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Searching for up to 100 curated homologs for CA265_RS04375 FitnessBrowser__Pedo557:CA265_RS04375 (453 a.a.)

Found high-coverage hits (≥70%) to 45 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

Q9EYM7 cysteine-S-conjugate beta-lyase (EC 4.4.1.13) from Streptomyces venezuelae (see paper)
    44% identity, 99% coverage of query (371 bits)

7xnzB / P9WP51 Native cystathionine beta-synthase of mycobacterium tuberculosis. (see paper)
    41% identity, 99% coverage of query (337 bits)

Y1077_MYCTU / P9WP51 Probable cystathionine beta-synthase Rv1077; Beta-thionase; Serine sulfhydrase; EC 4.2.1.22 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
    41% identity, 99% coverage of query (337 bits)

7xoyA Cystathionine beta-synthase of mycobacterium tuberculosis in the presence of s-adenosylmethionine and serine.
    41% identity, 99% coverage of query (337 bits)

7qgtB Crystal structure of human cystathionine beta-synthase (delta516-525) in complex with aoaa.
    37% identity, 99% coverage of query (305 bits)

8s5hA / P35520 Full-length human cystathionine beta-synthase with c-terminal 6xhis- tag, basal state, helical reconstruction (see paper)
    37% identity, 99% coverage of query (303 bits)

CBS / P35520 cystathionine β-synthase monomer (EC 4.2.1.22) from Homo sapiens (see 12 papers)
CBS_HUMAN / P35520 Cystathionine beta-synthase; Beta-thionase; Serine sulfhydrase; EC 4.2.1.22 from Homo sapiens (Human) (see 43 papers)
P35520 cystathionine beta-synthase (EC 4.2.1.22) from Homo sapiens (see 18 papers)
    37% identity, 99% coverage of query (303 bits)

Cbs / P32232 cystathionine β-synthase subunit (EC 4.2.1.22) from Rattus norvegicus (see 2 papers)
CBS_RAT / P32232 Cystathionine beta-synthase; Beta-thionase; Hemoprotein H-450; Serine sulfhydrase; EC 4.2.1.22 from Rattus norvegicus (Rat) (see 3 papers)
    38% identity, 95% coverage of query (302 bits)

4pcuA Crystal structure of delta516-525 e201s human cystathionine beta- synthase with adomet
    36% identity, 99% coverage of query (291 bits)

CBS / A0A563XPB1 cystathionine β-synthase (EC 4.2.1.22) from Gallus gallus (see 7 papers)
    39% identity, 95% coverage of query (288 bits)

uptG / AAK53485.1 cystathionine beta-lyase from Xanthomonas campestris pv. campestris (see 4 papers)
    34% identity, 99% coverage of query (271 bits)

3pc3A / Q9VRD9 Full length structure of cystathionine beta-synthase from drosophila in complex with aminoacrylate (see paper)
    36% identity, 99% coverage of query (268 bits)

3pc4A Full length structure of cystathionine beta-synthase from drosophila in complex with serine
    36% identity, 99% coverage of query (268 bits)

Q9VRD9 cystathionine beta-synthase (EC 4.2.1.22) from Drosophila melanogaster (see paper)
    36% identity, 99% coverage of query (267 bits)

3pc2A Full length structure of cystathionine beta-synthase from drosophila
    36% identity, 99% coverage of query (267 bits)

1jbqA Structure of human cystathionine beta-synthase: a unique pyridoxal 5'- phosphate dependent hemeprotein
    43% identity, 71% coverage of query (263 bits)

5ohxA / Q2V0C9 Structure of active cystathionine b-synthase from apis mellifera (see paper)
    38% identity, 99% coverage of query (262 bits)

CBS_APIME / Q2V0C9 Cystathionine beta-synthase; EC 4.2.1.22 from Apis mellifera (Honeybee) (see paper)
Q2V0C9 cystathionine beta-synthase (EC 4.2.1.22) from Apis mellifera (see paper)
    37% identity, 99% coverage of query (261 bits)

CYS4 / P32582 Cys4 (EC 4.2.1.22) from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (see 3 papers)
CBS_YEAST / P32582 Cystathionine beta-synthase; Beta-thionase; Serine sulfhydrase; Sulfur transfer protein 4; EC 4.2.1.22 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
P32582 cystathionine beta-synthase (EC 4.2.1.22) from Saccharomyces cerevisiae (see 3 papers)
    37% identity, 85% coverage of query (256 bits)

6c2hA / P32582 Crystal structures of cystathionine beta-synthase from saccharomyces cerevisiae: the structure of the catalytic core (see paper)
    41% identity, 72% coverage of query (249 bits)

6c2zA Crystal structures of cystathionine beta-synthase from saccharomyces cerevisiae: the structure of the plp-aminoacrylate intermediate
    41% identity, 72% coverage of query (249 bits)

6c2qA Crystal structures of cystathionine beta-synthase from saccharomyces cerevisiae: the structure of the plp-l-serine intermediate
    41% identity, 72% coverage of query (249 bits)

mecA cystathionine beta-synthase; EC 4.2.1.22 from Emericella nidulans (see 2 papers)
    38% identity, 88% coverage of query (248 bits)

6c4pA Crystal structures of cystathionine beta-synthase from saccharomyces cerevisiae: the structure of the pmp complex
    41% identity, 72% coverage of query (248 bits)

6xylA Crystal structure of delta466-491 cystathionine beta-synthase from toxoplasma gondii with l-serine
    36% identity, 88% coverage of query (241 bits)

6xwlC / A0A125YSJ9 Cystathionine beta-synthase from toxoplasma gondii (see paper)
    35% identity, 88% coverage of query (236 bits)

CYSK_SCHPO / O59701 Cysteine synthase 1; CS 1; O-acetylserine (thiol)-lyase 1; OAS-TL 1; O-acetylserine sulfhydrylase 1; O-succinylserine sulfhydrylase; EC 2.5.1.-; EC 2.5.1.47 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 3 papers)
cys11 / RF|NP_595332.1 cysteine synthase from Schizosaccharomyces pombe (see 2 papers)
    39% identity, 72% coverage of query (223 bits)

CYSK_EMENI / P50867 Cysteine synthase 1; CS 1; O-acetylserine (thiol)-lyase 1; OAS-TL 1; O-acetylserine sulfhydrylase 1; O-succinylserine sulfhydrylase; EC 2.5.1.-; EC 2.5.1.47 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see paper)
cysB / GB|AAC06128.1 cysteine synthase; EC 2.5.1.47 from Emericella nidulans (see 3 papers)
    38% identity, 71% coverage of query (222 bits)

6vjuB / Q5ZRD1 Crystal structure of cystathionine beta synthase from legionella pneumophila with llp, plp, and homocysteine
    43% identity, 72% coverage of query (215 bits)

CBS2_CAEEL / Q9N4K2 Putative cystathionine beta-synthase cbs-2; EC 4.2.1.22 from Caenorhabditis elegans (see 2 papers)
    42% identity, 71% coverage of query (214 bits)

CBS1_CAEEL / G5EFH8 Cystathionine beta-synthase cbs-1; Beta-thionase; Serine sulfhydrase; EC 4.2.1.22 from Caenorhabditis elegans (see 2 papers)
    41% identity, 71% coverage of query (212 bits)

CYSKL_SCHPO / P87131 Cysteine synthase 2; CS 2; Cysteine synthase-like protein; CSl; O-acetylserine (thiol)-lyase 2; OAS-TL 2; O-acetylserine sulfhydrylase 2; EC 2.5.1.47 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see 2 papers)
cys12 / RF|NP_593343.1 cysteine synthase Cys12; EC 2.5.1.47 from Schizosaccharomyces pombe (see 2 papers)
    37% identity, 70% coverage of query (206 bits)

OASB / P47999 O-acetylserine (thiol) lyase (EC 2.5.1.47) from Arabidopsis thaliana (see 3 papers)
CYSKP_ARATH / P47999 Cysteine synthase, chloroplastic/chromoplastic; At.OAS.7-4; Beta-substituted Ala synthase 2;1; ARAth-Bsas2;1; CSase B; AtCS-B; CS-B; O-acetylserine (thiol)-lyase; O-acetylserine sulfhydrylase; OAS-TL B; cpACS1; EC 2.5.1.47 from Arabidopsis thaliana (Mouse-ear cress) (see 4 papers)
P47999 cysteine synthase (EC 2.5.1.47) from Arabidopsis thaliana (see 2 papers)
    38% identity, 72% coverage of query (195 bits)

CAS1_SOLTU / Q76MX2 Bifunctional L-3-cyanoalanine synthase/cysteine synthase 1, mitochondrial; EC 2.5.1.47; EC 4.4.1.9 from Solanum tuberosum (Potato) (see 2 papers)
Q76MX2 L-3-cyanoalanine synthase (EC 4.4.1.9) from Solanum tuberosum (see paper)
    38% identity, 71% coverage of query (190 bits)

CAS1 / Q1KLZ2 β-cyanoalanine synthase (EC 4.4.1.9) from Malus domestica (see paper)
CAS1_MALDO / Q1KLZ2 L-3-cyanoalanine synthase 1, mitochondrial; MdCAS1; EC 4.4.1.9 from Malus domestica (Apple) (Pyrus malus) (see paper)
Q1KLZ2 L-3-cyanoalanine synthase (EC 4.4.1.9) from Malus domestica (see paper)
    36% identity, 71% coverage of query (182 bits)

CAS2_SOLTU / Q9FS29 Bifunctional L-3-cyanoalanine synthase/cysteine synthase 2, mitochondrial; EC 2.5.1.47; EC 4.4.1.9 from Solanum tuberosum (Potato) (see paper)
Q9FS29 L-3-cyanoalanine synthase (EC 4.4.1.9) from Solanum tuberosum (see paper)
    37% identity, 70% coverage of query (181 bits)

3vbeC / I1L6I6 Crystal structure of beta-cyanoalanine synthase in soybean (see paper)
    36% identity, 71% coverage of query (180 bits)

3vc3A Crystal structure of beta-cyanoalanine synthase k95a mutant in soybean
    36% identity, 71% coverage of query (178 bits)

sbnA / Q2G1N3 N-(2-amino-2-carboxyethyl)-L-glutamate synthase (EC 2.5.1.140) from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see 3 papers)
SBNA_STAAE / A6QDA0 N-(2-amino-2-carboxyethyl)-L-glutamate synthase; ACEGA synthase; Staphyloferrin B biosynthesis protein SbnA; EC 2.5.1.140 from Staphylococcus aureus (strain Newman) (see 3 papers)
SBNA_STAA8 / Q2G1N3 N-(2-amino-2-carboxyethyl)-L-glutamate synthase; ACEGA synthase; Staphyloferrin B biosynthesis protein SbnA; EC 2.5.1.140 from Staphylococcus aureus (strain NCTC 8325 / PS 47) (see 3 papers)
A6QDA0 N-(2-amino-2-carboxyethyl)-L-glutamate synthase (EC 2.5.1.140) from Staphylococcus aureus (see 2 papers)
Q2G1N3 N-(2-amino-2-carboxyethyl)-L-glutamate synthase (EC 2.5.1.140) from Staphylococcus aureus (see paper)
    33% identity, 70% coverage of query (150 bits)

5d84A / A6QDA0 Staphyloferrin b precursor biosynthetic enzyme sbna bound to plp (see paper)
    33% identity, 70% coverage of query (150 bits)

5d85A Staphyloferrin b precursor biosynthetic enzyme sbna bound to aminoacrylate intermediate
    33% identity, 70% coverage of query (150 bits)

5d86A Staphyloferrin b precursor biosynthetic enzyme sbna y152f variant
    32% identity, 70% coverage of query (149 bits)

5b55A Crystal structure of hydrogen sulfide-producing enzyme (fn1055) d232n mutant in complexed with alpha-aminoacrylate intermediate: lysine- dimethylated form
    33% identity, 77% coverage of query (131 bits)

cysK2 / Q79FV4 3-phospho-L-serine-dependent S-sulfo-L-cysteine synthase (EC 2.8.5.1) from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
CYSK2_MYCTU / Q79FV4 S-sulfocysteine synthase; O-phospho-L-serine-dependent S-sulfocysteine synthase; OPS-dependent S-sulfocysteine synthase; O-phosphoserine sulfhydrylase; EC 2.8.5.1; EC 2.5.1.65 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
Q79FV4 cysteine synthase (EC 2.5.1.47); O-phosphoserine sulfhydrylase (EC 2.5.1.65) from Mycobacterium tuberculosis (see 2 papers)
    30% identity, 71% coverage of query (106 bits)

Build an alignment

Build an alignment for CA265_RS04375 and 44 homologs with ≥ 30% identity

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Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Additional hits (identity < 30%)

Q19374 Putative pyridoxal-phosphate dependent protein F13B12.4 from Caenorhabditis elegans
    25% identity, 71% coverage of query (52.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory