Searching for up to 100 curated homologs for BWI76_RS14445 FitnessBrowser__Koxy:BWI76_RS14445 (250 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
GlnH / b0811 L-glutamine ABC transporter periplasmic binding protein (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 13 papers)
GlnH / P0AEQ3 L-glutamine ABC transporter periplasmic binding protein (EC 7.4.2.1) from Escherichia coli (strain K12) (see 13 papers)
GLNH_ECOLI / P0AEQ3 Glutamine-binding periplasmic protein; GlnBP from Escherichia coli (strain K12) (see paper)
TC 3.A.1.3.2 / P0AEQ3 Glutamine-binding periplasmic protein GlnH aka B0811 aka GlnBP, component of Three component ABC L-glutamine porter. The basal ATPase activity (ATP hydrolysis in the absence of substrate) is mainly caused by the docking of the closed-unliganded state of GlnH onto the transporter domain of GlnPQ. Unlike glutamine, arginine binds both GlnH domains, but does not trigger their closing. Comparison of the ATPase activity in nanodiscs with glutamine transport in proteoliposomes suggested that the stoichiometry of ATP per substrate is close to two from Escherichia coli (see 7 papers)
glnH / GB|AAN79369.1 glutamine ABC transporter, periplasmic glutamine-binding protein GlnH from Escherichia coli (see 7 papers)
53% identity, 97% coverage of query (261 bits)
8eyzA / P0AEQ3 Engineered glutamine binding protein bound to gln and a cobaloxime ligand (see paper)
53% identity, 90% coverage of query (250 bits)
4zv1A An ancestral arginine-binding protein bound to arginine (see paper)
48% identity, 87% coverage of query (187 bits)
4zv2A An ancestral arginine-binding protein bound to glutamine
48% identity, 88% coverage of query (186 bits)
Ac3H11_2555 ABC transporter for L-Histidine, periplasmic substrate-binding component 1 from Acidovorax sp. GW101-3H11
41% identity, 89% coverage of query (157 bits)
TC 3.A.1.3.17 / Q8YSA2 Basic amino acid uptake transporter, BgtAB (see paper)
37% identity, 96% coverage of query (150 bits)
4g4pA / Q837S0 Crystal structure of glutamine-binding protein from enterococcus faecalis at 1.5 a (see paper)
41% identity, 88% coverage of query (148 bits)
2q2aA / D0VWX8 Crystal structures of the arginine-, lysine-, histidine-binding protein artj from the thermophilic bacterium geobacillus stearothermophilus (see paper)
38% identity, 89% coverage of query (143 bits)
2pvuA Crystal structures of the arginine-, lysine-, histidine-binding protein artj from the thermophilic bacterium geobacillus stearothermophilus
38% identity, 89% coverage of query (143 bits)
2q2cA Crystal structures of the arginine-, lysine-, histidine-binding protein artj from the thermophilic bacterium geobacillus stearothermophilus
38% identity, 89% coverage of query (143 bits)
TC 3.A.1.3.12 / P73544 BgtB aka GLNH aka SLL1270, component of Arginine/lysine/histidine/glutamine porter (see paper)
33% identity, 92% coverage of query (130 bits)
4ymxA / Q8RCC4 Crystal structure of the substrate binding protein of an amino acid abc transporter (see paper)
35% identity, 88% coverage of query (129 bits)
5t0wA Crystal structure of the ancestral amino acid-binding protein anccdt- 1, a precursor of cyclohexadienyl dehydratase
39% identity, 89% coverage of query (129 bits)
6svfA / Q9WZ62 Crystal structure of the p235gk mutant of argbp from t. Maritima (see paper)
38% identity, 88% coverage of query (129 bits)
ArtJ / b0860 L-arginine ABC transporter periplasmic binding protein (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see paper)
ArtJ / P30860 L-arginine ABC transporter periplasmic binding protein (EC 7.4.2.1) from Escherichia coli (strain K12) (see paper)
ARTJ_ECOLI / P30860 ABC transporter arginine-binding protein 1 from Escherichia coli (strain K12) (see paper)
TC 3.A.1.3.3 / P30860 ArtJ aka B0860, component of Arginine porter from Escherichia coli (see 7 papers)
artJ / GB|BAA35574.1 arginine ABC transporter, periplasmic arginine-binding protein ArtJ from Escherichia coli K12 (see 8 papers)
34% identity, 95% coverage of query (128 bits)
ArtI / b0863 putative ABC transporter periplasmic binding protein ArtI from Escherichia coli K-12 substr. MG1655 (see 3 papers)
ARTI_ECOLI / P30859 Putative ABC transporter arginine-binding protein 2 from Escherichia coli (strain K12) (see paper)
TC 3.A.1.3.3 / P30859 ArtI aka B0863, component of Arginine porter from Escherichia coli (see 7 papers)
34% identity, 96% coverage of query (124 bits)
ARGT_SALTY / P02911 Lysine/arginine/ornithine-binding periplasmic protein; LAO-binding protein from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 6 papers)
argT / RF|NP_461297.1 lysine/arginine/ornithine ABC transporter, periplasmic lysine/arginine/ornithine-binding protein ArgT from Salmonella enterica subsp. enterica serovar Typhimurium (see 4 papers)
33% identity, 96% coverage of query (123 bits)
AO356_09900 ABC transporter for L-Lysine, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2C3
35% identity, 93% coverage of query (120 bits)
TC 3.A.1.3.25 / Q9CES5 Glutamine ABC transporter permease and substrate binding protein protein, component of Glutamine transporter, GlnQP. Takes up glutamine, asparagine and glutamate which compete for each other for binding both substrate and the transmembrane protein constituent of the system (Fulyani et al. 2015). Tandem substrate binding domains (SBDs) differ in substrate specificity and affinity, allowing cells to efficiently accumulate different amino acids via a single ABC transporter. Analysis revealed the roles of individual residues in determining the substrate affinity from Lactococcus lactis subsp. lactis (strain IL1403)
34% identity, 90% coverage of query (120 bits)
4kqpA / Q9CES5 Crystal structure of lactococcus lactis glnp substrate binding domain 2 (sbd2) in complex with glutamine at 0.95 a resolution (see paper)
34% identity, 90% coverage of query (120 bits)
TC 3.A.1.3.23 / Q9HU31 Amino acid (Lysine/arginine/ornithine/histidine/octopine) ABC transporter periplasmic binding protein, component of Amino acid transporter, PA5152-PA5155. Probably transports numerous amino acids including lysine, arginine, histidine, D-alanine and D-valine (Johnson et al. 2008). Regulated by ArgR from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
35% identity, 88% coverage of query (119 bits)
ArgT / b2310 lysine/arginine/ornithine ABC transporter periplasmic binding protein (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
TC 3.A.1.3.1 / TC 3.A.1.3.29 / P09551 ArgT aka B2310, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential from Escherichia coli (see 5 papers)
32% identity, 96% coverage of query (119 bits)
ARGBP_PSEAE / G3XD47 L-arginine-binding protein from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 3 papers)
TC 3.A.1.3.11 / O50181 AotJ aka PA0888, component of Arginine/ornithine (but not lysine) porter from Pseudomonas aeruginosa (see 2 papers)
35% identity, 91% coverage of query (117 bits)
5owfA Structure of a lao-binding protein mutant with glutamine
34% identity, 87% coverage of query (117 bits)
4zefA / Q837S0 Crystal structure of substrate binding domain 2 (sbd2) of abc transporter glnpq from enterococcus faecalis
35% identity, 86% coverage of query (115 bits)
1lafE / P02911 Structural bases for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein (see paper)
33% identity, 87% coverage of query (114 bits)
1lstA Three-dimensional structures of the periplasmic lysine-, arginine-, ornithine-binding protein with and without a ligand
33% identity, 87% coverage of query (114 bits)
1lahE Structural bases for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein
33% identity, 87% coverage of query (114 bits)
1lagE Structural bases for multiple ligand specificity of the periplasmic lysine-, arginine-, ornithine-binding protein
33% identity, 87% coverage of query (114 bits)
AO356_05495 ABC transporter for L-Lysine, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2C3
33% identity, 92% coverage of query (113 bits)
AO353_03055 ABC transporter for L-Arginine and L-Citrulline, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E3
33% identity, 97% coverage of query (112 bits)
AO356_18700 L-Arginine ABC transporter, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2C3
31% identity, 96% coverage of query (112 bits)
Pf6N2E2_5660 L-Arginine ABC transporter, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E2
31% identity, 96% coverage of query (111 bits)
8b5dA Exploring the ligand binding and conformational dynamics of receptor domain 1 of the abc transporter glnpq
33% identity, 86% coverage of query (111 bits)
Pf6N2E2_2958 ABC transporter for L-Lysine, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N2E2
32% identity, 92% coverage of query (110 bits)
ARTP_BACSU / P54535 Arginine-binding extracellular protein ArtP from Bacillus subtilis (strain 168) (see paper)
30% identity, 95% coverage of query (110 bits)
6fxgB / Q9CES5 Crystal structure of substrate binding domain 1 (sbd1) of abc transporter glnpq in complex with asparagine
32% identity, 86% coverage of query (110 bits)
SMc00140 L-lysine ABC transporter, substrate-binding component from Sinorhizobium meliloti 1021
31% identity, 96% coverage of query (110 bits)
1hslA / P0AEU0 Refined 1.89 angstroms structure of the histidine-binding protein complexed with histidine and its relationship with many other active transport(slash)chemosensory receptors (see paper)
32% identity, 88% coverage of query (110 bits)
8b5eA Exploring the ligand binding and conformational dynamics of receptor domain 1 of the abc transporter glnpq
32% identity, 86% coverage of query (110 bits)
HISJ_SALTY / P02910 Histidine-binding periplasmic protein; HBP from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
hisJ / GB|AAV76512.1 histidine ABC transporter, periplasmic histidine-binding protein HisJ from Salmonella enterica subsp. enterica serovar Typhimurium (see 5 papers)
32% identity, 88% coverage of query (109 bits)
HP15_3031 L-arginine ABC transporter, periplasmic substrate-binding component ArtJ/HisJ/ArtI/AotJ/ArgT from Marinobacter adhaerens HP15
32% identity, 98% coverage of query (109 bits)
HisJ / b2309 histidine ABC transporter periplasmic binding protein (EC 7.4.2.1) from Escherichia coli K-12 substr. MG1655 (see 5 papers)
HISJ_ECOLI / P0AEU0 Histidine-binding periplasmic protein; HBP from Escherichia coli (strain K12) (see paper)
TC 3.A.1.3.29 / P0AEU0 Histidine-binding periplasmic protein, component of Histidine/Arginine/Lysine (basic amino acid) uptake porter, HisJ/ArgT/HisP/HisM/HisQ [R, R, C, M, M, respectively] (Gilson et al. 1982). HisJ binds L-His (preferred), but 1-methyl-L-His and 3-methyl-L-His also bind, while the dipeptide carnosine binds weakly; D-histidine and the histidine degradation products, histamine, urocanic acid and imidazole do not bind. L-Arg, homo-L-Arg, and post-translationally modified methylated Arg-analogs also bind with the exception of symmetric dimethylated-L-Arg. L-Lys and L-Orn show weaker interactions with HisJ and methylated and acetylated Lys variants show poor binding.The carboxylate groups of these amino acids and their variants are essential from Escherichia coli (strain K12)
hisJ / GB|AAC75369.1 histidine ABC transporter, periplasmic histidine-binding protein HisJ from Escherichia coli (see 7 papers)
31% identity, 87% coverage of query (108 bits)
Pf1N1B4_3431 ABC transporter for L-Arginine and L-Citrulline, periplasmic substrate-binding component from Pseudomonas fluorescens FW300-N1B4
31% identity, 96% coverage of query (108 bits)
2pyyB / D0VWX9 Crystal structure of the glur0 ligand-binding core from nostoc punctiforme in complex with (l)-glutamate (see paper)
35% identity, 80% coverage of query (107 bits)
BPHYT_RS07735 ABC transporter for L-Arginine, periplasmic substrate-binding component from Burkholderia phytofirmans PsJN
32% identity, 88% coverage of query (106 bits)
4h5fA Crystal structure of an amino acid abc transporter substrate-binding protein from streptococcus pneumoniae canada mdr_19a bound to l- arginine, form 1
34% identity, 88% coverage of query (106 bits)
4i62A / A0A0H2ZN67 1.05 angstrom crystal structure of an amino acid abc transporter substrate-binding protein abpa from streptococcus pneumoniae canada mdr_19a bound to l-arginine
31% identity, 90% coverage of query (104 bits)
TcyJ / b1920 cystine ABC transporter periplasmic binding protein (EC 7.4.2.12) from Escherichia coli K-12 substr. MG1655 (see 12 papers)
tcyJ / P0AEM9 cystine ABC transporter periplasmic binding protein (EC 7.4.2.12) from Escherichia coli (strain K12) (see 13 papers)
TCYJ_ECOLI / P0AEM9 L-cystine-binding protein TcyJ; CBP; Protein FliY; Sulfate starvation-induced protein 7; SSI7 from Escherichia coli (strain K12) (see 6 papers)
TC 3.A.1.3.10 / P0AEM9 Cystine-binding periplasmic protein FLIY aka CysX aka B1920, component of Cystine/cysteine/diaminopimelate transporter, CysXYZ; these proteins are also designated FliY/YecS/YecC from Escherichia coli (see 7 papers)
32% identity, 97% coverage of query (102 bits)
2y7iA / Q8ZKA9 Structural basis for high arginine specificity in salmonella typhimurium periplasmic binding protein stm4351. (see paper)
31% identity, 86% coverage of query (100 bits)
PS417_21745 ABC transporter for L-Arginine, substrate-binding component from Pseudomonas simiae WCS417
34% identity, 71% coverage of query (99.4 bits)
Build an alignment for BWI76_RS14445 and 51 homologs with ≥ 30% identity
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PP_3593 L-lysine and D-lysine ABC transporter, substrate-binding component from Pseudomonas putida KT2440
29% identity, 84% coverage of query (99.4 bits)
GLNH_BACSU / O34563 ABC transporter glutamine-binding protein GlnH from Bacillus subtilis (strain 168) (see paper)
33% identity, 91% coverage of query (98.6 bits)
HISJ_CAMJE / Q46125 Probable histidine-binding protein; HBP; p29 from Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168) (see paper)
29% identity, 93% coverage of query (95.5 bits)
YXEM_BACSU / P54952 Probable amino-acid-binding protein YxeM from Bacillus subtilis (strain 168) (see 2 papers)
30% identity, 88% coverage of query (94.7 bits)
5eyfB / Q3XZW5 Crystal structure of solute-binding protein from enterococcus faecium with bound glutamate
36% identity, 78% coverage of query (93.2 bits)
5lomB / Q7D447 Crystal structure of the pbp soca from agrobacterium tumefaciens c58 in complex with dfg at 1.5 a resolution (see paper)
30% identity, 84% coverage of query (85.9 bits)
5l9oB Crystal structure of agrobacterium tumefaciens c58 strain pbp soca in complex with glucopine
30% identity, 84% coverage of query (85.9 bits)
5l9oA Crystal structure of agrobacterium tumefaciens c58 strain pbp soca in complex with glucopine
30% identity, 84% coverage of query (85.9 bits)
3k4uE / Q7MAG0 Crystal structure of putative binding component of abc transporter from wolinella succinogenes dsm 1740 complexed with lysine
28% identity, 87% coverage of query (84.3 bits)
5otcA Structure of the periplasmic binding protein (pbp) noct from agrobacterium tumefaciens c58 in complex with noroctopinic acid.
29% identity, 87% coverage of query (84.0 bits)
5ovzA / P35120 High resolution structure of the pbp noct in complex with nopaline (see paper)
29% identity, 87% coverage of query (83.6 bits)
5otaA Structure of the periplasmic binding protein (pbp) noct from agrobacterium tumefaciens c58 in complex with octopinic acid
29% identity, 87% coverage of query (83.6 bits)
5ot9A Structure of the periplasmic binding protein (pbp) noct from a.Tumefaciens c58 in complex with histopine.
29% identity, 87% coverage of query (83.6 bits)
4powA Structure of the pbp noct in complex with pyronopaline
29% identity, 87% coverage of query (83.6 bits)
5itoA Structure of the periplasmic binding protein m117n-noct from a. Tumefaciens in complex with octopine
29% identity, 87% coverage of query (83.6 bits)
8gtuA / C6XGT2 Crystal structure of putative amino acid binding periplasmic abc transporter protein from candidatus liberibacter asiaticus in complex with clidinium (see paper)
30% identity, 89% coverage of query (83.2 bits)
8gu1A Crystal structure of putative amino acid binding periplasmic abc transporter protein from candidatus liberibacter asiaticus in complex with pimozide
30% identity, 87% coverage of query (82.0 bits)
6aalA Crystal structure of putative amino acid binding periplasmic abc transporter protein from candidatus liberibacter asiaticus in complex with arginine
30% identity, 87% coverage of query (82.0 bits)
6a80A Crystal structure of putative amino acid binding periplasmic abc transporter protein from candidatus liberibacter asiaticus in complex with cystine
30% identity, 87% coverage of query (82.0 bits)
3vv5A Crystal structure of ttc0807 complexed with (s)-2-aminoethyl-l- cysteine (aec)
28% identity, 88% coverage of query (79.7 bits)
3vvfA Crystal structure of ttc0807 complexed with arginine
28% identity, 88% coverage of query (79.7 bits)
3vveA Crystal structure of ttc0807 complexed with lysine
28% identity, 88% coverage of query (79.7 bits)
3vvdA / Q72JG5 Crystal structure of ttc0807 complexed with ornithine (see paper)
28% identity, 88% coverage of query (79.7 bits)
4ohnA / A0A0H2UKY8 Crystal structure of an abc uptake transporter substrate binding protein from streptococcus pneumoniae with bound histidine
26% identity, 88% coverage of query (78.6 bits)
3tqlA / Q83E49 Structure of the amino acid abc transporter, periplasmic amino acid- binding protein from coxiella burnetii. (see paper)
28% identity, 88% coverage of query (76.3 bits)
6h20A Glnh bound to asn, mycobacterium tuberculosis
26% identity, 90% coverage of query (76.3 bits)
6h1uA Glnh bound to asp, mycobacterium tuberculosis
26% identity, 90% coverage of query (76.3 bits)
6h2tA / P96257 Glnh bound to glu, mycobacterium tuberculosis (see paper)
26% identity, 90% coverage of query (76.3 bits)
3i6vA / Q5LTV6 Crystal structure of a periplasmic his/glu/gln/arg/opine family- binding protein from silicibacter pomeroyi in complex with lysine
28% identity, 88% coverage of query (75.9 bits)
5orgA / P0A4F8 Structure of the periplasmic binding protein (pbp) occj from a. Tumefaciens b6 in complex with octopine. (see paper)
25% identity, 89% coverage of query (75.5 bits)
3oelA Crystal structure of glun2d ligand-binding core in complex with d- glutamate
25% identity, 84% coverage of query (66.2 bits)
3oekA / Q62645 Crystal structure of glun2d ligand-binding core in complex with l- aspartate (see paper)
25% identity, 79% coverage of query (66.2 bits)
4jwyA Glun2d ligand-binding core in complex with propyl-nhp5g
25% identity, 79% coverage of query (65.9 bits)
3oemA Crystal structure of glun2d ligand-binding core in complex with n- methyl-d-aspartate
25% identity, 79% coverage of query (65.9 bits)
7yfhB Structure of the rat glun1-glun2c nmda receptor in complex with glycine, glutamate and (r)-pyd-106
25% identity, 79% coverage of query (64.3 bits)
7yfgB / Q00961 Structure of the rat glun1-glun2c nmda receptor in complex with glycine and glutamate (major class in asymmetry) (see paper)
25% identity, 79% coverage of query (64.3 bits)
4gvoA / Q8Y4T3 Putative l-cystine abc transporter from listeria monocytogenes
28% identity, 87% coverage of query (63.5 bits)
1iitA Glur0 ligand binding core complex with l-serine
26% identity, 76% coverage of query (60.5 bits)
1ii5A / P73797 Crystal structure of the glur0 ligand binding core complex with l- glutamate (see paper)
26% identity, 76% coverage of query (60.5 bits)
2rc9A / Q9R1M7 Crystal structure of the nr3a ligand binding core complex with acpc at 1.96 angstrom resolution (see paper)
24% identity, 83% coverage of query (60.5 bits)
2rc8A Crystal structure of the nr3a ligand binding core complex with d- serine at 1.45 angstrom resolution
24% identity, 83% coverage of query (60.5 bits)
2rc7A Crystal structure of the nr3a ligand binding core complex with glycine at 1.58 angstrom resolution
24% identity, 83% coverage of query (60.5 bits)
3oenA / Q62645 Crystal structure of glun2d ligand-binding core in complex with l- glutamate (see paper)
24% identity, 79% coverage of query (59.7 bits)
2ylnA / Q5F9M1 Crystal structure of the l-cystine solute receptor of neisseria gonorrhoeae in the closed conformation (see paper)
24% identity, 88% coverage of query (58.5 bits)
6detA / S3MDF0 The crystal structure of tv2483 bound to l-arginine (see paper)
24% identity, 89% coverage of query (57.8 bits)
6uzgB Crystal structure of glun1/glun2a-4m mutant ligand-binding domain in complex with glycine and homoquinolinic acid
23% identity, 78% coverage of query (57.0 bits)
8bn5B / Q9ULK0 Crystal structure of the ligand-binding domain (lbd) of human iglur delta-1 (glud1) in complex with gaba (see paper)
27% identity, 81% coverage of query (57.0 bits)
8bn2A Crystal structure of the ligand-binding domain (lbd) of human iglur delta-1 (glud1) in complex with d-serine
27% identity, 81% coverage of query (56.6 bits)
8e96D / O15399 Glycine and glutamate bound human glun1a-glun2d nmda receptor (see paper)
22% identity, 79% coverage of query (55.8 bits)
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