Searching for up to 100 curated homologs for BWI76_RS18905 FitnessBrowser__Koxy:BWI76_RS18905 (452 a.a.)
Found high-coverage hits (≥70%) to 50 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
YeeF / b2014 putrescine:H+ symporter PlaP from Escherichia coli K-12 substr. MG1655 (see paper)
plaP / P0AA47 putrescine:H+ symporter PlaP from Escherichia coli (strain K12) (see 5 papers)
PLAP_ECOLI / P0AA47 Low-affinity putrescine importer PlaP; Putrescine low affinity permease from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.3.1.14 / P0AA47 Low-affinity putrescine importer PlaP from Escherichia coli (strain K12) (see 5 papers)
88% identity, 100% coverage of query (810 bits)
puuP / BAD88704.1 putrescine importer, partial from Escherichia coli K-12 (see paper)
65% identity, 99% coverage of query (598 bits)
YcjJ / b1296 putrescine:H+ symporter PuuP from Escherichia coli K-12 substr. MG1655 (see 4 papers)
puuP / P76037 putrescine:H+ symporter PuuP from Escherichia coli (strain K12) (see 2 papers)
PUUP_ECOLI / P76037 Putrescine importer PuuP from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.3.1.13 / P76037 Putrescine importer, PuuP from Escherichia coli (strain K12) (see 4 papers)
65% identity, 99% coverage of query (597 bits)
Build an alignment for BWI76_RS18905 and 3 homologs with ≥ 30% identity
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MTRTR_BACSU / Q797A7 Methylthioribose transporter from Bacillus subtilis (strain 168) (see paper)
24% identity, 90% coverage of query (99.4 bits)
BCAP_BACSU / O07576 Branched-chain amino acid permease BcaP; BCAA permease from Bacillus subtilis (strain 168) (see 4 papers)
25% identity, 81% coverage of query (95.5 bits)
CAAT4_ARATH / Q8W4K3 Cationic amino acid transporter 4, vacuolar from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 2.A.3.3.14 / Q8W4K3 Cationic amino acid transporter 4, vacuolar from Arabidopsis thaliana (see 4 papers)
25% identity, 81% coverage of query (94.4 bits)
CAAT3_ARATH / Q8GYB4 Cationic amino acid transporter 3, mitochondrial from Arabidopsis thaliana (Mouse-ear cress) (see paper)
25% identity, 83% coverage of query (88.6 bits)
6f34A / Q5L1G5 Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine. (see paper)
26% identity, 93% coverage of query (88.2 bits)
5oqtA Crystal structure of a bacterial cationic amino acid transporter (cat) homologue
26% identity, 93% coverage of query (87.4 bits)
CTR1_HUMAN / P30825 High affinity cationic amino acid transporter 1; CAT-1; CAT1; Ecotropic retroviral leukemia receptor homolog; Ecotropic retrovirus receptor homolog; Solute carrier family 7 member 1; System Y+ basic amino acid transporter from Homo sapiens (Human) (see 4 papers)
TC 2.A.3.3.9 / P30825 High affinity cationic amino acid transporter 1 (CAT-1) (CAT1) (Ecotropic retroviral leukemia receptor homologue) (Ecotropic retrovirus receptor homologue) (ERR) (Solute carrier family 7 member 1) (System Y+ basic amino acid transporter) from Homo sapiens (see 6 papers)
23% identity, 84% coverage of query (85.1 bits)
N515DRAFT_2924 L-proline transporter from Dyella japonica UNC79MFTsu3.2
26% identity, 87% coverage of query (83.6 bits)
CAAT2_ARATH / Q9ASS7 Cationic amino acid transporter 2, vacuolar from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 2.A.3.3.13 / Q9ASS7 Cationic amino acid transporter 2, vacuolar from Arabidopsis thaliana (see 4 papers)
24% identity, 89% coverage of query (83.6 bits)
CCNA_00435 L-proline transporter from Caulobacter crescentus NA1000
27% identity, 81% coverage of query (82.8 bits)
CTR1_RAT / P30823 High affinity cationic amino acid transporter 1; CAT-1; CAT1; Ecotropic retroviral leukemia receptor; Ecotropic retrovirus receptor; EcoR; Solute carrier family 7 member 1; System Y+ basic amino acid transporter from Rattus norvegicus (Rat) (see paper)
23% identity, 84% coverage of query (82.0 bits)
CTR1_MOUSE / Q09143 High affinity cationic amino acid transporter 1; CAT-1; CAT1; Ecotropic retroviral leukemia receptor; Ecotropic retrovirus receptor; ERR; EcoR; Solute carrier family 7 member 1; System Y+ basic amino acid transporter from Mus musculus (Mouse) (see 7 papers)
TC 2.A.3.3.1 / Q09143 System Y+ high affinity basic amino acid transporter (CAT1) (ecotropic retrovival leukemia virus receptor (ERR)) (transports arginine, lysine and ornithine; Na+-independent) from Mus musculus (Mouse) (see 2 papers)
Slc7a1 / RF|NP_031539.3 high affinity cationic amino acid transporter 1 from Mus musculus
22% identity, 84% coverage of query (81.6 bits)
CAAT9_ARATH / Q9C5D6 Cationic amino acid transporter 9, chloroplastic from Arabidopsis thaliana (Mouse-ear cress) (see paper)
24% identity, 87% coverage of query (81.3 bits)
TC 2.A.3.8.29 / F1R8V8 Cationic amino acid transporter, y+LAT1 from Danio rerio
25% identity, 85% coverage of query (79.0 bits)
CTR3_RAT / O08812 Cationic amino acid transporter 3; CAT-3; CAT3; Cationic amino acid transporter y+; Solute carrier family 7 member 3 from Rattus norvegicus (Rat) (see paper)
23% identity, 85% coverage of query (77.8 bits)
CAAT6_ARATH / Q9LZ20 Cationic amino acid transporter 6, chloroplastic from Arabidopsis thaliana (Mouse-ear cress) (see paper)
TC 2.A.3.3.4 / Q9LZ20 The amino acid transporter, CAT6. Mediates electrogenic transport of large neutral and cationic amino acids in preference to other amino acids. Present in lateral root primordia, flowers and seeds from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
T1E3_130 / GI|13430548 amino acid transport-like protein from Arabidopsis thaliana (see paper)
24% identity, 82% coverage of query (75.9 bits)
TC 2.A.3.1.18 / K7VV21 The lysine specific transporter, LysP of 488 aas and 12 TMSs from Lactococcus lactis subsp. cremoris UC509.9
26% identity, 71% coverage of query (75.9 bits)
RR42_RS33495 L-phenylalanine:H+ symporter AroP from Cupriavidus basilensis FW507-4G11
24% identity, 80% coverage of query (74.7 bits)
LYSP_LACLM / A2RNZ6 Lysine-specific permease LysP; Lysine transporter LysP from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
26% identity, 71% coverage of query (73.9 bits)
PheP / b0576 phenylalanine:H+ symporter PheP from Escherichia coli K-12 substr. MG1655 (see 3 papers)
pheP / P24207 phenylalanine:H+ symporter PheP from Escherichia coli (strain K12) (see 3 papers)
PHEP_ECOLI / P24207 Phenylalanine-specific permease; Phenylalanine:H(+) symporter PheP from Escherichia coli (strain K12) (see 6 papers)
TC 2.A.3.1.1 / P24207 Phenylalanine:H+ symporter, PheP of 458 aas and 12 established TMSs from Escherichia coli (see 6 papers)
24% identity, 78% coverage of query (73.9 bits)
S7A14_HUMAN / Q8TBB6 Solute carrier family 7 member 14; Gamma-aminobutyric acid transporter SLC7A14 from Homo sapiens (Human) (see 2 papers)
24% identity, 81% coverage of query (73.2 bits)
YhfM / b3370 fructoselysine/psicoselysine transporter from Escherichia coli K-12 substr. MG1655 (see 4 papers)
frlA / P45539 fructoselysine/psicoselysine transporter from Escherichia coli (strain K12) (see 4 papers)
FRLA_ECOLI / P45539 Probable fructoselysine/psicoselysine transporter FrlA from Escherichia coli (strain K12) (see paper)
24% identity, 71% coverage of query (72.0 bits)
S7A14_MOUSE / Q8BXR1 Solute carrier family 7 member 14; Gamma-aminobutyric acid transporter SLC7A14 from Mus musculus (Mouse) (see 2 papers)
23% identity, 84% coverage of query (70.9 bits)
YLAT1_HUMAN / Q9UM01 Y+L amino acid transporter 1; Monocyte amino acid permease 2; MOP-2; Solute carrier family 7 member 7; y(+)L-type amino acid transporter 1; Y+LAT1; y+LAT-1 from Homo sapiens (Human) (see 18 papers)
TC 2.A.3.8.22 / Q9UM01 Y+L amino acid transporter 1 (Monocyte amino acid permease 2) (MOP-2) (Solute carrier family 7 member 7) (y(+)L-type amino acid transporter 1) (Y+LAT1) (y+LAT-1) from Homo sapiens (see 20 papers)
24% identity, 87% coverage of query (70.9 bits)
SLC7A6 / Q92536 Y+L amino acid transporter 2 from Homo sapiens (see 3 papers)
YLAT2_HUMAN / Q92536 Y+L amino acid transporter 2; Cationic amino acid transporter, y+ system; Solute carrier family 7 member 6; y(+)L-type amino acid transporter 2; Y+LAT2; y+LAT-2 from Homo sapiens (Human) (see 13 papers)
TC 2.A.3.8.23 / Q92536 Y+L amino acid transporter 2 (Cationic amino acid transporter, y+ system) (Solute carrier family 7 member 6) (y(+)L-type amino acid transporter 2) (Y+LAT2) (y+LAT-2) from Homo sapiens (see 14 papers)
24% identity, 84% coverage of query (70.1 bits)
TC 2.A.3.3.23 / S6EX81 Branched chain amino acid (Leucine/isoleucine/valine) uptake transporter of 469 aas and 12 TMSs, BcaP or CitA from Lactococcus lactis subsp. lactis A12
24% identity, 96% coverage of query (68.6 bits)
YLAT1_MOUSE / Q9Z1K8 Y+L amino acid transporter 1; Solute carrier family 7 member 7; y(+)L-type amino acid transporter 1; Y+LAT1; y+LAT-1 from Mus musculus (Mouse) (see 3 papers)
24% identity, 87% coverage of query (68.6 bits)
YLAT1_RAT / Q9R0S5 Y+L amino acid transporter 1; Solute carrier family 7 member 7; y(+)L-type amino acid transporter 1; Y+LAT1; y+LAT-1 from Rattus norvegicus (Rat) (see 2 papers)
TC 2.A.3.8.7 / Q9R0S5 y+LAT1 (transports neutral amino acids (i.e., Leu) in symport with Na+, Li+ or H+ in 1:1 stoichiometry; transports basic amino acids (i.e., Lys) by facilitated diffusion without a symported cation). Also transports the neurotoxicant, methylmercury-L-cysteine by molecular mimicry. Causes the Lysinuric protein intolerance condition in humans (Q9UM01) (Broer, 2008) (see 2 papers)
24% identity, 86% coverage of query (67.8 bits)
TC 2.A.3.3.2 / P18581 Low affinity basic amino acid transporter (CAT2) (T-cell early activation protein (TEA)) (transports arginine, lysine and ornithine; Na+-independent) from Mus musculus (Mouse) (see 9 papers)
Slc7a2 / RF|NP_031540.2 low affinity cationic amino acid transporter 2 from Mus musculus (see paper)
22% identity, 81% coverage of query (67.8 bits)
CTR2_MOUSE / P18581 Cationic amino acid transporter 2; CAT-2; CAT2; 20.5; Low affinity cationic amino acid transporter 2; Solute carrier family 7 member 2; T-cell early activation protein; TEA from Mus musculus (Mouse) (see 6 papers)
22% identity, 81% coverage of query (67.0 bits)
GABP_BACSU / P46349 Gamma-aminobutyric acid permease; GABA permease; 4-aminobutyrate permease; Gamma-aminobutyrate permease; Proline transporter GabP from Bacillus subtilis (strain 168) (see 3 papers)
TC 2.A.3.1.5 / P46349 β-alanine/γ-aminobutyrate/proline/3,4-dehydroproline:H+ symporter, GabP from Bacillus subtilis (see 4 papers)
gabP / AAC44641.1 gamma-aminobutyrate permease from Bacillus subtilis (see 2 papers)
22% identity, 98% coverage of query (67.0 bits)
gabP / AAB62306.1 GabP from Bacillus subtilis (see 4 papers)
22% identity, 98% coverage of query (66.6 bits)
AO356_18530 L-tyrosine transporter from Pseudomonas fluorescens FW300-N2C3
25% identity, 71% coverage of query (66.2 bits)
BCAP_LACLM / A2RHI9 Branched-chain amino acid permease BcaP; BCAA permease; BCAA transporter from Lactococcus lactis subsp. cremoris (strain MG1363) (see 2 papers)
24% identity, 95% coverage of query (66.2 bits)
YLAT2_MOUSE / Q8BGK6 Y+L amino acid transporter 2; Solute carrier family 7 member 6; y(+)L-type amino acid transporter 2; Y+LAT2; y+LAT-2 from Mus musculus (Mouse) (see 5 papers)
25% identity, 84% coverage of query (66.2 bits)
S7A14_DANRE / B0UYF2 Probable cationic amino acid transporter; Solute carrier family 7 member 14 from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
24% identity, 81% coverage of query (65.9 bits)
YLAT2_RAT / D3ZMM8 Y+L amino acid transporter 2; Solute carrier family 7 member 6; y(+)L-type amino acid transporter 2; Y+LAT2; y+LAT-2 from Rattus norvegicus (Rat) (see 2 papers)
25% identity, 71% coverage of query (65.5 bits)
CTR2_CHICK / B3TP03 Cationic amino acid transporter 2; CAT-2; CAT2; cCAT-2; Low affinity cationic amino acid transporter 2; Solute carrier family 7 member 2 from Gallus gallus (Chicken) (see paper)
21% identity, 81% coverage of query (65.5 bits)
HISP_LACLM / A2RI97 Histidine permease HisP from Lactococcus lactis subsp. cremoris (strain MG1363) (see paper)
24% identity, 92% coverage of query (64.7 bits)
CTR2_HUMAN / P52569 Cationic amino acid transporter 2; CAT-2; CAT2; Low affinity cationic amino acid transporter 2; Solute carrier family 7 member 2 from Homo sapiens (Human) (see 3 papers)
TC 2.A.3.3.8 / P52569 Low affinity cationic amino acid transporter 2 (CAT-2) (CAT2) (Solute carrier family 7 member 2) from Homo sapiens (see 6 papers)
21% identity, 81% coverage of query (63.2 bits)
CadR / b2156 lysine:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 15 papers)
lysP / P25737 lysine:H+ symporter from Escherichia coli (strain K12) (see 13 papers)
LYSP_ECOLI / P25737 Lysine-specific permease LysP; Lysine transporter LysP; Trigger transporter LysP from Escherichia coli (strain K12) (see 7 papers)
TC 2.A.3.1.2 / P25737 Lysine:H+ symporter. Forms a stable complex with CadC to allow lysine-dependent adaptation to acidic stress (Rauschmeier et al. 2013). The Salmonella orthologue is 95% identical to the E. coli protein and is highly specific for Lysine. Residues involved in lysine binding have been identified from Escherichia coli (see 5 papers)
lysP lysine-specific permease from Escherichia coli K12 (see 5 papers)
24% identity, 71% coverage of query (61.2 bits)
SLC7A11 / Q9UPY5 cystine/glutamate transporter from Homo sapiens (see paper)
XCT_HUMAN / Q9UPY5 Cystine/glutamate transporter; Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; Solute carrier family 7 member 11; xCT from Homo sapiens (Human) (see 9 papers)
TC 2.A.3.8.18 / Q9UPY5 Cystine/glutamate antiporter (Amino acid transport system xCT) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) from Homo sapiens (see 7 papers)
20% identity, 85% coverage of query (56.6 bits)
BAT1_HUMAN / P82251 b(0,+)-type amino acid transporter 1; b(0,+)AT1; Glycoprotein-associated amino acid transporter b0,+AT1; Solute carrier family 7 member 9 from Homo sapiens (Human) (see 16 papers)
TC 2.A.3.8.19 / P82251 B(0,+)-type amino acid transporter 1 (B(0,+)AT) (Glycoprotein-associated amino acid transporter b0,+AT1) (Solute carrier family 7 member 9) from Homo sapiens (see 9 papers)
22% identity, 75% coverage of query (56.6 bits)
6li9B / P82251 Heteromeric amino acid transporter b0,+at-rbat complex bound with arginine (see paper)
22% identity, 75% coverage of query (56.2 bits)
7epzB Overall structure of erastin-bound xct-4f2hc complex
21% identity, 72% coverage of query (55.5 bits)
7p9uB / Q9UPY5 Cryo em structure of system xc- in complex with glutamate (see paper)
21% identity, 72% coverage of query (55.5 bits)
STET_BACSU / O34739 Serine/threonine exchanger SteT from Bacillus subtilis (strain 168) (see paper)
TC 2.A.3.8.12 / O34739 The Ser/Thr exchange transporter (SteT) (also transports aromatic amino acids with lower efficiency) (Reig et al., 2007). The substrate-bound state of SteT shows increased conformational flexibility and kinetic stability, enabling transport of substrate across the cell membrane (Bippes et al. 2009). TMS8 sculpts the substrate-binding site and undergoes conformational changes during the transport cycle of SteT (Bartoccioni et al., 2010). Mutations allow substrate binding but not translocation. Other mutations stabilize the protein and result in higher production levels from Bacillus subtilis (see 2 papers)
23% identity, 74% coverage of query (54.3 bits)
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Lawrence Berkeley National Laboratory