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Searching for up to 100 curated homologs for BWI76_RS17240 FitnessBrowser__Koxy:BWI76_RS17240 (543 a.a.)

Found high-coverage hits (≥70%) to 84 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TC 3.A.1.5.1 / P06202 OppA aka STM1746, component of Oligopeptide porter (also takes up amino glycoside antibiotics such as kanamycin, streptomycin and neomycin as well as cell wall-derived peptides such as murein tripeptide). It transports substrate peptides of 2-5 amino acids with highest affinity for tripeptides. Also transports δ-aminolevulinic acid (ALA). [May be regulated by PTS Enzyme INtr-aspartokinase.] ATP-binding to OppDF may result in donation of peptide to OppBC and simultaneous release of OppA from Salmonella typhimurium (see 7 papers)
    89% identity, 100% coverage of query (1007 bits)

1b05A / P06202 Structure of oligo-peptide binding protein complexed with lys-cys-lys (see paper)
    90% identity, 95% coverage of query (991 bits)

2rkmA Structure of oppa complexed with lys-lys
    90% identity, 95% coverage of query (991 bits)

1olcA Oligo-peptide binding protein (oppa) complexed with lys-lys- lys-ala
    90% identity, 95% coverage of query (991 bits)

OppA / b1243 oligopeptide ABC transporter periplasmic binding protein (EC 7.4.2.6) from Escherichia coli K-12 substr. MG1655 (see 19 papers)
oppA / P23843 oligopeptide ABC transporter periplasmic binding protein (EC 7.4.2.6) from Escherichia coli (strain K12) (see 20 papers)
TC 3.A.1.5.41 / P23843 Periplasmic oligopeptide-binding protein, component of Oligopeptide transporter, OppABCDF/MppA/YgiS from Escherichia coli (strain K12)
oppA / GB|BAA14775.2 periplasmic oligopeptide-binding protein from Escherichia coli K12 (see 7 papers)
    86% identity, 100% coverage of query (984 bits)

3tcfA / P23843 Crystal structure of e. Coli oppa complexed with endogenous ligands (see paper)
    86% identity, 95% coverage of query (948 bits)

2z23A / A0A0H2W5P5 Crystal structure of y.Pestis oligo peptide binding protein oppa with tri-lysine ligand (see paper)
    80% identity, 95% coverage of query (874 bits)

Q5V9S2 ABC-type oligopeptide transporter (EC 7.4.2.6) from Vibrio fluvialis (see paper)
TC 3.A.1.5.22 / Q5V9S2 OppA, component of The peptide transporter OppA,B,C,D,F (influences biofilm formation; Lee et al., 2004). Similar to 3.A.1.5.1, OppA is similar to the Vibrio furnissii OppA that provides several functions: hemolysis, antibiotic resistance, and virulence from Vibrio fluvialis (see paper)
    53% identity, 98% coverage of query (592 bits)

Q0PRU9 ABC-type oligopeptide transporter (EC 7.4.2.6) from Vibrio furnissii (see paper)
    53% identity, 98% coverage of query (583 bits)

6dtgA / Q4QLH0 Crystal structure of haemophilus influenzae oppa complex with ylgangrgggs (see paper)
    55% identity, 95% coverage of query (581 bits)

YnaH / b1329 murein tripeptide ABC transporter periplasmic binding protein (EC 7.4.2.6) from Escherichia coli K-12 substr. MG1655 (see 10 papers)
mppA / P77348 murein tripeptide ABC transporter periplasmic binding protein (EC 7.4.2.6) from Escherichia coli (strain K12) (see 9 papers)
TC 3.A.1.5.1 / TC 3.A.1.5.41 / P77348 MppA aka B1329, component of Oligopeptide transporter, OppABCDF/MppA/YgiS from Escherichia coli (see 4 papers)
    49% identity, 99% coverage of query (518 bits)

3o9pA / P77348 The structure of the escherichia coli murein tripeptide binding protein mppa (see paper)
    50% identity, 94% coverage of query (505 bits)

YgiS / b3020 putative deoxycholate binding periplasmic protein from Escherichia coli K-12 substr. MG1655 (see 5 papers)
YGIS_ECOLI / Q46863 Probable deoxycholate-binding periplasmic protein YgiS from Escherichia coli (strain K12) (see paper)
TC 3.A.1.5.41 / Q46863 Probable deoxycholate-binding periplasmic protein YgiS, component of Oligopeptide transporter, OppABCDF/MppA/YgiS from Escherichia coli (strain K12)
    44% identity, 97% coverage of query (446 bits)

3zs6A / Q63ID0 The structural characterization of burkholderia pseudomallei oppa. (see paper)
    45% identity, 94% coverage of query (442 bits)

H7C7K8 ABC-type oligopeptide transporter (EC 7.4.2.6) from Borreliella burgdorferi (see paper)
TC 3.A.1.5.18 / O31315 OppA4, component of The oligopeptide transporter OppA1-5, B1, C1, DF (functions with five binding proteins of differing induction properties and peptide specificities; OppA1-3 are chromosomally encoded; OppA4 and 5 are plasmid encoded.) from Borrelia burgdorferi (Lyme disease spirochete) (see 2 papers)
    35% identity, 83% coverage of query (285 bits)

4gl8A / H7C7K8 X-ray crystal structure of a periplasmic oligopeptide-binding protein/oligopeptide abc transporter(oppaiv) from borrelia burgdorferi
    35% identity, 83% coverage of query (285 bits)

TC 3.A.1.5.18 / O54584 OppA2, component of The oligopeptide transporter OppA1-5, B1, C1, DF (functions with five binding proteins of differing induction properties and peptide specificities; OppA1-3 are chromosomally encoded; OppA4 and 5 are plasmid encoded.) from Borrelia burgdorferi (Lyme disease spirochete) (see 3 papers)
    34% identity, 88% coverage of query (285 bits)

8arnA / P24141 Crystal structure of the peptide binding protein, oppa, from bacillus subtilis in complex with an endogenous tetrapeptide (see paper)
    35% identity, 88% coverage of query (279 bits)

OPPA_BACSU / P24141 Oligopeptide-binding protein OppA; Stage 0 sporulation protein KA from Bacillus subtilis (strain 168) (see 5 papers)
    35% identity, 88% coverage of query (279 bits)

TC 3.A.1.5.18 / O51308 OppA3, component of The oligopeptide transporter OppA1-5, B1, C1, DF (functions with five binding proteins of differing induction properties and peptide specificities; OppA1-3 are chromosomally encoded; OppA4 and 5 are plasmid encoded.) from Borrelia burgdorferi (Lyme disease spirochete) (see paper)
    33% identity, 88% coverage of query (264 bits)

TC 3.A.1.5.18 / O51307 OppA1, component of The oligopeptide transporter OppA1-5, B1, C1, DF (functions with five binding proteins of differing induction properties and peptide specificities; OppA1-3 are chromosomally encoded; OppA4 and 5 are plasmid encoded.) from Borrelia burgdorferi (Lyme disease spirochete) (see paper)
    33% identity, 91% coverage of query (249 bits)

DPPE_BACSU / P26906 Dipeptide-binding protein DppE from Bacillus subtilis (strain 168) (see paper)
TC 3.A.1.5.2 / P26906 DppE aka DCIAE, component of Dipeptide porter. Also transports δ-aminolevulinic acid (ALA) and heme from Bacillus subtilis (see 3 papers)
    32% identity, 95% coverage of query (241 bits)

8ay0B / P26906 Crystal structure of the peptide binding protein dppe from bacillus subtilis in complex with murein tripeptide (see paper)
    32% identity, 90% coverage of query (238 bits)

TC 3.A.1.5.18 / O50927 OppA5, component of The oligopeptide transporter OppA1-5, B1, C1, DF (functions with five binding proteins of differing induction properties and peptide specificities; OppA1-3 are chromosomally encoded; OppA4 and 5 are plasmid encoded.) from Borrelia burgdorferi (Lyme disease spirochete) (see paper)
    30% identity, 96% coverage of query (227 bits)

6npoA / Q81YA8 Crystal structure of oligopeptide abc transporter from bacillus anthracis str. Ames (substrate-binding domain)
    31% identity, 90% coverage of query (209 bits)

5kztB / A0A0H3GJB6 Listeria monocytogenes oppa bound to peptide
    31% identity, 93% coverage of query (206 bits)

Build an alignment

Build an alignment for BWI76_RS17240 and 26 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

TC 3.A.1.5.19 / Q2FZR3 OppA, component of The major oligopeptide uptake porter, Opp-3 (of four paralogues, this is the only one that mediates nitrogen nutrition from Staphylococcus aureus (strain NCTC 8325)
    29% identity, 99% coverage of query (194 bits)

TC 3.A.1.5.25 / Q9CIL2 Oligopeptide ABC transporter substrate binding protein, component of The ABC peptide/signalling peptide transporter. OptA binds peptides of 3-6 aas; OptS binds dipeptides. OptB,C,D are most similar to 3.A.1.5.19 from Lactococcus lactis subsp. lactis (see paper)
    30% identity, 87% coverage of query (174 bits)

TC 3.A.1.5.25 / Q64K09 OptS, component of The ABC peptide/signalling peptide transporter. OptA binds peptides of 3-6 aas; OptS binds dipeptides. OptB,C,D are most similar to 3.A.1.5.19 from Lactococcus lactis (see paper)
    29% identity, 94% coverage of query (174 bits)

DPPA_LACLM / A2RI74 Dipeptide-binding protein from Lactococcus lactis subsp. cremoris (strain MG1363) (see 2 papers)
    29% identity, 91% coverage of query (174 bits)

4fajA / Q51643 Structure and mode of peptide binding of pheromone receptor prgz (see paper)
    28% identity, 87% coverage of query (170 bits)

has / CAA78270.1 threonine kinase from Streptococcus dysgalactiae subsp. equisimilis (see 3 papers)
    29% identity, 89% coverage of query (150 bits)

6ofqA / A0A1U9ISL1 Abc transporter-associated periplasmic binding protein dppa from helicobacter pylori in complex with peptide stsa (see paper)
    27% identity, 87% coverage of query (129 bits)

7kz9A Crystal structure of pseudomonas sp. Pdc86 substrate-binding protein aapf in complex with a signaling molecule heheaa (see paper)
    26% identity, 79% coverage of query (125 bits)

Dpp / b3544 dipeptide ABC transporter periplasmic binding protein (EC 7.4.2.9) from Escherichia coli K-12 substr. MG1655 (see 18 papers)
dppA / P23847 dipeptide ABC transporter periplasmic binding protein (EC 7.4.2.9) from Escherichia coli (strain K12) (see 19 papers)
DPPA_ECOLI / P23847 Dipeptide-binding protein; DBP; Periplasmic dipeptide transport protein from Escherichia coli (strain K12) (see 8 papers)
dppA / GB|AAC76569.1 dipeptide ABC transporter, periplasmic dipeptide-binding protein DppA from Escherichia coli K12 (see 11 papers)
    25% identity, 99% coverage of query (119 bits)

1dppA / P23847 Dipeptide binding protein complex with glycyl-l-leucine (see paper)
    26% identity, 84% coverage of query (119 bits)

6hlxA / O50260 Structure of the pbp agaa in complex with agropinic acid from a.Tumefacien r10 (see paper)
    25% identity, 90% coverage of query (114 bits)

2nooA Crystal structure of mutant nika
    25% identity, 87% coverage of query (113 bits)

3e3kB / P33590 Structural characterization of a putative endogenous metal chelator in the periplasmic nickel transporter nika (butane-1,2,4-tricarboxylate without nickel form) (see paper)
    25% identity, 84% coverage of query (113 bits)

4i8cA X-ray structure of nika in complex with ni-(l-his)2
    25% identity, 84% coverage of query (113 bits)

1zlqA Crystallographic and spectroscopic evidence for high affinity binding of fe edta (h2o)- to the periplasmic nickel transporter nika
    25% identity, 84% coverage of query (113 bits)

7a0cA X-ray structure of nika from escherichia coli in complex with fe-6- me2-bpmcn
    25% identity, 84% coverage of query (112 bits)

5on1A Crystal structure of nika in complex with hydroxylated fe-l1 (n-(2- hydroxybenzyl)-n'-(2-thiomethylbenzyl)-n,n'-ethylenediamine diacetic acid)
    25% identity, 84% coverage of query (112 bits)

5on0A Crystal structure of nika in complex with fe-l2 (n-(2-hydroxy- 3methoxybenzyl)-n-n'-ethylenediaminediacetic acid)
    25% identity, 84% coverage of query (112 bits)

3mw0A X-ray structure of the doubly hydroxylated iron complex-nika species, nika1/o2
    25% identity, 84% coverage of query (112 bits)

3mvzA X-ray structure of the (hydro)peroxo intermediate nika/1-int", after monohydroxylation of the iron complex
    25% identity, 84% coverage of query (112 bits)

3mvwA X-ray structure of a "nika+iron complex" hybrid, nika/1
    25% identity, 84% coverage of query (112 bits)

4dcxA X-ray structure of nika in complex with fe(1r,2r)-n,n'-bis(2- pyridylmethyl)-n,n'-dicarboxymethyl-1,2-cyclohexanediamine
    25% identity, 84% coverage of query (112 bits)

5l8dB X-ray structure of nika from escherichia coli in complex with ru(bis(pyrzol-1-yl)acetate scorpionate)(co)2cl
    25% identity, 84% coverage of query (112 bits)

4i9dA X-ray structure of nika in complex with fe-n,n'-bis(2-pyridylmethyl)- n-carboxymethyl-n'-methyl
    25% identity, 84% coverage of query (112 bits)

4dcyA X-ray structure of nika in complex with fe(1s,2s)-n,n-kappa-bis(2- pyridylmethyl)-n-carboxymethyl-n-kappa-methyl-1,2-cyclohexanediamine
    25% identity, 84% coverage of query (112 bits)

3m8uA / B8F653 Crystal structure of glutathione-binding protein a (gbpa) from haemophilus parasuis sh0165 in complex with glutathione disulfide (gssg) (see paper)
    24% identity, 83% coverage of query (112 bits)

5yybA Crystal structure of sialic acid binding protein from haemophilus ducreyi with neu5gc
    28% identity, 75% coverage of query (111 bits)

5z99A / Q7VL18 Crystal structure of sialic acid binding protein from haemophilus ducreyi with neu5ac (see paper)
    28% identity, 75% coverage of query (111 bits)

1uqwA / P75797 Crystal structure of ylib protein from escherichia coi
    23% identity, 85% coverage of query (108 bits)

5f1qA / A0A0H2YM47 Crystal structure of periplasmic dipeptide transport protein from yersinia pestis
    25% identity, 88% coverage of query (107 bits)

8ckdA Pbp acca from a. Fabrum c58 in complex with agrocinopine d-like
    26% identity, 73% coverage of query (97.4 bits)

4zekA Pbp acca from a. Tumefaciens c58 in complex with l-arabinose-2- isopropylphosphate
    26% identity, 73% coverage of query (97.4 bits)

4zedA Pbp acca from a. Tumefaciens c58 in complex with agrocinopine-3'-o- benzoate
    26% identity, 73% coverage of query (97.4 bits)

4zecA Pbp acca from a. Tumefaciens c58 in complex with agrocin 84
    26% identity, 73% coverage of query (97.4 bits)

8ckoA / Q52012 Pbp acca from a.Tumefaciens c58 in complex with agrocinopinE C-like (see paper)
    26% identity, 73% coverage of query (97.1 bits)

6i7wA Structure of the periplasmic binding protein (pbp) acca in complex with 2-glucose-2-o-lactic acid phosphate (g2lp) from agrobacterium fabrum c58
    26% identity, 73% coverage of query (97.1 bits)

8ckeA Pbp acca from a.Tumefaciens c58 in complex with agrocinopine a in space group i222
    26% identity, 73% coverage of query (97.1 bits)

6e3dA / I6X811 Atomic structure of mycobacterium tuberculosis dppa (see paper)
    26% identity, 86% coverage of query (94.4 bits)

4qfpA Crystal structure of dipeptide binding protein from pseudoalteromonas sp. Sm9913 in complex with val-thr
    24% identity, 78% coverage of query (94.0 bits)

4qfoA Crystal structure of dipeptide binding protein from pseudoalteromonas sp. Sm9913 in complex with met-leu
    24% identity, 78% coverage of query (94.0 bits)

4qfnA Crystal structure of dipeptide binding protein from pseudoalteromonas sp. Sm9913 in complex with gly-glu
    24% identity, 78% coverage of query (94.0 bits)

4qflA / A7Y7W1 Crystal structure of dipeptide binding protein from pseudoalteromonas sp. Sm9913 in complex with ala-phe (see paper)
    24% identity, 78% coverage of query (94.0 bits)

4oesA / Q9AL82 Crystal structure of nika from brucella suis in complex with fe(iii)- edta (see paper)
    24% identity, 84% coverage of query (88.2 bits)

7ebiA Chitin-specific solute binding protein from vibrio harveyi co- crystalized with chitotetraose. (see paper)
    23% identity, 81% coverage of query (81.6 bits)

2wopA / Q8KRB4 Clavulanic acid biosynthesis oligopeptide binding protein 2 complexed with arginine (see paper)
    23% identity, 89% coverage of query (80.9 bits)

2wokA Clavulanic acid biosynthesis oligopeptide binding protein 2 complexed with bradykinin
    23% identity, 89% coverage of query (80.9 bits)

3rybA / A2RJ53 Lactococcal oppa complexed with slsqslsqs (see paper)
    24% identity, 84% coverage of query (66.6 bits)

4pfyA / Q9X0V0 Crystal structure of mannohexaose bound oligopeptide abc transporter, periplasmic oligopeptide-binding protein (tm1223) from thermotoga maritima at 1.5 a resolution (see paper)
    23% identity, 75% coverage of query (64.7 bits)

CNTA_STAA8 / Q2FVE7 Metal-staphylopine-binding protein CntA from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see 3 papers)
TC 3.A.1.5.43 / Q2FVE7 Peptide ABC transporter, peptide-binding protein, putative, component of The metal-staphylopine (nicotianamine-like metalophore) complex uptake system, CntABCDF from Staphylococcus aureus (strain NCTC 8325)
    22% identity, 91% coverage of query (63.9 bits)

5yh8A / Q2FVE7 The crystal structure of staphylococcus aureus cnta in complex with staphylopine and nickel (see paper)
    22% identity, 85% coverage of query (62.8 bits)

4jsdA The x-ray crystal structure of a thermophilic cellobiose binding protein bound with laminaribiose
    21% identity, 78% coverage of query (62.4 bits)

3i5oA / Q9WXN8 The x-ray crystal structure of a thermophilic cellobiose binding protein bound with cellopentaose (see paper)
    21% identity, 78% coverage of query (62.4 bits)

8i5jA Crystal structure of chitin oligosaccharide binding protein from vibrio cholera.
    23% identity, 81% coverage of query (61.2 bits)

4gfrA / Q9KUA3 Crystal structure of the liganded chitin oligasaccharide binding protein
    23% identity, 81% coverage of query (61.2 bits)

4ofoA / A0A5P8YI66 Crystal structure of ynta from yersinia pestis, unliganded form (see paper)
    20% identity, 71% coverage of query (60.1 bits)

4oflA Crystal structure of ynta from yersinia pestis in complex with ni(l- his)2
    20% identity, 71% coverage of query (60.1 bits)

4oeuA Crystal structure of nikz from campylobacter jejuni in complex with ni(l-his)
    23% identity, 84% coverage of query (55.5 bits)

4oevA / Q0P844 Crystal structure of nikz from campylobacter jejuni in complex with ni(ii) ion (see paper)
    23% identity, 84% coverage of query (55.1 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory