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Searching for up to 100 curated homologs for BWI76_RS15490 FitnessBrowser__Koxy:BWI76_RS15490 (487 a.a.)

Found high-coverage hits (≥70%) to 16 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

4im7A / A0A0H2V7F2 Crystal structure of fructuronate reductase (ydfi) from e. Coli cft073 (efi target efi-506389) complexed with nadh and d-mannonate
    79% identity, 99% coverage of query (803 bits)

YdfI / b1542 putative oxidoreductase YdfI from Escherichia coli K-12 substr. MG1655 (see 2 papers)
    79% identity, 99% coverage of query (799 bits)

UxuB / b4323 D-mannonate oxidoreductase (EC 1.1.1.57) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
uxuB / P39160 D-mannonate oxidoreductase (EC 1.1.1.57) from Escherichia coli (strain K12) (see 4 papers)
    59% identity, 97% coverage of query (566 bits)

YeiQ / b2172 putative oxidoreductase YeiQ from Escherichia coli K-12 substr. MG1655 (see 2 papers)
    58% identity, 95% coverage of query (559 bits)

DSF1_YEAST / P0CX08 Mannitol dehydrogenase DSF1; Deletion suppressor of MPT5 mutation protein 1; EC 1.1.1.67 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
MAN2_YEAST / P0CX09 Mannitol dehydrogenase 2; EC 1.1.1.67 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    41% identity, 96% coverage of query (344 bits)

O08355 mannitol 2-dehydrogenase (EC 1.1.1.67) from Pseudomonas fluorescens (see 5 papers)
    39% identity, 98% coverage of query (337 bits)

1lj8A / O08355 Crystal structure of mannitol dehydrogenase in complex with NAD (see paper)
    39% identity, 98% coverage of query (337 bits)

1m2wA Pseudomonas fluorescens mannitol 2-dehydrogenase ternary complex with NAD and d-mannitol
    39% identity, 98% coverage of query (337 bits)

M2DH_ASPFU / Q4WQY4 Mannitol 2-dehydrogenase; M2DH; MDH; EC 1.1.1.67 from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see paper)
Q4WQY4 mannitol 2-dehydrogenase (EC 1.1.1.67) from Aspergillus fumigatus (see 2 papers)
    39% identity, 97% coverage of query (330 bits)

7rk5B / Q4WQY4 Mannitol-2-dehydrogenase bound to nadh from aspergillus fumigatus
    39% identity, 97% coverage of query (328 bits)

Q9KWR5 L-iditol 2-dehydrogenase (EC 1.1.1.14) from Gluconobacter oxydans (see paper)
    39% identity, 85% coverage of query (304 bits)

sr / BAB83933.1 L-sorbose reductase from Gluconobacter oxydans (see paper)
    36% identity, 98% coverage of query (303 bits)

R9UHL6 mannitol 2-dehydrogenase (EC 1.1.1.67) from Saccharina japonica (see paper)
    37% identity, 98% coverage of query (292 bits)

Build an alignment

Build an alignment for BWI76_RS15490 and 13 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

uxuB / Q9WXS3 D-mannonate dehydrogenase (EC 1.1.1.57) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
UXUB_THEMA / Q9WXS3 D-mannonate oxidoreductase; Fructuronate reductase; Mannonate dehydrogenase; EC 1.1.1.57 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
    27% identity, 89% coverage of query (136 bits)

CA265_RS19880 Altronate oxidoreductase (EC 1.1.1.58) from Pedobacter sp. GW460-11-11-14-LB5
    26% identity, 85% coverage of query (117 bits)

UxaB / b1521 tagaturonate reductase (EC 1.1.1.58) from Escherichia coli K-12 substr. MG1655 (see 11 papers)
uxaB / P0A6L7 tagaturonate reductase (EC 1.1.1.58) from Escherichia coli (strain K12) (see 10 papers)
    24% identity, 82% coverage of query (99.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory