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Searching for up to 100 curated homologs for CA265_RS00955 FitnessBrowser__Pedo557:CA265_RS00955 (327 a.a.)

Found high-coverage hits (≥70%) to 100 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

1pz1A / P80874 Structure of NADPH-dependent family 11 aldo-keto reductase akr11b(holo) (see paper)
    39% identity, 92% coverage of query (214 bits)

GS69_BACSU / P80874 Aldo-keto reductase YhdN; AKR11B; General stress protein 69; GSP69; EC 1.1.1.- from Bacillus subtilis (strain 168) (see 3 papers)
    39% identity, 92% coverage of query (214 bits)

F2YCN5 D-xylose reductase (EC 1.1.1.307) from Zymomonas mobilis subsp. mobilis (see paper)
    36% identity, 96% coverage of query (186 bits)

Q5FQJ0 carbonyl reductase (NADPH) (EC 1.1.1.184) from Gluconobacter oxydans (see paper)
    35% identity, 96% coverage of query (186 bits)

IOLS_BACSU / P46336 Aldo-keto reductase IolS; AKR11A; Vegetative protein 147; VEG147; EC 1.1.1.- from Bacillus subtilis (strain 168) (see 4 papers)
    34% identity, 98% coverage of query (172 bits)

1pz0A / P46336 Structure of NADPH-dependent family 11 aldo-keto reductase akr11a(holo) (see paper)
    34% identity, 97% coverage of query (171 bits)

6ow0A / Q194Q1 Crystal structure of mithramycin 3-side chain keto-reductase mtmw in complex with NAD+ and peg (see paper)
    31% identity, 99% coverage of query (158 bits)

YdjG / b1771 NADH-dependent methylglyoxal reductase from Escherichia coli K-12 substr. MG1655 (see 5 papers)
ydjG / P77256 NADH-dependent methylglyoxal reductase from Escherichia coli (strain K12) (see 4 papers)
AKRMG_ECOLI / P77256 NADH-specific methylglyoxal reductase; AKR11B2; EC 1.1.1.- from Escherichia coli (strain K12) (see 3 papers)
ydjG / RF|NP_416285 uncharacterized oxidoreductase ydjG from Escherichia coli K12 (see paper)
    32% identity, 96% coverage of query (156 bits)

6ow0B / Q194Q1 Crystal structure of mithramycin 3-side chain keto-reductase mtmw in complex with NAD+ and peg (see paper)
    31% identity, 99% coverage of query (153 bits)

AKR1_SOYBN / C6TBN2 Probable aldo-keto reductase 1; GmAKR1; EC 1.1.1.- from Glycine max (Soybean) (Glycine hispida) (see paper)
    33% identity, 96% coverage of query (152 bits)

mtmW / Q194Q1 mithramycin dehydrogenase from Streptomyces argillaceus (see 2 papers)
    30% identity, 99% coverage of query (146 bits)

PR / Q3L181 perakine reductase (EC 1.1.1.317) from Rauvolfia serpentina (see 2 papers)
PERR_RAUSE / Q3L181 Perakine reductase; EC 1.1.1.317 from Rauvolfia serpentina (Serpentine wood) (Ophioxylon serpentinum) (see 2 papers)
Q3L181 perakine reductase (EC 1.1.1.317) from Rauvolfia serpentina (see 3 papers)
    32% identity, 98% coverage of query (144 bits)

Build an alignment

Build an alignment for CA265_RS00955 and 12 homologs with ≥ 30% identity

Select sequences

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Change minimum %identity:

Additional hits (identity < 30%)

ALKR4_ARATH / Q93ZN2 Probable aldo-keto reductase 4; EC 1.1.1.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    29% identity, 97% coverage of query (142 bits)

Q9X265 carbonyl reductase (NADPH) (EC 1.1.1.184) from Thermotoga maritima (see 2 papers)
    30% identity, 98% coverage of query (135 bits)

6kikA / Q9X265 Crystal structure of a thermostable aldo-keto reductase tm1743 in complex with inhibitor tolrestat (see paper)
    30% identity, 98% coverage of query (135 bits)

5danA Crystal structure of a novel aldo keto reductase tm1743 from thermotoga maritima in complex with NADP+
    30% identity, 98% coverage of query (135 bits)

6kiyA Crystal structure of a thermostable aldo-keto reductase tm1743 in complex with inhibitor epalrestat
    30% identity, 98% coverage of query (135 bits)

KCAB_SCHPO / O59826 Putative voltage-gated potassium channel subunit beta; K(+) channel subunit beta; EC 1.1.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    32% identity, 98% coverage of query (131 bits)

3v0sA / Q3L181 Crystal structure of perakine reductase, founder member of a novel akr subfamily with unique conformational changes during NADPH binding (see paper)
    31% identity, 98% coverage of query (130 bits)

6ciaA / A6T7Q7 Crystal structure of aldo-keto reductase from klebsiella pneumoniae in complex with NADPH.
    29% identity, 94% coverage of query (128 bits)

4wghA Crystal structure of aldo/keto reductase from klebsiella pneumoniae in complex with NADP and acetate at 1.8 a resolution
    29% identity, 94% coverage of query (128 bits)

SAN2_FUSV7 / C7ZBE5 Aldo-keto reductase NECHADRAFT_45914; Sansalvamide biosynthesis cluster protein NECHADRAFT_45914; EC 1.1.1.- from Fusarium vanettenii (strain ATCC MYA-4622 / CBS 123669 / FGSC 9596 / NRRL 45880 / 77-13-4) (Fusarium solani subsp. pisi) (see paper)
    29% identity, 98% coverage of query (127 bits)

YI7E_SCHPO / Q9P7U2 Putative aryl-alcohol dehydrogenase C977.14c; EC 1.1.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
    29% identity, 98% coverage of query (121 bits)

8hw0A / A0A6B8QIS5 The structure of akr6d1
    30% identity, 99% coverage of query (120 bits)

KCAB_ORYSJ / Q40648 Probable voltage-gated potassium channel subunit beta; K(+) channel subunit beta; EC 1.1.1.- from Oryza sativa subsp. japonica (Rice) (see paper)
    27% identity, 94% coverage of query (119 bits)

YeaE / b1781 methylglyoxal reductase YeaE from Escherichia coli K-12 substr. MG1655 (see 4 papers)
yeaE / P76234 methylglyoxal reductase YeaE (EC 1.1.1.21) from Escherichia coli (strain K12) (see 3 papers)
    29% identity, 95% coverage of query (118 bits)

IFD6 aldo-keto reductase family member from Candida albicans (see paper)
    30% identity, 97% coverage of query (118 bits)

KCAB_ARATH / O23016 Probable voltage-gated potassium channel subunit beta; K(+) channel subunit beta; Potassium voltage beta 1; KV-beta1; EC 1.1.1.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    28% identity, 94% coverage of query (118 bits)

6hg6A / A0A1S8QGT2 Clostridium beijerinckii aldo-keto reductase cbei_3974 with NADPH (see paper)
    29% identity, 98% coverage of query (116 bits)

AAD16_YEAST / Q02895 Putative aryl-alcohol dehydrogenase AAD16; EC 1.1.1.- from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 2 papers)
    28% identity, 97% coverage of query (115 bits)

VRDA_ASPPA / B9WYE6 Versiconal hemiacetal acetate reductase; VHA reductase; EC 1.1.1.353 from Aspergillus parasiticus (see paper)
B9WYE6 versiconal hemiacetal acetate reductase (EC 1.1.1.353) from Aspergillus parasiticus (see paper)
    27% identity, 98% coverage of query (115 bits)

STR7_STRTC / A0A3B1EFQ1 Aldo-keto reductase str7; Strobilurin A biosynthesis cluster protein r7; EC 1.1.1.- from Strobilurus tenacellus (see 3 papers)
    30% identity, 98% coverage of query (114 bits)

4aubB / Q46851 The complex structure of the bacterial aldo-keto reductase akr14a1 with NADP and citrate (see paper)
    28% identity, 98% coverage of query (112 bits)

PK81H_PSEFD / M2YMU7 Aldo-keto reductase MYCFIDRAFT_87468; PKS8-1 gene cluster protein MYCFIDRAFT_87468; EC 1.1.1.- from Pseudocercospora fijiensis (strain CIRAD86) (Black leaf streak disease fungus) (Mycosphaerella fijiensis) (see 2 papers)
    27% identity, 98% coverage of query (110 bits)

Q84L20 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Malus domestica (see paper)
    29% identity, 94% coverage of query (110 bits)

KCAB2_XENLA / Q9PTM5 Voltage-gated potassium channel subunit beta-2; K(+) channel subunit beta-2; Kv-beta-2; EC 1.1.1.- from Xenopus laevis (African clawed frog) (see paper)
    27% identity, 99% coverage of query (109 bits)

YajO / b0419 1-deoxyxylulose-5-phosphate synthase YajO from Escherichia coli K-12 substr. MG1655 (see 7 papers)
yajO / P77735 1-deoxyxylulose-5-phosphate synthase YajO from Escherichia coli (strain K12) (see 6 papers)
YAJO_ECOLI / P77735 1-deoxyxylulose-5-phosphate synthase YajO; EC 1.1.-.- from Escherichia coli (strain K12) (see 2 papers)
P77735 1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) from Escherichia coli (see paper)
    26% identity, 98% coverage of query (108 bits)

5t79A / Q8ZNA1 X-ray crystal structure of a novel aldo-keto reductases for the biocatalytic conversion of 3-hydroxybutanal to 1,3-butanediol (see paper)
    28% identity, 99% coverage of query (108 bits)

AMT2_ALTAL / Q75ZG2 Aldo-keto reductase AMT2; AM-toxin biosynthesis protein 2; EC 1.1.1.- from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see 3 papers)
    29% identity, 96% coverage of query (108 bits)

Gpr / b3001 L-glyceraldehyde 3-phosphate reductase from Escherichia coli K-12 substr. MG1655 (see 9 papers)
gpr / Q46851 L-glyceraldehyde 3-phosphate reductase (EC 1.1.1.21) from Escherichia coli (strain K12) (see 7 papers)
GPR_ECOLI / Q46851 L-glyceraldehyde 3-phosphate reductase; GAP reductase; EC 1.1.1.- from Escherichia coli (strain K12) (see 4 papers)
    27% identity, 98% coverage of query (108 bits)

AFTS1_ALTAL / Q75ZG3 Aldo-keto reductase AFTS1; AF-toxin biosynthesis protein S1; EC 1.1.1.- from Alternaria alternata (Alternaria rot fungus) (Torula alternata) (see 3 papers)
    27% identity, 98% coverage of query (108 bits)

CSH1 member of aldo-keto reductase family from Candida albicans (see 5 papers)
    30% identity, 97% coverage of query (107 bits)

KCAB2_MOUSE / P62482 Voltage-gated potassium channel subunit beta-2; K(+) channel subunit beta-2; Kv-beta-2; Neuroimmune protein F5; EC 1.1.1.- from Mus musculus (Mouse) (see 8 papers)
KCAB2_RAT / P62483 Voltage-gated potassium channel subunit beta-2; K(+) channel subunit beta-2; Kv-beta-2; EC 1.1.1.- from Rattus norvegicus (Rat) (see 19 papers)
    26% identity, 99% coverage of query (107 bits)

3eauA Voltage-dependent k+ channel beta subunit in complex with cortisone
    26% identity, 99% coverage of query (107 bits)

1exbA Structure of the cytoplasmic beta subunit-t1 assembly of voltage- dependent k channels
    26% identity, 99% coverage of query (107 bits)

7wf3C / Q13303 Composite map of human kv1.3 channel in apo state with beta subunits (see paper)
    26% identity, 99% coverage of query (105 bits)

Y1669_ARATH / Q94A68 Uncharacterized oxidoreductase At1g06690, chloroplastic; EC 1.-.-.- from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    28% identity, 96% coverage of query (105 bits)

C0LVA5 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Actinidia eriantha (see paper)
    27% identity, 94% coverage of query (105 bits)

KCAB2_HUMAN / Q13303 Voltage-gated potassium channel subunit beta-2; K(+) channel subunit beta-2; Kv-beta-2; hKvbeta2; EC 1.1.1.- from Homo sapiens (Human) (see 4 papers)
    26% identity, 99% coverage of query (105 bits)

3erpA Structure of idp01002, a putative oxidoreductase from and essential gene of salmonella typhimurium
    28% identity, 99% coverage of query (105 bits)

YAKC_SCHPO / Q09923 Aldo-keto reductase yakc [NADP(+)]; EC 1.1.1.- from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
yak3 aldose reductase YakC from Schizosaccharomyces pombe (see 3 papers)
    28% identity, 95% coverage of query (103 bits)

KCAB2_BOVIN / Q27955 Voltage-gated potassium channel subunit beta-2; K(+) channel subunit beta-2; Kv-beta-2; EC 1.1.1.- from Bos taurus (Bovine) (see paper)
    26% identity, 99% coverage of query (103 bits)

E9M5S4 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Citrus unshiu (see paper)
    26% identity, 94% coverage of query (103 bits)

3n6qD Crystal structure of yghz from e. Coli
    27% identity, 98% coverage of query (103 bits)

1ynpB / Q9KE47 Aldo-keto reductase akr11c1 from bacillus halodurans (apo form) (see paper)
    27% identity, 94% coverage of query (100 bits)

KCAB1_RAT / P63144 Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1; EC 1.1.1.- from Rattus norvegicus (Rat) (see 9 papers)
    25% identity, 95% coverage of query (100 bits)

KCAB1_MOUSE / P63143 Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1; EC 1.1.1.- from Mus musculus (Mouse) (see 5 papers)
    25% identity, 95% coverage of query (100 bits)

1ynqB Aldo-keto reductase akr11c1 from bacillus halodurans (holo form)
    27% identity, 94% coverage of query (100 bits)

KCAB1_MUSPU / Q28528 Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1; EC 1.1.1.- from Mustela putorius (European polecat) (see paper)
    25% identity, 94% coverage of query (99.8 bits)

7eziA / Q2QQV2 Rice l-galactose dehydrogenase (apo form)
    25% identity, 94% coverage of query (99.8 bits)

7ezlA Rice l-galactose dehydrogenase (holo form)
    25% identity, 94% coverage of query (99.4 bits)

YgdS / b2834 putative NADP(H)-dependent aldo-keto reductase Tas from Escherichia coli K-12 substr. MG1655 (see 6 papers)
1lqaA / P0A9T4 Tas protein from escherichia coli in complex with NADPH (see paper)
tas protein Tas from Escherichia coli str. K12 substr. MG1655 (see paper)
    25% identity, 98% coverage of query (98.6 bits)

KCAB3_XENLA / Q9PTM4 Voltage-gated potassium channel subunit beta-3; K(+) channel subunit beta-3; Kv-beta-3; EC 1.1.1.- from Xenopus laevis (African clawed frog) (see paper)
    25% identity, 99% coverage of query (98.6 bits)

P0A9T4 Protein tas from Escherichia coli (strain K12)
    25% identity, 98% coverage of query (98.6 bits)

Q6BDJ2 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Spinacia oleracea (see paper)
GDH / BAD32687.1 L-galactose dehydrogenase from Spinacia oleracea (see paper)
    25% identity, 99% coverage of query (98.2 bits)

7svqA / Q6BDJ2 Crystal structure of l-galactose dehydrogenase from spinacia oleracea in complex with NAD+ (see paper)
    25% identity, 99% coverage of query (98.2 bits)

KCAB1_RABIT / Q9XT31 Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1; EC 1.1.1.- from Oryctolagus cuniculus (Rabbit) (see paper)
    25% identity, 95% coverage of query (97.8 bits)

KCAB1_HUMAN / Q14722 Voltage-gated potassium channel subunit beta-1; K(+) channel subunit beta-1; Kv-beta-1; EC 1.1.1.- from Homo sapiens (Human) (see 13 papers)
    25% identity, 95% coverage of query (97.8 bits)

LGALDH / O81884 L-galactose dehydrogenase (EC 1.1.1.316) from Arabidopsis thaliana (see paper)
GALDH_ARATH / O81884 L-galactose dehydrogenase; At-GalDH; L-GalDH; EC 1.1.1.316 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
O81884 L-galactose 1-dehydrogenase (EC 1.1.1.316) from Arabidopsis thaliana (see paper)
L-GalDH / CAD10386.1 L-galactose dehydrogenase from Arabidopsis thaliana (see paper)
    26% identity, 94% coverage of query (96.7 bits)

5c7hA / Q92NR7 Crystal structure of aldo-keto reductase from sinorhizobium meliloti 1021 in complex with NADPH
    29% identity, 92% coverage of query (95.5 bits)

4pmjA Crystal structure of a putative oxidoreductase from sinorhizobium meliloti 1021 in complex with NADP
    29% identity, 92% coverage of query (95.5 bits)

1ynpA Aldo-keto reductase akr11c1 from bacillus halodurans (apo form)
    26% identity, 94% coverage of query (94.7 bits)

4aubE The complex structure of the bacterial aldo-keto reductase akr14a1 with NADP and citrate
    26% identity, 99% coverage of query (91.3 bits)

ARK73_HUMAN / O95154 Aflatoxin B1 aldehyde reductase member 3; AFB1 aldehyde reductase 2; AFB1-AR 2; EC 1.-.-.- from Homo sapiens (Human) (see 2 papers)
    26% identity, 94% coverage of query (88.6 bits)

2clpG Crystal structure of human aflatoxin b1 aldehyde reductase member 3
    26% identity, 90% coverage of query (87.4 bits)

2clpA / O95154 Crystal structure of human aflatoxin b1 aldehyde reductase member 3
    26% identity, 90% coverage of query (87.4 bits)

4aubF / Q46851 The complex structure of the bacterial aldo-keto reductase akr14a1 with NADP and citrate (see paper)
    25% identity, 98% coverage of query (84.7 bits)

ARK73_RAT / P38918 Aflatoxin B1 aldehyde reductase member 3; AFB1-AR; Aflatoxin B1 aldehyde reductase member 1; rAFAR1; EC 1.-.-.- from Rattus norvegicus (Rat) (see 2 papers)
    28% identity, 73% coverage of query (83.6 bits)

1gveA / P38918 Aflatoxin aldehyde reductase (akr7a1) from rat liver (see paper)
    28% identity, 73% coverage of query (83.6 bits)

P76187 Oxidoreductase YdhF; EC 1.-.-.- from Escherichia coli (strain K12)
    27% identity, 87% coverage of query (80.5 bits)

7twzA / A0A0H3GP70 Crystal structure of NADP-linked putative oxidoreductase from klebsiella pneumoniae
    27% identity, 86% coverage of query (79.0 bits)

1og6C / P76187 Ydhf, an aldo-keto reductase from e.Coli complexed with NADPH
    27% identity, 87% coverage of query (79.0 bits)

2bp1A Structure of the aflatoxin aldehyde reductase in complex with NADPH
    26% identity, 81% coverage of query (78.6 bits)

AKR7A2 / O43488 aflatoxin B1 aldehyde reductase member 2 from Homo sapiens (see 4 papers)
ARK72_HUMAN / O43488 Aflatoxin B1 aldehyde reductase member 2; AFB1 aldehyde reductase 1; AFB1-AR 1; Aldoketoreductase 7; Succinic semialdehyde reductase; SSA reductase; EC 1.1.1.n11 from Homo sapiens (Human) (see 3 papers)
    26% identity, 81% coverage of query (77.4 bits)

3d3fA / O32210 Crystal structure of yvgn and cofactor NADPH from bacillus subtilis (see paper)
    32% identity, 95% coverage of query (77.4 bits)

8hnqA / A0A6B8QJ47 The structure of a alcohol dehydrogenase akr13b2 with NADP
    26% identity, 95% coverage of query (76.6 bits)

4fziA Crystal structure of prostaglandin f synthase from trypanosoma cruzi
    26% identity, 91% coverage of query (72.8 bits)

4gieA / Q4DJ07 Crystal structure of prostaglandin f synthase from trypanosoma cruzi bound to NADP (see paper)
    26% identity, 91% coverage of query (72.4 bits)

E3W861 carbonyl reductase (NADPH) (EC 1.1.1.184) from Bacillus sp. (in: Bacteria) (see paper)
3b3dA / O34678 B.Subtilis ytbe (see paper)
    28% identity, 95% coverage of query (68.2 bits)

1vbjA / Q9GV41 The crystal structure of prostaglandin f synthase from trypanosoma brucei
    27% identity, 92% coverage of query (67.8 bits)

PGFS_TRYBB / Q9GV41 9,11-endoperoxide prostaglandin H2 reductase; Prostaglandin F2-alpha synthase; EC 1.1.1.- from Trypanosoma brucei brucei (see paper)
    27% identity, 92% coverage of query (67.8 bits)

4h8nA / Q76L36 Crystal structure of conjugated polyketone reductase c2 from candida parapsilosis complexed with NADPH (see paper)
    26% identity, 86% coverage of query (63.2 bits)

CPRC2_CANPA / Q76L36 NADPH-dependent conjugated polyketone reductase C2; CPR-C2; 2-dehydropantolactone reductase; Ketopantoyl-lactone reductase; EC 1.1.1.-; EC 1.1.1.358 from Candida parapsilosis (Yeast) (see 4 papers)
Q76L36 2-dehydropantolactone reductase (Si-specific) (EC 1.1.1.214); 2-dehydropantolactone reductase (EC 1.1.1.358) from Candida parapsilosis (see 4 papers)
    26% identity, 86% coverage of query (63.2 bits)

5y7nA Crystal structure of akr1b10 in complex with NADP+ and androst-4-ene- 3-beta-6-alpha-diol
    26% identity, 87% coverage of query (62.0 bits)

4jiiX Crystal structure of akr1b10 complexed with NADP+ and zopolrestat
    26% identity, 87% coverage of query (62.0 bits)

4jihA Crystal structure of akr1b10 complexed with NADP+ and epalrestat
    26% identity, 87% coverage of query (62.0 bits)

4gq0A / O60218 Crystal structure of akr1b10 complexed with NADP+ and caffeic acid phenethyl ester
    26% identity, 87% coverage of query (62.0 bits)

4gabA Human akr1b10 mutant v301l complexed with NADP+ and fidarestat
    26% identity, 87% coverage of query (62.0 bits)

4ga8A Human akr1b10 mutant v301l complexed with NADP+ and sorbinil
    26% identity, 87% coverage of query (62.0 bits)

5m2fX Crystal structure of human akr1b10 complexed with NADP+ and the synthetic retinoid uvi2008
    26% identity, 87% coverage of query (62.0 bits)

Or start over

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory