VANH_ENTFC / Q05709 D-specific alpha-keto acid dehydrogenase; Vancomycin resistance protein VanH; EC 1.1.1.- from Enterococcus faecium (Streptococcus faecium) (see paper)
31% identity, 95% coverage of query (176 bits)
4prlA Crystal structure of d-lactate dehydrogenase with NAD+ from lactobacillus jensenii (see paper)
32% identity, 98% coverage of query (176 bits)
ldhA / Q188H7 4-methyl-2-oxopentanoate reductase (EC 1.1.1.345) from Clostridioides difficile (strain 630) (see 2 papers)
ldhA / GI|115249400 (R)-2-hydroxyisocaproate dehydrogenase from Clostridium difficile 630 (see paper)
33% identity, 99% coverage of query (176 bits)
F8RPR8 D-lactate dehydrogenase (EC 1.1.1.28) from Weizmannia coagulans (see paper)
36% identity, 95% coverage of query (175 bits)
HGDH_ACIFV / D2RJU7 (R)-2-hydroxyglutarate dehydrogenase; HGDH; EC 1.1.1.399 from Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / CCUG 9996 / CIP 106432 / VR4) (see paper)
31% identity, 100% coverage of query (173 bits)
HPR_THEMA / Q9X1C1 Hydroxypyruvate reductase; HPR; EC 1.1.1.81 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
39% identity, 71% coverage of query (171 bits)
1wwkA / O50095 Crystal structure of phosphoglycerate dehydrogenase from pyrococcus horikoshii ot3
35% identity, 88% coverage of query (160 bits)
Q1GAA2 D-lactate dehydrogenase (EC 1.1.1.28); D-2-hydroxyacid dehydrogenase (NAD+) (EC 1.1.1.345) from Lactobacillus delbrueckii subsp. bulgaricus (see 2 papers)
30% identity, 97% coverage of query (156 bits)
2yq5C / Q1GAA2 Crystal structure of d-isomer specific 2-hydroxyacid dehydrogenase from lactobacillus delbrueckii ssp. Bulgaricus: NAD complexed form (see paper)
30% identity, 97% coverage of query (155 bits)
Q48534 D-2-hydroxyacid dehydrogenase (NAD+) (EC 1.1.1.345) from Lactobacillus delbrueckii (see paper)
30% identity, 97% coverage of query (154 bits)
Q03V58 D-2-hydroxyacid dehydrogenase (NAD+) (EC 1.1.1.345) from Leuconostoc mesenteroides subsp. mesenteroides (see paper)
34% identity, 79% coverage of query (148 bits)
GYAR_THELN / Q9C4M5 Glyoxylate reductase; EC 1.1.1.26 from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C) (see paper)
Q9C4M5 glyoxylate reductase (EC 1.1.1.26) from Thermococcus litoralis (see paper)
32% identity, 99% coverage of query (147 bits)
hprA / P73821 glycerate dehydrogenase (EC 1.1.1.29) from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
35% identity, 77% coverage of query (145 bits)
A0A0M3KL04 D-lactate dehydrogenase (EC 1.1.1.28) from Sporolactobacillus inulinus (see paper)
31% identity, 96% coverage of query (143 bits)
4xkjA / A0A0M3KL04 A novel d-lactate dehydrogenase from sporolactobacillus sp
31% identity, 96% coverage of query (143 bits)
HPR_BLAHS / C0CMQ8 Hydroxypyruvate reductase; EC 1.1.1.81 from Blautia hydrogenotrophica (strain DSM 10507 / JCM 14656 / S5a33) (Ruminococcus hydrogenotrophicus) (see paper)
31% identity, 81% coverage of query (143 bits)
Build an alignment for BWI76_RS12790 and 45 homologs with ≥ 30% identity
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5aovA / Q8U3Y2 Ternary crystal structure of pyrococcus furiosus glyoxylate hydroxypyruvate reductase in presence of glyoxylate (see paper)
28% identity, 88% coverage of query (131 bits)
Q8U3Y2 glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Pyrococcus furiosus (see paper)
28% identity, 88% coverage of query (131 bits)
A0A1Z4EAX3 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Beta vulgaris (see paper)
33% identity, 75% coverage of query (129 bits)
SERA3_ARATH / Q9LT69 D-3-phosphoglycerate dehydrogenase 3, chloroplastic; EC 1.1.1.95 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9LT69 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Arabidopsis thaliana (see 4 papers)
34% identity, 71% coverage of query (129 bits)
A0A2R6X868 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Marchantia polymorpha (see paper)
32% identity, 79% coverage of query (128 bits)
O58256 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Pyrococcus horikoshii (see paper)
31% identity, 83% coverage of query (128 bits)
hprA / Q59516 hydroxypyruvate reductase subunit (EC 1.1.1.81) from Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) (see 2 papers)
32% identity, 77% coverage of query (127 bits)
SERA2_ARATH / O04130 D-3-phosphoglycerate dehydrogenase 2, chloroplastic; PGDH; EC 1.1.1.95 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
O04130 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Arabidopsis thaliana (see 3 papers)
33% identity, 75% coverage of query (127 bits)
6cdfA / Q13363 Human ctbp1 (28-378) (see paper)
31% identity, 83% coverage of query (127 bits)
4u6sA Ctbp1 in complex with substrate phenylpyruvate
31% identity, 83% coverage of query (127 bits)
4u6qA Ctbp1 bound to inhibitor 2-(hydroxyimino)-3-phenylpropanoic acid
31% identity, 83% coverage of query (127 bits)
4lceA Ctbp1 in complex with substrate mtob
31% identity, 83% coverage of query (127 bits)
CTBP2_XENLA / Q9W758 C-terminal-binding protein 2; CtBP2; C-terminal-binding protein B; TCF-3 corepressor CtBP; XCtBP from Xenopus laevis (African clawed frog) (see paper)
30% identity, 83% coverage of query (126 bits)
6v89A Human ctbp1 (28-375) in complex with amp
31% identity, 83% coverage of query (126 bits)
1hl3A Ctbp/bars in ternary complex with NAD(h) and pidlskk peptide
31% identity, 81% coverage of query (126 bits)
1hkuA Ctbp/bars: a dual-function protein involved in transcription corepression and golgi membrane fission
31% identity, 81% coverage of query (126 bits)
CTBP_DROME / O46036 C-terminal-binding protein; CtBP protein; dCtBP from Drosophila melanogaster (Fruit fly) (see 2 papers)
31% identity, 80% coverage of query (125 bits)
CTBP2_BOVIN / Q0VCQ1 C-terminal-binding protein 2; CtBP2 from Bos taurus (Bovine) (see paper)
31% identity, 81% coverage of query (125 bits)
CTBP1 / Q13363 C-terminal-binding protein 1 (EC 1.1.1.428) from Homo sapiens (see 22 papers)
CTBP1_HUMAN / Q13363 C-terminal-binding protein 1; CtBP1; EC 1.1.1.- from Homo sapiens (Human) (see 24 papers)
31% identity, 81% coverage of query (125 bits)
CTBP1_MOUSE / O88712 C-terminal-binding protein 1; CtBP1; EC 1.1.1.- from Mus musculus (Mouse) (see 11 papers)
31% identity, 81% coverage of query (125 bits)
CTBP1_RAT / Q9Z2F5 C-terminal-binding protein 1; CtBP1; 50 kDa BFA-dependent ADP-ribosylation substrate; BARS-50; C-terminal-binding protein 3; CtBP3; EC 1.1.1.- from Rattus norvegicus (Rat) (see 6 papers)
31% identity, 81% coverage of query (125 bits)
8atiA / P56545 Human ctbp2(31-364) in complex with rai2 peptide(315-322)
30% identity, 81% coverage of query (125 bits)
4lcjA Ctbp2 in complex with substrate mtob
30% identity, 81% coverage of query (125 bits)
CTBP2_HUMAN / P56545 C-terminal-binding protein 2; CtBP2 from Homo sapiens (Human) (see 5 papers)
30% identity, 81% coverage of query (124 bits)
CTBP2_MOUSE / P56546 C-terminal-binding protein 2; CtBP2 from Mus musculus (Mouse) (see 4 papers)
30% identity, 81% coverage of query (123 bits)
CTBP2_RAT / Q9EQH5 C-terminal-binding protein 2; CtBP2 from Rattus norvegicus (Rat) (see paper)
30% identity, 81% coverage of query (123 bits)
phpE / Q5IW39 hydroxymethylphosphonate dehydrogenase from Streptomyces viridochromogenes (see paper)
30% identity, 92% coverage of query (122 bits)
6biiA / F8AEA4 Crystal structure of pyrococcus yayanosii glyoxylate hydroxypyruvate reductase in complex with NADP and malonate (re-refinement of 5aow) (see paper)
30% identity, 79% coverage of query (121 bits)
F8AEA4 glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Pyrococcus yayanosii (see paper)
30% identity, 79% coverage of query (121 bits)
3dc2A / P9WNX3 Crystal structure of serine bound d-3-phosphoglycerate dehydrogenase from mycobacterium tuberculosis (see paper)
32% identity, 80% coverage of query (120 bits)
P9WNX3 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Mycobacterium tuberculosis (see 5 papers)
32% identity, 80% coverage of query (120 bits)
Q972A9 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Sulfurisphaera tokodaii (see paper)
27% identity, 89% coverage of query (120 bits)
2eklA / Q972A9 Structure of st1218 protein from sulfolobus tokodaii
27% identity, 89% coverage of query (120 bits)
3ddnB Crystal structure of hydroxypyruvic acid phosphate bound d-3- phosphoglycerate dehydrogenase in mycobacterium tuberculosis
32% identity, 80% coverage of query (120 bits)
P87228 Putative D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
29% identity, 93% coverage of query (119 bits)
CTBP1_CAEEL / Q20595 C-terminal-binding protein 1 from Caenorhabditis elegans (see 4 papers)
28% identity, 81% coverage of query (103 bits)
3n7uA NAD-dependent formate dehydrogenase from higher-plant arabidopsis thaliana in complex with NAD and azide
29% identity, 75% coverage of query (100 bits)
3jtmA / Q9S7E4 Structure of recombinant formate dehydrogenase from arabidopsis thaliana
29% identity, 75% coverage of query (100 bits)
FDH1 / Q9S7E4 formate dehydrogenase (EC 1.17.1.9) from Arabidopsis thaliana (see 2 papers)
FDH_ARATH / Q9S7E4 Formate dehydrogenase, chloroplastic/mitochondrial; FDH; NAD-dependent formate dehydrogenase; EC 1.17.1.9 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9S7E4 formate dehydrogenase (EC 1.17.1.9) from Arabidopsis thaliana (see paper)
29% identity, 75% coverage of query (100 bits)
O58320 Glyoxylate reductase; EC 1.1.1.26 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)
26% identity, 99% coverage of query (97.8 bits)
4e5kA Thermostable phosphite dehydrogenase in complex with NAD and sulfite
29% identity, 79% coverage of query (97.4 bits)
2dbqA / O58320 Crystal structure of glyoxylate reductase (ph0597) from pyrococcus horikoshii ot3, complexed with NADP (i41) (see paper)
26% identity, 99% coverage of query (97.4 bits)
4e5mA Thermostable phosphite dehydrogenase e175a/a176r in complex with NADP
29% identity, 79% coverage of query (96.3 bits)
4e5pA / O69054 Thermostable phosphite dehydrogenase a176r variant in complex with nad (see paper)
29% identity, 79% coverage of query (96.3 bits)
7arzA / A9SQZ2 Ternary complex of NAD-dependent formate dehydrogenase from physcomitrium patens
27% identity, 78% coverage of query (94.7 bits)
6p2iA Acyclic imino acid reductase (bsp5) in complex with NADPH and d-arg (see paper)
28% identity, 92% coverage of query (92.0 bits)
6ih6A / G4XDR8 Phosphite dehydrogenase mutant i151r/p176r/m207a from ralstonia sp. 4506 in complex with non-natural cofactor nicotinamide cytosine dinucleotide
29% identity, 85% coverage of query (90.9 bits)
1psdA The allosteric ligand site in the vmax-type cooperative enzyme phosphoglycerate dehydrogenase
30% identity, 71% coverage of query (90.5 bits)
4njoA Crystal structure of cofactor(NAD+) bound 3-phosphoglycerate dehydrogenase in entamoeba histolytica
27% identity, 76% coverage of query (88.2 bits)
4njmA / Q76KF5 Crystal structure of phosphoglycerate bound 3-phosphoglycerate dehydrogenase in entamoeba histolytica (see paper)
27% identity, 76% coverage of query (88.2 bits)
HPPR / Q65CJ7 hydroxyphenylpyruvate reductase (EC 1.1.1.237) from Plectranthus scutellarioides (see paper)
HPPR_PLESU / Q65CJ7 Hydroxyphenylpyruvate reductase; HPPR; EC 1.1.1.237 from Plectranthus scutellarioides (Coleus) (Solenostemon scutellarioides) (see paper)
Q65CJ7 hydroxyphenylpyruvate reductase (EC 1.1.1.237) from Plectranthus scutellarioides (see 2 papers)
hppr / CAD47810.2 hydroxyphenylpyruvate reductase (HPPR) from Plectranthus scutellarioides (see paper)
27% identity, 72% coverage of query (85.5 bits)
3bazA / Q65CJ7 Structure of hydroxyphenylpyruvate reductase from coleus blumei in complex with NADP+ (see paper)
27% identity, 72% coverage of query (85.5 bits)
5v7gA Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc04462 (smghrb) from sinorhizobium meliloti in complex with NADPH and oxalate
28% identity, 71% coverage of query (79.3 bits)
5v7nA Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc04462 (smghrb) from sinorhizobium meliloti in complex with NADP and 2-keto-d-gluconic acid
28% identity, 71% coverage of query (79.3 bits)
5j23A Crystal structure of NADPH-dependent glyoxylate/hydroxypyruvate reductase smc04462 (smghrb) from sinorhizobium meliloti in complex with 2'-phospho-adp-ribose
28% identity, 71% coverage of query (79.0 bits)
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