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Searching for up to 100 curated homologs for BWI76_RS14190 FitnessBrowser__Koxy:BWI76_RS14190 (246 a.a.)

Found high-coverage hits (≥70%) to 17 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

5cgzA / Q88JX8 Crystal structure of galb, the 4-carboxy-2-hydroxymuconate hydratase, from pseuodomonas putida kt2440 (see paper)
    84% identity, 97% coverage of query (414 bits)

gllB / Q88JX8 4-oxalmesaconate hydratase monomer (EC 4.2.1.83) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
GALB_PSEPK / Q88JX8 4-oxalmesaconate hydratase; OMA hydratase; Gallate degradation protein B; EC 4.2.1.83 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
    82% identity, 100% coverage of query (414 bits)

AFK20864.1 HFX_5027 (DacHme) (EC 3.5.1.-) (see protein)
    30% identity, 74% coverage of query (70.1 bits)

Build an alignment

Build an alignment for BWI76_RS14190 and 3 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Additional hits (identity < 30%)

BSHB1_BACAN / Q81ST8 N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; GlcNAc-Mal deacetylase 1; EC 3.5.1.- from Bacillus anthracis (see 3 papers)
    26% identity, 93% coverage of query (58.5 bits)

dac / Q6F4N1 diacetylchitobiose deacetylase subunit (EC 3.5.1.33; EC 3.5.1.136) from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (see 3 papers)
DCHI_THEKO / Q6F4N1 Diacetylchitobiose deacetylase; N-acetylchitobiose deacetylase; Tk-Dac; EC 3.5.1.136 from Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Pyrococcus kodakaraensis (strain KOD1)) (see paper)
Q6F4N1 chitin disaccharide deacetylase (EC 3.5.1.105); N,N'-diacetylchitobiose non-reducing end deacetylase (EC 3.5.1.136); N-acetylglucosamine deacetylase (EC 3.5.1.33) from Thermococcus kodakarensis (see paper)
BAD85953.1 diacetylchitobiose deacetylase (TK-Dac;TK1764) (EC 3.5.1.-) (see protein)
    26% identity, 87% coverage of query (57.4 bits)

2ixdA / Q81FP2 Crystal structure of the putative deacetylase bc1534 from bacillus cereus (see paper)
    25% identity, 93% coverage of query (53.5 bits)

BSHB1_BACCR / Q81FP2 N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; GlcNAc-Mal deacetylase 1; B.cereus zinc-binding protein; BcZBP; EC 3.5.1.- from Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711) (see 2 papers)
AAP08514.1 Bc1534;BcZBP (zinc-binding) (EC 3.5.1.-) (see protein)
    25% identity, 93% coverage of query (53.1 bits)

O58235 chitin disaccharide deacetylase (EC 3.5.1.105); N,N'-diacetylchitobiose non-reducing end deacetylase (EC 3.5.1.136); N-acetylglucosamine deacetylase (EC 3.5.1.33) from Pyrococcus horikoshii (see 6 papers)
BAA29587.1 N,N'-diacetylchitobiose deacetylase (DacPh;Ph-Dac;PH0499) (EC 3.5.1.-) (see protein)
    25% identity, 83% coverage of query (52.4 bits)

5b2eA / O58235 N,n'-diacetylchitobiose deacetylase from pyrococcus horikoshii complexed with its inhibitor mpg (acetate-containing condition) (see paper)
    25% identity, 83% coverage of query (52.4 bits)

8bgoG / A0A160VQZ8 N,n-diacetylchitobiose deacetylase from pyrococcus chitonophagus with substrate n,n-diacetylchitobiose (see paper)
    24% identity, 96% coverage of query (52.4 bits)

3wl3A N,n'-diacetylchitobiose deacetylase from pyrococcus horikoshii
    25% identity, 83% coverage of query (52.4 bits)

BSHB2_BACCR / Q81AU5 Probable N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 2; GlcNAc-Mal deacetylase 2; EC 3.5.1.- from Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711) (see paper)
    25% identity, 78% coverage of query (49.3 bits)

6p2tA / P42981 Bshb from bacillus subtilis complexed with citrate (see paper)
    28% identity, 76% coverage of query (46.6 bits)

6ullA Bshb from bacillus subtilis complexed with a substrate analogue
    28% identity, 76% coverage of query (46.2 bits)

Q8U3V1 chitin disaccharide deacetylase (EC 3.5.1.105); N,N'-diacetylchitobiose non-reducing end deacetylase (EC 3.5.1.136) from Pyrococcus furiosus (see 2 papers)
AAL80478.1 N,N'-diacetylchitobiose deacetylase (Pf-Dac;PF0354) (EC 3.5.1.-) (see protein)
3wl4A / Q8U3V1 N,n'-diacetylchitobiose deacetylase (se-derivative) from pyrococcus furiosus (see paper)
    23% identity, 80% coverage of query (45.1 bits)

4xm0A N,n'-diacetylchitobiose deacetylase (semet derivative) from pyrococcus furiosus in the absence of cadmium
    23% identity, 80% coverage of query (45.1 bits)

4xm1A N,n'-diacetylchitobiose deacetylase from pyrococcus furiosus in the presence of cadmium
    23% identity, 80% coverage of query (45.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory