Searching for up to 100 curated homologs for BWI76_RS19590 FitnessBrowser__Koxy:BWI76_RS19590 (452 a.a.)
Found high-coverage hits (≥70%) to 55 curated proteins.
Removed hits that are identical to the query, leaving 54
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
PCAK_ACIAD / Q43975 4-hydroxybenzoate transporter PcaK; 4-HB transporter from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
44% identity, 90% coverage of query (335 bits)
PCAK_PSEPU / Q51955 4-hydroxybenzoate transporter PcaK from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 3 papers)
TC 2.A.1.15.1 / Q51955 4-Hydroxybenzoate/protocatechuate porter from Pseudomonas putida (see paper)
pcaK / AAA85137.1 PcaK from Pseudomonas putida (see paper)
42% identity, 94% coverage of query (331 bits)
GALT_PSEPU / E8ZB61 Gallate transporter; Gallate permease from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
galT / CBJ94499.1 gallic acid permease from Pseudomonas putida (see paper)
44% identity, 88% coverage of query (317 bits)
proT / BAB32694.1 putative transporter from Pseudomonas straminea (see 2 papers)
39% identity, 94% coverage of query (308 bits)
TC 2.A.1.15.7 / Q6FBB3 Aromatic compound (benzoate) uptake transporter of 450 aas from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
33% identity, 98% coverage of query (238 bits)
Build an alignment for BWI76_RS19590 and 5 homologs with ≥ 30% identity
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TC 2.A.1.15.5 / O30513 Benzoate porter, BenK from Acinetobacter calcoaceticus (see 2 papers)
29% identity, 95% coverage of query (210 bits)
TC 2.A.1.15.3 / Q46M63 2,4-Dichlorophenoxyacetate porter (see 5 papers)
31% identity, 95% coverage of query (201 bits)
YaiK / b0353 3-hydroxyphenylpropionate/3-hydroxycinnamate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
mhpT / P77589 3-hydroxyphenylpropionate/3-hydroxycinnamate:H+ symporter from Escherichia coli (strain K12) (see 2 papers)
MHPT_ECOLI / P77589 3-(3-hydroxy-phenyl)propionate transporter; 3HPP transporter; 3-(3-hydroxy-phenyl)propionate:H(+) symporter; 3HPP:H(+) symporter from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.15.2 / P77589 MhpT. A specific 3-(3-hydroxyphenyl)propionate (3HPP) transporter; vital for E. coli K-12 W3110 to grow on this substrate from Escherichia coli (see 3 papers)
39% identity, 84% coverage of query (199 bits)
TC 2.A.1.15.6 / O24842 Vanillate porter, VanK (see 4 papers)
31% identity, 93% coverage of query (191 bits)
TC 2.A.1.15.14 / Q8VUZ0 Probable uptake transporter for 2,4-dichlorophenoxyacetic acid (2,4-D), CadK from Bradyrhizobium sp. HW13
32% identity, 88% coverage of query (180 bits)
NIAP_ACIAD / Q6FFF7 Niacin transporter NiaP from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
28% identity, 96% coverage of query (160 bits)
TC 2.A.1.15.8 / O24723 Probable 1-hydroxy-2-naphthoate transporter, orf1 (see paper)
26% identity, 92% coverage of query (157 bits)
genK / Q8NLB7 gentisate transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 3 papers)
GENK_CORGL / Q8NLB7 Gentisate transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
27% identity, 91% coverage of query (143 bits)
TC 2.A.1.15.11 / Q6M372 The Vanillate porter, VanK from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
30% identity, 98% coverage of query (142 bits)
SVOP_BOVIN / Q1JP63 Synaptic vesicle 2-related protein; SV2-related protein from Bos taurus (Bovine) (see paper)
24% identity, 88% coverage of query (117 bits)
SVOP_XENLA / Q2XWK0 Synaptic vesicle 2-related protein; SV2-related protein from Xenopus laevis (African clawed frog) (see paper)
24% identity, 90% coverage of query (115 bits)
NIAP_BACSU / O34691 Putative niacin/nicotinamide transporter NiaP from Bacillus subtilis (strain 168) (see paper)
TC 2.A.1.82.4 / O34691 Niacin uptake porter NiaP from Bacillus subtilis (see 2 papers)
26% identity, 88% coverage of query (106 bits)
SVOP_RAT / Q9Z2I7 Synaptic vesicle 2-related protein; SV2-related protein from Rattus norvegicus (Rat) (see paper)
24% identity, 88% coverage of query (106 bits)
TC 2.A.1.82.3 / Q8BFT9 Synaptic vesicle 2-related protein (SV2-related protein), SVOP from Mus musculus (see 4 papers)
24% identity, 88% coverage of query (102 bits)
YgcS / b2771 putative transporter YgcS from Escherichia coli K-12 substr. MG1655 (see 2 papers)
TC 2.A.1.1.95 / Q46909 Inner membrane metabolite transport protein YgcS from Escherichia coli (strain K12) (see 3 papers)
30% identity, 85% coverage of query (95.5 bits)
TC 2.A.1.82.1 / F2CRE4 The barley copper uptake porter, CT-1 of 749 aas; nearly identical to the wheat orthologue from Hordeum vulgare var. distichum
25% identity, 85% coverage of query (93.2 bits)
YdjE / b1769 putative transporter YdjE from Escherichia coli K-12 substr. MG1655 (see 3 papers)
TC 2.A.1.1.92 / P38055 Inner membrane metabolite transport protein YdjE from Escherichia coli (strain K12) (see 6 papers)
24% identity, 96% coverage of query (92.0 bits)
TC 2.A.1.15.9 / O51798 Probable 4-methylmuconolactone transporter, MmlH from Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus) (see paper)
28% identity, 82% coverage of query (89.4 bits)
TC 2.A.1.15.4 / P94131 cis,cis-muconate porter, MucK from Acinetobacter calcoaceticus (see 2 papers)
mucK / AAC27117.1 cis,cis-muconate transport protein MucK from Acinetobacter baylyi (see paper)
24% identity, 84% coverage of query (89.0 bits)
S22A5_MOUSE / Q9Z0E8 Organic cation/carnitine transporter 2; High-affinity sodium-dependent carnitine cotransporter; Solute carrier family 22 member 5 from Mus musculus (Mouse) (see 4 papers)
27% identity, 80% coverage of query (82.4 bits)
S22A5_HUMAN / O76082 Organic cation/carnitine transporter 2; High-affinity sodium-dependent carnitine cotransporter; Solute carrier family 22 member 5 from Homo sapiens (Human) (see 28 papers)
TC 2.A.1.19.3 / O76082 The polyspecific organic cation (L- and D-carnitine, butyryl-L-carnitine, acetyl carnitine, γ-butyro-betaine, glycinebetaine, β-lactam antibiotics with a quaternary nitrogen such as cephaloridine, and others):Na+ symporter, OCTN2 (SLC22A5). Carnitine is transporter with high affinity (2 - 20 μM0 (Ingoglia et al. 2015). Associated with Crohn''s disease (Barton et al., 2005) as well as primary carnitine deficiency from Homo sapiens (Human) (see 28 papers)
27% identity, 80% coverage of query (80.1 bits)
S22AL_MOUSE / Q9WTN6 Solute carrier family 22 member 21; Organic cation/carnitine transporter 3; Solute carrier family 22 member 9 from Mus musculus (Mouse) (see 3 papers)
TC 2.A.1.19.41 / Q9WTN6 Organocation transporter, OCTN3. Identified only in mouse; mediates carnitine transport (Pochini et al. 2013). 81% identical to 2.A.1.19.3. Also called SLC22a21 and SLC22a9 from Mus musculus
26% identity, 80% coverage of query (77.8 bits)
GudP / b2789 galactarate/D-glucarate transporter GudP from Escherichia coli K-12 substr. MG1655 (see 5 papers)
gudP / Q46916 galactarate/D-glucarate transporter GudP from Escherichia coli (strain K12) (see 5 papers)
GUDP_ECOLI / Q46916 Probable galactarate/D-glucarate transporter GudP from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.14.40 / C4ZZU4 Glucarate transporter, GudP. Encoded in an operon with GudD, a glucarate dehydratase from Escherichia coli (strain K12 / MC4100 / BW2952)
22% identity, 94% coverage of query (77.4 bits)
YdjK / b1775 putative transporter YdjK from Escherichia coli K-12 substr. MG1655 (see 3 papers)
23% identity, 74% coverage of query (76.3 bits)
S22AD_HUMAN / Q9Y226 Solute carrier family 22 member 13; Organic anion transporter 10; OAT10; Organic cation transporter-like 3; ORCTL-3; ORCTL3 from Homo sapiens (Human) (see 5 papers)
TC 2.A.1.19.17 / Q9Y226 Kidney organic cation transporter-like 3 ORCTL-3 (OAT10; SLC22A13; Like-3) (Bahn et al., 2008) (transports nicotinate, p-aminohippurate and urate; KM=20-40 mμM) via exchange for lactate) from Homo sapiens (Human) (see 4 papers)
27% identity, 77% coverage of query (75.5 bits)
TC 2.A.1.1.106 / P46333 Probable metabolite transport protein CsbC from Bacillus subtilis (strain 168) (see 3 papers)
26% identity, 81% coverage of query (75.1 bits)
S22A5_RAT / O70594 Organic cation/carnitine transporter 2; CT1; High-affinity sodium-dependent carnitine cotransporter; Solute carrier family 22 member 5; UST2r from Rattus norvegicus (Rat) (see 2 papers)
28% identity, 80% coverage of query (74.3 bits)
S22A6_HUMAN / Q4U2R8 Solute carrier family 22 member 6; Organic anion transporter 1; hOAT1; PAH transporter; hPAHT; Renal organic anion transporter 1; hROAT1 from Homo sapiens (Human) (see 20 papers)
TC 2.A.1.19.31 / Q4U2R8 Solute carrier family 22 member 6 (Organic anion transporter 1) (hOAT1) (PAH transporter) (hPAHT) (Renal organic anion transporter 1) (hROAT1), from Homo sapiens (see 17 papers)
26% identity, 80% coverage of query (73.6 bits)
S22A6_MACFA / Q4W8A3 Solute carrier family 22 member 6; Organic anion transporter 1; mkOAT1; Renal organic anion transporter 1 from Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) (see paper)
26% identity, 80% coverage of query (73.2 bits)
8bvtA / O35956 Cryo-em structure of rat slc22a6 bound to probenecid (see paper)
26% identity, 80% coverage of query (72.8 bits)
8bw7A Cryo-em structure of rat slc22a6 bound to alpha-ketoglutaric acid
27% identity, 80% coverage of query (72.8 bits)
8bvsA Cryo-em structure of rat slc22a6 bound to tenofovir
26% identity, 80% coverage of query (72.4 bits)
NanX / b4279 sialic acid transporter NanX from Escherichia coli K-12 substr. MG1655 (see 5 papers)
nanX / P39352 sialic acid transporter NanX from Escherichia coli (strain K12) (see 4 papers)
YJHB_ECOLI / P39352 Putative metabolite transport protein YjhB from Escherichia coli (strain K12) (see paper)
21% identity, 84% coverage of query (72.0 bits)
S22AB_HUMAN / Q9NSA0 Solute carrier family 22 member 11; Organic anion transporter 4; OAT4; Organic anion:dicarboxylate exchanger OAT4 from Homo sapiens (Human) (see 11 papers)
TC 2.A.1.19.10 / Q9NSA0 The apical proximal tubular kidney/placenta organic anion transporter 4, Oat4 (Slc22a11) (transports estrone sulfate (Km = 1 µM), dehydroepiandrosterone sulfate (Km = 60µM), many anionic drugs, diuretics, bile salts, urate and ochratoxin A). Catalyzes Na+-independent efflux, possibly using glutamate as a counter anion in an exchange reaction, especially in the placenta from Homo sapiens (Human) (see 7 papers)
SLC22A11 / GB|BAA95316.1 solute carrier family 22 member 11 from Homo sapiens
28% identity, 77% coverage of query (70.9 bits)
S22A6_MOUSE / Q8VC69 Solute carrier family 22 member 6; Kidney-specific transport protein; Novel kidney transcript; mNKT; Organic anion transporter 1; mOAT1; Renal organic anion transporter 1; mROAT1 from Mus musculus (Mouse) (see 6 papers)
27% identity, 80% coverage of query (69.7 bits)
S22A1_RAT / Q63089 Solute carrier family 22 member 1; Organic cation transporter 1; rOCT1 from Rattus norvegicus (Rat) (see 27 papers)
TC 2.A.1.19.1 / Q63089 The basolateral multivalent, potential-sensitive, organic cation (tetramethyl-ammonium; N'-methylnicotinamide; cationic drugs, xenobiotics, vitamins, neuro-transmitters, etc.) transporter (uni-porter)-1, Oct1 from Rattus norvegicus (Rat) (see 18 papers)
27% identity, 77% coverage of query (64.3 bits)
S22A1_MOUSE / O08966 Solute carrier family 22 member 1; Organic cation transporter 1; mOCT1 from Mus musculus (Mouse) (see 12 papers)
26% identity, 77% coverage of query (63.2 bits)
8et8A Cryo-em structure of the organic cation transporter 1 in complex with verapamil
27% identity, 72% coverage of query (63.2 bits)
8et7A / O15245 Cryo-em structure of the organic cation transporter 1 in complex with diphenhydramine (see paper)
27% identity, 72% coverage of query (63.2 bits)
S22A1_HUMAN / O15245 Solute carrier family 22 member 1; Organic cation transporter 1; hOCT1 from Homo sapiens (Human) (see 26 papers)
TC 2.A.1.19.29 / O15245 Solute carrier family 22 member 1 (Organic cation transporter 1) (hOCT1) from Homo sapiens (see 18 papers)
27% identity, 72% coverage of query (62.0 bits)
S22AE_MOUSE / Q497L9 Solute carrier family 22 member 14 from Mus musculus (Mouse) (see 2 papers)
23% identity, 77% coverage of query (57.8 bits)
S22A3_HUMAN / O75751 Solute carrier family 22 member 3; Extraneuronal monoamine transporter; EMT; Organic cation transporter 3; OCT3 from Homo sapiens (Human) (see 11 papers)
TC 2.A.1.19.24 / O75751 Solute carrier family 22 member 3 (Extraneuronal monoamine transporter) (EMT) (Organic cation transporter 3) from Homo sapiens (see 3 papers)
26% identity, 83% coverage of query (57.0 bits)
7zhaA / O75751 Structure of human oct3 in complex with inhibitor decynium-22 (see paper)
25% identity, 83% coverage of query (55.5 bits)
S22A6_PSEAM / O57379 Solute carrier family 22 member 6; Organic anion transporter 1; Renal organic anion transporter 1; ROAT1; fROAT1 from Pseudopleuronectes americanus (Winter flounder) (Pleuronectes americanus) (see paper)
24% identity, 73% coverage of query (52.8 bits)
7zh6A Structure of human oct3 in complex with inhibitor corticosterone
24% identity, 83% coverage of query (52.4 bits)
OCT1_CAEEL / Q9U539 Organic cation transporter 1; CeOCT1 from Caenorhabditis elegans (see paper)
TC 2.A.1.19.37 / Q9U539 Organic cation transporter 1 (CeOCT1) of 568 aas and 12 TMSs from Caenorhabditis elegans (see 3 papers)
23% identity, 71% coverage of query (52.0 bits)
8sc2A / O15245 Human oct1 bound to diltiazem in inward-open conformation (see paper)
25% identity, 72% coverage of query (49.3 bits)
YAEC_SCHPO / Q09852 Putative inorganic phosphate transporter C23D3.12 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
24% identity, 81% coverage of query (48.5 bits)
S22A2_RAT / Q9R0W2 Solute carrier family 22 member 2; Organic cation transporter 2; rOCT2 from Rattus norvegicus (Rat) (see 15 papers)
TC 2.A.1.19.19 / Q9R0W2 The rat kidney basolateral potential-driven symport carrier, Oct2 (transports tetraethylammonium and many other organic cations) from Rattus norvegicus (see 12 papers)
25% identity, 72% coverage of query (45.4 bits)
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Lawrence Berkeley National Laboratory