Searching for up to 100 curated homologs for BWI76_RS16230 FitnessBrowser__Koxy:BWI76_RS16230 (241 a.a.)
Found high-coverage hits (≥70%) to 100 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
YdgB / b1606 dihydromonapterin reductase (EC 1.5.1.50; EC 1.5.1.3) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
folM / P0AFS3 dihydromonapterin reductase (EC 1.5.1.50; EC 1.5.1.3) from Escherichia coli (strain K12) (see 6 papers)
FOLM_ECOLI / P0AFS3 Dihydromonapterin reductase; H(2)-MPt reductase; Dihydrofolate reductase; DHFR; EC 1.5.1.50; EC 1.5.1.3 from Escherichia coli (strain K12) (see 2 papers)
P0AFS3 dihydromonapterin reductase (EC 1.5.1.50) from Escherichia coli (see 3 papers)
folM / RF|NP_416123 dihydrofolate reductase folM; EC 1.5.1.3 from Escherichia coli K12 (see 4 papers)
78% identity, 100% coverage of query (388 bits)
Build an alignment for BWI76_RS16230 and 1 homologs with ≥ 30% identity
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pruA / Q7CZX3 dihydropterin reductase monomer (EC 1.5.1.33; EC 1.5.1.50) from Agrobacterium fabrum (strain C58 / ATCC 33970) (see 2 papers)
27% identity, 98% coverage of query (90.5 bits)
5bt9C / A9MA73 Crystal structure of folm alternative dihydrofolate reductase 1 from brucella canis complexed with NADP (see paper)
29% identity, 97% coverage of query (89.4 bits)
NR_NARAP / A0A1C9II22 Noroxomaritidine/norcraugsodine reductase; NorRed; EC 1.1.1.- from Narcissus aff. pseudonarcissus MK-2014 (Daffodil) (see paper)
NR_NARPS / A0A1A9TAK5 Noroxomaritidine/norcraugsodine reductase; NorRed; EC 1.1.1.- from Narcissus pseudonarcissus (Daffodil) (see 2 papers)
5ff9B / A0A1A9TAK5 Noroxomaritidine/norcraugsodine reductase in complex with NADP+ and tyramine (see paper)
26% identity, 96% coverage of query (73.9 bits)
5fffA Noroxomaritidine/norcraugsodine reductase in complex with NADP+ and piperonal
26% identity, 96% coverage of query (73.9 bits)
4iqgD / Q12GY8 Crystal structure of bpro0239 oxidoreductase from polaromonas sp. Js666 in NADP bound form
30% identity, 96% coverage of query (73.6 bits)
2d1yA Crystal structure of tt0321 from thermus thermophilus hb8
29% identity, 96% coverage of query (70.5 bits)
4bo8A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 1-(2-amino-4- phenylimidazol-1-yl)-3-(2-fluorophenyl)urea at 2.7a resolution
30% identity, 99% coverage of query (67.4 bits)
4bo0A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 1-(4-methoxy-1- methylindazol-3-yl)-3-(2-methoxyphenyl)urea at 2.4a resolution
30% identity, 99% coverage of query (67.0 bits)
4bo2A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 1-(1-ethylbenzimidazol-2- yl)-3-(2-methoxyphenyl)urea at 1.9a resolution
30% identity, 99% coverage of query (67.0 bits)
Q5SLC4 aldose 1-dehydrogenase (NAD+) (EC 1.1.1.121) from Thermus thermophilus (see paper)
28% identity, 95% coverage of query (66.2 bits)
Q4AE87 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Pseudomonas sp. (see paper)
fabG / BAE19680.1 3-oxoacyl-(acyl-carrier-protein) reductase from Pseudomonas sp. 61-3 (see paper)
29% identity, 98% coverage of query (65.5 bits)
4bnzA Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 1-methyl-n-phenylindole- 3-carboxamide at 2.5a resolution
30% identity, 98% coverage of query (65.5 bits)
4bo9A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 5-(2-(furan-2-ylmethoxy) phenyl)-2-phenyltetrazole at 2.9a resolution
30% identity, 99% coverage of query (65.5 bits)
3bmoA Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (compound ax4)
27% identity, 96% coverage of query (65.1 bits)
fabG / D4YGY5 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Aerococcus viridans (strain ATCC 11563 / DSM 20340 / CCUG 4311 / JCM 20461 / NBRC 12219 / NCTC 8251 / M1) (see paper)
25% identity, 98% coverage of query (64.7 bits)
2qhxC Structure of pteridine reductase from leishmania major complexed with a ligand
26% identity, 96% coverage of query (64.3 bits)
O54438 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) from Pseudomonas aeruginosa (see paper)
30% identity, 98% coverage of query (63.9 bits)
4bo6A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 2,3-dihydroindol-1-yl-(2- thiophen-3-yl-1,3-thiazol-4-yl)methanone at 2.8a resolution
30% identity, 99% coverage of query (63.9 bits)
4bo4C / O54438 Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with n-(2-methoxyphenyl)-3,4- dihydro-2h-quinoline-1-carboxamide at 2.7a resolution (see paper)
29% identity, 98% coverage of query (63.5 bits)
4ag3A Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with NADPH at 1.8a resolution
30% identity, 98% coverage of query (63.5 bits)
3bmqA Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (compound ax5)
27% identity, 96% coverage of query (63.5 bits)
4iinA Crystal structure of a putative 3-oxoacyl-[acyl-carrier protein]reductase from helicobacter pylori 26695 complexed with NAD+
26% identity, 97% coverage of query (63.2 bits)
TRN1_COCOF / A7DY56 Tropinone reductase; EC 1.1.1.206; EC 1.1.1.236 from Cochlearia officinalis (Common scurvygrass) (see paper)
A7DY56 tropinone reductase I (EC 1.1.1.206); tropinone reductase II (EC 1.1.1.236) from Cochlearia officinalis (see paper)
27% identity, 95% coverage of query (62.8 bits)
DECR2_HUMAN / Q9NUI1 Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]; pDCR; 2,4-dienoyl-CoA reductase 2; Short chain dehydrogenase/reductase family 17C member 1; EC 1.3.1.124 from Homo sapiens (Human) (see 2 papers)
Q9NUI1 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] (EC 1.3.1.124) from Homo sapiens (see paper)
28% identity, 96% coverage of query (62.4 bits)
4fc6B / Q9NUI1 Studies on dcr shed new light on peroxisomal beta-oxidation: crystal structure of the ternary complex of pdcr (see paper)
30% identity, 96% coverage of query (62.4 bits)
4fc7A Studies on dcr shed new light on peroxisomal beta-oxidation: crystal structure of the ternary complex of pdcr
28% identity, 96% coverage of query (62.4 bits)
4bo7A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with n-(2,3-dihydro-1h-inden- 5-yl)tetrazolo(1,5-b)pyridazin-6-amine at 2.6a resolution
29% identity, 98% coverage of query (62.4 bits)
4bo5A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with n-(2-chlorophenyl)-4- pyrrol-1-yl-1,3,5-triazin-2-amine at 2.6a resolution
29% identity, 99% coverage of query (62.4 bits)
2c7vC / O76290 Structure of trypanosoma brucei pteridine reductase (ptr1) in ternary complex with cofactor and the antifolate methotrexate (see paper)
26% identity, 96% coverage of query (61.6 bits)
A1IG83 (R)-aminopropanol dehydrogenase (EC 1.1.1.75) from Rhodococcus erythropolis (see paper)
30% identity, 98% coverage of query (61.6 bits)
6rxcD Leishmania major pteridine reductase 1 (lmptr1) in complex with inhibitor 4 (nmt-c0026)
26% identity, 96% coverage of query (61.6 bits)
8jfgA / G2M827 Crystal structure of 3-oxoacyl-acp reductase fabg in complex with NADP+ and 3-keto-octanoyl-acp from helicobacter pylori (see paper)
27% identity, 97% coverage of query (61.2 bits)
DCXR_CAEEL / Q21929 L-xylulose reductase; XR; Dicarbonyl/L-xylulose reductase; DCXR; Short-chain dehydrogenase 21; EC 1.1.1.10 from Caenorhabditis elegans (see 2 papers)
Q21929 L-xylulose reductase (EC 1.1.1.10) from Caenorhabditis elegans (see paper)
25% identity, 98% coverage of query (61.2 bits)
4bnyA Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 4-(2-phenylthieno(3,2-d) pyrimidin-4-yl)morpholine at 1.8a resolution
29% identity, 98% coverage of query (61.2 bits)
4bnxA Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 6-(4-(2-chloroanilino)- 1h-quinazolin-2-ylidene)cyclohexa-2, 4-dien-1-one at 2.3a resolution
29% identity, 98% coverage of query (61.2 bits)
1mxhA / Q8I814 Crystal structure of substrate complex of putative pteridine reductase 2 (ptr2) from trypanosoma cruzi (see paper)
27% identity, 95% coverage of query (60.8 bits)
4bnuA Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 2-phenyl-4-(1,2,4- triazol-4-yl)quinazoline at 2.0a resolution
29% identity, 98% coverage of query (60.8 bits)
5ha5D Crystal structure of an NAD-bound oxidoreductase from brucella ovis
27% identity, 97% coverage of query (60.5 bits)
5iz4A / Q13GL4 Crystal structure of a putative short-chain dehydrogenase/reductase from burkholderia xenovorans
27% identity, 95% coverage of query (60.5 bits)
3pk0B / A0QQJ6 Crystal structure of short-chain dehydrogenase/reductase sdr from mycobacterium smegmatis (see paper)
29% identity, 100% coverage of query (60.5 bits)
4bo3A Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 2-(3-(trifluoromethyl) anilino)pyridine-3-sulfonamide at 2.5a resolution
29% identity, 98% coverage of query (60.1 bits)
6rx5A Trypanosoma brucei ptr1 (tbptr1) in complex with inhibitor 1 (nmt- c0003)
27% identity, 96% coverage of query (60.1 bits)
4bntB Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (fabg) from pseudomonas aeruginosa in complex with 2-(trifluoromethyl)-1h- benzimidazole at 2.3a resolution
29% identity, 99% coverage of query (60.1 bits)
6rx6A Trypanosoma brucei ptr1 (tbptr1) in complex with inhibitor 4 (nmt- c0026)
26% identity, 96% coverage of query (59.7 bits)
6rx0A Trypanosoma brucei ptr1 (tbptr1) in complex with inhibitor 3 (nmt- c0013)
26% identity, 96% coverage of query (59.7 bits)
6howA Trypanosoma brucei ptr1 in complex with the triazine inhibitor 2a (f219).
26% identity, 96% coverage of query (59.7 bits)
6gexA Trypanosoma brucei ptr1 in complex with inhibitor 2h (f246)
26% identity, 96% coverage of query (59.7 bits)
6gdoA Trypanosoma brucei ptr1 in complex with inhibitor 2g (f240)
26% identity, 96% coverage of query (59.7 bits)
5k6aA Trypanosoma brucei pteridine reductase 1 (ptr1) in complex with compound 1
26% identity, 96% coverage of query (59.7 bits)
2x9nA High resolution structure of tbptr1 in complex with cyromazine
26% identity, 96% coverage of query (59.7 bits)
4clhA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 96% coverage of query (59.7 bits)
4cleA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 96% coverage of query (59.7 bits)
6gd0A Trypanosoma brucei ptr1 in complex with inhibitor 4g (f133)
27% identity, 96% coverage of query (59.7 bits)
7pxxA The crystal structure of leishmania major pteridine reductase 1 in complex with substrate folic acid
26% identity, 96% coverage of query (59.7 bits)
2qhxA Structure of pteridine reductase from leishmania major complexed with a ligand
26% identity, 96% coverage of query (59.7 bits)
3jq8A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6,7,7- trimethyl-7,8-dihydropteridine-2,4-diamine (dx3)
27% identity, 96% coverage of query (59.3 bits)
5jdcC Trypanosoma brucei ptr1 in complex with inhibitor np-13 (hesperetin)
27% identity, 96% coverage of query (59.3 bits)
6gcqA Trypanosoma brucei ptr1 in complex with inhibitor 2b (f192)
26% identity, 96% coverage of query (59.3 bits)
6gcpA Trypanosoma brucei ptr1 in complex with inhibitor 2d (f186)
26% identity, 96% coverage of query (59.3 bits)
6gckA Trypanosoma brucei ptr1 in complex with inhibitor 1e (f206)
26% identity, 96% coverage of query (59.3 bits)
4cm1A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 96% coverage of query (59.3 bits)
6geyA Trypanosoma brucei ptr1 in complex with inhibitor 4g (f125)
26% identity, 96% coverage of query (59.3 bits)
6gdpA Trypanosoma brucei ptr1 in complex with inhibitor 4l (f162)
26% identity, 96% coverage of query (59.3 bits)
5izcC / O76290 Trypanosoma brucei ptr1 in complex with inhibitor f032 (see paper)
26% identity, 96% coverage of query (58.9 bits)
5jdcA Trypanosoma brucei ptr1 in complex with inhibitor np-13 (hesperetin)
27% identity, 96% coverage of query (58.9 bits)
5jcxA Trypanosoma brucei ptr1 in complex with inhibitor np-29
27% identity, 96% coverage of query (58.9 bits)
5jcjA Trypanosoma brucei ptr1 in complex with inhibitor nmt-h037 (compound 7)
27% identity, 96% coverage of query (58.9 bits)
5izcA Trypanosoma brucei ptr1 in complex with inhibitor f032
27% identity, 96% coverage of query (58.9 bits)
4wcfA Trypanosoma brucei ptr1 in complex with inhibitor 9
27% identity, 96% coverage of query (58.9 bits)
4cmeA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 96% coverage of query (58.9 bits)
4cm9A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
27% identity, 96% coverage of query (58.9 bits)
3jqgA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6-[(4- methoxybenzyl)sulfanyl]pyrimidine-2,4-diamine (ax6)
27% identity, 96% coverage of query (58.9 bits)
3jqfA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 1,3,5- triazine-2,4,6-triamine (ax2)
27% identity, 96% coverage of query (58.9 bits)
3jqeA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-6-(4-methoxyphenyl)-4-oxo-4,7-dihydro-3h-pyrrolo[2,3- d]pyrimidine-5-carbonitrile (dx8)
27% identity, 96% coverage of query (58.9 bits)
3jqdA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-4-oxo-6-phenyl-4,7-dihydro-3h-pyrrolo[2,3-d]pyrimidine-5- carbonitrile (dx7)
27% identity, 96% coverage of query (58.9 bits)
3jqcA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-6-bromo-4-oxo-4,7-dihydro-3h-pyrrolo[2,3-d]pyrimidine-5- carbonitrile (ju2)
27% identity, 96% coverage of query (58.9 bits)
3jqbA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-5-(2-phenylethyl)-3,7-dihydro-4h-pyrrolo[2,3-d]pyrimidin-4-one (dx6)
27% identity, 96% coverage of query (58.9 bits)
3jqaA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-1,9-dihydro-6h-purine-6-thione (dx4)
27% identity, 96% coverage of query (58.9 bits)
3jq9A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2- amino-6-(1,3-benzodioxol-5-yl)-4-oxo-4,7-dihydro-3h-pyrrolo[2,3- d]pyrimidine-5-carbonitrile (ax1)
27% identity, 96% coverage of query (58.9 bits)
3jq7A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6- phenylpteridine-2,4,7-triamine (dx2)
27% identity, 96% coverage of query (58.9 bits)
3jq6A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 6,7- bis(1-methylethyl)pteridine-2,4-diamine (dx1)
27% identity, 96% coverage of query (58.9 bits)
3gn2A Structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor (ddd00066730)
27% identity, 96% coverage of query (58.9 bits)
2yhiA Trypanosoma brucei ptr1 in complex with inhibitor wh16
27% identity, 96% coverage of query (58.9 bits)
2wd8A Pteridine reductase 1 (ptr1) from trypanosoma brucei in complex with NADP and ddd00071204
27% identity, 96% coverage of query (58.9 bits)
2wd7A Pteridine reductase 1 (ptr1) from trypanosoma brucei in complex with NADP and ddd00066750
27% identity, 96% coverage of query (58.9 bits)
2vz0A Pteridine reductase 1 (ptr1) from trypanosoma brucei in complex with NADP and ddd00066641
27% identity, 96% coverage of query (58.9 bits)
7opjA Trypanosoma brucei ptr1 (tbptr1) in complex with pyrimethamine
26% identity, 96% coverage of query (58.9 bits)
6gd4A Trypanosoma brucei ptr1 in complex with inhibitor 4c (f188)
26% identity, 96% coverage of query (58.9 bits)
6gclA Trypanosoma brucei ptr1 in complex with inhibitor 3a (f020)
26% identity, 96% coverage of query (58.9 bits)
4wcdA Trypanosoma brucei ptr1 in complex with inhibitor 10
26% identity, 96% coverage of query (58.9 bits)
4cmkA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 96% coverage of query (58.9 bits)
4cm8A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 96% coverage of query (58.9 bits)
4clrA Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 96% coverage of query (58.9 bits)
2x9vA High resolution structure of tbptr1 with trimetrexate
26% identity, 96% coverage of query (58.9 bits)
5l42A Leishmania major pteridine reductase 1 (ptr1) in complex with compound 3
26% identity, 96% coverage of query (58.9 bits)
7xqmB / Q72LQ6 Indel-mutant short chain dehydrogenase bound to sah (see paper)
28% identity, 95% coverage of query (58.9 bits)
S5U393 7alpha-hydroxysteroid dehydrogenase (EC 1.1.1.159) from Comamonas testosteroni (see paper)
25% identity, 95% coverage of query (58.5 bits)
GMDH_GLUOX / Q5FPE5 Glucose 1-dehydrogenase; EC 1.1.1.119 from Gluconobacter oxydans (strain 621H) (Gluconobacter suboxydans) (see paper)
28% identity, 97% coverage of query (58.5 bits)
4cm7A Crystal structure of pteridine reductase 1 (ptr1) from trypanosoma brucei in ternary complex with cofactor and inhibitor
26% identity, 96% coverage of query (58.5 bits)
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Lawrence Berkeley National Laboratory