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Searching for up to 100 curated homologs for BWI76_RS26970 FitnessBrowser__Koxy:BWI76_RS26970 (452 a.a.)

Found high-coverage hits (≥70%) to 45 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

PCAK_PSEPU / Q51955 4-hydroxybenzoate transporter PcaK from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 3 papers)
TC 2.A.1.15.1 / Q51955 4-Hydroxybenzoate/protocatechuate porter from Pseudomonas putida (see paper)
pcaK / AAA85137.1 PcaK from Pseudomonas putida (see paper)
    55% identity, 94% coverage of query (457 bits)

PCAK_ACIAD / Q43975 4-hydroxybenzoate transporter PcaK; 4-HB transporter from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
    52% identity, 92% coverage of query (439 bits)

proT / BAB32694.1 putative transporter from Pseudomonas straminea (see 2 papers)
    52% identity, 98% coverage of query (437 bits)

GALT_PSEPU / E8ZB61 Gallate transporter; Gallate permease from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
galT / CBJ94499.1 gallic acid permease from Pseudomonas putida (see paper)
    51% identity, 87% coverage of query (380 bits)

MHBT_KLEOX / Q5EXK5 3-hydroxybenzoate transporter MhbT from Klebsiella oxytoca (see paper)
    45% identity, 96% coverage of query (351 bits)

TC 2.A.1.15.5 / O30513 Benzoate porter, BenK from Acinetobacter calcoaceticus (see 2 papers)
    33% identity, 98% coverage of query (236 bits)

TC 2.A.1.15.7 / Q6FBB3 Aromatic compound (benzoate) uptake transporter of 450 aas from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)
    31% identity, 98% coverage of query (221 bits)

TC 2.A.1.15.3 / Q46M63 2,4-Dichlorophenoxyacetate porter (see 5 papers)
    32% identity, 97% coverage of query (210 bits)

TC 2.A.1.15.14 / Q8VUZ0 Probable uptake transporter for 2,4-dichlorophenoxyacetic acid (2,4-D), CadK from Bradyrhizobium sp. HW13
    30% identity, 91% coverage of query (204 bits)

YaiK / b0353 3-hydroxyphenylpropionate/3-hydroxycinnamate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 2 papers)
mhpT / P77589 3-hydroxyphenylpropionate/3-hydroxycinnamate:H+ symporter from Escherichia coli (strain K12) (see 2 papers)
MHPT_ECOLI / P77589 3-(3-hydroxy-phenyl)propionate transporter; 3HPP transporter; 3-(3-hydroxy-phenyl)propionate:H(+) symporter; 3HPP:H(+) symporter from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.15.2 / P77589 MhpT. A specific 3-(3-hydroxyphenyl)propionate (3HPP) transporter; vital for E. coli K-12 W3110 to grow on this substrate from Escherichia coli (see 3 papers)
    38% identity, 86% coverage of query (199 bits)

TC 2.A.1.15.6 / O24842 Vanillate porter, VanK (see 4 papers)
    30% identity, 98% coverage of query (194 bits)

TC 2.A.1.15.11 / Q6M372 The Vanillate porter, VanK from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
    30% identity, 86% coverage of query (166 bits)

Build an alignment

Build an alignment for BWI76_RS26970 and 12 homologs with ≥ 30% identity

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Additional hits (identity < 30%)

NIAP_ACIAD / Q6FFF7 Niacin transporter NiaP from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) (see paper)
    28% identity, 92% coverage of query (161 bits)

TC 2.A.1.15.8 / O24723 Probable 1-hydroxy-2-naphthoate transporter, orf1 (see paper)
    27% identity, 91% coverage of query (154 bits)

genK / Q8NLB7 gentisate transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see 3 papers)
GENK_CORGL / Q8NLB7 Gentisate transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) (see paper)
    28% identity, 85% coverage of query (137 bits)

NIAP_BACSU / O34691 Putative niacin/nicotinamide transporter NiaP from Bacillus subtilis (strain 168) (see paper)
TC 2.A.1.82.4 / O34691 Niacin uptake porter NiaP from Bacillus subtilis (see 2 papers)
    28% identity, 88% coverage of query (125 bits)

SVOP_BOVIN / Q1JP63 Synaptic vesicle 2-related protein; SV2-related protein from Bos taurus (Bovine) (see paper)
    27% identity, 87% coverage of query (120 bits)

SVOP_XENLA / Q2XWK0 Synaptic vesicle 2-related protein; SV2-related protein from Xenopus laevis (African clawed frog) (see paper)
    25% identity, 87% coverage of query (117 bits)

NanT / b3224 N-acetylneuraminate:H+ symporter from Escherichia coli K-12 substr. MG1655 (see 10 papers)
nanT / P41036 N-acetylneuraminate:H+ symporter from Escherichia coli (strain K12) (see 16 papers)
NANT_ECOLI / P41036 Sialic acid transporter NanT; Sialic acid permease; Sialic acid/H(+) symporter from Escherichia coli (strain K12) (see 4 papers)
TC 2.A.1.12.1 / P41036 The sialic acid porter, NanT.  N-acetylneuraminic acid (Neu5Ac) serves as a sole source of carbon and nitrogen for E. coli.  It is a mucus-derived carbon source in the mammalian gut. NanT can also take up and allow efficient growth on the related sialic acids, N-glycolylneuraminic acid (Neu5Gc) and 3-keto-3-deoxy-d-glycero-d-galactonononic acid (KDN) from Escherichia coli (see 4 papers)
    23% identity, 92% coverage of query (107 bits)

SVOP_RAT / Q9Z2I7 Synaptic vesicle 2-related protein; SV2-related protein from Rattus norvegicus (Rat) (see paper)
    26% identity, 87% coverage of query (105 bits)

TC 2.A.1.15.4 / P94131 cis,cis-muconate porter, MucK from Acinetobacter calcoaceticus (see 2 papers)
mucK / AAC27117.1 cis,cis-muconate transport protein MucK from Acinetobacter baylyi (see paper)
    26% identity, 90% coverage of query (104 bits)

TC 2.A.1.82.3 / Q8BFT9 Synaptic vesicle 2-related protein (SV2-related protein), SVOP from Mus musculus (see 4 papers)
    26% identity, 87% coverage of query (102 bits)

TC 2.A.1.15.9 / O51798 Probable 4-methylmuconolactone transporter, MmlH from Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus) (see paper)
    26% identity, 80% coverage of query (102 bits)

PHT14_LOTJA / B5RHV8 Low affinity inorganic phosphate transporter 4; LjPT4; LjPht1;4; Arbuscular mycorrhiza-induced phosphate transporter PT4; AM-induced phosphate transporter PT4; H(+)/Pi cotransporter PT4 from Lotus japonicus (Lotus corniculatus var. japonicus) (see 2 papers)
    26% identity, 74% coverage of query (89.4 bits)

TC 2.A.1.1.116 / C4B4V9 Arabinose/xylose transporter, AraE from Corynebacterium glutamicum
    26% identity, 85% coverage of query (89.4 bits)

PT111_ORYSJ / Q94DB8 Inorganic phosphate transporter 1-11; OsPT11; OsPht1;11; H(+)/Pi cotransporter from Oryza sativa subsp. japonica (Rice) (see paper)
    26% identity, 76% coverage of query (87.0 bits)

NanX / b4279 sialic acid transporter NanX from Escherichia coli K-12 substr. MG1655 (see 5 papers)
nanX / P39352 sialic acid transporter NanX from Escherichia coli (strain K12) (see 4 papers)
YJHB_ECOLI / P39352 Putative metabolite transport protein YjhB from Escherichia coli (strain K12) (see paper)
    23% identity, 80% coverage of query (85.5 bits)

Q5CC71 ABC-type phosphate transporter (EC 7.3.2.1) from Zea mays (see paper)
    25% identity, 74% coverage of query (84.0 bits)

PHT14_PETHY / B2CPI6 Low affinity inorganic phosphate transporter 4; PhPT4; PhPht1;4; Arbuscular mycorrhiza-induced phosphate transporter PT4; AM-induced phosphate transporter PT4; H(+)/Pi cotransporter PT4; Protein Pi TRANSPORTER DOWN-REGULATED from Petunia hybrida (Petunia) (see 2 papers)
    26% identity, 74% coverage of query (83.2 bits)

GudP / b2789 galactarate/D-glucarate transporter GudP from Escherichia coli K-12 substr. MG1655 (see 5 papers)
gudP / Q46916 galactarate/D-glucarate transporter GudP from Escherichia coli (strain K12) (see 5 papers)
GUDP_ECOLI / Q46916 Probable galactarate/D-glucarate transporter GudP from Escherichia coli (strain K12) (see 2 papers)
TC 2.A.1.14.40 / C4ZZU4 Glucarate transporter, GudP.  Encoded in an operon with GudD, a glucarate dehydratase from Escherichia coli (strain K12 / MC4100 / BW2952)
    22% identity, 94% coverage of query (81.6 bits)

PHT15_PETHY / B2CPI7 Low affinity inorganic phosphate transporter 5; PhPT5; PhPht1;5; Arbuscular mycorrhiza-induced phosphate transporter PT5; AM-induced phosphate transporter PT5; H(+)/Pi cotransporter PT5 from Petunia hybrida (Petunia) (see 2 papers)
    26% identity, 74% coverage of query (80.9 bits)

YdjK / b1775 putative transporter YdjK from Escherichia coli K-12 substr. MG1655 (see 3 papers)
    23% identity, 82% coverage of query (80.1 bits)

K0IIN5 ABC-type phosphate transporter (EC 7.3.2.1) from Astragalus sinicus (see paper)
    26% identity, 75% coverage of query (79.0 bits)

TC 2.A.1.82.1 / F2CRE4 The barley copper uptake porter, CT-1 of 749 aas; nearly identical to the wheat orthologue from Hordeum vulgare var. distichum
    23% identity, 90% coverage of query (78.6 bits)

Q563I3 ABC-type phosphate transporter (EC 7.3.2.1) from Solanum lycopersicum (see paper)
    25% identity, 74% coverage of query (78.6 bits)

8bvsA Cryo-em structure of rat slc22a6 bound to tenofovir
    25% identity, 90% coverage of query (68.2 bits)

8bw7A Cryo-em structure of rat slc22a6 bound to alpha-ketoglutaric acid
    25% identity, 90% coverage of query (67.8 bits)

8bvtA / O35956 Cryo-em structure of rat slc22a6 bound to probenecid (see paper)
    25% identity, 89% coverage of query (67.4 bits)

S22A1_MOUSE / O08966 Solute carrier family 22 member 1; Organic cation transporter 1; mOCT1 from Mus musculus (Mouse) (see 12 papers)
    24% identity, 75% coverage of query (66.2 bits)

S22A1_RAT / Q63089 Solute carrier family 22 member 1; Organic cation transporter 1; rOCT1 from Rattus norvegicus (Rat) (see 27 papers)
TC 2.A.1.19.1 / Q63089 The basolateral multivalent, potential-sensitive, organic cation (tetramethyl-ammonium; N'-methylnicotinamide; cationic drugs, xenobiotics, vitamins, neuro-transmitters, etc.) transporter (uni-porter)-1, Oct1 from Rattus norvegicus (Rat) (see 18 papers)
    24% identity, 75% coverage of query (65.1 bits)

S22A1_HUMAN / O15245 Solute carrier family 22 member 1; Organic cation transporter 1; hOCT1 from Homo sapiens (Human) (see 26 papers)
TC 2.A.1.19.29 / O15245 Solute carrier family 22 member 1 (Organic cation transporter 1) (hOCT1) from Homo sapiens (see 18 papers)
    25% identity, 73% coverage of query (60.8 bits)

7zhaA / O75751 Structure of human oct3 in complex with inhibitor decynium-22 (see paper)
    24% identity, 73% coverage of query (60.5 bits)

S22A6_HUMAN / Q4U2R8 Solute carrier family 22 member 6; Organic anion transporter 1; hOAT1; PAH transporter; hPAHT; Renal organic anion transporter 1; hROAT1 from Homo sapiens (Human) (see 20 papers)
TC 2.A.1.19.31 / Q4U2R8 Solute carrier family 22 member 6 (Organic anion transporter 1) (hOAT1) (PAH transporter) (hPAHT) (Renal organic anion transporter 1) (hROAT1), from Homo sapiens (see 17 papers)
    25% identity, 88% coverage of query (59.7 bits)

S22A3_HUMAN / O75751 Solute carrier family 22 member 3; Extraneuronal monoamine transporter; EMT; Organic cation transporter 3; OCT3 from Homo sapiens (Human) (see 11 papers)
TC 2.A.1.19.24 / O75751 Solute carrier family 22 member 3 (Extraneuronal monoamine transporter) (EMT) (Organic cation transporter 3) from Homo sapiens (see 3 papers)
    23% identity, 73% coverage of query (58.9 bits)

PHO84 / P25297 phosphate transporter phoT from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 76 papers)
PHO84_YEAST / P25297 Inorganic phosphate transporter PHO84 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P25297 ABC-type phosphate transporter (EC 7.3.2.1) from Saccharomyces cerevisiae (see paper)
TC 2.A.1.9.1 / P25297 High affinity Pi from Saccharomyces cerevisiae (Baker's yeast) (see 7 papers)
PHO84 / GB|CAA89157.1 inorganic phosphate transporter PHO84 from Saccharomyces cerevisiae (see paper)
    21% identity, 72% coverage of query (47.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory