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Searching for up to 100 curated homologs for CA265_RS09565 FitnessBrowser__Pedo557:CA265_RS09565 (388 a.a.)

Found high-coverage hits (≥70%) to 61 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

galK / CAB44216.1 galactokinase from Lactococcus lactis (see paper)
    47% identity, 97% coverage of query (322 bits)

Q9R7D7 Galactokinase; Galactose kinase; EC 2.7.1.6 from Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
    47% identity, 97% coverage of query (322 bits)

1pieA / Q9R7D7 Crystal structure of lactococcus lactis galactokinase complexed with galactose (see paper)
    47% identity, 97% coverage of query (320 bits)

CA265_RS06125 galactokinase, -1-phosphate forming (EC 2.7.1.6) from Pedobacter sp. GW460-11-11-14-LB5
    38% identity, 93% coverage of query (255 bits)

B1KRG2 glucokinase (EC 2.7.1.2) from Shewanella woodyi (see paper)
    35% identity, 97% coverage of query (230 bits)

B1KDE7 glucokinase (EC 2.7.1.2) from Shewanella woodyi (see paper)
    35% identity, 96% coverage of query (226 bits)

GalA / b0757 galactokinase (EC 2.7.1.6) from Escherichia coli K-12 substr. MG1655 (see 23 papers)
galK / P0A6T3 galactokinase (EC 2.7.1.6) from Escherichia coli (strain K12) (see 22 papers)
GAL1_ECOLI / P0A6T3 Galactokinase; Galactose kinase; EC 2.7.1.6 from Escherichia coli (strain K12) (see 3 papers)
galK / MB|P0A6T3 galactose kinase from Escherichia coli K12 (see 3 papers)
    35% identity, 97% coverage of query (226 bits)

A0A085HKM4 galactokinase (EC 2.7.1.6) from Leminorella grimontii (see paper)
    35% identity, 93% coverage of query (221 bits)

B2UQR6 galactokinase (EC 2.7.1.6) from Akkermansia muciniphila (see paper)
    36% identity, 96% coverage of query (219 bits)

GALK1 / P51570 galactokinase (EC 2.7.1.6) from Homo sapiens (see 5 papers)
GALK1_HUMAN / P51570 Galactokinase; Galactose kinase; EC 2.7.1.6 from Homo sapiens (Human) (see 8 papers)
P51570 galactokinase (EC 2.7.1.6) from Homo sapiens (see 6 papers)
    35% identity, 96% coverage of query (214 bits)

6q8zA Structure of human galactokinase 1 bound with n-(cyclobutylmethyl)-1, 5-dimethyl-1h-pyrazole-4-carboxamide
    35% identity, 96% coverage of query (214 bits)

6q3wC Structure of human galactokinase 1 bound with ethyl 1-(2-pyrazinyl)-4- piperidinecarboxylate
    34% identity, 96% coverage of query (212 bits)

6q3xA / P51570 Structure of human galactokinase in complex with galactose and 2'- (benzo[d]oxazol-2-ylamino)-7',8'-dihydro-1'h-spiro[cyclohexane-1,4'- quinazolin]-5'(6'h)-one (see paper)
    34% identity, 96% coverage of query (211 bits)

Q9GKK4 galactokinase (EC 2.7.1.6) from Canis lupus familiaris (see paper)
    34% identity, 96% coverage of query (211 bits)

6qjeA Structure of human galactokinase 1 bound with 4-{[2-(methylsulfonyl)- 1h-imidazol-1-yl]methyl}-1,3-thiazole
    34% identity, 96% coverage of query (211 bits)

7s4cA Crystal structure of inhibitor-bound galactokinase
    34% identity, 96% coverage of query (211 bits)

7s49A Crystal structure of inhibitor-bound galactokinase
    34% identity, 96% coverage of query (211 bits)

7rclA Crystal structure of adp-bound galactokinase
    34% identity, 96% coverage of query (211 bits)

7ozxB Structure of human galactokinase 1 bound with azepan-1-yl(2,6- difluorophenyl)methanone
    34% identity, 96% coverage of query (211 bits)

6zgyA Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-n- (pyrimidin-2-yl)acetamide
    34% identity, 96% coverage of query (211 bits)

6q91A Structure of human galactokinase 1 bound with 5-chloro-n-isobutyl-2- methoxybenzamide
    34% identity, 96% coverage of query (211 bits)

1wuuA Crystal structure of human galactokinase complexed with mgamppnp and galactose
    35% identity, 96% coverage of query (211 bits)

6zh0A Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-n- (pyrimidin-2-yl)acetamide
    34% identity, 96% coverage of query (209 bits)

6teqA / B7GUI0 Crystal structure of a galactokinase from bifidobacterium infantis in complex with 2-deoxy-2-fluoro-galactose (see paper)
    36% identity, 93% coverage of query (207 bits)

GALK1_MOUSE / Q9R0N0 Galactokinase; Galactose kinase; EC 2.7.1.6 from Mus musculus (Mouse) (see paper)
    34% identity, 96% coverage of query (207 bits)

6terA Crystal structure of a galactokinase from bifidobacterium infantis in complex with galactose
    36% identity, 93% coverage of query (207 bits)

6q90C Structure of human galactokinase 1 bound with 1-(4-methoxyphenyl)-3- (4-pyridinyl)urea
    34% identity, 96% coverage of query (206 bits)

6zfhA Structure of human galactokinase in complex with galactose and 2'- (benzo[d]oxazol-2-ylamino)-7',8'-dihydro-1'h-spiro[cyclopentane-1,4'- quinazolin]-5'(6'h)-one
    34% identity, 96% coverage of query (205 bits)

6gr2A Structure of human galactokinase in complex with galactose and adp
    34% identity, 96% coverage of query (203 bits)

6zgvD Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-n- (pyrimidin-2-yl)acetamide
    36% identity, 96% coverage of query (203 bits)

B1KD89 glucokinase (EC 2.7.1.2) from Shewanella woodyi (see paper)
    34% identity, 99% coverage of query (202 bits)

6zgwD Structure of human galactokinase 1 bound with (4-chlorophenyl)methyl pyridine-3-carboxylate
    37% identity, 92% coverage of query (200 bits)

6tepA Crystal structure of a galactokinase from bifidobacterium infantis in complex with adp
    35% identity, 93% coverage of query (199 bits)

6zgzD Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-n- (pyrimidin-2-yl)acetamide
    36% identity, 92% coverage of query (196 bits)

6zgxD Structure of human galactokinase 1 bound with 2-(4-chlorophenyl)-n- (pyrimidin-2-yl)acetamide
    37% identity, 92% coverage of query (196 bits)

Q9K3S8 galactokinase (EC 2.7.1.6) from Streptomyces coelicolor (see paper)
    34% identity, 91% coverage of query (192 bits)

6qjeD Structure of human galactokinase 1 bound with 4-{[2-(methylsulfonyl)- 1h-imidazol-1-yl]methyl}-1,3-thiazole
    34% identity, 97% coverage of query (190 bits)

1s4eF / Q9HHB6 Pyrococcus furiosus galactokinase in complex with galactose, adp and magnesium (see paper)
    36% identity, 92% coverage of query (189 bits)

GAL1_PYRFU / Q9HHB6 Galactokinase; Galactose kinase; EC 2.7.1.6 from Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) (see 3 papers)
    36% identity, 92% coverage of query (189 bits)

GAL1_PYRHO / O58107 Galactokinase; Galactose kinase; EC 2.7.1.6 from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see paper)
2deiA / O58107 Crystal structure of galaktokinase from pyrococcus horikoshii with amp-pnp and galactose
    35% identity, 92% coverage of query (189 bits)

6q91D / P51570 Structure of human galactokinase 1 bound with 5-chloro-n-isobutyl-2- methoxybenzamide
    34% identity, 96% coverage of query (185 bits)

2dejA Crystal structure of galaktokinase from pyrococcus horikoshii with amp-pn and galactose
    34% identity, 92% coverage of query (178 bits)

Build an alignment

Build an alignment for CA265_RS09565 and 42 homologs with ≥ 30% identity

Select sequences

Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

Or download the sequences

Change minimum %identity:

Additional hits (identity < 30%)

GALK / B6V3B9 galactokinase (EC 2.7.1.6) from Cucumis melo (see paper)
    29% identity, 93% coverage of query (126 bits)

AGK1 / Q9SEE5 galactokinase (EC 2.7.1.6) from Arabidopsis thaliana (see paper)
GALK1_ARATH / Q9SEE5 Galactokinase; Galactose kinase; EC 2.7.1.6 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
    30% identity, 88% coverage of query (119 bits)

GALAK_ARATH / Q8VYG2 Galacturonokinase; D-galacturonic acid-1-P kinase; EC 2.7.1.44 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    28% identity, 88% coverage of query (119 bits)

2a2cA X-ray structure of human n-acetyl galactosamine kinase complexed with mg-adp and n-acetyl galactosamine 1-phosphate
    28% identity, 97% coverage of query (119 bits)

2a2dA / Q01415 X-ray structure of human n-acetyl galactosamine kinase complexed with mn-amppnp and n-acetyl glactosamine (see paper)
    28% identity, 97% coverage of query (117 bits)

GALK2_HUMAN / Q01415 N-acetylgalactosamine kinase; GalNAc kinase; Galactokinase 2; EC 2.7.1.157 from Homo sapiens (Human) (see paper)
Q01415 N-acetylgalactosamine kinase (EC 2.7.1.157) from Homo sapiens (see 2 papers)
    28% identity, 93% coverage of query (117 bits)

Q4DF18 galactokinase (EC 2.7.1.6) from Trypanosoma cruzi (see paper)
    28% identity, 94% coverage of query (114 bits)

galE galactokinase from Emericella nidulans (see paper)
    26% identity, 98% coverage of query (105 bits)

Q4DFH6 galactokinase (EC 2.7.1.6) from Trypanosoma cruzi (see paper)
    26% identity, 94% coverage of query (102 bits)

1s4eG / Q9HHB6 Pyrococcus furiosus galactokinase in complex with galactose, adp and magnesium (see paper)
    29% identity, 82% coverage of query (82.8 bits)

ARA1 / O23461 arabinose kinase (EC 2.7.1.46) from Arabidopsis thaliana (see paper)
ARAK_ARATH / O23461 L-arabinokinase; AtISA1; EC 2.7.1.46 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
O23461 L-arabinokinase (EC 2.7.1.46) from Arabidopsis thaliana (see paper)
    22% identity, 81% coverage of query (72.4 bits)

A0A1I9LRU1 L-arabinokinase (EC 2.7.1.46) from Arabidopsis thaliana (see paper)
    24% identity, 82% coverage of query (71.6 bits)

mvk / Q58487 mevalonate kinase monomer (EC 2.7.1.36) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (see 2 papers)
MVK_METJA / Q58487 Mevalonate kinase; MK; MVK; EC 2.7.1.36 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see 2 papers)
Q58487 mevalonate kinase (EC 2.7.1.36) from Methanocaldococcus jannaschii (see paper)
    27% identity, 83% coverage of query (70.1 bits)

4hacA / Q8PW39 Crystal structure of the mevalonate kinase from an archaeon methanosarcina mazei (see paper)
    25% identity, 83% coverage of query (62.4 bits)

6mdeA Mevalonate kinase from methanosarcina mazei with mevalonate bound
    25% identity, 83% coverage of query (62.4 bits)

6mdfA Mevalonate kinase from methanosarcina mazei with 5-phosphomevalonate bound
    25% identity, 83% coverage of query (62.4 bits)

mvk / Q8PW39 mevalonate kinase monomer (EC 2.7.1.36) from Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (see 7 papers)
Q8PW39 mevalonate kinase (EC 2.7.1.36) from Methanosarcina mazei (see paper)
    25% identity, 83% coverage of query (62.0 bits)

8tebA / Q12TI0 Structure of mkbur (see paper)
    24% identity, 84% coverage of query (54.7 bits)

ERG12_CANAL / A0A1D8PEL1 Mevalonate kinase; MK; MvK; Ergosterol biosynthesis protein 12; Regulation of autonomous replication protein 1; EC 2.7.1.36 from Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (see paper)
    23% identity, 89% coverage of query (51.6 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory