Sites on a Tree

 

Searching for up to 100 curated homologs for BWI76_RS27575 FitnessBrowser__Koxy:BWI76_RS27575 (104 a.a.)

Found high-coverage hits (≥70%) to 23 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

TC 4.A.2.1.9 / Q8FC73 PTS system, fructose-like-2 IIB component 1, component of The FrzABC PTS putative transporter (promotes bacterial fitness under stress conditions and promotes fimbrial (fim) gene expression indirectly (Rouquet et al., 2009). Might transport D-tagatose, D-psicose and/or D-sorbose, or a disaccharide of these (Rouquet et al. 2009); involved in environmental sensing, host adaptation and virulence from Escherichia coli O6 (see paper)
    89% identity, 99% coverage of query (187 bits)

TC 4.A.2.1.22 / Q3JZE2 PTS system, fructose-specific, IIB component, component of D-allose/D-ribose transporting Enzyme II complex (Fru2; IIA/IIB/IIC) (Patron et al. 2017). This system is similar to Frz of E. coli (TC#4.A.2.1.9) which is involved in environmental sensing, host adaptation and virulence from Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)
    63% identity, 99% coverage of query (131 bits)

FrwB / b3950 putative PTS enzyme IIB component FrwB from Escherichia coli K-12 substr. MG1655 (see 4 papers)
FrwB / P69816 putative PTS enzyme IIB component FrwB from Escherichia coli (strain K12) (see 2 papers)
    53% identity, 97% coverage of query (102 bits)

FrwD / b3953 putative PTS enzyme IIB component FrwD from Escherichia coli K-12 substr. MG1655 (see 4 papers)
    42% identity, 96% coverage of query (84.0 bits)

FrvB / b3899 putative PTS enzyme IIBC component FrvB from Escherichia coli K-12 substr. MG1655 (see 4 papers)
frvB / P32154 putative PTS enzyme IIBC component FrvB from Escherichia coli (strain K12) (see 3 papers)
TC 4.A.2.1.25 / P32154 Fructose-like PTS system EIIBC component, component of Fructose-like PTS Enzyme II complex, FrvA (IIA of 148 aas) - FrvB (IIBC of 483 aas and 9 predicted TMSs) from Escherichia coli (strain K12)
    42% identity, 97% coverage of query (82.8 bits)

TC 4.A.2.1.16 / Q9RMF5 Fructose-specific Enzyme IIABC from Spiroplasma citri
    46% identity, 90% coverage of query (80.9 bits)

TC 4.A.2.1.18 / Q9RZP7 Fructose PTS Enzyme IIBC, FruA from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
    45% identity, 83% coverage of query (79.0 bits)

PTN3B_BACSU / O31645 PTS system mannose-specific EIIBCA component; EIIBCA-Man; EII-Man; EC 2.7.1.191 from Bacillus subtilis (strain 168) (see 2 papers)
O31645 protein-Npi-phosphohistidine-D-mannose phosphotransferase (EC 2.7.1.191) from Bacillus subtilis (see paper)
TC 4.A.2.1.6 / O31645 The mannose porter (ManP) (37% identical to 4.A.2.1.1). It is encoded in an operon with 3 genes: from Bacillus subtilis (see 5 papers)
    43% identity, 92% coverage of query (78.6 bits)

tagL / A0A415J7H7 tagatose-specific PTS enzyme IIBC component from Bacillus licheniformis (see 2 papers)
TC 4.A.2.1.23 / T5HN74 PTS fructose transporter subunit IIC, component of The tagatose-1-P-forming tagatose phosphorylating Enzyme IIA/IIBC, TagM/L (Van der Heiden et al. 2015). The product is phosphorylated by tagatose-1-P kinase (TagK), and then cleaved by tagatose-1,6-bisphosphate aldolase (GatY) from Bacillus licheniformis CG-B52
    42% identity, 98% coverage of query (76.3 bits)

TC 4.A.2.1.4 / P71012 The fructose porter, FruA (fructose-1-P forming IIABC) (Delobbe et al. 1975) FruA is 39% identical to 4.A.2.1.1). fructose can be metabolized to Fru-1-P via this system as well as Fru-6-P by another PTS system from Bacillus subtilis (see paper)
    43% identity, 90% coverage of query (75.5 bits)

PTFBC_XANCP / P23355 PTS system fructose-specific EIIB'BC component; EIIB'BC-Fru; EC 2.7.1.202 from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see 2 papers)
    43% identity, 90% coverage of query (75.1 bits)

AZOBR_RS32335 fructose-specific PTS system (fructose 1-phosphate forming), EII-B'BC components (FruA) from Azospirillum brasilense Sp245
    40% identity, 98% coverage of query (73.9 bits)

Q8DWE7 protein-Npi-phosphohistidine-D-fructose phosphotransferase (subunit 2/2) (EC 2.7.1.202) from Streptococcus mutans serotype c (see paper)
TC 4.A.2.1.8 / Q8DWE7 Putative PTS system, fructose-specific IIBC component aka FruC, component of The constitutive fructose porter FruC/FruD from Streptococcus mutans (see paper)
    41% identity, 88% coverage of query (71.6 bits)

PTFB_HALVD / D4GYE1 PTS system fructose-specific EIIB component; EIIB-Fru; Fructose-specific phosphotransferase enzyme IIB component; EC 2.7.1.202 from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) (see paper)
TC 4.A.2.1.15 / D4GYE1 Phosphotransferase system IIB component, component of Fructose-specific PTS, PtfABC from Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (see paper)
    40% identity, 77% coverage of query (70.5 bits)

TC 4.A.2.1.14 / D2RXA4 PTS system, fructose-specific, IIB subunnit, component of Fructose Enzyme II complex (IIAFru - IIBFru - IICFru) (based on homology) from Haloterrigena turkmenica (strain ATCC 51198 / DSM 5511 / NCIMB 13204 / VKM B-1734) (see paper)
    43% identity, 76% coverage of query (68.6 bits)

TC 4.A.2.1.13 / Q0S1N2 The fructose-specific PTS Enzyme IIABC FruA from Rhodococcus sp. (strain RHA1) (see paper)
    40% identity, 98% coverage of query (68.6 bits)

TC 4.A.2.1.7 / Q1LZ59 The fructose inducible fructose/xylitol porter, FruI from Streptococcus mutans UA159 (see paper)
    41% identity, 98% coverage of query (68.6 bits)

YpdH / b2387 putative PTS enzyme IIB component FryB from Escherichia coli K-12 substr. MG1655 (see 4 papers)
    33% identity, 97% coverage of query (68.2 bits)

TC 4.A.2.1.19 / M7PF02 PTS family enzyme IIB'BC, fructose-specific, component of The tagatose-specific PTS transporter/kinase, TagIIA-TPr/TagIIB'BC (tagatose-1-P forming) from Klebsiella pneumoniae ATCC BAA-2146
    39% identity, 91% coverage of query (67.4 bits)

PTFBC_VIBCH / Q9KM72 PTS system fructose-specific EIIB'BC component; EC 2.7.1.202 from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) (see 2 papers)
    40% identity, 87% coverage of query (67.0 bits)

FruA / b2167 fructose-specific PTS multiphosphoryl transfer protein FruA from Escherichia coli K-12 substr. MG1655 (see 4 papers)
fruA / P20966 fructose-specific PTS multiphosphoryl transfer protein FruA from Escherichia coli (strain K12) (see 2 papers)
PTFBC_ECOLI / P20966 PTS system fructose-specific EIIB'BC component; EIIB'BC-Fru; EC 2.7.1.202 from Escherichia coli (strain K12) (see 3 papers)
TC 4.A.2.1.1 / P20966 PTFB aka FRUA aka PTSF aka B2167, component of Fructose porter (FruAB) (fructose-1-P forming) from Escherichia coli (see 6 papers)
    38% identity, 90% coverage of query (67.0 bits)

TC 4.A.2.1.20 / Q3K0G6 Chromosomal fructose Enzyme IIABC (Fru1) of 654 aas; in an operon with fructose-1-P kinase from Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS700)
    48% identity, 74% coverage of query (63.9 bits)

TC 4.A.2.1.17 / Q9HY57 Phosphotransferase system transporter fructose-specific IIBC component, FruA, component of Fructose-specific PTS permease, FruIIBC/FruI-HPr-IIA from Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
    45% identity, 96% coverage of query (58.5 bits)

Build an alignment

Build an alignment for BWI76_RS27575 and 23 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory