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Searching for up to 100 curated homologs for BWI76_RS16280 FitnessBrowser__Koxy:BWI76_RS16280 (392 a.a.)

Found high-coverage hits (≥70%) to 19 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

P25081 mannose-6-phosphate isomerase (EC 5.3.1.8) from Salmonella enterica subsp. enterica serovar Typhimurium (see paper)
    83% identity, 100% coverage of query (667 bits)

3h1mA / P25081 Crystal structure of mannose 6-phosphate isomerase (holo; zinc bound)
    83% identity, 100% coverage of query (664 bits)

3h1yA Crystal structure of mannose 6-phosphate isomerase from salmonella typhimurium bound to substrate (f6p)and metal atom (zn)
    83% identity, 100% coverage of query (663 bits)

Pmi / b1613 mannose-6-phosphate isomerase (EC 5.3.1.8) from Escherichia coli K-12 substr. MG1655 (see 12 papers)
manA / P00946 mannose-6-phosphate isomerase (EC 5.3.1.8) from Escherichia coli (strain K12) (see 10 papers)
    82% identity, 100% coverage of query (662 bits)

P00946 Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; EC 5.3.1.8 from Escherichia coli (strain K12)
    82% identity, 100% coverage of query (662 bits)

MPI_HUMAN / P34949 Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; EC 5.3.1.8 from Homo sapiens (Human) (see 8 papers)
    37% identity, 95% coverage of query (209 bits)

MPI_MOUSE / Q924M7 Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; EC 5.3.1.8 from Mus musculus (Mouse) (see paper)
    36% identity, 94% coverage of query (196 bits)

Q66WM4 mannose-6-phosphate isomerase (EC 5.3.1.8) from Aspergillus fumigatus (see paper)
    33% identity, 89% coverage of query (177 bits)

MPI_SCHPO / O43014 Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; EC 5.3.1.8 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    35% identity, 95% coverage of query (177 bits)

MPI_YEAST / P29952 Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; EC 5.3.1.8 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    31% identity, 94% coverage of query (175 bits)

manA mannose-6-phosphate isomerase; EC 5.3.1.8 from Emericella nidulans (see paper)
    32% identity, 97% coverage of query (169 bits)

G1E7A7 mannose-6-phosphate isomerase (EC 5.3.1.8) from Brassica rapa subsp. chinensis (see paper)
    30% identity, 99% coverage of query (166 bits)

PMI1 / Q9M884 mannose-6-phosphate isomerase 1 (EC 5.3.1.8) from Arabidopsis thaliana (see 2 papers)
MPI1_ARATH / Q9M884 Mannose-6-phosphate isomerase 1; Phosphohexomutase 1; Phosphomannose isomerase 1; PMI1; Protein MATERNAL EFFECT EMBRYO ARREST 31; EC 5.3.1.8 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9M884 mannose-6-phosphate isomerase (EC 5.3.1.8) from Arabidopsis thaliana (see paper)
    32% identity, 93% coverage of query (164 bits)

Q9FTR6 mannose-6-phosphate isomerase (EC 5.3.1.8) from Oryza sativa Japonica Group (see paper)
    32% identity, 94% coverage of query (163 bits)

MPI_CANAL / P34948 Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; EC 5.3.1.8 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see 2 papers)
P34948 mannose-6-phosphate isomerase (EC 5.3.1.8) from Candida albicans (see paper)
PMI1 / GI|557637 mannose-6-phosphate isomerase; EC 5.3.1.8 from Candida albicans (see 3 papers)
    36% identity, 73% coverage of query (162 bits)

5nw7A / P34948 Crystal structure of candida albicans phosphomannose isomerase in complex with inhibitor (see paper)
    36% identity, 73% coverage of query (162 bits)

E1ZPT8 mannose-6-phosphate isomerase (EC 5.3.1.8) from Chlorella variabilis (see paper)
    35% identity, 75% coverage of query (157 bits)

Q9GRS9 mannose-6-phosphate isomerase (EC 5.3.1.8) from Leishmania mexicana (see paper)
pmi / CAC17142.1 phosphomannose isomerase from Leishmania mexicana (see paper)
    32% identity, 89% coverage of query (157 bits)

Build an alignment

Build an alignment for BWI76_RS16280 and 18 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

MPI2_ARATH / Q9FZH5 Mannose-6-phosphate isomerase 2; Phosphohexomutase 2; Phosphomannose isomerase 2; PMI2; Protein DARK INDUCIBLE 9; EC 5.3.1.8 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    29% identity, 99% coverage of query (157 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory