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Searching for up to 100 curated homologs for CA265_RS10200 FitnessBrowser__Pedo557:CA265_RS10200 (260 a.a.)

Found high-coverage hits (≥70%) to 46 curated proteins.

You can add additional sequences or change the %identity threshold for inclusion. Once you have selected sequences, you can build an alignment and a tree.

Hits with ≥ 30% identity

HDPA_CORGB / A4QFW4 Dihydroxyacetone phosphatase; EC 3.1.3.- from Corynebacterium glutamicum (strain R) (see paper)
    41% identity, 98% coverage of query (202 bits)

UmpH / b0675 UMP phosphatase (EC 3.1.3.5) from Escherichia coli K-12 substr. MG1655 (see 9 papers)
umpH / P0AF24 UMP phosphatase (EC 3.1.3.5) from Escherichia coli (strain K12) (see 7 papers)
NAGD_ECOLI / P0AF24 Ribonucleotide monophosphatase NagD; EC 3.1.3.5 from Escherichia coli (strain K12) (see 2 papers)
2c4nA / P0AF24 Nagd from e.Coli k-12 strain (see paper)
    38% identity, 95% coverage of query (174 bits)

Sama_2099 UMP phosphatase (EC 3.1.3.5) from Shewanella amazonensis SB2B
    36% identity, 95% coverage of query (172 bits)

Q8L1N9 4-nitrophenylphosphatase (EC 3.1.3.41) from Geobacillus stearothermophilus (see paper)
    37% identity, 96% coverage of query (161 bits)

4o8cB / Q8L1N9 Structure of the h170y mutant of thermostable p-nitrophenylphosphatase from bacillus stearothermophilus (see paper)
    37% identity, 96% coverage of query (160 bits)

YUTF_BACSU / O32125 5'-nucleotidase YutF; EC 3.1.3.5 from Bacillus subtilis (strain 168) (see paper)
O32125 5'-nucleotidase (EC 3.1.3.5) from Bacillus subtilis (see paper)
    35% identity, 95% coverage of query (152 bits)

NAGD_STAAM / Q99VE8 Acid sugar phosphatase; EC 3.1.3.- from Staphylococcus aureus (strain Mu50 / ATCC 700699) (see paper)
    37% identity, 92% coverage of query (138 bits)

1ydfA / A0A0H2UQJ9 Crystal structure of a had-like phosphatase from streptococcus pneumoniae
    34% identity, 97% coverage of query (131 bits)

4jdpB / O29873 Crystal structure of probable p-nitrophenyl phosphatase (pho2) (target efi-501307) from archaeoglobus fulgidus dsm 4304 with magnesium bound
    31% identity, 96% coverage of query (129 bits)

3qgmA P-nitrophenyl phosphatase from archaeoglobus fulgidus
    31% identity, 96% coverage of query (129 bits)

1zjjB / O59622 Crystal structure of hypothetical protein ph1952 from pyrococcus horikoshii ot3
    33% identity, 95% coverage of query (124 bits)

4bx2A Crystal structure of murine chronophin (pyridoxal phosphate phosphatase) in complex with beryllium trifluoride
    30% identity, 90% coverage of query (119 bits)

5aesA Crystal structure of murine chronophin (pyridoxal phosphate phosphatase) in complex with a pnp-derived inhibitor
    30% identity, 90% coverage of query (119 bits)

PLPP_MOUSE / P60487 Chronophin; Pyridoxal 5'-phosphate phosphatase; Pyridoxal phosphate phosphatase; PLP phosphatase; EC 3.1.3.16; EC 3.1.3.74 from Mus musculus (Mouse) (see 3 papers)
P60487 pyridoxal phosphatase (EC 3.1.3.74) from Mus musculus (see 2 papers)
    30% identity, 90% coverage of query (116 bits)

gtp3 / Q9R919 glycerol-2-phosphotransferase from Streptococcus pneumoniae (see paper)
    30% identity, 96% coverage of query (116 bits)

5gynA / Q96GD0 Crystal structure of human pyridoxal 5'-phosphate phosphatase (chronophin) mutant - c221s
    30% identity, 90% coverage of query (115 bits)

2oycA Crystal structure of human pyridoxal phosphate phosphatase
    30% identity, 90% coverage of query (114 bits)

2cftA Crystal structure of human pyridoxal 5'-phosphate phosphatase with its substrate
    30% identity, 90% coverage of query (114 bits)

Build an alignment

Build an alignment for CA265_RS10200 and 18 homologs with ≥ 30% identity

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Add sequences from UniProt, PDB, RefSeq, or MicrobesOnline (separate identifiers with commas or spaces):

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Change minimum %identity:

Additional hits (identity < 30%)

PLPP_HUMAN / Q96GD0 Chronophin; Pyridoxal phosphate phosphatase; PLP phosphatase; EC 3.1.3.16; EC 3.1.3.74 from Homo sapiens (Human) (see 4 papers)
Q96GD0 pyridoxal phosphatase (EC 3.1.3.74) from Homo sapiens (see 6 papers)
    29% identity, 90% coverage of query (113 bits)

PLPP_BOVIN / Q3ZBF9 Chronophin; Protein serine phosphatase; Pyridoxal phosphate phosphatase; PLP phosphatase; EC 3.1.3.16; EC 3.1.3.74 from Bos taurus (Bovine) (see paper)
    29% identity, 90% coverage of query (111 bits)

pnppase / CAM57980.1 para nitrophenyl phosphate phosphatase from Plasmodium falciparum (see paper)
    30% identity, 95% coverage of query (103 bits)

ARAL_BACSU / P94526 Sugar-phosphatase AraL; Arabinose operon protein AraL; Phosphoserine phosphatase; EC 3.1.3.23; EC 3.1.3.3 from Bacillus subtilis (strain 168) (see 3 papers)
    30% identity, 95% coverage of query (101 bits)

4bkmA / P60487,Q8CHP8 Crystal structure of the murine aum (phosphoglycolate phosphatase) capping domain as a fusion protein with the catalytic core domain of murine chronophin (pyridoxal phosphate phosphatase) (see paper)
    29% identity, 90% coverage of query (100 bits)

PGLP2 / Q8GWU0 phosphoglycolate phosphatase 2 monomer (EC 3.1.3.18) from Arabidopsis thaliana (see 4 papers)
PGP2_ARATH / Q8GWU0 Phosphoglycolate phosphatase 2; EC 3.1.3.18 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    30% identity, 95% coverage of query (93.6 bits)

PGLP1A / P0DKC3 phosphoglycolate phosphatase 1A monomer (EC 3.1.3.18) from Arabidopsis thaliana (see 4 papers)
PGP1A_ARATH / P0DKC3 Phosphoglycolate phosphatase 1A, chloroplastic; EC 3.1.3.18 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
    30% identity, 97% coverage of query (92.8 bits)

PGP_HUMAN / A6NDG6 Glycerol-3-phosphate phosphatase; G3PP; Aspartate-based ubiquitous Mg(2+)-dependent phosphatase; AUM; Phosphoglycolate phosphatase; PGP; EC 3.1.3.21; EC 3.1.3.48 from Homo sapiens (Human) (see 2 papers)
    28% identity, 95% coverage of query (91.3 bits)

G3PP_MYCTU / O33194 D-glycerol 3-phosphate phosphatase; D,L-glycerol 3-phosphate phosphatase; G3P phosphatase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
O33194 glycerol-1-phosphatase (EC 3.1.3.21) from Mycobacterium tuberculosis (see 2 papers)
    30% identity, 87% coverage of query (87.0 bits)

4i9fA / L7N4Y2 Crystal structure of glycerol phosphate phosphatase rv1692 from mycobacterium tuberculosis in complex with calcium (see paper)
    30% identity, 87% coverage of query (87.0 bits)

4i9gA Crystal structure of glycerol phosphate phosphatase rv1692 from mycobacterium tuberculosis in complex with magnesium
    30% identity, 87% coverage of query (87.0 bits)

Pgp1 / Q948T5 phosphoglycolate phosphatase monomer (EC 3.1.3.18) from Chlamydomonas reinhardtii (see 2 papers)
Q948T5 phosphoglycolate phosphatase (EC 3.1.3.18) from Chlamydomonas reinhardtii (see paper)
Pgp1 / BAB69477.1 phosphoglycolate phosphatase precursor from Chlamydomonas reinhardtii (see paper)
    29% identity, 95% coverage of query (85.5 bits)

PGP_MOUSE / Q8CHP8 Glycerol-3-phosphate phosphatase; G3PP; Aspartate-based ubiquitous Mg(2+)-dependent phosphatase; AUM; Phosphoglycolate phosphatase; PGP; EC 3.1.3.21; EC 3.1.3.48 from Mus musculus (Mouse) (see 2 papers)
Q8CHP8 phosphoglycolate phosphatase (EC 3.1.3.18); protein-tyrosine-phosphatase (EC 3.1.3.48); pyridoxal phosphatase (EC 3.1.3.74) from Mus musculus (see 4 papers)
    30% identity, 87% coverage of query (85.1 bits)

PGP_RAT / D3ZDK7 Glycerol-3-phosphate phosphatase; G3PP; Aspartate-based ubiquitous Mg(2+)-dependent phosphatase; AUM; Phosphoglycolate phosphatase; PGP; EC 3.1.3.21; EC 3.1.3.48 from Rattus norvegicus (Rat) (see paper)
    29% identity, 87% coverage of query (84.7 bits)

7po7H / Q8CHP8 Phosphoglycolate phosphatase from mus musculus
    28% identity, 95% coverage of query (83.2 bits)

7poeA Phosphoglycolate phosphatase with inhibitor cp1
    28% identity, 95% coverage of query (83.2 bits)

Q9D7I5 phosphohistidine phosphatase (EC 3.9.1.3) from Mus musculus (see paper)
    30% identity, 86% coverage of query (81.6 bits)

LHPP_HUMAN / Q9H008 Phospholysine phosphohistidine inorganic pyrophosphate phosphatase; hLHPP; EC 3.1.3.-; EC 3.6.1.1 from Homo sapiens (Human) (see 2 papers)
Q9H008 phosphohistidine phosphatase (EC 3.9.1.3) from Homo sapiens (see paper)
    26% identity, 92% coverage of query (75.9 bits)

PHO15 p-nitrophenyl phosphatase from Candida albicans (see paper)
    27% identity, 88% coverage of query (75.1 bits)

Q3UGR5 Haloacid dehalogenase-like hydrolase domain-containing protein 2 from Mus musculus (Mouse)
    25% identity, 86% coverage of query (73.9 bits)

2ho4B / Q3UGR5 Crystal structure of protein from mouse mm.236127
    26% identity, 86% coverage of query (72.8 bits)

CG15739 / Q9VYT0 farnesyl phosphatase (EC 3.6.1.68) from Drosophila melanogaster (see paper)
    26% identity, 87% coverage of query (69.7 bits)

2x4dA / Q9H008 Crystal structure of human phospholysine phosphohistidine inorganic pyrophosphate phosphatase lhpp
    25% identity, 92% coverage of query (67.0 bits)

LHPP_BOVIN / Q0VD18 Phospholysine phosphohistidine inorganic pyrophosphate phosphatase; EC 3.1.3.-; EC 3.6.1.1 from Bos taurus (Bovine) (see 2 papers)
    26% identity, 95% coverage of query (64.7 bits)

pho2 / RF|NP_596255.1 4-nitrophenylphosphatase; EC 3.1.3.41 from Schizosaccharomyces pombe (see 2 papers)
    25% identity, 88% coverage of query (63.9 bits)

PNPP_YEAST / P19881 4-nitrophenylphosphatase; PNPPase; EC 3.1.3.41 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
    23% identity, 80% coverage of query (62.8 bits)

2x4dB / Q9H008 Crystal structure of human phospholysine phosphohistidine inorganic pyrophosphate phosphatase lhpp
    25% identity, 85% coverage of query (52.8 bits)

2hx1A Crystal structure of possible sugar phosphatase, had superfamily (zp_00311070.1) from cytophaga hutchinsonii atcc 33406 at 2.10 a resolution
    25% identity, 88% coverage of query (50.4 bits)

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by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory