Searching for up to 100 curated homologs for BWI76_RS15105 FitnessBrowser__Koxy:BWI76_RS15105 (504 a.a.)
Found high-coverage hits (≥70%) to 33 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
pheA1(2) / CDU26669.1 phenol hydroxylase, PheA1(2) from Rhodococcus opacus (see paper)
63% identity, 96% coverage of query (687 bits)
Q0SDR7 phenol 2-monooxygenase (FADH2) (EC 1.14.14.20) from Rhodococcus jostii (see paper)
62% identity, 96% coverage of query (681 bits)
A7LCL0 phenol 2-monooxygenase (NADH) (subunit 2/2) (EC 1.14.13.244); phenol 2-monooxygenase (FADH2) (EC 1.14.14.20) from Rhodococcus erythropolis (see 2 papers)
62% identity, 96% coverage of query (678 bits)
A0A069AW73 phenol 2-monooxygenase (FADH2) (EC 1.14.14.20) from Rhodococcus opacus (see paper)
pheA1(1) / CDU26676.1 phenol hydroxylase, PheA1(1) from Rhodococcus opacus (see paper)
61% identity, 96% coverage of query (663 bits)
nphA1 / Q8RQQ0 4-nitrophenol 2-monooxygenase oxygenase component (EC 1.14.13.29) from Rhodococcus sp. (see 2 papers)
NPHA1_RHOSO / Q8RQQ0 4-nitrophenol 2-monooxygenase, oxygenase component; 4-nitrophenol hydroxylase; 4-NP hydroxylase; Two-component 4-nitrophenol hydroxylase; EC 1.14.13.29 from Rhodococcus sp. (see 2 papers)
Q8RQQ0 4-nitrophenol 2-monooxygenase (EC 1.14.13.29) from Rhodococcus sp. PN1 (see paper)
62% identity, 97% coverage of query (654 bits)
Q2EYY8 unspecific monooxygenase (EC 1.14.14.1) from Saccharothrix espanaensis (see paper)
61% identity, 97% coverage of query (654 bits)
SGCC_STRGL / Q8GMG6 (3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase; Antibiotic C-1027 biosynthesis two-component monooxygenase system, oxygenase component; EC 1.14.14.15 from Streptomyces globisporus (see 3 papers)
Q8GMG6 (3S)-3-amino-3-(3-chloro-4-hydroxyphenyl)propanoyl-[peptidyl-carrier protein SgcC2] monooxygenase (subunit 1/2) (EC 1.14.14.15) from Streptomyces globisporus (see paper)
61% identity, 97% coverage of query (652 bits)
HPAB_PSEAE / Q9HWT7 4-hydroxyphenylacetate 3-monooxygenase oxygenase component; HPA 3-monooxygenase oxygenase component; p-hydroxyphenylacetate 3-hydroxylase large component; HPAH large component; EC 1.14.14.9 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 2 papers)
Q9HWT7 4-hydroxyphenylacetate 3-monooxygenase (subunit 2/2) (EC 1.14.14.9) from Pseudomonas aeruginosa (see paper)
53% identity, 98% coverage of query (555 bits)
6qyiB / Q57160 Structure of hpab from e.Coli in complex with fad (see paper)
53% identity, 96% coverage of query (548 bits)
6eb0C Structure of 4-hydroxyphenylacetate 3-monooxygenase (hpab), oxygenase component from escherichia coli
53% identity, 96% coverage of query (548 bits)
6b1bA Structure of 4-hydroxyphenylacetate 3-monooxygenase (hpab), oxygenase component from escherichia coli mutant xs6 (apo enzyme)
53% identity, 96% coverage of query (548 bits)
6qyhB Structure of apo hpab from e.Coli
53% identity, 96% coverage of query (547 bits)
hpaB / Q57160 4-coumarate 3-monooxygenase (EC 1.14.14.9) from Escherichia coli (see 9 papers)
HPAB_ECOLX / Q57160 4-hydroxyphenylacetate 3-monooxygenase oxygenase component; 4-HPA 3-hydroxylase; 4-HPA 3-monooxygenase large component; EC 1.14.14.9 from Escherichia coli (see paper)
Q57160 4-hydroxyphenylacetate 3-monooxygenase (EC 1.14.14.9) from Escherichia coli (see paper)
hpaB / CAA82321.1 4-hydroxyphenylacetic hydroxylase from Escherichia coli (see 3 papers)
hpaB / CAA86048.1 component B of the 4HPA-hydroxylase from Escherichia coli (see 2 papers)
52% identity, 96% coverage of query (542 bits)
pheA1 / Q9LAG3 phenol 2-monooxygenase (FADH2) monomer (EC 1.14.14.20) from Parageobacillus thermoglucosidasius (see paper)
Q9LAG3 phenol 2-monooxygenase (FADH2) (EC 1.14.14.20) from Parageobacillus thermoglucosidasius (see 3 papers)
51% identity, 97% coverage of query (525 bits)
pvcC / O30372 paerucumarin synthase from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
42% identity, 97% coverage of query (405 bits)
RHA1_ro03853 / Q0S9Y3 pyrrole-2-carboxylate monooxygenase subunit (EC 1.14.13.130) from Rhodococcus jostii (strain RHA1) (see paper)
33% identity, 89% coverage of query (252 bits)
GTNG_3160 / A4IT51 anthranilate hydroxylase (EC 1.14.14.8) from Geobacillus thermodenitrificans (strain NG80-2) (see paper)
HPAH_GEOTN / A4IT51 Anthranilate 3-monooxygenase oxygenase component; 4-hydroxyphenylacetate 3-monooxygenase oxygenase component; 4 HPA 3-hydroxylase; Anthranilate 3-hydroxylase; Anthranilate hydroxylase; EC 1.14.14.8; EC 1.14.14.9 from Geobacillus thermodenitrificans (strain NG80-2) (see paper)
32% identity, 89% coverage of query (242 bits)
HPAB_THET8 / Q5SJP8 4-hydroxyphenylacetate 3-monooxygenase oxygenase component; 4-HPA 3-hydroxylase; 4-HPA 3-monooxygenase large component; EC 1.14.14.9 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
Q5SJP8 4-hydroxyphenylacetate 3-monooxygenase (EC 1.14.14.9) from Thermus thermophilus (see 2 papers)
33% identity, 89% coverage of query (238 bits)
2yyjA / Q5SJP8 Crystal structure of the oxygenase component (hpab) of 4- hydroxyphenylacetate 3-monooxygenase complexed with fad and 4- hydroxyphenylacetate (see paper)
33% identity, 89% coverage of query (237 bits)
AAur_0618 / A1R2G2 pyrrole-2-carboxylate monooxygenase monomer (EC 1.14.13.130) from Paenarthrobacter aurescens (strain TC1) (see paper)
31% identity, 90% coverage of query (235 bits)
HPAH_GEOP9 / Q4L1M7 4-hydroxyphenylacetate 3-monooxygenase oxygenase component; 4-HPA 3-hydroxylase; 4-hydroxyphenylacetate-3-hydroxylase; EC 1.14.14.9 from Geobacillus sp. (strain PA-9) (see paper)
Q4L1M7 4-hydroxyphenylacetate 3-monooxygenase (EC 1.14.14.9) from Geobacillus sp. (see paper)
30% identity, 89% coverage of query (214 bits)
Build an alignment for BWI76_RS15105 and 21 homologs with ≥ 30% identity
Or download the sequences
npcA / Q6F4M8 4-nitrophenol 2-monooxygenase hydroxylase component (EC 1.14.13.29; EC 1.14.13.166) from Rhodococcus opacus (see paper)
NPCA_RHOOP / Q6F4M8 4-nitrophenol 4-monooxygenase/4-nitrocatechol 2-monooxygenase, oxygenase component; 4-NP/4-NCA monooxygenase; PNP monooxygenase; EC 1.14.13.166; EC 1.14.13.29 from Rhodococcus opacus (Nocardia opaca) (see 2 papers)
Q6F4M8 4-nitrocatechol 4-monooxygenase (subunit 2/2) (EC 1.14.13.166) from Lysinibacillus sphaericus (see paper)
npcA / BAD30042.1 oxygenase component of 4-NP monooxygenase from Rhodococcus opacus (see paper)
27% identity, 94% coverage of query (151 bits)
tcpA / Q471I2 2,4,6-trichlorophenol monooxygenase (EC 1.14.14.173) from Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (see 3 papers)
TCPA_CUPPJ / Q471I2 2,4,6-trichlorophenol monooxygenase; 2,4,6-TCP monooxygenase; TCP-MO; FADH(2)-utilizing monooxygenase TcpA; EC 1.14.14.173 from Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator (strain JMP 134)) (see 5 papers)
27% identity, 92% coverage of query (141 bits)
tftD / O87009 chlorophenol-4-monooxygenase from Burkholderia cepacia (see 4 papers)
TFTD_BURCE / O87009 FADH(2)-dependent monooxygenase TftD; Chlorophenol-4-monooxygenase component 2; Two component enzyme D; EC 1.14.14.- from Burkholderia cepacia (Pseudomonas cepacia) (see 2 papers)
27% identity, 89% coverage of query (139 bits)
7e8pD / Q53008 Crystal structure of a flavin-dependent monooxygenase hada wild type complexed with reduced fad and 4-nitrophenol (see paper)
26% identity, 95% coverage of query (138 bits)
A7YVV2 4-nitrocatechol 4-monooxygenase (EC 1.14.13.166); 4-nitrophenol 2-monooxygenase (EC 1.14.13.29) from Arthrobacter sp. (see 2 papers)
25% identity, 88% coverage of query (135 bits)
tcpA / L7VFL7 3,5,6-trichloro-2-pyridinol monooxygenase (EC 1.14.14.172) from Ralstonia sp. T6 (see 3 papers)
L7VFL7 3,5,6-trichloropyridin-2-ol monooxygenase (EC 1.14.14.172) from Ralstonia sp. T6 (see paper)
26% identity, 92% coverage of query (134 bits)
phzO / Q9F0I2 2-hydroxyphenazine-1-carboxylate monooxygenase from Pseudomonas chlororaphis subsp. aureofaciens (see paper)
25% identity, 92% coverage of query (132 bits)
Nmar_0207 / A9A1Y2 4-hydroxybutanoyl-CoA dehydratase (EC 4.2.1.120) from Nitrosopumilus maritimus (strain SCM1) (see paper)
25% identity, 86% coverage of query (113 bits)
6vjrA / A9A1Y2 Oxygen tolerant archeal 4hydroxybutyrylcoa dehydratase (4hbd) from n. Maritimus
25% identity, 85% coverage of query (111 bits)
hbd / A4YGC7 4-hydroxybutyryl-CoA dehydratase (EC 4.2.1.120) from Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) (see 3 papers)
A4YGC7 4-hydroxybutanoyl-CoA dehydratase (EC 4.2.1.120) from Metallosphaera sedula (see paper)
21% identity, 86% coverage of query (77.8 bits)
B1YBY6 4-hydroxybutanoyl-CoA dehydratase (EC 4.2.1.120) from Pyrobaculum neutrophilum (see paper)
21% identity, 88% coverage of query (73.6 bits)
A8AA25 4-hydroxybutanoyl-CoA dehydratase (EC 4.2.1.120) from Ignicoccus hospitalis (see paper)
22% identity, 84% coverage of query (66.6 bits)
Or start over
Lawrence Berkeley National Laboratory