Searching for up to 100 curated homologs for BWI76_RS13140 FitnessBrowser__Koxy:BWI76_RS13140 (438 a.a.)

Found high-coverage hits (≥70%) to 23 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

PaaK / b1398 phenylacetate-CoA ligase (EC 6.2.1.30) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
PAAK_ECOLI / P76085 Phenylacetate-coenzyme A ligase; Phenylacetyl-CoA ligase; PA-CoA ligase; EC 6.2.1.30 from Escherichia coli (strain K12) (see 3 papers)
    93% identity, 99% coverage of query (851 bits)

paaF / CAD76926.1 phenylacetate-CoA ligase from Pseudomonas sp. Y2 (see paper)
    68% identity, 97% coverage of query (618 bits)

PAAK_PSEPU / O33469 Phenylacetate-coenzyme A ligase; Phenylacetyl-CoA ligase; PA-CoA ligase; EC 6.2.1.30 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 3 papers)
    67% identity, 98% coverage of query (609 bits)

B4EL89 phenylacetate-CoA ligase (EC 6.2.1.30) from Burkholderia cenocepacia (see 2 papers)
    66% identity, 98% coverage of query (607 bits)

2y4oA / B4EL89 Crystal structure of paak2 in complex with phenylacetyl adenylate (see paper)
    66% identity, 97% coverage of query (603 bits)

2y4oB Crystal structure of paak2 in complex with phenylacetyl adenylate
    66% identity, 97% coverage of query (603 bits)

B4E7B5 phenylacetate-CoA ligase (EC 6.2.1.30) from Burkholderia cenocepacia (see 2 papers)
    66% identity, 99% coverage of query (597 bits)

2y27B / B4E7B5 Crystal structure of paak1 in complex with atp from burkholderia cenocepacia (see paper)
    66% identity, 97% coverage of query (592 bits)

2y4nA Paak1 in complex with phenylacetyl adenylate
    66% identity, 97% coverage of query (585 bits)

paaK / Q9L9C1 phenylacetate-CoA ligase (aerobic) (EC 6.2.1.30) from Aromatoleum evansii (see paper)
PAAK_AROEV / Q9L9C1 Phenylacetate-coenzyme A ligase; Phenylacetyl-CoA ligase; PA-CoA ligase; EC 6.2.1.30 from Aromatoleum evansii (Azoarcus evansii) (see 3 papers)
pacD / CAC10605.1 aerobic phenylacetate-CoA ligase from Aromatoleum evansii (see paper)
    66% identity, 97% coverage of query (579 bits)

PAAK_THET2 / Q72K16 Phenylacetate-coenzyme A ligase; Phenylacetyl-CoA ligase; PA-CoA ligase; EC 6.2.1.30 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see paper)
Q72K16 phenylacetate-CoA ligase (EC 6.2.1.30) from Thermus thermophilus (see paper)
    51% identity, 97% coverage of query (433 bits)

4r1mA / Q8AAN6 Crystal structure of a putative acyl-coa ligase (bt_0428) from bacteroides thetaiotaomicron vpi-5482 at 2.48 a resolution
    44% identity, 99% coverage of query (359 bits)

4r1lA Crystal structure of a putative acyl-coa ligase (bt_0428) from bacteroides thetaiotaomicron vpi-5482 at 2.42 a resolution
    44% identity, 99% coverage of query (350 bits)

mdpP / A2SP20 2-hydroxyisobutanoate-CoA ligase from Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1) (see paper)
    31% identity, 93% coverage of query (188 bits)

6he0A / I3VE75 Crystal structure of 2-hydroxyisobutyryl-coa ligase (hcl) in complex with 2-hib-amp and coa in the thioesterfication state (see paper)
    31% identity, 93% coverage of query (185 bits)

6hdyA Crystal structure of 2-hydroxyisobutyryl-coa ligase (hcl) in the postadenylation state in complex with s3-hb-amp
    30% identity, 93% coverage of query (174 bits)

6hdxA Crystal structure of 2-hydroxyisobutyryl-coa ligase (hcl) in the postadenylation state in complex with r3-hib-amp
    30% identity, 93% coverage of query (174 bits)

Build an alignment

Build an alignment for BWI76_RS13140 and 17 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

bal / Q5P5G7 benzoylacetate-CoA ligase from Aromatoleum aromaticum (strain EbN1) (see paper)
    28% identity, 95% coverage of query (146 bits)

ind3 / A0A0D4BST1 4,5-dehydro-L-arginine--indolmycenate ligase from Streptomyces griseus subsp. griseus (see paper)
    29% identity, 72% coverage of query (112 bits)

ptmA1 / D8L2T7 7α-hydroxy-ent-kauranol-carboxylate adenylase from Streptomyces platensis (see paper)
    26% identity, 93% coverage of query (98.6 bits)

6siwA Paak family amp-ligase with amp
    29% identity, 86% coverage of query (95.1 bits)

6sixB / A0A022MRT4 Paak family amp-ligase with anp (see paper)
    29% identity, 86% coverage of query (94.7 bits)

6siyA Paak family amp-ligase with amp and substrate
    29% identity, 86% coverage of query (94.7 bits)

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