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Searching for up to 100 curated homologs for CA265_RS08130 FitnessBrowser__Pedo557:CA265_RS08130 (325 a.a.)

Found high-coverage hits (≥70%) to 18 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

ASPG_ELIMR / Q47898 N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase; Aspartylglucosaminidase; AGA; Glycosylasparaginase; N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase; EC 3.5.1.26 from Elizabethkingia miricola (Chryseobacterium miricola) (see 4 papers)
Q47898 N4-(beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) from Elizabethkingia miricola (see paper)
    66% identity, 93% coverage of query (415 bits)

1p4vA / Q47898 Crystal structure of the glycosylasparaginase precursor d151n mutant with glycine (see paper)
    68% identity, 90% coverage of query (409 bits)

4r4yA Structural basis of a point mutation that causes the genetic disease aspartylglucosaminuria
    68% identity, 90% coverage of query (408 bits)

A0A141NXG8 N4-(beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) from Leptopilina heterotoma (see paper)
    37% identity, 91% coverage of query (201 bits)

AGA / P20933 glycosylasparaginase α chain (EC 3.5.1.26) from Homo sapiens (see 6 papers)
ASPG_HUMAN / P20933 N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; Aspartylglucosaminidase; Glycosylasparaginase; N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase; EC 3.5.1.26 from Homo sapiens (Human) (see 9 papers)
P20933 N4-(beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) from Homo sapiens (see 5 papers)
    40% identity, 91% coverage of query (193 bits)

ASPG_MOUSE / Q64191 N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; Aspartylglucosaminidase; AGA; Glycosylasparaginase; N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase; EC 3.5.1.26 from Mus musculus (Mouse) (see paper)
    39% identity, 90% coverage of query (182 bits)

ASPG_RAT / P30919 N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase; Aspartylglucosaminidase; AGA; Glycosylasparaginase; N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase; EC 3.5.1.26 from Rattus norvegicus (Rat) (see 2 papers)
    38% identity, 90% coverage of query (172 bits)

ASGL1_RAT / Q8VI04 Isoaspartyl peptidase/L-asparaginase; Asparaginase-like protein 1; Asparaginase-like sperm autoantigen; Beta-aspartyl-peptidase; Glial asparaginase; Isoaspartyl dipeptidase; L-asparagine amidohydrolase; EC 3.4.19.5; EC 3.5.1.1 from Rattus norvegicus (Rat) (see 2 papers)
    38% identity, 82% coverage of query (138 bits)

IAAA_SALTY / Q7CQV5 Isoaspartyl peptidase; Beta-aspartyl-peptidase; Isoaspartyl dipeptidase; EC 3.4.19.5 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
    37% identity, 79% coverage of query (137 bits)

ASGL1_MOUSE / Q8C0M9 Isoaspartyl peptidase/L-asparaginase; Asparaginase-like protein 1; Beta-aspartyl-peptidase; Isoaspartyl dipeptidase; L-asparagine amidohydrolase; EC 3.4.19.5; EC 3.5.1.1 from Mus musculus (Mouse) (see paper)
    37% identity, 82% coverage of query (135 bits)

IAAA_ECOLI / P37595 Isoaspartyl peptidase; Beta-aspartyl-peptidase; EcAIII; Isoaspartyl dipeptidase; EC 3.4.19.5 from Escherichia coli (strain K12) (see 5 papers)
P37595 beta-aspartyl-peptidase (EC 3.4.19.5); asparaginase (EC 3.5.1.1) from Escherichia coli (see 2 papers)
IaaA / ECOCYC|MONOMER0-3 L-asparaginase from Escherichia coli K12 (see paper)
    35% identity, 79% coverage of query (128 bits)

Q5JHT1 asparaginase (EC 3.5.1.1) from Thermococcus kodakarensis (see paper)
    36% identity, 83% coverage of query (128 bits)

ASPG_LUPLU / Q9ZSD6 Isoaspartyl peptidase/L-asparaginase; LlA; L-asparagine amidohydrolase; Potassium-independent L-asparaginase; EC 3.4.19.5 from Lupinus luteus (European yellow lupine) (see paper)
Q9ZSD6 beta-aspartyl-peptidase (EC 3.4.19.5) from Lupinus luteus (see paper)
    36% identity, 80% coverage of query (119 bits)

ASGL1_DANRE / Q5BKW9 Isoaspartyl peptidase/L-asparaginase; Asparaginase-like protein 1; Beta-aspartyl-peptidase; Isoaspartyl dipeptidase; L-asparagine amidohydrolase; EC 3.4.19.5; EC 3.5.1.1 from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
    36% identity, 71% coverage of query (117 bits)

ASPGA_ARATH / P50287 Isoaspartyl peptidase/L-asparaginase 1; L-asparagine amidohydrolase 1; EC 3.4.19.5 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    36% identity, 70% coverage of query (111 bits)

4o48A Crystal structure of cleaved guinea pig l-asparaginase type iii in complex with l-aspartate (see paper)
    36% identity, 71% coverage of query (110 bits)

Q8GXG1 asparaginase (EC 3.5.1.1) from Arabidopsis thaliana (see paper)
    34% identity, 78% coverage of query (105 bits)

Build an alignment

Build an alignment for CA265_RS08130 and 17 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

ASGX_SYNY3 / P74383 Isoaspartyl peptidase/L-asparaginase; Beta-aspartyl-peptidase; Isoaspartyl dipeptidase; EC 3.4.19.5 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
    27% identity, 80% coverage of query (80.5 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory