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Searching for up to 100 curated homologs for BWI76_RS16270 FitnessBrowser__Koxy:BWI76_RS16270 (466 a.a.)

Found high-coverage hits (≥70%) to 45 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

FumC / b1611 fumarase C (EC 4.2.1.2) from Escherichia coli K-12 substr. MG1655 (see 28 papers)
fumC / P05042 fumarase C (EC 4.2.1.2) from Escherichia coli (strain K12) (see 26 papers)
FUMC_ECOLI / P05042 Fumarate hydratase class II; Fumarase C; Aerobic fumarase; Iron-independent fumarase; EC 4.2.1.2 from Escherichia coli (strain K12) (see 8 papers)
    89% identity, 99% coverage of query (839 bits)

1fuoA / P05042 FumarasE C with bound citrate (see paper)
    89% identity, 98% coverage of query (828 bits)

1fuqA Fumarase with bound 3-trimethylsilylsuccinic acid
    89% identity, 98% coverage of query (828 bits)

1fupA Fumarase with bound pyromellitic acid
    89% identity, 98% coverage of query (828 bits)

Q13VI0 fumarate hydratase (EC 4.2.1.2) from Paraburkholderia xenovorans (see paper)
    74% identity, 98% coverage of query (682 bits)

fumC / O25883 fumarase (EC 4.2.1.2) from Helicobacter pylori (strain ATCC 700392 / 26695) (see paper)
    63% identity, 98% coverage of query (613 bits)

7c18B / Q65UJ3 Crystal structure of fumarasec from mannheimia succiniciproducens in complex with fumarate
    62% identity, 99% coverage of query (582 bits)

P55250 fumarate hydratase (EC 4.2.1.2) from Rhizopus arrhizus (see 2 papers)
    61% identity, 98% coverage of query (570 bits)

FUMH_PIG / P10173 Fumarate hydratase, mitochondrial; Fumarase; EC 4.2.1.2 from Sus scrofa (Pig) (see paper)
    61% identity, 98% coverage of query (568 bits)

FUM2 / Q9FI53 fumarase (EC 4.2.1.2) from Arabidopsis thaliana (see paper)
FUM2_ARATH / Q9FI53 Fumarate hydratase 2; AtFUM2; Fumarase 2; EC 4.2.1.2 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
Q9FI53 fumarate hydratase (EC 4.2.1.2) from Arabidopsis thaliana (see 4 papers)
    60% identity, 99% coverage of query (567 bits)

FUMH_RAT / P14408 Fumarate hydratase, mitochondrial; Fumarase; EC 4.2.1.2 from Rattus norvegicus (Rat) (see paper)
P14408 fumarate hydratase (EC 4.2.1.2) from Rattus norvegicus (see paper)
    60% identity, 98% coverage of query (563 bits)

FH / P07954 fumarate hydratase monomer (EC 4.2.1.2) from Homo sapiens (see 7 papers)
FUMH_HUMAN / P07954 Fumarate hydratase, mitochondrial; Fumarase; HsFH; EC 4.2.1.2 from Homo sapiens (Human) (see 10 papers)
P07954 fumarate hydratase (EC 4.2.1.2) from Homo sapiens (see 3 papers)
    61% identity, 98% coverage of query (562 bits)

7lubB / P07954 Crystal structure of recombinant human fumarase in complex with d-2- amino-3-phosphono-propionic acid (see paper)
    61% identity, 98% coverage of query (562 bits)

FUMH_MOUSE / P97807 Fumarate hydratase, mitochondrial; Fumarase; EF-3; EC 4.2.1.2 from Mus musculus (Mouse) (see 3 papers)
    60% identity, 98% coverage of query (561 bits)

A0A251UZF1 fumarate hydratase (EC 4.2.1.2) from Helianthus annuus (see paper)
    59% identity, 99% coverage of query (559 bits)

FUM1_ARATH / P93033 Fumarate hydratase 1, mitochondrial; AtFUM1; Fumarase 1; EC 4.2.1.2 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
P93033 fumarate hydratase (EC 4.2.1.2) from Arabidopsis thaliana (see 4 papers)
    61% identity, 99% coverage of query (556 bits)

A0A251UH44 fumarate hydratase (EC 4.2.1.2) from Helianthus annuus (see paper)
    58% identity, 99% coverage of query (556 bits)

FUMH_YEAST / P08417 Fumarate hydratase, mitochondrial; Fumarase; EC 4.2.1.2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 7 papers)
P08417 fumarate hydratase (EC 4.2.1.2) from Saccharomyces cerevisiae (see 2 papers)
    58% identity, 99% coverage of query (553 bits)

FUMC_RICPR / Q9ZCQ4 Fumarate hydratase class II; Fumarase C; Aerobic fumarase; Iron-independent fumarase; EC 4.2.1.2 from Rickettsia prowazekii (strain Madrid E) (see paper)
Q9ZCQ4 fumarate hydratase (EC 4.2.1.2) from Rickettsia prowazekii (see paper)
    57% identity, 99% coverage of query (550 bits)

FUMC_RHIME / Q92PB6 Fumarate hydratase class II; Fumarase C; Aerobic fumarase; Iron-independent fumarase; EC 4.2.1.2 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti)
    57% identity, 99% coverage of query (541 bits)

Q5SKT5 fumarate hydratase (EC 4.2.1.2) from Thermus thermophilus (see paper)
    59% identity, 98% coverage of query (537 bits)

fumC / O84863 fumarate hydratase (EC 4.2.1.2) from Chlamydia trachomatis (strain D/UW-3/Cx) (see 4 papers)
    55% identity, 98% coverage of query (510 bits)

Q8NRN8 fumarate hydratase (EC 4.2.1.2) from Corynebacterium glutamicum (see 2 papers)
    49% identity, 96% coverage of query (414 bits)

FUMC_MYCTU / P9WN93 Fumarate hydratase class II; Fumarase C; Aerobic fumarase; Iron-independent fumarase; EC 4.2.1.2 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
P9WN93 fumarate hydratase (EC 4.2.1.2) from Mycobacterium tuberculosis (see paper)
    51% identity, 96% coverage of query (410 bits)

4adlA Crystal structures of rv1098c in complex with malate
    51% identity, 96% coverage of query (410 bits)

A5Y6J1 fumarate hydratase (EC 4.2.1.2) from Streptomyces thermovulgaris (see paper)
    50% identity, 98% coverage of query (408 bits)

4apbD / P9WN93 Crystal structure of mycobacterium tuberculosis fumarase (rv1098c) s318c in complex with fumarate (see paper)
    51% identity, 96% coverage of query (408 bits)

6s88A Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator n-(2-methoxy-5-((1,2,4,5-tetrahydro- 3h-benzo[d]azepin-3-yl)sulfonyl)phenyl)-2-(4-oxo-3,4- dihydrophthalazin-1-yl)acetamide
    49% identity, 96% coverage of query (386 bits)

6s7wA Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator n-(5-(azepan-1-ylsulfonyl)-2- methoxyphenyl)-2-(quinolin-4-yl)acetamide
    49% identity, 96% coverage of query (386 bits)

6s7sA Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator n-(2-methoxy-5-(n-phenylsulfamoyl) phenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
    49% identity, 96% coverage of query (386 bits)

6s7uA Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator n-(5-(azepan-1-ylsulfonyl)-2- methoxyphenyl)-2-(1h-indol-3-yl)acetamide
    49% identity, 96% coverage of query (384 bits)

6s7kA Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator n-(2-methoxy-5-(n-methylsulfamoyl) phenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
    49% identity, 96% coverage of query (384 bits)

6s43A Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator n-(5-(azocan-1-ylsulfonyl)-2- methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide
    49% identity, 96% coverage of query (384 bits)

6s7zA Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator n-(5-((3,4-dihydroisoquinolin-2(1h)- yl)sulfonyl)-2-methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl) acetamide
    49% identity, 96% coverage of query (383 bits)

Q9LCC6 aspartate ammonia-lyase (EC 4.3.1.1) from Bacillus sp. (in: Bacteria) (see 4 papers)
    41% identity, 98% coverage of query (382 bits)

3r6vG / Q9LCC6 Crystal structure of aspartase from bacillus sp. Ym55-1 with bound l- aspartate (see paper)
    41% identity, 98% coverage of query (382 bits)

3r6qA A triclinic-lattice structure of aspartase from bacillus sp. Ym55-1
    41% identity, 98% coverage of query (382 bits)

5f91A Fumarate hydratase of mycobacterium tuberculosis in complex with formate and allosteric modulator (n-(5-(azepan-1-ylsulfonyl)-2- methoxyphenyl)-2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetamide)
    48% identity, 96% coverage of query (372 bits)

FUMC2_PSEAE / Q51404 Fumarate hydratase class II 2; Fumarase C 2; Aerobic fumarase 2; Iron-independent fumarase 2; EC 4.2.1.2 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
    45% identity, 98% coverage of query (366 bits)

3oceA / Q2YLW1 Crystal structure of fumarate lyase:delta crystallin from brucella melitensis bound to cobalt
    43% identity, 94% coverage of query (352 bits)

Q0PC50 aspartate ammonia-lyase (EC 4.3.1.1) from Campylobacter jejuni (see paper)
    40% identity, 98% coverage of query (348 bits)

Q9HTD7 aspartate ammonia-lyase (EC 4.3.1.1) from Pseudomonas aeruginosa (see paper)
    43% identity, 92% coverage of query (346 bits)

6wngA / A0A077EBQ3 Crystal structure of an aspartate ammonia-lyase from elizabethkingia anophelis nuhp1
    41% identity, 98% coverage of query (346 bits)

AspA / b4139 aspartate ammonia-lyase (EC 4.3.1.1) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
aspA / P0AC38 aspartate ammonia-lyase (EC 4.3.1.1) from Escherichia coli (strain K12) (see paper)
ASPA_ECOLI / P0AC38 Aspartate ammonia-lyase; Aspartase; EC 4.3.1.1 from Escherichia coli (strain K12) (see paper)
P0AC38 aspartate ammonia-lyase (EC 4.3.1.1) from Escherichia coli (see 2 papers)
aspA / RF|NP_418562 aspartate ammonia-lyase from Escherichia coli K12 (see 3 papers)
    41% identity, 98% coverage of query (332 bits)

Build an alignment

Build an alignment for BWI76_RS16270 and 44 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Additional hits (identity < 30%)

2e9fB / Q5SLL0 Crystal structure of t.Th.Hb8 argininosuccinate lyase complexed with l-arginine
    24% identity, 85% coverage of query (56.2 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory