Searching for up to 100 curated homologs for BWI76_RS27260 FitnessBrowser__Koxy:BWI76_RS27260 (310 a.a.)
Found high-coverage hits (≥70%) to 84 curated proteins.
You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.
HldD / b3619 ADP-L-glycero-D-mannoheptose 6-epimerase (EC 5.1.3.20) from Escherichia coli K-12 substr. MG1655 (see 15 papers)
rfaD / P67910 ADP-L-glycero-D-mannoheptose 6-epimerase (EC 5.1.3.20) from Escherichia coli (strain K12) (see 13 papers)
HLDD_ECOLI / P67910 ADP-L-glycero-D-manno-heptose-6-epimerase; ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME; EC 5.1.3.20 from Escherichia coli (strain K12) (see 4 papers)
P67910 ADP-glyceromanno-heptose 6-epimerase (EC 5.1.3.20) from Escherichia coli (see 3 papers)
hldD / RF|NP_418076 ADP-L-glycero-D-manno-heptose-6-epimerase; EC 5.1.3.20 from Escherichia coli K12 (see 17 papers)
HtrM / CAA38364.1 acidic 34,893Da HtrM protein from Escherichia coli (see paper)
96% identity, 100% coverage of query (624 bits)
2x6tG / P67910 Agme bound to adp-b-mannose (see paper)
96% identity, 99% coverage of query (618 bits)
1eq2B The crystal structure of adp-l-glycero-d-mannoheptose 6-epimerase
94% identity, 99% coverage of query (595 bits)
1eq2A / P67910 The crystal structure of adp-l-glycero-d-mannoheptose 6-epimerase (see paper)
86% identity, 99% coverage of query (530 bits)
Q2SY18 ADP-glyceromanno-heptose 6-epimerase (EC 5.1.3.20) from Burkholderia thailandensis (see paper)
4ej0A / Q2SY18 Crystal structure of adp-l-glycero-d-manno-heptose-6-epimerase from burkholderia thailandensis (see paper)
57% identity, 98% coverage of query (353 bits)
gme / AAA79173.1 ADP-L-glycero-D-mannoheptose epimerase from Neisseria gonorrhoeae (see paper)
52% identity, 98% coverage of query (322 bits)
B5Z7L9 ADP-glyceromanno-heptose 6-epimerase (EC 5.1.3.20) from Helicobacter pylori (see paper)
30% identity, 99% coverage of query (129 bits)
3sxpD / B5Z7L9 Crystal structure of helicobacter pylori adp-l-glycero-d-manno- heptose-6-epimerase (rfad, hp0859) (see paper)
30% identity, 99% coverage of query (124 bits)
Build an alignment for BWI76_RS27260 and 8 homologs with ≥ 30% identity
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6dntA / D3E402 Udp-n-acetylglucosamine 4-epimerase from methanobrevibacter ruminantium m1 in complex with udp-n-acetylmuramic acid (see paper)
27% identity, 98% coverage of query (100 bits)
Q9WYX9 UDP-glucose 4-epimerase (EC 5.1.3.2); UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) from Thermotoga maritima (see paper)
4zrnA / Q9WYX9 Crystal structure of udp-glucose 4-epimerase (tm0509) with udp-glucose from hyperthermophilic eubacterium thermotoga maritima (see paper)
31% identity, 78% coverage of query (91.7 bits)
2c20A / A0A6L8PTV5 Crystal structure of udp-glucose 4-epimerase
29% identity, 80% coverage of query (85.1 bits)
F2NQX6 UDP-glucose 4-epimerase (EC 5.1.3.2) from Marinithermus hydrothermalis (see paper)
26% identity, 98% coverage of query (84.0 bits)
7k3pA / Q0P9C3 The structure of the udp-glc/glcnac 4-epimerase from the human pathogen campylobacter jejuni
29% identity, 80% coverage of query (81.6 bits)
F6DEY6 UDP-glucose 4-epimerase (EC 5.1.3.2) from Thermus thermophilus (see paper)
31% identity, 80% coverage of query (79.7 bits)
4twrA / Q2YKG6 Structure of udp-glucose 4-epimerase from brucella abortus
29% identity, 79% coverage of query (77.0 bits)
uxe / Q92WA3 UDP-xylose 4-epimerase subunit (EC 5.1.3.5) from Rhizobium meliloti (strain 1021) (see paper)
Q92WA3 UDP-arabinose 4-epimerase (EC 5.1.3.5) from Sinorhizobium meliloti (see paper)
28% identity, 79% coverage of query (76.3 bits)
2p5uA / Q5SKQ2 Crystal structure of thermus thermophilus hb8 udp-glucose 4-epimerase complex with NAD
31% identity, 80% coverage of query (75.9 bits)
6zllA Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp-galacturonic acid and NAD (see paper)
27% identity, 76% coverage of query (74.7 bits)
6zldA Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp-glucuronic acid and NAD
27% identity, 76% coverage of query (74.7 bits)
6zl6A Crystal structure of udp-glucuronic acid 4-epimerase from bacillus cereus in complex with udp and NAD
27% identity, 76% coverage of query (74.7 bits)
Q8L0V2 UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) from Escherichia coli (see paper)
28% identity, 78% coverage of query (74.3 bits)
6zljA Crystal structure of udp-glucuronic acid 4-epimerase y149f mutant from bacillus cereus in complex with udp-4-deoxy-4-fluoro-glucuronic acid and NAD
27% identity, 76% coverage of query (73.2 bits)
galE / CAB44218.1 UDP-galactose 4-epimerase from Lactococcus lactis (see paper)
27% identity, 78% coverage of query (72.4 bits)
UGE3_ARATH / Q8LDN8 Bifunctional UDP-glucose 4-epimerase and UDP-xylose 4-epimerase 3; UDP-D-xylose 4-epimerase; UDP-L-arabinose 4-epimerase; UDP-galactose 4-epimerase 3; UDP-glucose 4-epimerase 3; AtUGE3; EC 5.1.3.2; EC 5.1.3.5 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
Q8LDN8 UDP-glucose 4-epimerase (EC 5.1.3.2); UDP-arabinose 4-epimerase (EC 5.1.3.5) from Arabidopsis thaliana (see 2 papers)
27% identity, 85% coverage of query (72.0 bits)
tunF / E5KJ99 UDP-6-deoxy-5,6-ene-GlcNAc 4-epimerase (EC 5.1.3.7) from Streptomyces chartreusis (see paper)
27% identity, 80% coverage of query (70.5 bits)
galE / P21977 UDP-glucose-4-epimerase (EC 5.1.3.2) from Streptococcus thermophilus (see paper)
GALE_STRTR / P21977 UDP-glucose 4-epimerase; Galactowaldenase; UDP-galactose 4-epimerase; EC 5.1.3.2 from Streptococcus thermophilus (see paper)
P21977 UDP-glucose 4-epimerase (EC 5.1.3.2) from Streptococcus thermophilus (see paper)
29% identity, 76% coverage of query (70.1 bits)
UAE / Q868I5 UDP-N-acetylglucosamine 4'-epimerase (EC 5.1.3.7) from Giardia intestinalis (see 7 papers)
30% identity, 71% coverage of query (69.7 bits)
6bwlA / Q3ESA4 X-ray structure of pal from bacillus thuringiensis (see paper)
27% identity, 84% coverage of query (68.9 bits)
UGE1_PEA / B0M3E8 Bifunctional UDP-glucose 4-epimerase and UDP-xylose 4-epimerase 1; UDP-D-xylose 4-epimerase; UDP-L-arabinose 4-epimerase; UDP-galactose 4-epimerase 1; UDP-glucose 4-epimerase 1; PsUGE1; EC 5.1.3.2; EC 5.1.3.5 from Pisum sativum (Garden pea) (Lathyrus oleraceus) (see paper)
B0M3E8 UDP-glucose 4-epimerase (EC 5.1.3.2); UDP-arabinose 4-epimerase (EC 5.1.3.5) from Pisum sativum (see paper)
27% identity, 85% coverage of query (67.4 bits)
GI|1143392 uridine diphosphate glucose epimerase; EC 5.1.3.2 from Arabidopsis thaliana (see 2 papers)
CAA90941.1 uridine diphosphate glucose epimerase from Arabidopsis thaliana (see 2 papers)
28% identity, 85% coverage of query (66.2 bits)
GALE_LACHE / Q7WTB1 UDP-glucose 4-epimerase; Galactowaldenase; UDP-galactose 4-epimerase; EC 5.1.3.2 from Lactobacillus helveticus (Lactobacillus suntoryeus) (see paper)
29% identity, 78% coverage of query (65.9 bits)
galE / CAA89986.1 UDP-galactose 4-epimease from Corynebacterium glutamicum (see paper)
27% identity, 80% coverage of query (64.7 bits)
GALE_CAEEL / Q564Q1 UDP-glucose 4-epimerase; Galactowaldenase; UDP-N-acetylgalactosamine 4-epimerase; UDP-GalNAc 4-epimerase; UDP-N-acetylglucosamine 4-epimerase; UDP-GlcNAc 4-epimerase; UDP-galactose 4-epimerase; EC 5.1.3.2; EC 5.1.3.7 from Caenorhabditis elegans (see paper)
27% identity, 80% coverage of query (64.3 bits)
epsS / BAC55147.1 UDP-glucose 4-epimerase EpsS from Methylobacillus sp. 12S (see paper)
25% identity, 80% coverage of query (64.3 bits)
agl14 / D4GU71 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (see 3 papers)
AGL14_HALVD / D4GU71 Probable low-salt glycan biosynthesis reductase Agl14; EC 1.1.1.- from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
D4GU71 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) from Haloferax volcanii (see paper)
26% identity, 76% coverage of query (64.3 bits)
Q8LNZ3 UDP-glucose 4-epimerase (EC 5.1.3.2) from Oryza sativa Japonica Group (see paper)
26% identity, 85% coverage of query (63.9 bits)
UGE1 / Q42605 UDP-D-glucose/UDP-D-galactose 4-epimerase subunit (EC 5.1.3.2) from Arabidopsis thaliana (see 2 papers)
UGE1_ARATH / Q42605 Bifunctional UDP-glucose 4-epimerase and UDP-xylose 4-epimerase 1; UDP-D-xylose 4-epimerase; UDP-L-arabinose 4-epimerase; UDP-galactose 4-epimerase 1; UDP-glucose 4-epimerase 1; AtUGE1; EC 5.1.3.2; EC 5.1.3.5 from Arabidopsis thaliana (Mouse-ear cress) (see 7 papers)
Q42605 UDP-glucose 4-epimerase (EC 5.1.3.2); UDP-arabinose 4-epimerase (EC 5.1.3.5) from Arabidopsis thaliana (see 2 papers)
27% identity, 85% coverage of query (63.9 bits)
A3MUJ4 UDP-glucose 4-epimerase (EC 5.1.3.2) from Pyrobaculum calidifontis (see paper)
28% identity, 97% coverage of query (63.9 bits)
wbgU / Q7BJX9 UDP-N-acetylglucosamine C4-epimerase subunit (EC 5.1.3.7) from Plesiomonas shigelloides (see paper)
GNE_PLESH / Q7BJX9 UDP-N-acetylglucosamine 4-epimerase; UDP-GalNAc 4-epimerase; EC 5.1.3.7 from Plesiomonas shigelloides (Aeromonas shigelloides) (see 3 papers)
Q7BJX9 UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) from Plesiomonas shigelloides (see 2 papers)
24% identity, 99% coverage of query (63.2 bits)
MUR4 / Q9SA77 UDP-D-xylose 4-epimerase (EC 5.1.3.5) from Arabidopsis thaliana (see 3 papers)
ARAE1_ARATH / Q9SA77 UDP-arabinose 4-epimerase 1; UDP-D-xylose 4-epimerase 1; EC 5.1.3.5 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Q9SA77 UDP-arabinose 4-epimerase (EC 5.1.3.5) from Arabidopsis thaliana (see paper)
24% identity, 91% coverage of query (61.6 bits)
6wj9B / Q4KCF6 Udp-glcnac c4-epimerase mutant s121a/y146f from pseudomonas protegens in complex with udp-glcnac (see paper)
27% identity, 73% coverage of query (60.5 bits)
6wjaA Udp-glcnac c4-epimerase mutant s121a/y146f from pseudomonas protegens in complex with udp-galnac
27% identity, 73% coverage of query (60.5 bits)
O64749 UDP-arabinose 4-epimerase (EC 5.1.3.5) from Arabidopsis thaliana (see paper)
24% identity, 80% coverage of query (60.1 bits)
3lu1A / Q7BJX9 Crystal structure analysis of wbgu: a udp-galnac 4-epimerase (see paper)
23% identity, 99% coverage of query (60.1 bits)
3ruhA Alternative analogs as viable substrates of udp-hexose 4-epimerases
23% identity, 99% coverage of query (60.1 bits)
3rufA Alternative analogs as viable substrates of udp-hexose 4-epimerases
23% identity, 99% coverage of query (60.1 bits)
tunA / E5KJ94 UDP-N-acetyl-α-D-glucosamine 5,6-dehydratase from Streptomyces chartreusis (see paper)
25% identity, 79% coverage of query (59.7 bits)
3vpsA / E5KJ94 Structure of a novel NAD dependent-ndp-hexosamine 5,6-dehydratase, tuna, involved in tunicamycin biosynthesis
25% identity, 79% coverage of query (59.7 bits)
agl12 / D4GU72 dTDP-glucose-4,6-dehydratase (EC 4.2.1.46) from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (see 3 papers)
AGL12_HALVD / D4GU72 Low-salt glycan biosynthesis protein Agl12; EC 4.2.1.- from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
25% identity, 93% coverage of query (58.9 bits)
Q9SUN3 UDP-arabinose 4-epimerase (EC 5.1.3.5) from Arabidopsis thaliana (see paper)
25% identity, 80% coverage of query (58.9 bits)
3aw9A / A3MUJ4 Structure of udp-galactose 4-epimerase mutant
25% identity, 97% coverage of query (58.5 bits)
7xpoA / C0HI30 Crystal structure of udp-glc/glcnac 4-epimerase with NAD/udp-glc (see paper)
28% identity, 85% coverage of query (58.5 bits)
7xpqA Crystal structure of udp-glc/glcnac 4-epimerase with NAD/udp-glcnac
28% identity, 85% coverage of query (58.5 bits)
2cnbA Trypanosoma brucei udp-galactose-4-epimerase in ternary complex with NAD and the substrate analogue udp-4-deoxy-4- fluoro-alpha-d-galactose
25% identity, 88% coverage of query (58.5 bits)
fcfA / Q6E7F2 dTDP-4-dehydro-6-deoxyglucose reductase [NAD(P)H] (EC 1.1.1.266) from Escherichia coli (see 2 papers)
FCF1_ECOLX / Q6E7F2 dTDP-4-dehydro-6-deoxyglucose reductase; dTDP-4-dehydro-6-deoxy-D-glucose reductase; dTDP-4-keto-6-deoxyglucose reductase; dTDP-6-deoxy-D-xylo-hex-4-ulopyranose reductase; EC 1.1.1.266 from Escherichia coli (see paper)
23% identity, 80% coverage of query (58.2 bits)
Q58IJ6 UDP-glucose 4-epimerase (EC 5.1.3.2) from Hordeum vulgare (see paper)
27% identity, 84% coverage of query (58.2 bits)
1gy8C / Q8T8E9 Trypanosoma brucei udp-galactose 4' epimerase (see paper)
25% identity, 88% coverage of query (57.4 bits)
Q9FI17 UDP-arabinose 4-epimerase (EC 5.1.3.5) from Arabidopsis thaliana (see paper)
23% identity, 80% coverage of query (57.4 bits)
gla / P96481 UDP-glucuronate 4-epimerase (EC 5.1.3.6) from Streptococcus pneumoniae (see 2 papers)
28% identity, 70% coverage of query (57.0 bits)
GALE_NEIGO / Q05026 UDP-glucose 4-epimerase; Galactowaldenase; UDP-galactose 4-epimerase; EC 5.1.3.2 from Neisseria gonorrhoeae (see paper)
galE / CAA79721.1 UDP-glucose 4-epimerase from Neisseria gonorrhoeae (see 2 papers)
26% identity, 95% coverage of query (57.0 bits)
6kvcA Moee5 in complex with udp-glucose and NAD
25% identity, 80% coverage of query (56.6 bits)
6kv9A / A0A003 Moee5 in complex with udp-glucuronic acid and NAD (see paper)
25% identity, 80% coverage of query (55.1 bits)
1sb9A Crystal structure of pseudomonas aeruginosa udp-n-acetylglucosamine 4- epimerase complexed with udp-glucose
23% identity, 82% coverage of query (54.7 bits)
Q8KN66 UDP-N-acetylglucosamine 4-epimerase (EC 5.1.3.7) from Pseudomonas aeruginosa (see paper)
1sb8A / Q8KN66 Crystal structure of pseudomonas aeruginosa udp-n-acetylglucosamine 4- epimerase complexed with udp-n-acetylgalactosamine (see paper)
23% identity, 82% coverage of query (54.7 bits)
3m2pB / Q814Z6 The crystal structure of udp-n-acetylglucosamine 4-epimerase from bacillus cereus
27% identity, 80% coverage of query (54.7 bits)
2pzjA Crystal structure of the bordetella bronchiseptica enzyme wbmf in complex with NAD+
26% identity, 79% coverage of query (53.9 bits)
2q1tA Crystal structure of the bordetella bronchiseptica enzyme wbmf in complex with NAD+ and udp
26% identity, 79% coverage of query (53.9 bits)
3eheA / O29886 Crystal structure of udp-glucose 4 epimerase (gale-1) from archaeoglobus fulgidus
24% identity, 76% coverage of query (53.9 bits)
2q1sA / O87989 Crystal structure of the bordetella bronchiseptica enzyme wbmf in complex with nadh (see paper)
26% identity, 79% coverage of query (53.9 bits)
8du1A / A0A077ELH2 Crystal structure of NAD bound dtdp-glucose 4,6-dehydratase from elizabethkingia anophelis
26% identity, 98% coverage of query (52.4 bits)
4lisA / C8VAU8 Crystal structure of udp-galactose-4-epimerase from aspergillus nidulans (see paper)
26% identity, 78% coverage of query (51.6 bits)
4lisB Crystal structure of udp-galactose-4-epimerase from aspergillus nidulans
26% identity, 78% coverage of query (51.6 bits)
1kvrA Udp-galactose 4-epimerase complexed with udp-phenol
24% identity, 80% coverage of query (48.5 bits)
2b69A / Q8NBZ7 Crystal structure of human udp-glucoronic acid decarboxylase
25% identity, 76% coverage of query (48.1 bits)
UXS1_HUMAN / Q8NBZ7 UDP-glucuronic acid decarboxylase 1; UDP-glucuronate decarboxylase 1; UGD; UXS-1; hUXS; hUXS1; EC 4.1.1.35 from Homo sapiens (Human) (see 3 papers)
25% identity, 76% coverage of query (47.8 bits)
6pnlA / O26475 Structure of epimerase mth375 from the thermophilic pseudomurein- containing methanogen methanothermobacter thermautotrophicus
26% identity, 76% coverage of query (46.6 bits)
6pmhA Structure of epimerase mth375 from the thermophilic pseudomurein- containing methanogen methanothermobacter thermautotrophicus
26% identity, 76% coverage of query (46.6 bits)
6k0iA Crystal structure of udp-glucose 4-epimerase from bifidobacterium longum in complex with NAD+ and udp-glc
27% identity, 87% coverage of query (46.2 bits)
6k0hA Crystal structure of udp-glucose 4-epimerase from bifidobacterium longum in complex with NAD+ and udp-glcnac
27% identity, 87% coverage of query (46.2 bits)
6k0gA / E8MF10 Crystal structure of udp-glucose 4-epimerase from bifidobacterium longum in complex with NAD+ and udp (see paper)
27% identity, 87% coverage of query (46.2 bits)
1z45A / P04397 Crystal structure of the gal10 fusion protein galactose mutarotase/udp-galactose 4-epimerase from saccharomyces cerevisiae complexed with NAD, udp-glucose, and galactose (see paper)
26% identity, 78% coverage of query (45.8 bits)
UXS1_DANRE / Q6GMI9 UDP-glucuronic acid decarboxylase 1; UDP-glucuronate decarboxylase 1; UXS-1; EC 4.1.1.35 from Danio rerio (Zebrafish) (Brachydanio rerio) (see 3 papers)
22% identity, 99% coverage of query (44.7 bits)
4lk3C Crystal structure of human udp-xylose synthase r236a substitution
26% identity, 87% coverage of query (44.3 bits)
2hunA / O58151 Crystal structure of hypothetical protein ph0414 from pyrococcus horikoshii ot3
23% identity, 98% coverage of query (42.7 bits)
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Lawrence Berkeley National Laboratory