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Searching for up to 100 curated homologs for BWI76_RS21205 FitnessBrowser__Koxy:BWI76_RS21205 (478 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

XylE / b4031 D-xylose:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 7 papers)
xylE / P0AGF4 D-xylose:H+ symporter from Escherichia coli (strain K12) (see 8 papers)
XYLE_ECOLI / P0AGF4 D-xylose-proton symporter; D-xylose transporter from Escherichia coli (strain K12) (see paper)
TC 2.A.1.1.3 / P0AGF4 Xylose (xylopyranose):H+ symporter of 491 aas and 12 TMSs from Escherichia coli (see 7 papers)
xylE D-xylose-proton symporter from Escherichia coli K12 (see 7 papers)
    38% identity, 95% coverage of query (313 bits)

4gbyA / P0AGF4 The structure of the mfs (major facilitator superfamily) proton:xylose symporter xyle bound to d-xylose (see paper)
    38% identity, 94% coverage of query (311 bits)

4gc0A The structure of the mfs (major facilitator superfamily) proton:xylose symporter xyle bound to 6-bromo-6-deoxy-d-glucose
    38% identity, 94% coverage of query (311 bits)

4gbzA The structure of the mfs (major facilitator superfamily) proton:xylose symporter xyle bound to d-glucose
    38% identity, 94% coverage of query (311 bits)

TC 2.A.1.1.120 / E1WAV3 Major myo-inositol transporter, IolT1, of 456 aas from Salmonella typhimurium (strain SL1344)
    35% identity, 95% coverage of query (294 bits)

CCNA_00857 D-xylose transporter from Caulobacter crescentus NA1000
    35% identity, 96% coverage of query (275 bits)

TC 2.A.1.1.32 / P15729 Glucose/fructose:H+ symporter, GlcP (see 4 papers)
    39% identity, 95% coverage of query (274 bits)

IOLT_BACSU / O34718 Major myo-inositol transporter IolT from Bacillus subtilis (strain 168) (see paper)
TC 2.A.1.1.26 / O34718 Major myoinositol:H+ symporter, IolT from Bacillus subtilis (see 3 papers)
    34% identity, 99% coverage of query (260 bits)

TC 2.A.1.1.81 / Q0SE66 The glucose uptake porter, GluP from Rhodococcus sp. (strain RHA1) (see paper)
    40% identity, 93% coverage of query (259 bits)

TC 2.A.1.1.106 / P46333 Probable metabolite transport protein CsbC from Bacillus subtilis (strain 168) (see 3 papers)
    33% identity, 94% coverage of query (253 bits)

TC 2.A.1.1.35 / Q7BEC4 The major glucose (or 2-deoxyglucose) uptake transporter, GlcP from Streptomyces lividans (see paper)
    36% identity, 94% coverage of query (252 bits)

XYLT_LEVBR / O52733 D-xylose transporter; D-xylose-proton symporter from Levilactobacillus brevis (Lactobacillus brevis) (see paper)
TC 2.A.1.1.41 / O52733 The D-xylose:H+ symporter, XylT (Km=220 μM; inhibited competitively by 6-deoxyglucose (Ki=220 μM), but not by other sugars tested) from Lactobacillus brevis
    33% identity, 99% coverage of query (251 bits)

Ga0059261_1777 D-fructose transporter, sugar porter family from Sphingomonas koreensis DSMZ 15582
    37% identity, 90% coverage of query (247 bits)

ARAE_BACSU / P96710 Arabinose-proton symporter; Arabinose transporter from Bacillus subtilis (strain 168) (see 4 papers)
TC 2.A.1.1.55 / P96710 L-arabinose:proton symporter, AraE (Sa-Nogueira and Ramos, 1997). Also transports xylose, galactose and α-1,5 arabinobiose from Bacillus subtilis (see 4 papers)
    35% identity, 96% coverage of query (247 bits)

TC 2.A.1.1.65 / A0QZX3 Glucose permease GlcP (Pimentel-Schmitt et al., 2008) (most similar to 2.A.1.1.32) from Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
    38% identity, 93% coverage of query (237 bits)

TC 2.A.1.1.116 / C4B4V9 Arabinose/xylose transporter, AraE from Corynebacterium glutamicum
    34% identity, 93% coverage of query (235 bits)

GLF_ZYMMO / P21906 Glucose facilitated diffusion protein from Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) (see 2 papers)
TC 2.A.1.1.4 / P21906 Glucose uniporter from Zymomonas mobilis (see 2 papers)
    33% identity, 95% coverage of query (232 bits)

ARAE_KLEOX / P45598 Arabinose-proton symporter; Arabinose transporter from Klebsiella oxytoca (see paper)
    34% identity, 94% coverage of query (231 bits)

TC 2.A.1.1.121 / E1WAV4 Minor myo-inositol transporter, IolT2, of 478 aas from Salmonella typhimurium (strain SL1344)
    31% identity, 99% coverage of query (230 bits)

GLCP_STAES / A0A0H2VG78 Glucose transporter GlcP; Glucose/H(+) symporter from Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) (see paper)
    31% identity, 91% coverage of query (228 bits)

AraE / b2841 arabinose:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 5 papers)
araE / P0AE24 arabinose:H+ symporter from Escherichia coli (strain K12) (see 5 papers)
ARAE_ECOLI / P0AE24 Arabinose-proton symporter; Arabinose transporter from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.1.2 / P0AE24 Arabinose (xylose; galactose):H+ symporter, AraE (low affinity high capacity) from Escherichia coli (see 6 papers)
    33% identity, 94% coverage of query (224 bits)

TC 2.A.1.1.53 / Q8NTX0 Myo-Inositol uptake porter, IolT1 (Km=0.2mM) from Corynebacterium glutamicum (Brevibacterium flavum) (see paper)
    35% identity, 95% coverage of query (221 bits)

TC 2.A.1.1.42 / Q8G3X1 The D-glucose:H+ symporter, GlcP (glucose uptake is inhibited by 2-deoxyglucose, mannose and galactose) from Bifidobacterium longum (see paper)
    32% identity, 97% coverage of query (213 bits)

b2943 galactose:H+ symporter (galP) from Escherichia coli BW25113
GalP / b2943 galactose:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 6 papers)
GalP / P0AEP1 galactose:H+ symporter from Escherichia coli (strain K12) (see 7 papers)
GALP_ECOLI / P0AEP1 Galactose-proton symporter; Galactose transporter from Escherichia coli (strain K12) (see paper)
TC 2.A.1.1.1 / P0AEP1 Galactose:H+ symporter, GalP. Also transports glucose, xylose, fucose (6-deoxygalactose), 2-deoxygalactose and 2-deoxyglucose) (Henderson and Giddens 1977; from Escherichia coli (strain K12)
    34% identity, 94% coverage of query (211 bits)

pGlcT / Q56ZZ7 glucose transporter from Arabidopsis thaliana (see 4 papers)
PLST4_ARATH / Q56ZZ7 Plastidic glucose transporter 4; AtpGlcT from Arabidopsis thaliana (Mouse-ear cress) (see paper)
TC 2.A.1.1.102 / Q56ZZ7 Plastidic glucose transporter 4 (AtpGlcT) from Arabidopsis thaliana (see 5 papers)
    33% identity, 94% coverage of query (209 bits)

Build an alignment

Build an alignment for BWI76_RS21205 and 25 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

GTR1_DROME / Q8IRI6 Glucose transporter type 1 from Drosophila melanogaster (Fruit fly) (see paper)
    29% identity, 92% coverage of query (201 bits)

TC 2.A.1.1.103 / Q0WWW9 D-xylose-proton symporter-like 3, chloroplastic from Arabidopsis thaliana (see 7 papers)
    33% identity, 93% coverage of query (196 bits)

TC 2.A.1.1.20 / Q01440 Myoinositol:H+ symporter, MIT from Leishmania donovani (see paper)
    31% identity, 94% coverage of query (189 bits)

TC 2.A.1.1.45 / Q8L6Z8 Vacuolar (tonoplast) glucose transporter1, Vgt1 (important for seed germination and flowering) from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
RF|NP_186959.2 D-xylose-proton symporter-like 1 from Arabidopsis thaliana
    29% identity, 93% coverage of query (184 bits)

TC 2.A.1.1.123 / AIU41385.1 Sorbitol (D-Glucitol):H+ co-transporter, SOT1 (Km for sorbitol of 0.64 mM) of 509 aas and 12 TMSs (Gao et al. 2003). SOT1 of P. cerasus is expressed throughout fruit development, but especially when growth and sorbitol accumulation rates are highest. In leaves, PcSOT1 expression is highest in young, expanding tissues, but substantially less in mature leaves from Prunus salicina
    29% identity, 94% coverage of query (183 bits)

ITR2_CRYNH / J9VLA6 Myo-inositol transporter 2 from Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) (see 2 papers)
    32% identity, 94% coverage of query (182 bits)

INT1_ARATH / Q8VZR6 Inositol transporter 1 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 2.A.1.1.66 / Q8VZR6 The tonoplast H+:Inositol symporter 1, Int1 (mediates efflux from the tonoplast to the cytoplasm (Schneider et al., 2008) (most similar to 2.A.1.1.63 and 2.A.1.1.62) from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
int1 / CAJ00303.1 inositol transporter 1 from Arabidopsis thaliana (see paper)
    30% identity, 97% coverage of query (182 bits)

STP2_ARATH / Q9LNV3 Sugar transport protein 2; Hexose transporter 2 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
TC 2.A.1.1.48 / Q9LNV3 The pentose/hexose transporter (sugar transport protein 2), STP2. (Expressed during pollen maturation and early stages of gametophyte development) from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    29% identity, 95% coverage of query (180 bits)

TC 2.A.1.1.54 / Q8NL90 Myo-Inositol (Km=0.45mM) uptake porter, IolT2 (Krings et al., 2006).  Can not transport D-glucose from Corynebacterium glutamicum (Brevibacterium flavum) (see paper)
    31% identity, 93% coverage of query (179 bits)

TC 2.A.1.1.69 / A1Z264 Sugar & polyol transporter 1 (SPT1): broad specificity; takes up glucose (Schilling and Oesterhelt, 2007). Loss of the first 3 TMSs of the 12 TMSs does not prevent sugar uptake or sugar recognition but lowers substrate affinity & transport rate, and abolished H+ symport from Galdieria sulphuraria (see paper)
    29% identity, 94% coverage of query (179 bits)

TC 2.A.1.1.40 / Q64L87 The xylose facilitator, Xylhp from Debaryomyces hansenii (Yeast) (Torulaspora hansenii)
    31% identity, 95% coverage of query (178 bits)

STP1_ARATH / P23586 Sugar transport protein 1; Glucose transporter; Hexose transporter 1 from Arabidopsis thaliana (Mouse-ear cress) (see 8 papers)
TC 2.A.1.1.60 / P23586 The major hexose transporter, Htr1 (mediates the active uptake of hexoses by sugar:H+ symport. Can transport glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose. Confers sensitivity to galactose in seedlings. Km=20 uM for glucose) from Arabidopsis thaliana (Mouse-ear cress) (see 14 papers)
STP1 / RF|NP_172592.1 sugar transport protein 1 from Arabidopsis thaliana (see paper)
    28% identity, 94% coverage of query (177 bits)

PLT5_ARATH / Q8VZ80 Polyol transporter 5; Protein POLYOL TRANSPORTER 5; AtPLT5; Sugar-proton symporter PLT5 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 2.A.1.1.34 / Q8VZ80 The broad specificity sugar/sugar alcohol (myo-inositol, glycerol, ribose, sorbitol, mannitol, xylitol, erythritol, etc) H+ symporter, AtPLT5 (transports a wide range of hexoses, pentoses, tetroses, sugar alcohols and a sugar acid, but not disaccharides) (Reinders et al., 2005) (expressed in roots, leaves and floral organs) from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
PLT5 / RF|NP_188513.1 polyol transporter 5 from Arabidopsis thaliana (see paper)
    27% identity, 96% coverage of query (176 bits)

GTR3_SHEEP / P47843 Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3 from Ovis aries (Sheep) (see paper)
    28% identity, 95% coverage of query (176 bits)

STP10_ARATH / Q9LT15 Sugar transport protein 10; AtSTP10; D-glucose-H(+) symport protein STP10; D-glucose-proton symporter STP10; Hexose transporter 10 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 2.A.1.1.124 / Q9LT15 The high affinity sugar:H+ symporter (sugar uptake) porter of 514 aas and 12 TMSs, STP10. It transports glucose, galactose and mannose, and is therefore a hexose transporter (Rottmann et al. 2016). The 2.4 from Arabidopsis thaliana
    29% identity, 94% coverage of query (176 bits)

STP9_ARATH / Q9SX48 Sugar transport protein 9; Hexose transporter 9 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
stp9 / CAC69072.1 STP9 protein from Arabidopsis thaliana (see paper)
    30% identity, 94% coverage of query (176 bits)

GTR3_RABIT / Q9XSC2 Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3 from Oryctolagus cuniculus (Rabbit) (see paper)
    30% identity, 94% coverage of query (176 bits)

7aaqA / Q9LT15 Sugar/h+ symporter stp10 in outward occluded conformation (see paper)
    29% identity, 94% coverage of query (176 bits)

MST4_ORYSJ / Q10PW9 Sugar transport protein MST4; Monosaccharide transporter 4; OsMST4; Sugar:proton symporter MST4 from Oryza sativa subsp. japonica (Rice) (see 2 papers)
    27% identity, 94% coverage of query (175 bits)

STP6_ARATH / Q9SFG0 Sugar transport protein 6; Hexose transporter 6 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
TC 2.A.1.1.56 / Q9SFG0 High affinity monosaccharide (KM ≈ 20 µM):H+ symporter, Stp6 (takes up glucose, 3-O-methylglucose, mannose, fructose, galactose and to a lesser extent, xylose and ribulose. from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
STP6 / RF|NP_187247.1 sugar transport protein 6 from Arabidopsis thaliana (see paper)
    29% identity, 95% coverage of query (175 bits)

ITR2_SCHPO / P87110 Myo-inositol transporter 2 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
itr2 / RF|NP_593320.1 MFS myo-inositol transporter from Schizosaccharomyces pombe (see 2 papers)
    30% identity, 98% coverage of query (175 bits)

TC 2.A.1.1.98 / Q9FRL3 Sugar transporter ERD6-like 6 from Arabidopsis thaliana (see 3 papers)
    31% identity, 83% coverage of query (175 bits)

TC 2.A.1.1.75 / Q9XIH7 The fructose/xylose:H+ symporter, PMT1 (polyol monosaccharide transporter-1). Also transports other substrates at lower rates. PMT2 is largely of the same sequence and function. Both are present in pollen and young xylem cells (Klepek et al., 2005). A similar ortholog has been identifed in pollen grains of Petunia hybrida from Arabidopsis thaliana (see 2 papers)
    28% identity, 94% coverage of query (175 bits)

P38695 Probable glucose transporter HXT5 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    29% identity, 95% coverage of query (175 bits)

TC 2.A.1.1.122 / AGG19156.1 Sorbitol (glucitol):H+ co-transporter, SOT2 (Km for sorbitol of 0.81 mM) of 491 aas and 12 TMSs (Gao et al. 2003). SOT2 of Prunus cerasus is mainly expressed only early in fruit development and not in leaves from Pyrus pyrifolia
    27% identity, 94% coverage of query (174 bits)

TC 2.A.1.1.50 / Q94AZ2 The glucose/fructose:H+ symporter, STP13 (sugar transport protein 13). Expressed in vascular tissues and induced during programmed cell death from Arabidopsis thaliana (Mouse-ear cress) (see 6 papers)
STP13 / RF|NP_198006.1 sugar transport protein 13 from Arabidopsis thaliana (see paper)
    28% identity, 94% coverage of query (174 bits)

ITR1A_CRYNH / J9VTS6 Myo-inositol transporter 1A from Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) (see 4 papers)
    30% identity, 96% coverage of query (172 bits)

plt1 / CAD58709.1 polyol transporter from Plantago major (see paper)
    28% identity, 94% coverage of query (172 bits)

TRE12_DROME / Q8MKK4 Facilitated trehalose transporter Tret1-2 homolog; DmTret1-2 from Drosophila melanogaster (Fruit fly) (see paper)
    29% identity, 88% coverage of query (172 bits)

INT2_ARATH / Q9C757 Probable inositol transporter 2 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
TC 2.A.1.1.63 / Q9C757 Low affinity inositol (myoinsoitol (Km = 1 mM), scylloinositol, d-chiroinositol and mucoinositol):H+ symporter (expressed in the anther tapetum, the vasculature, and the leaf mesophyll from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
    36% identity, 72% coverage of query (172 bits)

7aarA Sugar/h+ symporter stp10 in inward open conformation
    28% identity, 94% coverage of query (172 bits)

MST8_ORYSJ / Q94EC4 Sugar transport protein MST8; Monosaccharide transporter 8; OsMST8; Sugar:proton symporter MST8 from Oryza sativa subsp. japonica (Rice) (see 2 papers)
    29% identity, 94% coverage of query (171 bits)

INT3_ARATH / Q9ZQP6 Probable inositol transporter 3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    33% identity, 72% coverage of query (171 bits)

GTR3_RAT / Q07647 Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3 from Rattus norvegicus (Rat) (see 3 papers)
TC 2.A.1.1.12 / Q07647 Glucose uniporter, Glut3 (also transports dehydro-ascorbate; Maulén et al., 2003). Down-regulated in the brains of Alzheimer's disease patients (Liu et al., 2008b) from Rattus norvegicus (Rat) (see 2 papers)
    29% identity, 96% coverage of query (171 bits)

TC 2.A.1.1.79 / Q1XF07 Polyol (xylitol):H+ symporter, PLT4 from Lotus japonicus
    26% identity, 97% coverage of query (171 bits)

CH_124119 high-affinity glucose transporter from Magnaporthe grisea 70-15 (see paper)
    29% identity, 99% coverage of query (169 bits)

TC 2.A.1.1.117 / G4N740 Glucose transporter Rco-3 or MoST1. MoST1 plays a specific role in conidiation and mycelial melanization which is not shared by other hexose transporter family members in M. oryzae from Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)
    30% identity, 93% coverage of query (169 bits)

KHT2 / CAA87389.1 permease from Kluyveromyces lactis (see paper)
    28% identity, 93% coverage of query (169 bits)

TC 2.A.1.1.57 / Q8J0V1 High affinity (15 μM) glucose (monosaccharides including xylose):H+ symporter, MstA from Aspergillus niger
    28% identity, 94% coverage of query (167 bits)

GTR3_MOUSE / P32037 Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3 from Mus musculus (Mouse) (see 2 papers)
    28% identity, 96% coverage of query (167 bits)

GTR3_HUMAN / P11169 Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3 from Homo sapiens (Human) (see 5 papers)
TC 2.A.1.1.91 / P11169 Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3 or GLUT3). It mediates the facilitative uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably dehydroascorbate, but not fructose from Homo sapiens (see 6 papers)
    28% identity, 96% coverage of query (165 bits)

INT4_ARATH / O23492 Inositol transporter 4; Myo-inositol-proton symporter INT4; Protein INOSITOL TRANSPORTER 4 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
TC 2.A.1.1.62 / O23492 High affinity (0.24mM) plasma membrane myoinositol-specific H+ symporter, INT4 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
INT4 / RF|NP_193381.1 inositol transporter 4 from Arabidopsis thaliana (see paper)
    33% identity, 75% coverage of query (164 bits)

GTR1_MOUSE / P17809 Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; GT1 from Mus musculus (Mouse) (see 7 papers)
    28% identity, 93% coverage of query (164 bits)

4zw9A Crystal structure of human glut3 bound to d-glucose in the outward- occluded conformation at 1.5 angstrom
    29% identity, 94% coverage of query (163 bits)

7crzA Crystal structure of human glucose transporter glut3 bound with c3361
    29% identity, 94% coverage of query (163 bits)

7spsA Crystal structure of human glucose transporter glut3 bound with exofacial inhibitor sa47
    29% identity, 94% coverage of query (163 bits)

6m20B / O97467 Crystal structure of plasmodium falciparum hexose transporter pfht1 bound with glucose (see paper)
    28% identity, 84% coverage of query (162 bits)

5c65A Structure of the human glucose transporter glut3 / slc2a3
    28% identity, 92% coverage of query (162 bits)

SLC2A1 / P11166 solute carrier family 2, facilitated glucose transporter member 1 from Homo sapiens (see 25 papers)
GTR1_HUMAN / P11166 Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; HepG2 glucose transporter from Homo sapiens (Human) (see 34 papers)
TC 2.A.1.1.28 / P11166 The erythrocyte/brain hexose facilitator, glucose transporter-1, Gtr1 or Glut1. Transports D-glucose, dehydroascorbate, arsenite and the flavonone, quercetin, via one pathway and water via a distinct channel. Sugar transport has been suggested to function via a sliding mechanism involving several sugar binding sites (Cunningham et al., 2006). Glut1 is the receptor for human T-cell leukemia virus (HTLV)) (Manel et al., 2003). It is regulated by stomatin (TC# 8.A.21) to take up dehydroascorbate (Montel-Hagen et al., 2008). Mutations cause Glut1 deficiency syndrome, a human encephalopathy that results from decreased glucose flux through the blood brain barrier from Homo sapiens (Human) (see 21 papers)
    26% identity, 93% coverage of query (162 bits)

6rw3A The molecular basis for sugar import in malaria parasites.
    28% identity, 84% coverage of query (162 bits)

SLC2A2 / P11168 solute carrier family 2, facilitated glucose transporter member 2 from Homo sapiens (see 3 papers)
GTR2_HUMAN / P11168 Solute carrier family 2, facilitated glucose transporter member 2; Glucose transporter type 2, liver; GLUT-2 from Homo sapiens (Human) (see 9 papers)
TC 2.A.1.1.29 / P11168 Glucosamine/glucose uniporter, Glut-2; it may also transport dehydroascorbate (Mardones et al., 2011; from Homo sapiens (Human) (see 7 papers)
    27% identity, 87% coverage of query (159 bits)

6m2lA Crystal structure of plasmodium falciparum hexose transporter pfht1 bound with c3361
    28% identity, 83% coverage of query (159 bits)

TRE11_DROME / A1Z8N1 Facilitated trehalose transporter Tret1-1; DmTret1-1 from Drosophila melanogaster (Fruit fly) (see 2 papers)
TC 2.A.1.1.99 / A1Z8N1 Facilitated trehalose transporter Tret1-1 (DmTret1-1); transports trehalose with a Km of 11 mM from Drosophila melanogaster (see 4 papers)
    30% identity, 81% coverage of query (158 bits)

7sptA / P11169 Crystal structure of exofacial state human glucose transporter glut3 (see paper)
    29% identity, 94% coverage of query (158 bits)

HXT7_YEAST / P39004 High-affinity hexose transporter HXT7 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
TC 2.A.1.1.31 / P39004 High affinity, glucose-repressible, glucose (hexose) uniporter (Hxt6/Hxt7). Asn331 and hydrophobic residue side chains in TMS5 determine substrate affinity from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 6 papers)
    28% identity, 93% coverage of query (158 bits)

P39003 High-affinity hexose transporter HXT6 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    28% identity, 93% coverage of query (157 bits)

GTR5_RAT / P43427 Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5 from Rattus norvegicus (Rat) (see 4 papers)
    28% identity, 96% coverage of query (156 bits)

5eqiA Human glut1 in complex with cytochalasin b
    26% identity, 90% coverage of query (154 bits)

5eqhA Human glut1 in complex with inhibitor (2~{s})-3-(2-bromophenyl)-2-[2- (4-methoxyphenyl)ethanoylamino]-~{n}-[(1~{s})-1- phenylethyl]propanamide
    26% identity, 90% coverage of query (154 bits)

5eqgA / P11166 Human glut1 in complex with inhibitor (2~{s})-3-(4-fluorophenyl)-2-[2- (3-hydroxyphenyl)ethanoylamino]-~{n}-[(1~{s})-1- phenylethyl]propanamide (see paper)
    26% identity, 90% coverage of query (154 bits)

GLUT4_HUMAN / P14672 Solute carrier family 2, facilitated glucose transporter member 4; Glucose transporter type 4, insulin-responsive; GLUT-4 from Homo sapiens (Human) (see 7 papers)
TC 2.A.1.1.80 / P14672 Insulin-responsive facilitative glucose transporter in skeletal and cardiac muscle, adipose, and other tissues, Glut4 (GTR4; SLC2A4; 509aas). Defects in Glut4 cause noninsulin-dependent diabetes mellitus (NIDDM) from Homo sapiens (see 12 papers)
    30% identity, 95% coverage of query (149 bits)

7wsmA / P14672 Cryo-em structure of human glucose transporter glut4 bound to cytochalasin b in lipid nanodiscs (see paper)
    30% identity, 92% coverage of query (149 bits)

HXT4_YEAST / P32467 Low-affinity glucose transporter HXT4; Low-affinity glucose transporter LGT1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
TC 2.A.1.1.30 / P32467 Low affinity, constitutive, glucose (hexose; xylose) uniporter, Hxt4 (LGT1; Rag1) (also transports arsenic trioxide [As(OH)3] as do Hxtl, 3, 5, 7 and 9) from Saccharomyces cerevisiae (Baker's yeast) (see 5 papers)
HXT4 low-affinity glucose transporter HXT4 from Saccharomyces cerevisiae (see paper)
    27% identity, 93% coverage of query (147 bits)

SNF3_YEAST / P10870 Low glucose sensor SNF3; High-affinity glucose receptor SNF3; High-affinity transporter-like sensor SNF3; Sucrose nonfermenting protein 3 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 5 papers)
TC 2.A.1.1.17 / P10870 Glucose transporter from Saccharomyces cerevisiae (see 7 papers)
    28% identity, 97% coverage of query (147 bits)

SL2A8_MOUSE / Q9JIF3 Solute carrier family 2, facilitated glucose transporter member 8; Glucose transporter type 8; GLUT-8; Glucose transporter type X1 from Mus musculus (Mouse) (see 6 papers)
    30% identity, 82% coverage of query (145 bits)

GLUT4_MOUSE / P14142 Solute carrier family 2, facilitated glucose transporter member 4; GT2; Glucose transporter type 4, insulin-responsive; GLUT-4 from Mus musculus (Mouse) (see 8 papers)
    30% identity, 92% coverage of query (145 bits)

GTR9_MOUSE / Q3T9X0 Solute carrier family 2, facilitated glucose transporter member 9; Glucose transporter type 9; GLUT-9; Urate transporter from Mus musculus (Mouse) (see 3 papers)
    28% identity, 95% coverage of query (143 bits)

SL2A8_RAT / Q9JJZ1 Solute carrier family 2, facilitated glucose transporter member 8; Glucose transporter type 8; GLUT-8; Glucose transporter type X1 from Rattus norvegicus (Rat) (see 3 papers)
    30% identity, 82% coverage of query (142 bits)

GTR7_HUMAN / Q6PXP3 Solute carrier family 2, facilitated glucose transporter member 7; Glucose transporter type 7; GLUT-7; hGLUT7 from Homo sapiens (Human) (see 4 papers)
TC 2.A.1.1.37 / Q6PXP3 The glucose/fructose facilitator, Glut7 (SLC2A7) (a single mutation, I314V, results in loss of fructose transport but retention of glucose transport from Homo sapiens (Human) (see 2 papers)
    26% identity, 94% coverage of query (142 bits)

ESL1_ARATH / Q94KE0 Sugar transporter ESL1; Protein EARLY-RESPONSIVE TO DEHYDRATION 6-LIKE 1; ERD six-like 1; Sugar transporter ERD6-like 3; Sugar transporter-like protein 2 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    30% identity, 84% coverage of query (141 bits)

O74969 High-affinity glucose transporter ght2; Hexose transporter 2 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    26% identity, 95% coverage of query (140 bits)

GTR9_HUMAN / Q9NRM0 Solute carrier family 2, facilitated glucose transporter member 9; Glucose transporter type 9; GLUT-9; Urate transporter from Homo sapiens (Human) (see 18 papers)
    27% identity, 92% coverage of query (137 bits)

RGT2_YEAST / Q12300 High glucose sensor RGT2; Low-affinity glucose receptor RGT2; Low-affinity transporter-like sensor RGT2; Restores glucose transport protein 2 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 4 papers)
TC 2.A.1.1.19 / Q12300 Glucose transporter and low affinity sensor, Rgt2p (regulates glucose transport in conjunction with Snf3p). Rgt2 generates an intracellular signal in response to glucose that leads to inhibition of the Rgt1 transcriptional repressor and consequently to derepression of HXT genes encoding glucose transporters. They have unusually long C-terminal tails that bind to Mth1 and Std1, paralogous proteins that regulate the function of the Rgt1 transcription factor from Saccharomyces cerevisiae (Baker's yeast) (see 4 papers)
RGT2 / RF|NP_010143.1 high-affinity glucose transporter RGT2 from Saccharomyces cerevisiae
    27% identity, 95% coverage of query (132 bits)

FST1_GIBM7 / W7MAT5 Myo-inositol transporter FST1 from Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot fungus) (Fusarium verticillioides) (see 3 papers)
TC 2.A.1.1.126 / A8DCT2 Myo inositol uptake porter of 574 aas and 12 TMSs, Fst1 from Gibberella moniliformis
    27% identity, 94% coverage of query (127 bits)

P78831 High-affinity glucose transporter ght5; Hexose transporter 5 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
    24% identity, 94% coverage of query (127 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory