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Searching for up to 100 curated homologs for CA265_RS03135 FitnessBrowser__Pedo557:CA265_RS03135 (388 a.a.)

Found high-coverage hits (≥70%) to 16 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

SO1963 Homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Shewanella oneidensis MR-1
    47% identity, 99% coverage of query (352 bits)

Psest_3513 Homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Pseudomonas stutzeri RCH2
    32% identity, 92% coverage of query (182 bits)

Build an alignment

Build an alignment for CA265_RS03135 and 2 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

RR42_RS31275 Homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Cupriavidus basilensis FW507-4G11
    25% identity, 73% coverage of query (85.9 bits)

HGD / Q93099 Homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Homo sapiens (see paper)
HGD_HUMAN / Q93099 Homogentisate 1,2-dioxygenase; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Homo sapiens (Human) (see 14 papers)
    24% identity, 74% coverage of query (76.3 bits)

HGD_MOUSE / O09173 Homogentisate 1,2-dioxygenase; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Mus musculus (Mouse) (see paper)
    24% identity, 74% coverage of query (75.5 bits)

B8YB76 homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Bos taurus (see 2 papers)
    24% identity, 75% coverage of query (73.9 bits)

HGD_PSEPU / Q6EMI9 Homogentisate 1,2-dioxygenase; HGDO; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see paper)
    22% identity, 97% coverage of query (64.7 bits)

HGD_CAEEL / Q9Y041 Homogentisate 1,2-dioxygenase; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Caenorhabditis elegans (see paper)
    24% identity, 75% coverage of query (63.5 bits)

HGD_RHIME / Q9X4F5 Homogentisate 1,2-dioxygenase; HGDO; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium meliloti) (see paper)
    24% identity, 71% coverage of query (61.6 bits)

Q9ZRA2 homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Arabidopsis thaliana (see paper)
    21% identity, 97% coverage of query (60.1 bits)

4aq6D / Q88E47 Substrate bound homogentisate 1,2-dioxygenase (see paper)
    23% identity, 71% coverage of query (58.2 bits)

3zdsA Structure of homogentisate 1,2-dioxygenase in complex with reaction intermediates of homogentisate with oxygen.
    23% identity, 71% coverage of query (58.2 bits)

3zdsF Structure of homogentisate 1,2-dioxygenase in complex with reaction intermediates of homogentisate with oxygen.
    23% identity, 71% coverage of query (58.2 bits)

3zdsC Structure of homogentisate 1,2-dioxygenase in complex with reaction intermediates of homogentisate with oxygen.
    23% identity, 71% coverage of query (58.2 bits)

HGD_PSEPK / Q88E47 Homogentisate 1,2-dioxygenase; HGDO; Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase; EC 1.13.11.5 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see 2 papers)
Q88E47 homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Pseudomonas putida (see paper)
    23% identity, 71% coverage of query (57.8 bits)

PfGW456L13_4962 Homogentisate 1,2-dioxygenase (EC 1.13.11.5) from Pseudomonas fluorescens GW456-L13
    23% identity, 71% coverage of query (57.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory