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Searching for up to 100 curated homologs for BWI76_RS16110 FitnessBrowser__Koxy:BWI76_RS16110 (501 a.a.)

Found high-coverage hits (≥70%) to 21 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

YgjC / b3063 L-tartrate:succinate antiporter from Escherichia coli K-12 substr. MG1655
ttdT / P39414 L-tartrate:succinate antiporter from Escherichia coli (strain K12) (see 5 papers)
TTDT_ECOLI / P39414 L-tartrate/succinate antiporter; Tartrate carrier; Tartrate transporter from Escherichia coli (strain K12) (see 3 papers)
TC 2.A.47.3.3 / P39414 L-tartrate:succinate antiporter, TtdT (YgjE). (also takes up meso and L-tartrate and succinate; does not transport D-tartrate) from Escherichia coli (see 8 papers)
ttdT / RF|NP_417535 L-tartrate/succinate antiporter from Escherichia coli K12 (see 8 papers)
    55% identity, 94% coverage of query (505 bits)

YbdS / b0612 citrate:succinate antiporter from Escherichia coli K-12 substr. MG1655 (see 3 papers)
citT / P0AE74 citrate:succinate antiporter from Escherichia coli (strain K12) (see 3 papers)
CITT_ECOLI / P0AE74 Citrate/succinate antiporter; Citrate carrier; Citrate transporter from Escherichia coli (strain K12) (see paper)
TC 2.A.47.3.2 / P0AE74 Citrate:succinate antiporter from Escherichia coli (see 4 papers)
    49% identity, 97% coverage of query (494 bits)

TC 2.A.47.3.4 / Q6D017 The pmf-dependent citrate uptake system, Cit1 from Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum) (see paper)
    37% identity, 94% coverage of query (279 bits)

DIT21_ARATH / Q9FMF7 Dicarboxylate transporter 2.1, chloroplastic; AtpDCT1; Glutamate/malate translocator from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    36% identity, 93% coverage of query (273 bits)

YbhI / b0770 putative tricarboxylate transporter from Escherichia coli K-12 substr. MG1655 (see 3 papers)
    35% identity, 97% coverage of query (261 bits)

DIT1_SPIOL / Q41364 Dicarboxylate transporter 1, chloroplastic; SODIT1; 2-oxoglutarate/malate translocator from Spinacia oleracea (Spinach) (see 2 papers)
TC 2.A.47.3.1 / Q41364 2-oxoglutarate:malate antiporter (SodiTl) from Spinacia oleracea (Spinach) (see paper)
SODIT1 2-oxoglutarate/malate translocator from Spinacia oleracea (see paper)
SODiT1 / AAA68148.1 2-oxoglutarate/malate translocator from Spinacia oleracea (see paper)
    34% identity, 96% coverage of query (261 bits)

DIT1_ARATH / Q9LXV3 Dicarboxylate transporter 1, chloroplastic; 2-oxoglutarate/malate translocator 1; AtpOMT1 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
    34% identity, 96% coverage of query (256 bits)

DIT22_ARATH / Q9FMF8 Dicarboxylate transporter 2.2, chloroplastic; AtpDCT2 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    35% identity, 91% coverage of query (247 bits)

DIT2_SPIOL / Q8L7Z9 Dicarboxylate transporter 2, chloroplastic; Glutamate/malate translocator from Spinacia oleracea (Spinach) (see paper)
    36% identity, 95% coverage of query (246 bits)

Build an alignment

Build an alignment for BWI76_RS16110 and 9 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Additional hits (identity < 30%)

TC 2.A.47.1.11 / Q2FFH9 The Na+ (or Li+):dicarboxylate (2:1) symporter, SdcS (catalyzes succinate:succinate antiport as well as electroneutral symport in reconstituted proteoliposomes from Staphylococcus aureus (strain USA300) (see paper)
    22% identity, 87% coverage of query (67.8 bits)

SDCS_STAAM / Q99SX1 Sodium-dependent dicarboxylate transporter SdcS; Na(+)/dicarboxylate symporter from Staphylococcus aureus (strain Mu50 / ATCC 700699) (see 2 papers)
    22% identity, 87% coverage of query (67.0 bits)

TC 2.A.47.1.13 / Q65NC0 The Na+-coupled dicarboxylate (succinate; malate; fumarate) transporter, SdcL (transports aspartate, α-ketoglutarate and oxaloacetate with low affinity). Km for succinate, ~6 from Bacillus licheniformis (strain DSM 13 / ATCC 14580) (see 2 papers)
    26% identity, 73% coverage of query (66.6 bits)

TC 2.A.47.1.12 / A4QAL6 The aerobic dicarboxylate (succinate (Km, 30 μM), fumarate (Km, 79 from Corynebacterium glutamicum (strain R) (see paper)
    25% identity, 77% coverage of query (62.4 bits)

7jsjA / Q86YT5 Structure of the nact-pf2 complex (see paper)
    23% identity, 78% coverage of query (57.0 bits)

YBH4_SCHPO / O59712 Uncharacterized transporter C3B8.04c from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    24% identity, 79% coverage of query (48.9 bits)

TC 2.A.47.5.1 / Q58086 Hypothetical Na+ cotransporter, Orfl from Methanococcus jannaschii (see paper)
    21% identity, 75% coverage of query (48.9 bits)

S13A3_MOUSE / Q91Y63 Na(+)/dicarboxylate cotransporter 3; NaDC-3; mNaDC3; Na(+)-coupled carboxylate transporter 3; NaC3; Sodium-dependent high-affinity dicarboxylate transporter 2; Solute carrier family 13 member 3 from Mus musculus (Mouse) (see paper)
    22% identity, 74% coverage of query (48.1 bits)

TDT_ARATH / Q8LG88 Tonoplast dicarboxylate transporter; AttDT; Sodium-dicarboxylate cotransporter-like; AtSDAT; Vacuolar malate transporter from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 2.A.47.1.6 / Q8LG88 The tonoplast dicarboxylate (malate) transporter, AtDCT (see 3 papers)
TDT / GB|BAA96091.1 tonoplast dicarboxylate transporter from Arabidopsis thaliana (see paper)
    22% identity, 76% coverage of query (48.1 bits)

6okzB Structure of vcindy bound to fumarate
    24% identity, 74% coverage of query (45.4 bits)

7t9gA / Q9KNE0 Structure of vcindy-na+ (see paper)
    24% identity, 74% coverage of query (45.1 bits)

6wtxA Structure of vcindy in complex with terephthalate
    24% identity, 74% coverage of query (45.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory