Searching for up to 100 curated homologs for BWI76_RS23920 FitnessBrowser__Koxy:BWI76_RS23920 (410 a.a.)
Found high-coverage hits (≥70%) to 41 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
SerA / b2913 phosphoglycerate dehydrogenase (EC 1.1.1.95; EC 1.1.1.399) from Escherichia coli K-12 substr. MG1655 (see 36 papers)
serA / P0A9T0 phosphoglycerate dehydrogenase (EC 1.1.1.95; EC 1.1.1.399) from Escherichia coli (strain K12) (see 36 papers)
SERA_ECOLI / P0A9T0 D-3-phosphoglycerate dehydrogenase; PGDH; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Escherichia coli (strain K12) (see paper)
C3SVM7 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Escherichia coli (see paper)
P0A9T0 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Escherichia coli (see 7 papers)
serA / RF|NP_417388 D-3-phosphoglycerate dehydrogenase; EC 1.1.1.95 from Escherichia coli K12 (see 5 papers)
91% identity, 100% coverage of query (771 bits)
1ybaA The active form of phosphoglycerate dehydrogenase
91% identity, 99% coverage of query (764 bits)
1psdA The allosteric ligand site in the vmax-type cooperative enzyme phosphoglycerate dehydrogenase
91% identity, 99% coverage of query (761 bits)
2p9eA / P0A9T0 Crystal structure of g336v mutant of e.Coli phosphoglycerate dehydrogenase (see paper)
90% identity, 99% coverage of query (748 bits)
1sc6D / P0A9T0 Crystal structure of w139g d-3-phosphoglycerate dehydrogenase complexed with NAD+ (see paper)
86% identity, 99% coverage of query (685 bits)
Q9I6H5 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Pseudomonas aeruginosa (see paper)
65% identity, 100% coverage of query (550 bits)
A4VGK3 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Pseudomonas stutzeri (see paper)
65% identity, 100% coverage of query (547 bits)
Echvi_2777 fused D-3-phosphoglycerate dehydrogenase / phosphoserine phosphatase (EC 1.1.1.95; EC 3.1.3.3) from Echinicola vietnamensis KMM 6221, DSM 17526
52% identity, 100% coverage of query (437 bits)
P87228 Putative D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
49% identity, 98% coverage of query (397 bits)
U3RH61 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Acanthamoeba castellanii (see paper)
49% identity, 99% coverage of query (393 bits)
SERA_YEAST / P40054 D-3-phosphoglycerate dehydrogenase 1; 3-PGDH 1; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
47% identity, 98% coverage of query (382 bits)
SER33_YEAST / P40510 D-3-phosphoglycerate dehydrogenase 2; 3-PGDH 2; 2-oxoglutarate reductase; EC 1.1.1.95; EC 1.1.1.399 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
47% identity, 98% coverage of query (382 bits)
1wwkA / O50095 Crystal structure of phosphoglycerate dehydrogenase from pyrococcus horikoshii ot3
41% identity, 74% coverage of query (198 bits)
hprA / P73821 glycerate dehydrogenase (EC 1.1.1.29) from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
34% identity, 77% coverage of query (181 bits)
SERA_MOUSE / Q61753 D-3-phosphoglycerate dehydrogenase; 3-PGDH; A10; EC 1.1.1.95 from Mus musculus (Mouse) (see paper)
Q61753 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Mus musculus (see 2 papers)
35% identity, 77% coverage of query (172 bits)
PHGDH / O43175 D-3-phosphoglycerate dehydrogenase (EC 1.1.1.95) from Homo sapiens (see 3 papers)
SERA_HUMAN / O43175 D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; Malate dehydrogenase; EC 1.1.1.95; EC 1.1.1.399; EC 1.1.1.37 from Homo sapiens (Human) (see 7 papers)
O43175 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Homo sapiens (see 8 papers)
36% identity, 70% coverage of query (172 bits)
Phgdh / O08651 3-phosphoglycerate dehydrogenase subunit (EC 1.1.1.95) from Rattus norvegicus (see paper)
SERA_RAT / O08651 D-3-phosphoglycerate dehydrogenase; 3-PGDH; EC 1.1.1.95 from Rattus norvegicus (Rat) (see paper)
O08651 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Rattus norvegicus (see paper)
34% identity, 77% coverage of query (171 bits)
SERA2_ARATH / O04130 D-3-phosphoglycerate dehydrogenase 2, chloroplastic; PGDH; EC 1.1.1.95 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
O04130 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Arabidopsis thaliana (see 3 papers)
35% identity, 79% coverage of query (170 bits)
H9JRZ9 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Bombyx mori (see paper)
33% identity, 75% coverage of query (159 bits)
Q972A9 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Sulfurisphaera tokodaii (see paper)
34% identity, 72% coverage of query (153 bits)
2eklA / Q972A9 Structure of st1218 protein from sulfolobus tokodaii
34% identity, 72% coverage of query (153 bits)
A0A2R6X868 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Marchantia polymorpha (see paper)
33% identity, 78% coverage of query (153 bits)
SERA3_ARATH / Q9LT69 D-3-phosphoglycerate dehydrogenase 3, chloroplastic; EC 1.1.1.95 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
Q9LT69 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Arabidopsis thaliana (see 4 papers)
34% identity, 79% coverage of query (152 bits)
A0A1Z4EAX4 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Beta vulgaris (see paper)
33% identity, 80% coverage of query (151 bits)
HPR_BLAHS / C0CMQ8 Hydroxypyruvate reductase; EC 1.1.1.81 from Blautia hydrogenotrophica (strain DSM 10507 / JCM 14656 / S5a33) (Ruminococcus hydrogenotrophicus) (see paper)
34% identity, 73% coverage of query (150 bits)
SERA1_ARATH / O49485 D-3-phosphoglycerate dehydrogenase 1, chloroplastic; Protein EMBRYO SAC DEVELOPMENT ARREST 9; EC 1.1.1.95 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
O49485 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Arabidopsis thaliana (see 4 papers)
35% identity, 70% coverage of query (150 bits)
Q8U3Y2 glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Pyrococcus furiosus (see paper)
31% identity, 75% coverage of query (148 bits)
A0A1Z4EAX3 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Beta vulgaris (see paper)
34% identity, 71% coverage of query (148 bits)
5aovA / Q8U3Y2 Ternary crystal structure of pyrococcus furiosus glyoxylate hydroxypyruvate reductase in presence of glyoxylate (see paper)
31% identity, 75% coverage of query (148 bits)
F8AEA4 glyoxylate reductase (NADP+) (EC 1.1.1.79); hydroxypyruvate reductase (EC 1.1.1.81) from Pyrococcus yayanosii (see paper)
32% identity, 77% coverage of query (143 bits)
6biiA / F8AEA4 Crystal structure of pyrococcus yayanosii glyoxylate hydroxypyruvate reductase in complex with NADP and malonate (re-refinement of 5aow) (see paper)
32% identity, 77% coverage of query (143 bits)
Build an alignment for BWI76_RS23920 and 31 homologs with ≥ 30% identity
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PGDH1 / A2DLU8 phosphoglycerate dehydrogenase (EC 1.1.1.95) from Trichomonas vaginalis (strain ATCC PRA-98 / G3) (see paper)
29% identity, 91% coverage of query (130 bits)
Q608T2 hydroxypyruvate reductase (EC 1.1.1.81) from Methylococcus capsulatus (see paper)
30% identity, 75% coverage of query (129 bits)
4xkjA / A0A0M3KL04 A novel d-lactate dehydrogenase from sporolactobacillus sp
32% identity, 72% coverage of query (119 bits)
A0A0M3KL04 D-lactate dehydrogenase (EC 1.1.1.28) from Sporolactobacillus inulinus (see paper)
32% identity, 72% coverage of query (119 bits)
DHD2_LACPA / P17584 D-2-hydroxyisocaproate dehydrogenase; D-HICDH; EC 1.1.1.- from Lacticaseibacillus paracasei (Lactobacillus paracasei) (see paper)
P17584 D-2-hydroxyacid dehydrogenase (NAD+) (EC 1.1.1.345) from Lacticaseibacillus paracasei (see 2 papers)
CH_091798 D-2-hydroxyisocaproate dehydrogenase; EC 1.1.1.- from Lactobacillus paracasei (see 2 papers)
29% identity, 72% coverage of query (111 bits)
1dxyA / P17584 Structure of d-2-hydroxyisocaproate dehydrogenase (see paper)
29% identity, 71% coverage of query (110 bits)
4e5pA / O69054 Thermostable phosphite dehydrogenase a176r variant in complex with nad (see paper)
28% identity, 77% coverage of query (101 bits)
4e5kA Thermostable phosphite dehydrogenase in complex with NAD and sulfite
28% identity, 77% coverage of query (101 bits)
4e5mA Thermostable phosphite dehydrogenase e175a/a176r in complex with NADP
28% identity, 77% coverage of query (101 bits)
6ih6A / G4XDR8 Phosphite dehydrogenase mutant i151r/p176r/m207a from ralstonia sp. 4506 in complex with non-natural cofactor nicotinamide cytosine dinucleotide
31% identity, 78% coverage of query (99.0 bits)
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Lawrence Berkeley National Laboratory