Searching for up to 100 curated homologs for BWI76_RS22070 FitnessBrowser__Koxy:BWI76_RS22070 (354 a.a.)

Found high-coverage hits (≥70%) to 15 curated proteins.

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Hits with ≥ 30% identity

OsrA / b2678 glycine betaine ABC transporter membrane subunit ProW (EC 7.6.2.9) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
proW / P14176 glycine betaine ABC transporter membrane subunit ProW (EC 7.6.2.9) from Escherichia coli (strain K12) (see paper)
PROW_ECOLI / P14176 Glycine betaine/proline betaine transport system permease protein ProW from Escherichia coli (strain K12) (see 4 papers)
TC 3.A.1.12.1 / P14176 ProW aka B2678, component of Glycine betaine/proline porter, ProU or ProVWX (also transports proline betaine, carnitine, dimethyl proline, homobetaine, γ-butyrobetaine and choline with low affinity) from Escherichia coli (see 5 papers)
    91% identity, 100% coverage of query (599 bits)

OUSW_DICD3 / E0SCY2 Glycine betaine/choline transport system permease protein OusW from Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)) (see paper)
    77% identity, 99% coverage of query (556 bits)

A0A077T980 ABC-type quaternary amine transporter (subunit 3/3) (EC 7.6.2.9) from Vibrio anguillarum serotype O1 (see paper)
    68% identity, 96% coverage of query (444 bits)

OPUAB_BACSU / P46921 Glycine betaine transport system permease protein OpuAB from Bacillus subtilis (strain 168) (see 2 papers)
P46921 ABC-type quaternary amine transporter (EC 7.6.2.9) from Bacillus subtilis (see 2 papers)
TC 3.A.1.12.2 / P46921 OPAB aka OpuAB, component of Glycine betaine OpuAA/AB/AC porter (also transports dimethylsulfonioacetate and dimethylsulfoniopropionate) from Bacillus subtilis (see 3 papers)
    47% identity, 78% coverage of query (246 bits)

TC 3.A.1.12.5 / Q9RQ05 BusAB aka OPUABC, component of Uptake system for glycine-betaine (high affinity) and proline (low affinity) (OpuAA-OpuABC) or BusAA-ABC of Lactococcus lactis). BusAA, the ATPase subunit, has a C-terminal tandem cystathionine β-synthase (CBS) domain which is the cytoplasmic K+ sensor for osmotic stress (osmotic strength)while the BusABC subunit has the membrane and receptor domains fused to each other (Biemans-Oldehinkel et al., 2006; Mahmood et al., 2006; Gul et al. 2012). An N-terminal amphipathic α-helix of OpuA is necessary for high activity but is not critical for biogenesis or the ionic regulation of transport from Lactococcus lactis (see 2 papers)
    46% identity, 79% coverage of query (226 bits)

Q7DAU8 ABC-type quaternary amine transporter (EC 7.6.2.9) from Lactococcus lactis (see paper)
    46% identity, 79% coverage of query (226 bits)

AO356_09615 ABC transporter for L-Histidine, permease component from Pseudomonas fluorescens FW300-N2C3
    46% identity, 80% coverage of query (224 bits)

TC 3.A.1.12.6 / Q9KKE2 HutW aka HISW, component of Uptake system for hisitidine, proline, proline-betaine and glycine-betaine from Rhizobium meliloti (Sinorhizobium meliloti) (see paper)
    44% identity, 81% coverage of query (215 bits)

TC 3.A.1.12.9 / Q8U4S4 OtaB, component of The salt-induced glycine betaine OtaABC transporter from Methanosarcina mazei (see paper)
    43% identity, 75% coverage of query (212 bits)

GBUB_LISM4 / Q9RR45 Glycine betaine/carnitine transport permease protein GbuB from Listeria monocytogenes serotype 1/2a (strain 10403S) (see 4 papers)
    48% identity, 77% coverage of query (207 bits)

TC 3.A.1.12.7 / Q92N36 ChoW, component of High affinity (3 μM) choline-specific uptake system from Rhizobium meliloti (Sinorhizobium meliloti) (see 2 papers)
    44% identity, 77% coverage of query (204 bits)

TC 3.A.1.12.13 / Q7CXG1 ABC transporter, membrane spanning protein (Proline/glycine betaine), component of High affinity (2mμM) choline uptake porter. The choline binding receptor exhibits a venus fly trap mechanism of substrate binding. (ChoX binds acetyl choline and betaine with low affinity (80μM and 470μM, respectively) (Aktas et al., 2011) (most similar to 3.A.1.12.7) from Agrobacterium tumefaciens (strain C58 / ATCC 33970) (see 2 papers)
    43% identity, 76% coverage of query (190 bits)

AO353_07785 ABC transporter for Carnitine, permease component from Pseudomonas fluorescens FW300-N2E3
    40% identity, 76% coverage of query (187 bits)

TC 3.A.1.12.12 / Q9HTI7 Probable permease of ABC transporter, component of The CbcWV/CbcX (choline)/CaiX (carnitine)/BetX (betaine) transporter with 3 binding receptors for distinct quaternary ammonium compounds. Only the ligand-bound receptor binds to the transporter with high affinity from Pseudomonas aeruginosa (see paper)
    41% identity, 75% coverage of query (174 bits)

TMOV_PELUB / Q4FL38 Trimethylamine N-oxide transport system permease protein TmoV; TMAO transport system permease protein TmoV from Pelagibacter ubique (strain HTCC1062) (see paper)
    31% identity, 79% coverage of query (122 bits)

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